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Protein

NADH-ubiquinone oxidoreductase 51 kDa subunit homolog SPBC18E5.10, mitochondrial

Gene

SPBC18E5.10

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Caution

Was previously considered as a subunit of the NADH dehydrogenase of the mitochondrial respiratory chain complex I. Due to lack of 38 of the other 40 subunits that are present in that complex in mammals, this attribution is unlikely.Curated

Cofactori

Protein has several cofactor binding sites:
  • FMNSequence analysisNote: Binds 1 FMN.Sequence analysis
  • [4Fe-4S] clusterSequence analysisNote: Binds 1 [4Fe-4S] cluster.Sequence analysis

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi377Iron-sulfur (4Fe-4S)Sequence analysis1
Metal bindingi380Iron-sulfur (4Fe-4S)Sequence analysis1
Metal bindingi383Iron-sulfur (4Fe-4S)Sequence analysis1
Metal bindingi424Iron-sulfur (4Fe-4S)Sequence analysis1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi80 – 89NADSequence analysis10
Nucleotide bindingi198 – 245FMNSequence analysisAdd BLAST48

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
Ligand4Fe-4S, Flavoprotein, FMN, Iron, Iron-sulfur, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-ubiquinone oxidoreductase 51 kDa subunit homolog SPBC18E5.10, mitochondrialCurated (EC:1.6.-.-Curated)
Gene namesi
ORF Names:SPBC18E5.10Imported
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC18E5.10
PomBaseiSPBC18E5.10

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 25MitochondrionSequence analysisAdd BLAST25
ChainiPRO_000031730926 – 452NADH-ubiquinone oxidoreductase 51 kDa subunit homolog SPBC18E5.10, mitochondrialAdd BLAST427

Proteomic databases

MaxQBiO94500
PaxDbiO94500
PRIDEiO94500

Interactioni

Protein-protein interaction databases

STRINGi4896.SPBC18E5.10.1

Structurei

3D structure databases

ProteinModelPortaliO94500
SMRiO94500
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I 51 kDa subunit family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOGENOMiHOG000251534
InParanoidiO94500
KOiK03942
OMAiSGMKWSF
OrthoDBiEOG092C2XKH
PhylomeDBiO94500

Family and domain databases

Gene3Di1.20.1440.230, 1 hit
3.40.50.11540, 1 hit
InterProiView protein in InterPro
IPR011538 Nuo51_FMN-bd
IPR037225 Nuo51_FMN-bd_sf
IPR019575 Nuop51_4Fe4S-bd
IPR037207 Nuop51_4Fe4S-bd_sf
IPR019554 Soluble_ligand-bd
PfamiView protein in Pfam
PF01512 Complex1_51K, 1 hit
PF10589 NADH_4Fe-4S, 1 hit
PF10531 SLBB, 1 hit
SMARTiView protein in SMART
SM00928 NADH_4Fe-4S, 1 hit
SUPFAMiSSF140490 SSF140490, 1 hit
SSF142019 SSF142019, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O94500-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSRGHCCKL KHSFNGLRNV ALKRLVGSKA GYRMFPNLIE KRIRRIDDAL
60 70 80 90 100
ADGEYENLSE ILKYDPLNII ELVQESELRG RGRYGFPTGE KMLSLYKATS
110 120 130 140 150
SERGRKEKPV VIVNAAENDI GSFKDRLLLR HEPHKIIEGA IIAARAVEAS
160 170 180 190 200
ACYLFIRKDY YEETVMMQKC IIQAYAKKLL GKNLLGTSIG LELLIHPGAG
210 220 230 240 250
SYITGEESAL IQSLQGEFPV PDIPINNTIT SGLFGLPTLV LNVETVSNLP
260 270 280 290 300
AIIKKGPKFF ISMGRPNNRG TKLFSISGEV NEPNVIEACM SIPLKDLIEN
310 320 330 340 350
YAGGVRGGWN KLVGIFPGGP CSGILNKNQC EQVTMDFDSL KALDSSLGTG
360 370 380 390 400
SVIVLNDHDQ IFESLLNFAK FYSTNTCHTC PVCRDGVEDV IETLKGLKDG
410 420 430 440 450
HAHLSQLKDM FSKFNMPSSS KVFCGFGDSM RHQIHSIQRN FPDQITFRTK

VT
Length:452
Mass (Da):50,095
Last modified:May 1, 1999 - v1
Checksum:i6C199251A7598374
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA Translation: CAA22670.1
PIRiT39761
RefSeqiNP_595857.1, NM_001021761.2

Genome annotation databases

EnsemblFungiiSPBC18E5.10.1; SPBC18E5.10.1:pep; SPBC18E5.10
GeneIDi2540740
KEGGispo:SPBC18E5.10

Entry informationi

Entry nameiNDUV1_SCHPO
AccessioniPrimary (citable) accession number: O94500
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: May 1, 1999
Last modified: March 28, 2018
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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