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Protein

Putative enoyl reductase C646.07c

Gene

SPBC646.07c

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Acyl-CoA + NADP+ = trans-2,3-dehydroacyl-CoA + NADPH.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism

Keywords - Ligandi

NADP

Enzyme and pathway databases

ReactomeiR-SPO-75876. Synthesis of very long-chain fatty acyl-CoAs.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative enoyl reductase C646.07c (EC:1.3.1.38)
Gene namesi
ORF Names:SPBC646.07c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC646.07c.
PomBaseiSPBC646.07c.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 84CytoplasmicSequence analysisAdd BLAST84
Transmembranei85 – 105HelicalSequence analysisAdd BLAST21
Topological domaini106 – 157LumenalSequence analysisAdd BLAST52
Transmembranei158 – 178HelicalSequence analysisAdd BLAST21
Topological domaini179 – 186CytoplasmicSequence analysis8
Transmembranei187 – 207HelicalSequence analysisAdd BLAST21
Topological domaini208 – 223LumenalSequence analysisAdd BLAST16
Transmembranei224 – 246HelicalSequence analysisAdd BLAST23
Topological domaini247 – 250CytoplasmicSequence analysis4
Transmembranei251 – 268HelicalSequence analysisAdd BLAST18
Topological domaini269 – 295LumenalSequence analysisAdd BLAST27

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003176981 – 295Putative enoyl reductase C646.07cAdd BLAST295

Proteomic databases

MaxQBiO94511.
PRIDEiO94511.

Interactioni

Protein-protein interaction databases

BioGridi277585. 2 interactors.
MINTiMINT-4684798.

Family & Domainsi

Sequence similaritiesi

Belongs to the steroid 5-alpha reductase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000190918.
InParanoidiO94511.
KOiK10258.
OMAiWAFAGYV.
OrthoDBiEOG092C3I75.
PhylomeDBiO94511.

Family and domain databases

InterProiIPR001104. 3-oxo-5_a-steroid_4-DH_C.
IPR029071. Ubiquitin-rel_dom.
IPR000626. Ubiquitin_dom.
[Graphical view]
PfamiPF02544. Steroid_dh. 1 hit.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 1 hit.
PROSITEiPS50244. S5A_REDUCTASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O94511-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSITLSSRGR KIRKLPKSLE FPLDGSIDKL RDEVSSVTRL PVERLRFSTA
60 70 80 90 100
DGTTLLPNTT LRKYGVGPGA TIWVKDLGPQ IGWRTVFMIE YLGPLVIHLF
110 120 130 140 150
FILNYKWIYR KDYNLCLNQK IAFVLVMLHF MKREYESIFV HRFSLATMPL
160 170 180 190 200
RNIFKNCAHY HLLSGLFLAY FIYGPWHAND YIKPNHLLFL IVGWAFAVLS
210 220 230 240 250
NFRTHIILRD LRPAGSKKRV IPTGYGFNLV SFPNYFFESL GWLFFALLTK
260 270 280 290
SWASWIFLFV GSAQMFVWAK KKHARYLKEF PNYPRSRKIM IPFFL
Length:295
Mass (Da):34,640
Last modified:May 1, 1999 - v1
Checksum:iB4181D13E0F3C333
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA22811.1.
PIRiT40583.
RefSeqiNP_595365.1. NM_001021273.2.

Genome annotation databases

EnsemblFungiiSPBC646.07c.1; SPBC646.07c.1:pep; SPBC646.07c.
GeneIDi2541070.
KEGGispo:SPBC646.07c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA22811.1.
PIRiT40583.
RefSeqiNP_595365.1. NM_001021273.2.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi277585. 2 interactors.
MINTiMINT-4684798.

Proteomic databases

MaxQBiO94511.
PRIDEiO94511.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC646.07c.1; SPBC646.07c.1:pep; SPBC646.07c.
GeneIDi2541070.
KEGGispo:SPBC646.07c.

Organism-specific databases

EuPathDBiFungiDB:SPBC646.07c.
PomBaseiSPBC646.07c.

Phylogenomic databases

HOGENOMiHOG000190918.
InParanoidiO94511.
KOiK10258.
OMAiWAFAGYV.
OrthoDBiEOG092C3I75.
PhylomeDBiO94511.

Enzyme and pathway databases

ReactomeiR-SPO-75876. Synthesis of very long-chain fatty acyl-CoAs.

Miscellaneous databases

PROiO94511.

Family and domain databases

InterProiIPR001104. 3-oxo-5_a-steroid_4-DH_C.
IPR029071. Ubiquitin-rel_dom.
IPR000626. Ubiquitin_dom.
[Graphical view]
PfamiPF02544. Steroid_dh. 1 hit.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 1 hit.
PROSITEiPS50244. S5A_REDUCTASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiYN67_SCHPO
AccessioniPrimary (citable) accession number: O94511
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: May 1, 1999
Last modified: November 30, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.