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O94511

- YN67_SCHPO

UniProt

O94511 - YN67_SCHPO

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Protein
Putative enoyl reductase C646.07c
Gene
SPBC646.07c
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Acyl-CoA + NADP+ = trans-2,3-dehydroacyl-CoA + NADPH.

GO - Molecular functioni

  1. enoyl-[acyl-carrier-protein] reductase activity Source: PomBase
  2. trans-2-enoyl-CoA reductase (NADPH) activity Source: UniProtKB-EC

GO - Biological processi

  1. fatty acid elongation Source: PomBase
  2. very long-chain fatty acid metabolic process Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism

Keywords - Ligandi

NADP

Enzyme and pathway databases

ReactomeiREACT_218263. Synthesis of very long-chain fatty acyl-CoAs.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative enoyl reductase C646.07c (EC:1.3.1.38)
Gene namesi
ORF Names:SPBC646.07c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome II

Organism-specific databases

PomBaseiSPBC646.07c.

Subcellular locationi

Endoplasmic reticulum membrane; Multi-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 8484Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei85 – 10521Helical; Reviewed prediction
Add
BLAST
Topological domaini106 – 15752Lumenal Reviewed prediction
Add
BLAST
Transmembranei158 – 17821Helical; Reviewed prediction
Add
BLAST
Topological domaini179 – 1868Cytoplasmic Reviewed prediction
Transmembranei187 – 20721Helical; Reviewed prediction
Add
BLAST
Topological domaini208 – 22316Lumenal Reviewed prediction
Add
BLAST
Transmembranei224 – 24623Helical; Reviewed prediction
Add
BLAST
Topological domaini247 – 2504Cytoplasmic Reviewed prediction
Transmembranei251 – 26818Helical; Reviewed prediction
Add
BLAST
Topological domaini269 – 29527Lumenal Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum Source: PomBase
  2. endoplasmic reticulum membrane Source: PomBase
  3. integral component of membrane Source: UniProtKB-KW
  4. mitochondrion Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 295295Putative enoyl reductase C646.07c
PRO_0000317698Add
BLAST

Proteomic databases

MaxQBiO94511.
PaxDbiO94511.

Interactioni

Protein-protein interaction databases

BioGridi277585. 4 interactions.
MINTiMINT-4684798.
STRINGi4896.SPBC646.07c-1.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG306265.
HOGENOMiHOG000190918.
KOiK10258.
OMAiGPQIGWK.
OrthoDBiEOG74XSHP.
PhylomeDBiO94511.

Family and domain databases

InterProiIPR001104. 3-oxo-5_a-steroid_4-DH_C.
IPR000626. Ubiquitin-like.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF02544. Steroid_dh. 1 hit.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 1 hit.
PROSITEiPS50244. S5A_REDUCTASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O94511-1 [UniParc]FASTAAdd to Basket

« Hide

MSITLSSRGR KIRKLPKSLE FPLDGSIDKL RDEVSSVTRL PVERLRFSTA    50
DGTTLLPNTT LRKYGVGPGA TIWVKDLGPQ IGWRTVFMIE YLGPLVIHLF 100
FILNYKWIYR KDYNLCLNQK IAFVLVMLHF MKREYESIFV HRFSLATMPL 150
RNIFKNCAHY HLLSGLFLAY FIYGPWHAND YIKPNHLLFL IVGWAFAVLS 200
NFRTHIILRD LRPAGSKKRV IPTGYGFNLV SFPNYFFESL GWLFFALLTK 250
SWASWIFLFV GSAQMFVWAK KKHARYLKEF PNYPRSRKIM IPFFL 295
Length:295
Mass (Da):34,640
Last modified:May 1, 1999 - v1
Checksum:iB4181D13E0F3C333
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329671 Genomic DNA. Translation: CAA22811.1.
PIRiT40583.
RefSeqiNP_595365.1. NM_001021273.2.

Genome annotation databases

EnsemblFungiiSPBC646.07c.1; SPBC646.07c.1:pep; SPBC646.07c.
GeneIDi2541070.
KEGGispo:SPBC646.07c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329671 Genomic DNA. Translation: CAA22811.1 .
PIRi T40583.
RefSeqi NP_595365.1. NM_001021273.2.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 277585. 4 interactions.
MINTi MINT-4684798.
STRINGi 4896.SPBC646.07c-1.

Proteomic databases

MaxQBi O94511.
PaxDbi O94511.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPBC646.07c.1 ; SPBC646.07c.1:pep ; SPBC646.07c .
GeneIDi 2541070.
KEGGi spo:SPBC646.07c.

Organism-specific databases

PomBasei SPBC646.07c.

Phylogenomic databases

eggNOGi NOG306265.
HOGENOMi HOG000190918.
KOi K10258.
OMAi GPQIGWK.
OrthoDBi EOG74XSHP.
PhylomeDBi O94511.

Enzyme and pathway databases

Reactomei REACT_218263. Synthesis of very long-chain fatty acyl-CoAs.

Miscellaneous databases

NextBioi 20802184.
PROi O94511.

Family and domain databases

InterProi IPR001104. 3-oxo-5_a-steroid_4-DH_C.
IPR000626. Ubiquitin-like.
IPR029071. Ubiquitin-rel_dom.
[Graphical view ]
Pfami PF02544. Steroid_dh. 1 hit.
[Graphical view ]
SUPFAMi SSF54236. SSF54236. 1 hit.
PROSITEi PS50244. S5A_REDUCTASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
    Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
    Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiYN67_SCHPO
AccessioniPrimary (citable) accession number: O94511
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: May 1, 1999
Last modified: September 3, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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