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Protein

Nucleolar protein 56

Gene

nop56

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Required for 60S ribosomal subunit synthesis.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein

Keywords - Biological processi

Ribosome biogenesis

Enzyme and pathway databases

ReactomeiR-SPO-6791226. Major pathway of rRNA processing in the nucleolus.

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleolar protein 56
Alternative name(s):
Ribosome biosynthesis protein sik1
Gene namesi
Name:nop56
Synonyms:sik1
ORF Names:SPBC646.10c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC646.10c.
PomBaseiSPBC646.10c. nop56.

Subcellular locationi

GO - Cellular componenti

  • nucleolus Source: PomBase
  • nucleus Source: PomBase
  • small nuclear ribonucleoprotein complex Source: PomBase
  • small nucleolar ribonucleoprotein complex Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 497497Nucleolar protein 56PRO_0000337263Add
BLAST

Proteomic databases

MaxQBiO94514.

Interactioni

Subunit structurei

Component of the ribosomal small subunit (SSU) processome.By similarity

Protein-protein interaction databases

BioGridi277602. 11 interactions.
IntActiO94514. 1 interaction.
MINTiMINT-4684829.

Structurei

3D structure databases

ProteinModelPortaliO94514.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini295 – 413119NopPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the NOP5/NOP56 family.Curated
Contains 1 Nop domain.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000196309.
InParanoidiO94514.
KOiK14564.
OMAiNTECALE.
OrthoDBiEOG7C5MJW.
PhylomeDBiO94514.

Family and domain databases

InterProiIPR012974. NOP5_N.
IPR002687. Nop_dom.
IPR012976. NOSIC.
[Graphical view]
PfamiPF01798. Nop. 1 hit.
PF08156. NOP5NT. 1 hit.
[Graphical view]
SMARTiSM00931. NOSIC. 1 hit.
[Graphical view]
SUPFAMiSSF89124. SSF89124. 1 hit.
PROSITEiPS51358. NOP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O94514-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADYLLYESA TGYSLFDVVG ADQIAAKTKE VQLSLQDISK FGKVVQLRSF
60 70 80 90 100
IPFKNAAHAL ENANDISEGV LNDFLKNFLE LNLPKASKKK KVSLGVQDKN
110 120 130 140 150
LATSIKSEID AIECDTSELT QDLLRGIRFH GDKLLKQLSP GDFERAQLGL
160 170 180 190 200
GHSYSRAKVK FNVNRNDNMI IQAIAILDQL DKDINTFAMR MKEWYSWHFP
210 220 230 240 250
ELSKIVGDNY KYAVIVTLVG DKTTINDEML HDLAAVVDDD KDIAQSIINA
260 270 280 290 300
GKVSMGQDIS EIDLENILSF AERVIKLSNY RKQLHNYLVQ KMNVVAPNLA
310 320 330 340 350
ELIGEMVGAR LISHAGSLTN LSKCPASTVQ ILGAEKALFR ALKTRGNTPK
360 370 380 390 400
YGIIYHSSFI GKAGAKNKGR ISRFLANKCS IASRIDNFSD APTTAFGQVL
410 420 430 440 450
RRQVEERLNF FDTGVAPTRN SIAMAEAYEK ALSSVNIDGD EEVDIDVEET
460 470 480 490
VETISEKPSK KEKKDKKEKK KEKSKKKRSA DDASEEVKKS KKKKKSH
Length:497
Mass (Da):55,388
Last modified:May 1, 1999 - v1
Checksum:i27F94313F72AB987
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA22814.1.
PIRiT40586.
RefSeqiNP_595368.1. NM_001021276.2.

Genome annotation databases

EnsemblFungiiSPBC646.10c.1; SPBC646.10c.1:pep; SPBC646.10c.
GeneIDi2541087.
KEGGispo:SPBC646.10c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA22814.1.
PIRiT40586.
RefSeqiNP_595368.1. NM_001021276.2.

3D structure databases

ProteinModelPortaliO94514.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi277602. 11 interactions.
IntActiO94514. 1 interaction.
MINTiMINT-4684829.

Proteomic databases

MaxQBiO94514.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC646.10c.1; SPBC646.10c.1:pep; SPBC646.10c.
GeneIDi2541087.
KEGGispo:SPBC646.10c.

Organism-specific databases

EuPathDBiFungiDB:SPBC646.10c.
PomBaseiSPBC646.10c. nop56.

Phylogenomic databases

HOGENOMiHOG000196309.
InParanoidiO94514.
KOiK14564.
OMAiNTECALE.
OrthoDBiEOG7C5MJW.
PhylomeDBiO94514.

Enzyme and pathway databases

ReactomeiR-SPO-6791226. Major pathway of rRNA processing in the nucleolus.

Miscellaneous databases

PROiO94514.

Family and domain databases

InterProiIPR012974. NOP5_N.
IPR002687. Nop_dom.
IPR012976. NOSIC.
[Graphical view]
PfamiPF01798. Nop. 1 hit.
PF08156. NOP5NT. 1 hit.
[Graphical view]
SMARTiSM00931. NOSIC. 1 hit.
[Graphical view]
SUPFAMiSSF89124. SSF89124. 1 hit.
PROSITEiPS51358. NOP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
    Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
    Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiNOP56_SCHPO
AccessioniPrimary (citable) accession number: O94514
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 1, 1999
Last modified: June 8, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.