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O94500

- NDUV1_SCHPO

UniProt

O94500 - NDUV1_SCHPO

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Protein
NADH-ubiquinone oxidoreductase 51 kDa subunit, mitochondrial
Gene
SPBC18E5.10
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone By similarity.

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).
NADH + acceptor = NAD+ + reduced acceptor.

Cofactori

Binds 1 FMN Reviewed prediction.
Binds 1 4Fe-4S cluster Reviewed prediction.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi377 – 3771Iron-sulfur (4Fe-4S) Reviewed prediction
Metal bindingi380 – 3801Iron-sulfur (4Fe-4S) Reviewed prediction
Metal bindingi383 – 3831Iron-sulfur (4Fe-4S) Reviewed prediction
Metal bindingi424 – 4241Iron-sulfur (4Fe-4S) Reviewed prediction

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi80 – 8910NAD By similarity
Nucleotide bindingi198 – 24548FMN By similarity
Add
BLAST

GO - Molecular functioni

  1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
  2. NADH dehydrogenase (ubiquinone) activity Source: UniProtKB-EC
  3. metal ion binding Source: UniProtKB-KW
  4. quinone binding Source: UniProtKB-KW

GO - Biological processi

  1. iron-sulfur cluster assembly Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

4Fe-4S, Flavoprotein, FMN, Iron, Iron-sulfur, Metal-binding, NAD

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-ubiquinone oxidoreductase 51 kDa subunit, mitochondrial (EC:1.6.5.3, EC:1.6.99.3)
Alternative name(s):
Complex I-51kD
Short name:
CI-51kD
Gene namesi
ORF Names:SPBC18E5.10
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome II

Organism-specific databases

PomBaseiSPBC18E5.10.

Subcellular locationi

Mitochondrion 1 Publication

GO - Cellular componenti

  1. mitochondrion Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2525Mitochondrion Reviewed prediction
Add
BLAST
Chaini26 – 452427NADH-ubiquinone oxidoreductase 51 kDa subunit, mitochondrial
PRO_0000317309Add
BLAST

Keywords - PTMi

Quinone

Proteomic databases

MaxQBiO94500.

Interactioni

Subunit structurei

Complex I is composed of about 40 different subunits. This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme By similarity.

Protein-protein interaction databases

MINTiMINT-4684703.
STRINGi4896.SPBC18E5.10-1.

Structurei

3D structure databases

ProteinModelPortaliO94500.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG1894.
HOGENOMiHOG000251534.
KOiK03942.
OMAiAITEDSC.
OrthoDBiEOG7M3J8B.
PhylomeDBiO94500.

Family and domain databases

InterProiIPR019575. NADH-UbQ_OxRdtase_Fsu_4Fe4S-bd.
IPR011538. NADH_UbQ_OxRdtase_51kDa_su.
IPR019554. Soluble_ligand-bd.
[Graphical view]
PfamiPF01512. Complex1_51K. 1 hit.
PF10531. SLBB. 1 hit.
[Graphical view]
SMARTiSM00928. NADH_4Fe-4S. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O94500-1 [UniParc]FASTAAdd to Basket

« Hide

MLSRGHCCKL KHSFNGLRNV ALKRLVGSKA GYRMFPNLIE KRIRRIDDAL    50
ADGEYENLSE ILKYDPLNII ELVQESELRG RGRYGFPTGE KMLSLYKATS 100
SERGRKEKPV VIVNAAENDI GSFKDRLLLR HEPHKIIEGA IIAARAVEAS 150
ACYLFIRKDY YEETVMMQKC IIQAYAKKLL GKNLLGTSIG LELLIHPGAG 200
SYITGEESAL IQSLQGEFPV PDIPINNTIT SGLFGLPTLV LNVETVSNLP 250
AIIKKGPKFF ISMGRPNNRG TKLFSISGEV NEPNVIEACM SIPLKDLIEN 300
YAGGVRGGWN KLVGIFPGGP CSGILNKNQC EQVTMDFDSL KALDSSLGTG 350
SVIVLNDHDQ IFESLLNFAK FYSTNTCHTC PVCRDGVEDV IETLKGLKDG 400
HAHLSQLKDM FSKFNMPSSS KVFCGFGDSM RHQIHSIQRN FPDQITFRTK 450
VT 452
Length:452
Mass (Da):50,095
Last modified:May 1, 1999 - v1
Checksum:i6C199251A7598374
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329671 Genomic DNA. Translation: CAA22670.1.
PIRiT39761.
RefSeqiNP_595857.1. NM_001021761.2.

Genome annotation databases

EnsemblFungiiSPBC18E5.10.1; SPBC18E5.10.1:pep; SPBC18E5.10.
GeneIDi2540740.
KEGGispo:SPBC18E5.10.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329671 Genomic DNA. Translation: CAA22670.1 .
PIRi T39761.
RefSeqi NP_595857.1. NM_001021761.2.

3D structure databases

ProteinModelPortali O94500.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-4684703.
STRINGi 4896.SPBC18E5.10-1.

Proteomic databases

MaxQBi O94500.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPBC18E5.10.1 ; SPBC18E5.10.1:pep ; SPBC18E5.10 .
GeneIDi 2540740.
KEGGi spo:SPBC18E5.10.

Organism-specific databases

PomBasei SPBC18E5.10.

Phylogenomic databases

eggNOGi COG1894.
HOGENOMi HOG000251534.
KOi K03942.
OMAi AITEDSC.
OrthoDBi EOG7M3J8B.
PhylomeDBi O94500.

Miscellaneous databases

NextBioi 20801862.
PROi O94500.

Family and domain databases

InterProi IPR019575. NADH-UbQ_OxRdtase_Fsu_4Fe4S-bd.
IPR011538. NADH_UbQ_OxRdtase_51kDa_su.
IPR019554. Soluble_ligand-bd.
[Graphical view ]
Pfami PF01512. Complex1_51K. 1 hit.
PF10531. SLBB. 1 hit.
[Graphical view ]
SMARTi SM00928. NADH_4Fe-4S. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
    Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
    Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiNDUV1_SCHPO
AccessioniPrimary (citable) accession number: O94500
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: May 1, 1999
Last modified: May 14, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3