SPBC646.16

Functionⁱ

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity).By similarity

Catalytic activityⁱ

Cleavage of peptide bonds with very broad specificity.PROSITE-ProRule annotation

GO - Molecular functionⁱ

threonine-type endopeptidase activity Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

positive regulation of mitotic metaphase/anaphase transition Source: PomBase
proteasome-mediated ubiquitin-dependent protein catabolic process Source: PomBase

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Hydrolase, Protease, Threonine protease

Molecular function

Hydrolase, Protease, Threonine protease

Enzyme and pathway databases

Reactomeⁱ	R-SPO-1236978 Cross-presentation of soluble exogenous antigens (endosomes) R-SPO-174113 SCF-beta-TrCP mediated degradation of Emi1 R-SPO-5689603 UCH proteinases R-SPO-5689880 Ub-specific processing proteases R-SPO-68949 Orc1 removal from chromatin R-SPO-69017 CDK-mediated phosphorylation and removal of Cdc6 R-SPO-69601 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-SPO-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-SPO-983168 Antigen processing: Ubiquitination & Proteasome degradation

Reactomeⁱ

R-SPO-1236978 Cross-presentation of soluble exogenous antigens (endosomes)
R-SPO-174113 SCF-beta-TrCP mediated degradation of Emi1
R-SPO-5689603 UCH proteinases
R-SPO-5689880 Ub-specific processing proteases
R-SPO-68949 Orc1 removal from chromatin
R-SPO-69017 CDK-mediated phosphorylation and removal of Cdc6
R-SPO-69601 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
R-SPO-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
R-SPO-983168 Antigen processing: Ubiquitination & Proteasome degradation

Protein family/group databases

MEROPS protease database More...MEROPSⁱ	T01.971

MEROPSⁱ

T01.971

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Probable proteasome subunit alpha type-1 (EC:3.4.25.1)
Gene namesⁱ	ORF Names:SPBC646.16
Organismⁱ	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifierⁱ	284812 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces › Schizosaccharomyces pombe
Proteomesⁱ	UP000002485 Componentⁱ: Chromosome II

Organism-specific databases

EuPathDBⁱ	FungiDB:SPBC646.16
PomBaseⁱ	SPBC646.16

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus, Proteasome

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000124140	1 – 244	Probable proteasome subunit alpha type-1Add BLAST		244

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O94517
PaxDbⁱ	O94517
PRIDEⁱ	O94517

PTM databases

iPTMnetⁱ	O94517

iPTMnetⁱ

O94517

Interactionⁱ

Subunit structureⁱ

The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel (By similarity).By similarity

Protein-protein interaction databases

BioGridⁱ	2776547 interactors.
STRINGⁱ	4896.SPBC646.16.1

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O94517
SMRⁱ	O94517
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the peptidase T1A family.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMⁱ	HOG000091084
InParanoidⁱ	O94517
KEGG Orthology (KO) More...KOⁱ	K02730
OMAⁱ	YGYEITP
Database of Orthologous Groups More...OrthoDBⁱ	EOG092C47D8
PhylomeDBⁱ	O94517

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd03754 proteasome_alpha_type_6, 1 hit
Gene3Dⁱ	3.60.20.101 hit
InterProⁱ	View protein in InterPro IPR029055 Ntn_hydrolases_N IPR023332 Proteasome_alpha-type IPR000426 Proteasome_asu_N IPR001353 Proteasome_sua/b IPR034642 Proteasome_subunit_alpha6
PANTHERⁱ	PTHR11599:SF11 PTHR11599:SF11, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00227 Proteasome, 1 hit PF10584 Proteasome_A_N, 1 hit
SMARTⁱ	View protein in SMART SM00948 Proteasome_A_N, 1 hit
SUPFAMⁱ	SSF56235 SSF56235, 1 hit
PROSITEⁱ	View protein in PROSITE PS00388 PROTEASOME_ALPHA_1, 1 hit PS51475 PROTEASOME_ALPHA_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

O94517-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSQARGFDRT ITVFSPEGRL YQVEYAFKAF NNAGITSVGV TGKNCACVIS 
        60         70         80         90        100
QKKVPDKLID ASTVKHVFPI TKGIGCVMTG SIADARAQVS RARSEAAEFE 
       110        120        130        140        150
YKNGYPMPCD VLAKRMANIA QVSTQRAAMR PLGVAMTLVA VDDEIGPSLF 
       160        170        180        190        200
KLDPAGFYIG YKATSAGPKQ TETINWLEKR FKKDGIPSNL TDTVETGIQA 
       210        220        230        240 
LMSSLSTDFK STELQIGVVE DDKPFRVLSV EEIEAHLQSI AEKD

Length:244

Mass (Da):26,539

Last modified:May 1, 1999 - v1

Checksum:ⁱD8F66AE6155CCD59

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CU329671 Genomic DNA Translation: CAA22820.1
PIRⁱ	T40592
NCBI Reference Sequences More...RefSeqⁱ	NP_595374.1, NM_001021282.2

Genome annotation databases

EnsemblFungiⁱ	SPBC646.16.1; SPBC646.16.1:pep; SPBC646.16
GeneIDⁱ	2541139
KEGGⁱ	spo:SPBC646.16

Similar proteinsⁱ

50% Identity

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
O94517	A0A0P5A4R8 A0A0P5JEB5 A0A0P4Z966 A0A0P4Z783 A0A0P5TVH4 A0A0P5A464 F2TYH4 A0A1E3PKZ8 D5GL27 A0A024GN74 +197	Daphnia magna Salpingoeca rosetta (strain ATCC 50818 / BSB-021) Nadsonia fulvescens var. elongata DSM 6958 Tuber melanosporum (strain Mel28) (Perigord black truffle) Albugo candida Albugo laibachii Nc14 Dictyostelium purpureum (Slime mold) Metschnikowia bicuspidata var. bicuspidata NRRL YB-4993 [Candida] intermedia Clavispora lusitaniae (strain ATCC 42720) (Yeast) (Candida lusitaniae) And more	244	UniRef50_O94517	Cluster: Probable proteasome subunit alpha type-1	208

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CU329671 Genomic DNA Translation: CAA22820.1
PIRⁱ	T40592
NCBI Reference Sequences More...RefSeqⁱ	NP_595374.1, NM_001021282.2

3D structure databases

ProteinModelPortalⁱ	O94517
SMRⁱ	O94517
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	2776547 interactors.
STRINGⁱ	4896.SPBC646.16.1

Protein family/group databases

MEROPS protease database More...MEROPSⁱ	T01.971

MEROPSⁱ

T01.971

PTM databases

iPTMnetⁱ	O94517

iPTMnetⁱ

O94517

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O94517
PaxDbⁱ	O94517
PRIDEⁱ	O94517

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblFungiⁱ	SPBC646.16.1; SPBC646.16.1:pep; SPBC646.16
GeneIDⁱ	2541139
KEGGⁱ	spo:SPBC646.16

Organism-specific databases

EuPathDBⁱ	FungiDB:SPBC646.16
PomBaseⁱ	SPBC646.16

Phylogenomic databases

HOGENOMⁱ	HOG000091084
InParanoidⁱ	O94517
KEGG Orthology (KO) More...KOⁱ	K02730
OMAⁱ	YGYEITP
Database of Orthologous Groups More...OrthoDBⁱ	EOG092C47D8
PhylomeDBⁱ	O94517

Enzyme and pathway databases

Reactomeⁱ	R-SPO-1236978 Cross-presentation of soluble exogenous antigens (endosomes) R-SPO-174113 SCF-beta-TrCP mediated degradation of Emi1 R-SPO-5689603 UCH proteinases R-SPO-5689880 Ub-specific processing proteases R-SPO-68949 Orc1 removal from chromatin R-SPO-69017 CDK-mediated phosphorylation and removal of Cdc6 R-SPO-69601 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-SPO-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-SPO-983168 Antigen processing: Ubiquitination & Proteasome degradation

Reactomeⁱ

R-SPO-1236978 Cross-presentation of soluble exogenous antigens (endosomes)
R-SPO-174113 SCF-beta-TrCP mediated degradation of Emi1
R-SPO-5689603 UCH proteinases
R-SPO-5689880 Ub-specific processing proteases
R-SPO-68949 Orc1 removal from chromatin
R-SPO-69017 CDK-mediated phosphorylation and removal of Cdc6
R-SPO-69601 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
R-SPO-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
R-SPO-983168 Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:O94517

PROⁱ

PR:O94517

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd03754 proteasome_alpha_type_6, 1 hit
Gene3Dⁱ	3.60.20.101 hit
InterProⁱ	View protein in InterPro IPR029055 Ntn_hydrolases_N IPR023332 Proteasome_alpha-type IPR000426 Proteasome_asu_N IPR001353 Proteasome_sua/b IPR034642 Proteasome_subunit_alpha6
PANTHERⁱ	PTHR11599:SF11 PTHR11599:SF11, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00227 Proteasome, 1 hit PF10584 Proteasome_A_N, 1 hit
SMARTⁱ	View protein in SMART SM00948 Proteasome_A_N, 1 hit
SUPFAMⁱ	SSF56235 SSF56235, 1 hit
PROSITEⁱ	View protein in PROSITE PS00388 PROTEASOME_ALPHA_1, 1 hit PS51475 PROTEASOME_ALPHA_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PSA1_SCHPO
Accessionⁱ	O94517Primary (citable) accession number: O94517
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 8, 2000
	Last sequence update:	May 1, 1999
	Last modified:	February 28, 2018
	This is version 142 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Fungal Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

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Supporting data

UniProtKB - O94517 (PSA1_SCHPO)

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Probable proteasome subunit alpha type-1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Cytosol

Nucleus

Other locations

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ