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Protein

Fumarate hydratase, mitochondrial

Gene

fum1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Miscellaneous

There are 2 substrate-binding sites: the catalytic A site, and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively, the B site may bind allosteric effectors (By similarity).By similarity

Catalytic activityi

(S)-malate = fumarate + H2O.

Pathwayi: tricarboxylic acid cycle

This protein is involved in step 1 of the subpathway that synthesizes (S)-malate from fumarate.
Proteins known to be involved in this subpathway in this organism are:
  1. Fumarate hydratase, mitochondrial (fum1)
This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-malate from fumarate, the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei155SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processTricarboxylic acid cycle

Enzyme and pathway databases

ReactomeiR-SPO-71403 Citric acid cycle (TCA cycle)
UniPathwayiUPA00223; UER01007

Names & Taxonomyi

Protein namesi
Recommended name:
Fumarate hydratase, mitochondrial (EC:4.2.1.2)
Short name:
Fumarase
Gene namesi
Name:fum1
ORF Names:SPCC18.18c, SPCC290.01c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:SPCC18.18c
PomBaseiSPCC18.18c fum1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 39MitochondrionSequence analysisAdd BLAST39
ChainiPRO_000001033240 – 520Fumarate hydratase, mitochondrialAdd BLAST481

Proteomic databases

MaxQBiO94552
PaxDbiO94552
PRIDEiO94552

PTM databases

SwissPalmiO94552

Interactioni

Protein-protein interaction databases

BioGridi2759111 interactor.
STRINGi4896.SPCC18.18c.1

Structurei

3D structure databases

ProteinModelPortaliO94552
SMRiO94552
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni184 – 187B siteBy similarity4
Regioni194 – 196Substrate bindingBy similarity3

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOGENOMiHOG000061736
InParanoidiO94552
KOiK01679
OMAiVSFTDNC
OrthoDBiEOG092C5NA9
PhylomeDBiO94552

Family and domain databases

CDDicd01362 Fumarase_classII, 1 hit
Gene3Di1.10.275.101 hit
HAMAPiMF_00743 FumaraseC, 1 hit
InterProiView protein in InterPro
IPR005677 Fum_hydII
IPR024083 Fumarase/histidase_N
IPR018951 Fumarase_C_C
IPR020557 Fumarate_lyase_CS
IPR000362 Fumarate_lyase_fam
IPR022761 Fumarate_lyase_N
IPR008948 L-Aspartase-like
PANTHERiPTHR11444 PTHR11444, 1 hit
PfamiView protein in Pfam
PF10415 FumaraseC_C, 1 hit
PF00206 Lyase_1, 1 hit
PRINTSiPR00149 FUMRATELYASE
SUPFAMiSSF48557 SSF48557, 1 hit
TIGRFAMsiTIGR00979 fumC_II, 1 hit
PROSITEiView protein in PROSITE
PS00163 FUMARATE_LYASES, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O94552-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASVAHISTA KAIFRAGGLP CRRLITPTLT GLPLKTHRMN STTPTYHLIP
60 70 80 90 100
KGGKHGEFRQ ESDTFGPIQV PAEKYWGAQT QRSLQNFRIG GEKERLPLPL
110 120 130 140 150
VRAFGVLKRA AASVNREFGL DPKLADAIEQ AAQEVIDGRL DDNFPLVVFQ
160 170 180 190 200
TGSGTQSNMN SNEVIANRAI EILGGTLGSK KPVHPNDHVN MSQSSNDTFP
210 220 230 240 250
TVMHIASVLQ IHTHLLPAMK HLHRALKGKE EEFKNIIKIG RTHMQDATPL
260 270 280 290 300
SLGQEFSGYV TQVGYGIERI NNALPRLCLL AQGGTAVGTG LNTFEGFDVK
310 320 330 340 350
VAEKVSKLTN IEFKTAPNKF EALAAHDAIV EMSGALNVIA CSLMKIANDI
360 370 380 390 400
RQLGSGPRCG LGELILPANE PGSSIMPGKV NPTQCEALTM VCAQVMGNHA
410 420 430 440 450
TITVAGASGH CELNVFKPLL AKNILSSIRL LGDACESFTD HCVVGIEPNY
460 470 480 490 500
EGIARHLRDS LMLVTALNPH IGYDNCAKIA KTALKNKSTL KHEFVTLGFG
510 520
TPEQFDEWVR PELMISAKKV
Length:520
Mass (Da):56,322
Last modified:September 22, 2009 - v3
Checksum:i4AF0DA8BF5E14AE8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA Translation: CAA21432.3
PIRiT41265
RefSeqiNP_588397.3, NM_001023388.3

Genome annotation databases

EnsemblFungiiSPCC18.18c.1; SPCC18.18c.1:pep; SPCC18.18c
GeneIDi2539345
KEGGispo:SPCC18.18c

Similar proteinsi

Entry informationi

Entry nameiFUMH_SCHPO
AccessioniPrimary (citable) accession number: O94552
Secondary accession number(s): O74868
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: September 22, 2009
Last modified: February 28, 2018
This is version 122 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome