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Protein

Probable proteasome subunit alpha type-1

Gene

SPBC646.16

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity).By similarity

Catalytic activityi

Cleavage of peptide bonds with very broad specificity.PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Threonine protease

Enzyme and pathway databases

ReactomeiR-SPO-1236978. Cross-presentation of soluble exogenous antigens (endosomes).
R-SPO-174113. SCF-beta-TrCP mediated degradation of Emi1.
R-SPO-5689603. UCH proteinases.
R-SPO-5689880. Ub-specific processing proteases.
R-SPO-68949. Orc1 removal from chromatin.
R-SPO-69017. CDK-mediated phosphorylation and removal of Cdc6.
R-SPO-69601. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.
R-SPO-8854050. FBXL7 down-regulates AURKA during mitotic entry and in early mitosis.
R-SPO-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Protein family/group databases

MEROPSiT01.971.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable proteasome subunit alpha type-1 (EC:3.4.25.1)
Gene namesi
ORF Names:SPBC646.16
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC646.16.
PomBaseiSPBC646.16.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus, Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001241401 – 244Probable proteasome subunit alpha type-1Add BLAST244

Proteomic databases

MaxQBiO94517.
PRIDEiO94517.

PTM databases

iPTMnetiO94517.

Interactioni

Subunit structurei

The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel (By similarity).By similarity

Protein-protein interaction databases

BioGridi277654. 7 interactors.
MINTiMINT-4684852.
STRINGi4896.SPBC646.16.1.

Structurei

3D structure databases

ProteinModelPortaliO94517.
SMRiO94517.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase T1A family.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000091084.
InParanoidiO94517.
KOiK02730.
OMAiYGYEITP.
OrthoDBiEOG092C47D8.
PhylomeDBiO94517.

Family and domain databases

CDDicd03754. proteasome_alpha_type_6. 1 hit.
Gene3Di3.60.20.10. 1 hit.
InterProiView protein in InterPro
IPR029055. Ntn_hydrolases_N.
IPR023332. Proteasome_alpha-type.
IPR000426. Proteasome_asu_N.
IPR001353. Proteasome_sua/b.
IPR034642. Proteasome_subunit_alpha6.
PANTHERiPTHR11599:SF11. PTHR11599:SF11. 1 hit.
PfamiView protein in Pfam
PF00227. Proteasome. 1 hit.
PF10584. Proteasome_A_N. 1 hit.
SMARTiView protein in SMART
SM00948. Proteasome_A_N. 1 hit.
SUPFAMiSSF56235. SSF56235. 1 hit.
PROSITEiView protein in PROSITE
PS00388. PROTEASOME_ALPHA_1. 1 hit.
PS51475. PROTEASOME_ALPHA_2. 1 hit.

Sequencei

Sequence statusi: Complete.

O94517-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQARGFDRT ITVFSPEGRL YQVEYAFKAF NNAGITSVGV TGKNCACVIS
60 70 80 90 100
QKKVPDKLID ASTVKHVFPI TKGIGCVMTG SIADARAQVS RARSEAAEFE
110 120 130 140 150
YKNGYPMPCD VLAKRMANIA QVSTQRAAMR PLGVAMTLVA VDDEIGPSLF
160 170 180 190 200
KLDPAGFYIG YKATSAGPKQ TETINWLEKR FKKDGIPSNL TDTVETGIQA
210 220 230 240
LMSSLSTDFK STELQIGVVE DDKPFRVLSV EEIEAHLQSI AEKD
Length:244
Mass (Da):26,539
Last modified:May 1, 1999 - v1
Checksum:iD8F66AE6155CCD59
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA22820.1.
PIRiT40592.
RefSeqiNP_595374.1. NM_001021282.2.

Genome annotation databases

EnsemblFungiiSPBC646.16.1; SPBC646.16.1:pep; SPBC646.16.
GeneIDi2541139.
KEGGispo:SPBC646.16.

Similar proteinsi

Entry informationi

Entry nameiPSA1_SCHPO
AccessioniPrimary (citable) accession number: O94517
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 8, 2000
Last sequence update: May 1, 1999
Last modified: October 25, 2017
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families