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O94552

- FUMH_SCHPO

UniProt

O94552 - FUMH_SCHPO

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Protein

Fumarate hydratase, mitochondrial

Gene

fum1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-malate = fumarate + H2O.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei155 – 1551SubstrateBy similarity

GO - Molecular functioni

  1. fumarate hydratase activity Source: PomBase

GO - Biological processi

  1. fumarate metabolic process Source: PomBase
  2. tricarboxylic acid cycle Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Tricarboxylic acid cycle

Enzyme and pathway databases

ReactomeiREACT_213505. Citric acid cycle (TCA cycle).
UniPathwayiUPA00223; UER01007.

Names & Taxonomyi

Protein namesi
Recommended name:
Fumarate hydratase, mitochondrial (EC:4.2.1.2)
Short name:
Fumarase
Gene namesi
Name:fum1
ORF Names:SPCC18.18c, SPCC290.01c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome III

Organism-specific databases

PomBaseiSPCC18.18c.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: PomBase
  2. mitochondrial matrix Source: PomBase
  3. tricarboxylic acid cycle enzyme complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3939MitochondrionSequence AnalysisAdd
BLAST
Chaini40 – 520481Fumarate hydratase, mitochondrialPRO_0000010332Add
BLAST

Proteomic databases

MaxQBiO94552.
PaxDbiO94552.

Interactioni

Protein-protein interaction databases

BioGridi275911. 1 interaction.
MINTiMINT-4685155.
STRINGi4896.SPCC18.18c-1.

Structurei

3D structure databases

ProteinModelPortaliO94552.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni184 – 1874B siteBy similarity
Regioni194 – 1963Substrate bindingBy similarity

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0114.
HOGENOMiHOG000061736.
InParanoidiO94552.
KOiK01679.
OMAiMFSGPMT.
OrthoDBiEOG73NGC9.
PhylomeDBiO94552.

Family and domain databases

Gene3Di1.10.275.10. 1 hit.
HAMAPiMF_00743. FumaraseC.
InterProiIPR005677. Fum_hydII.
IPR024083. Fumarase/histidase_N.
IPR018951. Fumarase_C_C.
IPR020557. Fumarate_lyase_CS.
IPR000362. Fumarate_lyase_fam.
IPR022761. Fumarate_lyase_N.
IPR008948. L-Aspartase-like.
[Graphical view]
PANTHERiPTHR11444. PTHR11444. 1 hit.
PfamiPF10415. FumaraseC_C. 1 hit.
PF00206. Lyase_1. 1 hit.
[Graphical view]
PRINTSiPR00149. FUMRATELYASE.
SUPFAMiSSF48557. SSF48557. 1 hit.
TIGRFAMsiTIGR00979. fumC_II. 1 hit.
PROSITEiPS00163. FUMARATE_LYASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O94552-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MASVAHISTA KAIFRAGGLP CRRLITPTLT GLPLKTHRMN STTPTYHLIP
60 70 80 90 100
KGGKHGEFRQ ESDTFGPIQV PAEKYWGAQT QRSLQNFRIG GEKERLPLPL
110 120 130 140 150
VRAFGVLKRA AASVNREFGL DPKLADAIEQ AAQEVIDGRL DDNFPLVVFQ
160 170 180 190 200
TGSGTQSNMN SNEVIANRAI EILGGTLGSK KPVHPNDHVN MSQSSNDTFP
210 220 230 240 250
TVMHIASVLQ IHTHLLPAMK HLHRALKGKE EEFKNIIKIG RTHMQDATPL
260 270 280 290 300
SLGQEFSGYV TQVGYGIERI NNALPRLCLL AQGGTAVGTG LNTFEGFDVK
310 320 330 340 350
VAEKVSKLTN IEFKTAPNKF EALAAHDAIV EMSGALNVIA CSLMKIANDI
360 370 380 390 400
RQLGSGPRCG LGELILPANE PGSSIMPGKV NPTQCEALTM VCAQVMGNHA
410 420 430 440 450
TITVAGASGH CELNVFKPLL AKNILSSIRL LGDACESFTD HCVVGIEPNY
460 470 480 490 500
EGIARHLRDS LMLVTALNPH IGYDNCAKIA KTALKNKSTL KHEFVTLGFG
510 520
TPEQFDEWVR PELMISAKKV
Length:520
Mass (Da):56,322
Last modified:September 22, 2009 - v3
Checksum:i4AF0DA8BF5E14AE8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA. Translation: CAA21432.3.
PIRiT41265.
RefSeqiNP_588397.3. NM_001023388.3.

Genome annotation databases

EnsemblFungiiSPCC18.18c.1; SPCC18.18c.1:pep; SPCC18.18c.
GeneIDi2539345.
KEGGispo:SPCC18.18c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA. Translation: CAA21432.3 .
PIRi T41265.
RefSeqi NP_588397.3. NM_001023388.3.

3D structure databases

ProteinModelPortali O94552.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 275911. 1 interaction.
MINTi MINT-4685155.
STRINGi 4896.SPCC18.18c-1.

Proteomic databases

MaxQBi O94552.
PaxDbi O94552.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPCC18.18c.1 ; SPCC18.18c.1:pep ; SPCC18.18c .
GeneIDi 2539345.
KEGGi spo:SPCC18.18c.

Organism-specific databases

PomBasei SPCC18.18c.

Phylogenomic databases

eggNOGi COG0114.
HOGENOMi HOG000061736.
InParanoidi O94552.
KOi K01679.
OMAi MFSGPMT.
OrthoDBi EOG73NGC9.
PhylomeDBi O94552.

Enzyme and pathway databases

UniPathwayi UPA00223 ; UER01007 .
Reactomei REACT_213505. Citric acid cycle (TCA cycle).

Miscellaneous databases

NextBioi 20800510.
PROi O94552.

Family and domain databases

Gene3Di 1.10.275.10. 1 hit.
HAMAPi MF_00743. FumaraseC.
InterProi IPR005677. Fum_hydII.
IPR024083. Fumarase/histidase_N.
IPR018951. Fumarase_C_C.
IPR020557. Fumarate_lyase_CS.
IPR000362. Fumarate_lyase_fam.
IPR022761. Fumarate_lyase_N.
IPR008948. L-Aspartase-like.
[Graphical view ]
PANTHERi PTHR11444. PTHR11444. 1 hit.
Pfami PF10415. FumaraseC_C. 1 hit.
PF00206. Lyase_1. 1 hit.
[Graphical view ]
PRINTSi PR00149. FUMRATELYASE.
SUPFAMi SSF48557. SSF48557. 1 hit.
TIGRFAMsi TIGR00979. fumC_II. 1 hit.
PROSITEi PS00163. FUMARATE_LYASES. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.

Entry informationi

Entry nameiFUMH_SCHPO
AccessioniPrimary (citable) accession number: O94552
Secondary accession number(s): O74868
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: September 22, 2009
Last modified: October 29, 2014
This is version 99 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

There are 2 substrate-binding sites: the catalytic A site, and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively, the B site may bind allosteric effectors (By similarity).By similarity

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3