Reviewed,
UniProtKB/Swiss-Prot O94526 (PTEN_SCHPO)
Last modified
January 19, 2010.
Version 46.
History...
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase ptn1 EC=3.1.3.67 | ||||
| Gene names |
| ||||
| Organism | Schizosaccharomyces pombe (Fission yeast) [Complete proteome] | ||||
| Taxonomic identifier | 4896 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces |
Protein attributes
| Sequence length | 348 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Acts as a phosphoinositide 3-phosphatase and regulates PtdIns(3,4,5)P3 levels. Ref.2 |
| Catalytic activity | Phosphatidylinositol 3,4,5-trisphosphate + H2O = phosphatidylinositol 4,5-bisphosphate + phosphate. |
| Subcellular location | |
| Sequence similarities | Contains 1 phosphatase tensin-type domain. |
Ontologies
Sequence annotation (Features)
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "The genome sequence of Schizosaccharomyces pombe." Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. Nurse P.Nature 415:871-880(2002) [PubMed: 11859360] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 38366 / 972. |
| [2] | "A novel phosphatidylinositol(3,4,5)P3 pathway in fission yeast." Mitra P., Zhang Y., Rameh L.E., Ivshina M.P., McCollum D., Nunnari J.J., Hendricks G.M., Kerr M.L., Field S.J., Cantley L.C., Ross A.H. J. Cell Biol. 166:205-211(2004) [PubMed: 15249580] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | CU329671 Genomic DNA. Translation: CAA22831.1. |
| PIR | T40573. |
| RefSeq | NP_596312.1. |
3D structure databases | |
| HSSP | HSSP built from PDB template 2BZL based on UniProtKB Q15678. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | O94526. |
Genome annotation databases | |
| GeneID | 2541101. |
| GenomeReviews | Gene locus ptn1 in contig CU329671_GR. |
| KEGG | spo:SPBC609.02. |
| NMPDR | fig|4896.1.peg.2178. |
Organism-specific databases | |
| GeneDB_Spombe | SPBC609.02. |
Phylogenomic databases | |
| eggNOG | fuNOG06623. |
| OrthoDB | EOG9DZ3BQ. |
| PhylomeDB | O94526. |
Gene expression databases | |
| ArrayExpress | O94526. |
Family and domain databases | |
| InterPro | IPR000340. Dual-sp_phosphatase_cat-dom. IPR014019. Phosphatase_tensin-typ. IPR016130. Tyr_Pase_AS. [Graphical view] |
| Pfam | PF00782. DSPc. 1 hit. [Graphical view] |
| PROSITE | PS51181. PPASE_TENSIN. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | PTEN_SCHPO | ||||||||
| Accession | Primary (citable) accession number: O94526 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | FPAP (Fungal Proteome Annotation Project) | ||||||||
Relevant documents
| Schizosaccharomyces pombe Schizosaccharomyces pombe: entries and gene names |
| SIMILARITY comments Index of protein domains and families |

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