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O94524 (GTO2_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glutathione S-transferase omega-like 2

EC=2.5.1.18
Alternative name(s):
Glutathione-dependent dehydroascorbate reductase
EC=1.8.5.1
Gene names
Name:gto2
ORF Names:SPCC1281.07c
OrganismSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) [Reference proteome]
Taxonomic identifier284812 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces

Protein attributes

Sequence length313 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Active as '1-Cys' thiol transferase against beta-hydroxyethyl disulfide (HED), as dehydroascorbate reductase and as dimethylarsinic acid reductase, while not active against the standard GST substrate 1-chloro-2,4-dinitrobenzene (CDNB). May be involved in cell wall organization and biogenesis By similarity.

Catalytic activity

RX + glutathione = HX + R-S-glutathione.

2 glutathione + dehydroascorbate = glutathione disulfide + ascorbate.

Subcellular location

Cytoplasm. Nucleus. Golgi apparatus Ref.2.

Sequence similarities

Belongs to the GST superfamily. Omega family.

Contains 1 GST C-terminal domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 313313Glutathione S-transferase omega-like 2
PRO_0000343153

Regions

Domain161 – 289129GST C-terminal

Sites

Active site491Nucleophile By similarity

Sequences

Sequence LengthMass (Da)Tools
O94524 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: BF05B5D02FE8E196

FASTA31337,056
        10         20         30         40         50         60 
MSNTHITDWS SKDGEFRRQV SSFRERISPE HKYFQPEKDR YHLYVSYACP WAHRTLIVRK 

        70         80         90        100        110        120 
LKGLENVIPV HVVGWLMGPN GWNFDKENDS TGDPLYNSPY LRNLYFRADP NYNMRFTVPV 

       130        140        150        160        170        180 
LWDSKYNTIV NNESAEIIRM FNDAFNEVIE DEEKRVVDLY PSSLRTKIDE LNDYFYDTVN 

       190        200        210        220        230        240 
NGVYKTGFAT TAEAYEKNVR VVFQGLDRLE QVLKESKGPF LLGDHLTETD VRLYTTIVRF 

       250        260        270        280        290        300 
DPVYVQHFKC NIGTIRHNYP HINQWLKRLY WKHPAFHETT DFKHIKCHYT QSHTQINPLG 

       310 
ITPLGPIPNV EYF 

« Hide

References

[1]"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. expand/collapse author list , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 972 / ATCC 24843.
[2]"ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CU329672 Genomic DNA. Translation: CAA22828.1.
PIRT40926.
RefSeqNP_588171.1. NM_001023160.2.

3D structure databases

ProteinModelPortalO94524.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid275601. 8 interactions.
MINTMINT-4684905.
STRING4896.SPCC1281.07c-1.

Proteomic databases

MaxQBO94524.
PRIDEO94524.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2539028.
KEGGspo:SPCC1281.07c.

Organism-specific databases

PomBaseSPCC1281.07c.

Phylogenomic databases

eggNOGCOG0435.
HOGENOMHOG000245143.
KOK07393.
OMAFNTEFNG.
OrthoDBEOG722JK6.
PhylomeDBO94524.

Enzyme and pathway databases

BioCycRETL1328306-WGS:GSTH-3102-MONOMER.

Family and domain databases

Gene3D1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR016639. GST.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PANTHERPTHR32419. PTHR32419. 1 hit.
PfamPF13409. GST_N_2. 1 hit.
[Graphical view]
PIRSFPIRSF015753. GST. 1 hit.
SUPFAMSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20800202.
PROO94524.

Entry information

Entry nameGTO2_SCHPO
AccessionPrimary (citable) accession number: O94524
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: May 1, 1999
Last modified: July 9, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names