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Protein

Glutathione S-transferase omega-like 2

Gene

gto2

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Active as '1-Cys' thiol transferase against beta-hydroxyethyl disulfide (HED), as dehydroascorbate reductase and as dimethylarsinic acid reductase, while not active against the standard GST substrate 1-chloro-2,4-dinitrobenzene (CDNB). May be involved in cell wall organization and biogenesis (By similarity).By similarity

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.
2 glutathione + dehydroascorbate = glutathione disulfide + ascorbate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei49NucleophileBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase, Transferase
Biological processCell wall biogenesis/degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase omega-like 2 (EC:2.5.1.18)
Alternative name(s):
Glutathione-dependent dehydroascorbate reductase (EC:1.8.5.1)
Gene namesi
Name:gto2
ORF Names:SPCC1281.07c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:SPCC1281.07c.
PomBaseiSPCC1281.07c.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: PomBase
  • cytosol Source: PomBase
  • Golgi apparatus Source: PomBase
  • nucleus Source: PomBase

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003431531 – 313Glutathione S-transferase omega-like 2Add BLAST313

Proteomic databases

MaxQBiO94524.
PRIDEiO94524.

Interactioni

Protein-protein interaction databases

BioGridi275601. 9 interactors.
MINTiMINT-4684905.
STRINGi4896.SPCC1281.07c.1.

Structurei

3D structure databases

ProteinModelPortaliO94524.
SMRiO94524.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini161 – 289GST C-terminalAdd BLAST129

Sequence similaritiesi

Belongs to the GST superfamily. Omega family.Curated

Phylogenomic databases

HOGENOMiHOG000245143.
InParanoidiO94524.
KOiK07393.
OrthoDBiEOG092C3FEI.
PhylomeDBiO94524.

Family and domain databases

InterProiView protein in InterPro
IPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR016639. GST.
IPR012336. Thioredoxin-like_fold.
PANTHERiPTHR32419. PTHR32419. 1 hit.
PfamiView protein in Pfam
PF13409. GST_N_2. 1 hit.
PIRSFiPIRSF015753. GST. 1 hit.
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiView protein in PROSITE
PS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.

Sequencei

Sequence statusi: Complete.

O94524-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNTHITDWS SKDGEFRRQV SSFRERISPE HKYFQPEKDR YHLYVSYACP
60 70 80 90 100
WAHRTLIVRK LKGLENVIPV HVVGWLMGPN GWNFDKENDS TGDPLYNSPY
110 120 130 140 150
LRNLYFRADP NYNMRFTVPV LWDSKYNTIV NNESAEIIRM FNDAFNEVIE
160 170 180 190 200
DEEKRVVDLY PSSLRTKIDE LNDYFYDTVN NGVYKTGFAT TAEAYEKNVR
210 220 230 240 250
VVFQGLDRLE QVLKESKGPF LLGDHLTETD VRLYTTIVRF DPVYVQHFKC
260 270 280 290 300
NIGTIRHNYP HINQWLKRLY WKHPAFHETT DFKHIKCHYT QSHTQINPLG
310
ITPLGPIPNV EYF
Length:313
Mass (Da):37,056
Last modified:May 1, 1999 - v1
Checksum:iBF05B5D02FE8E196
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA. Translation: CAA22828.1.
PIRiT40926.
RefSeqiNP_588171.1. NM_001023160.2.

Genome annotation databases

GeneIDi2539028.
KEGGispo:SPCC1281.07c.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiGTO2_SCHPO
AccessioniPrimary (citable) accession number: O94524
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: May 1, 1999
Last modified: July 5, 2017
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families