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O94511

- YN67_SCHPO

UniProt

O94511 - YN67_SCHPO

Protein

Putative enoyl reductase C646.07c

Gene

SPBC646.07c

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Acyl-CoA + NADP+ = trans-2,3-dehydroacyl-CoA + NADPH.

    GO - Molecular functioni

    1. enoyl-[acyl-carrier-protein] reductase activity Source: PomBase
    2. trans-2-enoyl-CoA reductase (NADPH) activity Source: UniProtKB-EC

    GO - Biological processi

    1. fatty acid elongation Source: PomBase
    2. very long-chain fatty acid metabolic process Source: PomBase

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Lipid biosynthesis, Lipid metabolism

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    ReactomeiREACT_218263. Synthesis of very long-chain fatty acyl-CoAs.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative enoyl reductase C646.07c (EC:1.3.1.38)
    Gene namesi
    ORF Names:SPBC646.07c
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome II

    Organism-specific databases

    PomBaseiSPBC646.07c.

    Subcellular locationi

    Endoplasmic reticulum membrane 1 Publication; Multi-pass membrane protein 1 Publication

    GO - Cellular componenti

    1. endoplasmic reticulum Source: PomBase
    2. endoplasmic reticulum membrane Source: PomBase
    3. integral component of membrane Source: UniProtKB-KW
    4. mitochondrion Source: PomBase

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 295295Putative enoyl reductase C646.07cPRO_0000317698Add
    BLAST

    Proteomic databases

    MaxQBiO94511.
    PaxDbiO94511.

    Interactioni

    Protein-protein interaction databases

    BioGridi277585. 4 interactions.
    MINTiMINT-4684798.
    STRINGi4896.SPBC646.07c-1.

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 8484CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini106 – 15752LumenalSequence AnalysisAdd
    BLAST
    Topological domaini179 – 1868CytoplasmicSequence Analysis
    Topological domaini208 – 22316LumenalSequence AnalysisAdd
    BLAST
    Topological domaini247 – 2504CytoplasmicSequence Analysis
    Topological domaini269 – 29527LumenalSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei85 – 10521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei158 – 17821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei187 – 20721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei224 – 24623HelicalSequence AnalysisAdd
    BLAST
    Transmembranei251 – 26818HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the steroid 5-alpha reductase family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG306265.
    HOGENOMiHOG000190918.
    KOiK10258.
    OMAiGPQIGWK.
    OrthoDBiEOG74XSHP.
    PhylomeDBiO94511.

    Family and domain databases

    InterProiIPR001104. 3-oxo-5_a-steroid_4-DH_C.
    IPR000626. Ubiquitin-like.
    IPR029071. Ubiquitin-rel_dom.
    [Graphical view]
    PfamiPF02544. Steroid_dh. 1 hit.
    [Graphical view]
    SUPFAMiSSF54236. SSF54236. 1 hit.
    PROSITEiPS50244. S5A_REDUCTASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O94511-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSITLSSRGR KIRKLPKSLE FPLDGSIDKL RDEVSSVTRL PVERLRFSTA    50
    DGTTLLPNTT LRKYGVGPGA TIWVKDLGPQ IGWRTVFMIE YLGPLVIHLF 100
    FILNYKWIYR KDYNLCLNQK IAFVLVMLHF MKREYESIFV HRFSLATMPL 150
    RNIFKNCAHY HLLSGLFLAY FIYGPWHAND YIKPNHLLFL IVGWAFAVLS 200
    NFRTHIILRD LRPAGSKKRV IPTGYGFNLV SFPNYFFESL GWLFFALLTK 250
    SWASWIFLFV GSAQMFVWAK KKHARYLKEF PNYPRSRKIM IPFFL 295
    Length:295
    Mass (Da):34,640
    Last modified:May 1, 1999 - v1
    Checksum:iB4181D13E0F3C333
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329671 Genomic DNA. Translation: CAA22811.1.
    PIRiT40583.
    RefSeqiNP_595365.1. NM_001021273.2.

    Genome annotation databases

    EnsemblFungiiSPBC646.07c.1; SPBC646.07c.1:pep; SPBC646.07c.
    GeneIDi2541070.
    KEGGispo:SPBC646.07c.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329671 Genomic DNA. Translation: CAA22811.1 .
    PIRi T40583.
    RefSeqi NP_595365.1. NM_001021273.2.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 277585. 4 interactions.
    MINTi MINT-4684798.
    STRINGi 4896.SPBC646.07c-1.

    Proteomic databases

    MaxQBi O94511.
    PaxDbi O94511.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPBC646.07c.1 ; SPBC646.07c.1:pep ; SPBC646.07c .
    GeneIDi 2541070.
    KEGGi spo:SPBC646.07c.

    Organism-specific databases

    PomBasei SPBC646.07c.

    Phylogenomic databases

    eggNOGi NOG306265.
    HOGENOMi HOG000190918.
    KOi K10258.
    OMAi GPQIGWK.
    OrthoDBi EOG74XSHP.
    PhylomeDBi O94511.

    Enzyme and pathway databases

    Reactomei REACT_218263. Synthesis of very long-chain fatty acyl-CoAs.

    Miscellaneous databases

    NextBioi 20802184.
    PROi O94511.

    Family and domain databases

    InterProi IPR001104. 3-oxo-5_a-steroid_4-DH_C.
    IPR000626. Ubiquitin-like.
    IPR029071. Ubiquitin-rel_dom.
    [Graphical view ]
    Pfami PF02544. Steroid_dh. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54236. SSF54236. 1 hit.
    PROSITEi PS50244. S5A_REDUCTASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.
    2. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
      Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
      Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiYN67_SCHPO
    AccessioniPrimary (citable) accession number: O94511
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 84 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3