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O94511 (YN67_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative enoyl reductase C646.07c

EC=1.3.1.38
Gene names
ORF Names:SPBC646.07c
OrganismSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) [Reference proteome]
Taxonomic identifier284812 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces

Protein attributes

Sequence length295 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Acyl-CoA + NADP+ = trans-2,3-dehydroacyl-CoA + NADPH.

Subcellular location

Endoplasmic reticulum membrane; Multi-pass membrane protein Ref.2.

Sequence similarities

Belongs to the steroid 5-alpha reductase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 295295Putative enoyl reductase C646.07c
PRO_0000317698

Regions

Topological domain1 – 8484Cytoplasmic Potential
Transmembrane85 – 10521Helical; Potential
Topological domain106 – 15752Lumenal Potential
Transmembrane158 – 17821Helical; Potential
Topological domain179 – 1868Cytoplasmic Potential
Transmembrane187 – 20721Helical; Potential
Topological domain208 – 22316Lumenal Potential
Transmembrane224 – 24623Helical; Potential
Topological domain247 – 2504Cytoplasmic Potential
Transmembrane251 – 26818Helical; Potential
Topological domain269 – 29527Lumenal Potential

Sequences

Sequence LengthMass (Da)Tools
O94511 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: B4181D13E0F3C333

FASTA29534,640
        10         20         30         40         50         60 
MSITLSSRGR KIRKLPKSLE FPLDGSIDKL RDEVSSVTRL PVERLRFSTA DGTTLLPNTT 

        70         80         90        100        110        120 
LRKYGVGPGA TIWVKDLGPQ IGWRTVFMIE YLGPLVIHLF FILNYKWIYR KDYNLCLNQK 

       130        140        150        160        170        180 
IAFVLVMLHF MKREYESIFV HRFSLATMPL RNIFKNCAHY HLLSGLFLAY FIYGPWHAND 

       190        200        210        220        230        240 
YIKPNHLLFL IVGWAFAVLS NFRTHIILRD LRPAGSKKRV IPTGYGFNLV SFPNYFFESL 

       250        260        270        280        290 
GWLFFALLTK SWASWIFLFV GSAQMFVWAK KKHARYLKEF PNYPRSRKIM IPFFL 

« Hide

References

[1]"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. expand/collapse author list , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 972 / ATCC 24843.
[2]"ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CU329671 Genomic DNA. Translation: CAA22811.1.
PIRT40583.
RefSeqNP_595365.1. NM_001021273.2.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid277585. 4 interactions.
MINTMINT-4684798.
STRING4896.SPBC646.07c-1.

Proteomic databases

MaxQBO94511.
PaxDbO94511.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiSPBC646.07c.1; SPBC646.07c.1:pep; SPBC646.07c.
GeneID2541070.
KEGGspo:SPBC646.07c.

Organism-specific databases

PomBaseSPBC646.07c.

Phylogenomic databases

eggNOGNOG306265.
HOGENOMHOG000190918.
KOK10258.
OMAGPQIGWK.
OrthoDBEOG74XSHP.
PhylomeDBO94511.

Family and domain databases

InterProIPR001104. 3-oxo-5_a-steroid_4-DH_C.
IPR000626. Ubiquitin-like.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamPF02544. Steroid_dh. 1 hit.
[Graphical view]
SUPFAMSSF54236. SSF54236. 1 hit.
PROSITEPS50244. S5A_REDUCTASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20802184.
PROO94511.

Entry information

Entry nameYN67_SCHPO
AccessionPrimary (citable) accession number: O94511
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: May 1, 1999
Last modified: June 11, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names