UniProtKB - O94517 (PSA1_SCHPO)
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Protein
Probable proteasome subunit alpha type-1
Gene
SPBC646.16
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Functioni
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity).By similarity
Catalytic activityi
Cleavage of peptide bonds with very broad specificity.PROSITE-ProRule annotation
GO - Molecular functioni
- threonine-type endopeptidase activity Source: UniProtKB-KW
GO - Biological processi
- positive regulation of mitotic metaphase/anaphase transition Source: PomBase
- proteasome-mediated ubiquitin-dependent protein catabolic process Source: PomBase
Keywordsi
Molecular function | Hydrolase, Protease, Threonine protease |
Enzyme and pathway databases
Reactomei | R-SPO-1236978 Cross-presentation of soluble exogenous antigens (endosomes) R-SPO-174113 SCF-beta-TrCP mediated degradation of Emi1 R-SPO-5689603 UCH proteinases R-SPO-5689880 Ub-specific processing proteases R-SPO-68949 Orc1 removal from chromatin R-SPO-69017 CDK-mediated phosphorylation and removal of Cdc6 R-SPO-69601 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-SPO-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-SPO-983168 Antigen processing: Ubiquitination & Proteasome degradation |
Protein family/group databases
MEROPSi | T01.971 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | ORF Names:SPBC646.16 |
Organismi | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
Taxonomic identifieri | 284812 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces › |
Proteomesi |
|
Organism-specific databases
EuPathDBi | FungiDB:SPBC646.16 |
PomBasei | SPBC646.16 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000124140 | 1 – 244 | Probable proteasome subunit alpha type-1Add BLAST | 244 |
Proteomic databases
MaxQBi | O94517 |
PaxDbi | O94517 |
PRIDEi | O94517 |
PTM databases
iPTMneti | O94517 |
Interactioni
Subunit structurei
The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel (By similarity).By similarity
Protein-protein interaction databases
BioGridi | 2776547 interactors. |
STRINGi | 4896.SPBC646.16.1 |
Structurei
3D structure databases
ProteinModelPortali | O94517 |
SMRi | O94517 |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the peptidase T1A family.PROSITE-ProRule annotation
Phylogenomic databases
HOGENOMi | HOG000091084 |
InParanoidi | O94517 |
KOi | K02730 |
OMAi | YGYEITP |
OrthoDBi | EOG092C47D8 |
PhylomeDBi | O94517 |
Family and domain databases
CDDi | cd03754 proteasome_alpha_type_6, 1 hit |
Gene3Di | 3.60.20.101 hit |
InterProi | View protein in InterPro IPR029055 Ntn_hydrolases_N IPR023332 Proteasome_alpha-type IPR000426 Proteasome_asu_N IPR001353 Proteasome_sua/b IPR034642 Proteasome_subunit_alpha6 |
PANTHERi | PTHR11599:SF11 PTHR11599:SF11, 1 hit |
Pfami | View protein in Pfam PF00227 Proteasome, 1 hit PF10584 Proteasome_A_N, 1 hit |
SMARTi | View protein in SMART SM00948 Proteasome_A_N, 1 hit |
SUPFAMi | SSF56235 SSF56235, 1 hit |
PROSITEi | View protein in PROSITE PS00388 PROTEASOME_ALPHA_1, 1 hit PS51475 PROTEASOME_ALPHA_2, 1 hit |
i Sequence
Sequence statusi: Complete.
O94517-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSQARGFDRT ITVFSPEGRL YQVEYAFKAF NNAGITSVGV TGKNCACVIS
60 70 80 90 100
QKKVPDKLID ASTVKHVFPI TKGIGCVMTG SIADARAQVS RARSEAAEFE
110 120 130 140 150
YKNGYPMPCD VLAKRMANIA QVSTQRAAMR PLGVAMTLVA VDDEIGPSLF
160 170 180 190 200
KLDPAGFYIG YKATSAGPKQ TETINWLEKR FKKDGIPSNL TDTVETGIQA
210 220 230 240
LMSSLSTDFK STELQIGVVE DDKPFRVLSV EEIEAHLQSI AEKD
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CU329671 Genomic DNA Translation: CAA22820.1 |
PIRi | T40592 |
RefSeqi | NP_595374.1, NM_001021282.2 |
Genome annotation databases
EnsemblFungii | SPBC646.16.1; SPBC646.16.1:pep; SPBC646.16 |
GeneIDi | 2541139 |
KEGGi | spo:SPBC646.16 |
Similar proteinsi
Entry informationi
Entry namei | PSA1_SCHPO | |
Accessioni | O94517Primary (citable) accession number: O94517 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 8, 2000 |
Last sequence update: | May 1, 1999 | |
Last modified: | February 28, 2018 | |
This is version 142 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |