O94526 (PTEN_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase ptn1
EC=3.1.3.67

Gene names

Name:	ptn1
ORF Names:	SPBC609.02

Organism

Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)

Taxonomic identifier

284812 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces

Protein attributes

Sequence length	348 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Acts as a phosphoinositide 3-phosphatase and regulates PtdIns(3,4,5)P3 levels. Ref.2
Catalytic activity	Phosphatidylinositol 3,4,5-trisphosphate + H2O = phosphatidylinositol 4,5-bisphosphate + phosphate.
Subcellular location	Cytoplasmic vesicle Ref.2.
Sequence similarities	Contains 1 phosphatase tensin-type domain.

Ontologies

Keywords
Cellular component	Cytoplasmic vesicle
Molecular function	Hydrolase Protein phosphatase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	cellular water homeostasis Inferred from mutant phenotype. Source: GeneDB_Spombe phosphatidylinositol metabolic process Inferred from mutant phenotype. Source: GeneDB_Spombe signal transduction Inferred by curator. Source: GeneDB_Spombe vacuole organization Inferred from mutant phenotype. Source: GeneDB_Spombe
Cellular component	cytoplasmic membrane-bounded vesicle Inferred from electronic annotation. Source: UniProtKB-SubCell cytosol Inferred from direct assay. Source: GeneDB_Spombe mitochondrion Inferred from direct assay. Source: GeneDB_Spombe
Molecular function	phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity Inferred from direct assay. Source: GeneDB_Spombe protein tyrosine phosphatase activity Inferred from electronic annotation. Source: InterPro protein tyrosine/serine/threonine phosphatase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 348	348	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase ptn1		PRO_0000353823
Regions
	Domain	18 – 189	172	Phosphatase tensin-type
Sites
	Active site	129	1	Phosphocysteine intermediate Potential

Sequences

	Sequence		Length	Mass (Da)
	O94526 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: ABF91D58CB93C492	FASTA	348	40,157
	10 20 30 40 50 60 MNILRSVVSR GRKGLKQEKV NRSFAYLDMV YITSKVIAMS TPAAGIHKLY RNDELDVFKY 70 80 90 100 110 120 LTTQLKDNWI LLNLCAEETV YHLELFKPNV INYGFQDHNP PPLLFLWAIV MNMDALFQTQ 130 140 150 160 170 180 PLLTLVVHCK AGKGRTGTVI CSYLVAFGGL TAKQSLELYT EKRMVRGHGL TISSQIRYVY 190 200 210 220 230 240 YIEILKQFPN YLKAVEFNTG TTFFKSFKCL NIKKNSSLIL SLHAFSKGRN INPVALWKSS 250 260 270 280 290 300 DISSHNVSIK EGKRIWGIQC NLETSEKDLL LRVERKGQFY FPSSVQCWFH THFQPMLVEY 310 320 330 340 TNGINFQQGI NSFLQGQQSI SFSWSEMDNS RRSDPFFEQL TIVYENVF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genome sequence of Schizosaccharomyces pombe." Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P. Nature 415:871-880(2002) [PubMed: 11859360] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 972 / ATCC 24843.
[2]	"A novel phosphatidylinositol(3,4,5)P3 pathway in fission yeast." Mitra P., Zhang Y., Rameh L.E., Ivshina M.P., McCollum D., Nunnari J.J., Hendricks G.M., Kerr M.L., Field S.J., Cantley L.C., Ross A.H. J. Cell Biol. 166:205-211(2004) [PubMed: 15249580] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CU329671 Genomic DNA. Translation: CAA22831.1.
PIR	T40573.
RefSeq	NP_596312.1. NM_001022234.1.
3D structure databases
HSSP	HSSP built from PDB template 2BZL based on UniProtKB Q15678.
ProteinModelPortal	O94526.
ModBase	Search...
Protein-protein interaction databases
STRING	O94526.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	SPBC609.02.1; SPBC609.02.1:pep; SPBC609.02.
GeneID	2541101.
GenomeReviews	Gene locus ptn1 in contig CU329671_GR.
KEGG	spo:SPBC609.02.
NMPDR	fig|4896.1.peg.2178.
Organism-specific databases
GeneDB_Spombe	SPBC609.02.
Phylogenomic databases
eggNOG	fuNOG06623.
GeneTree	EFGT00050000003421.
OrthoDB	EOG44F9JH.
Gene expression databases
ArrayExpress	O94526.
Family and domain databases
InterPro	IPR000340. Dual-sp_phosphatase_cat-dom. IPR014019. Phosphatase_tensin-typ. IPR016130. Tyr_Pase_AS. [Graphical view]
KO	K01110.
Pfam	PF00782. DSPc. 1 hit. [Graphical view]
PROSITE	PS51181. PPASE_TENSIN. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PTEN_SCHPO

Accession

Primary (citable) accession number: O94526

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 4, 2008
Last sequence update:	May 1, 1999
Last modified:	December 14, 2011
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program