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O94500

- NDUV1_SCHPO

UniProt

O94500 - NDUV1_SCHPO

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Protein

NADH-ubiquinone oxidoreductase 51 kDa subunit, mitochondrial

Gene

SPBC18E5.10

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).By similarity

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).
NADH + acceptor = NAD+ + reduced acceptor.

Cofactori

Binds 1 FMN.Curated
Binds 1 4Fe-4S cluster.Curated

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi377 – 3771Iron-sulfur (4Fe-4S)Sequence Analysis
Metal bindingi380 – 3801Iron-sulfur (4Fe-4S)Sequence Analysis
Metal bindingi383 – 3831Iron-sulfur (4Fe-4S)Sequence Analysis
Metal bindingi424 – 4241Iron-sulfur (4Fe-4S)Sequence Analysis

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi80 – 8910NADBy similarity
Nucleotide bindingi198 – 24548FMNBy similarityAdd
BLAST

GO - Molecular functioni

  1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. NADH dehydrogenase (ubiquinone) activity Source: UniProtKB-EC
  4. quinone binding Source: UniProtKB-KW

GO - Biological processi

  1. iron-sulfur cluster assembly Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

4Fe-4S, Flavoprotein, FMN, Iron, Iron-sulfur, Metal-binding, NAD

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-ubiquinone oxidoreductase 51 kDa subunit, mitochondrial (EC:1.6.5.3, EC:1.6.99.3)
Alternative name(s):
Complex I-51kD
Short name:
CI-51kD
Gene namesi
ORF Names:SPBC18E5.10
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome II

Organism-specific databases

PomBaseiSPBC18E5.10.

Subcellular locationi

Mitochondrion 1 Publication

GO - Cellular componenti

  1. mitochondrion Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2525MitochondrionSequence AnalysisAdd
BLAST
Chaini26 – 452427NADH-ubiquinone oxidoreductase 51 kDa subunit, mitochondrialPRO_0000317309Add
BLAST

Keywords - PTMi

Quinone

Proteomic databases

MaxQBiO94500.

Interactioni

Subunit structurei

Complex I is composed of about 40 different subunits. This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme (By similarity).By similarity

Protein-protein interaction databases

MINTiMINT-4684703.
STRINGi4896.SPBC18E5.10-1.

Structurei

3D structure databases

ProteinModelPortaliO94500.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I 51 kDa subunit family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG1894.
HOGENOMiHOG000251534.
InParanoidiO94500.
KOiK03942.
OMAiAITEDSC.
OrthoDBiEOG7M3J8B.
PhylomeDBiO94500.

Family and domain databases

InterProiIPR019575. NADH-UbQ_OxRdtase_Fsu_4Fe4S-bd.
IPR011538. NADH_UbQ_OxRdtase_51kDa_su.
IPR019554. Soluble_ligand-bd.
[Graphical view]
PfamiPF01512. Complex1_51K. 1 hit.
PF10531. SLBB. 1 hit.
[Graphical view]
SMARTiSM00928. NADH_4Fe-4S. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O94500-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLSRGHCCKL KHSFNGLRNV ALKRLVGSKA GYRMFPNLIE KRIRRIDDAL
60 70 80 90 100
ADGEYENLSE ILKYDPLNII ELVQESELRG RGRYGFPTGE KMLSLYKATS
110 120 130 140 150
SERGRKEKPV VIVNAAENDI GSFKDRLLLR HEPHKIIEGA IIAARAVEAS
160 170 180 190 200
ACYLFIRKDY YEETVMMQKC IIQAYAKKLL GKNLLGTSIG LELLIHPGAG
210 220 230 240 250
SYITGEESAL IQSLQGEFPV PDIPINNTIT SGLFGLPTLV LNVETVSNLP
260 270 280 290 300
AIIKKGPKFF ISMGRPNNRG TKLFSISGEV NEPNVIEACM SIPLKDLIEN
310 320 330 340 350
YAGGVRGGWN KLVGIFPGGP CSGILNKNQC EQVTMDFDSL KALDSSLGTG
360 370 380 390 400
SVIVLNDHDQ IFESLLNFAK FYSTNTCHTC PVCRDGVEDV IETLKGLKDG
410 420 430 440 450
HAHLSQLKDM FSKFNMPSSS KVFCGFGDSM RHQIHSIQRN FPDQITFRTK

VT
Length:452
Mass (Da):50,095
Last modified:May 1, 1999 - v1
Checksum:i6C199251A7598374
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329671 Genomic DNA. Translation: CAA22670.1.
PIRiT39761.
RefSeqiNP_595857.1. NM_001021761.2.

Genome annotation databases

EnsemblFungiiSPBC18E5.10.1; SPBC18E5.10.1:pep; SPBC18E5.10.
GeneIDi2540740.
KEGGispo:SPBC18E5.10.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329671 Genomic DNA. Translation: CAA22670.1 .
PIRi T39761.
RefSeqi NP_595857.1. NM_001021761.2.

3D structure databases

ProteinModelPortali O94500.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-4684703.
STRINGi 4896.SPBC18E5.10-1.

Proteomic databases

MaxQBi O94500.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPBC18E5.10.1 ; SPBC18E5.10.1:pep ; SPBC18E5.10 .
GeneIDi 2540740.
KEGGi spo:SPBC18E5.10.

Organism-specific databases

PomBasei SPBC18E5.10.

Phylogenomic databases

eggNOGi COG1894.
HOGENOMi HOG000251534.
InParanoidi O94500.
KOi K03942.
OMAi AITEDSC.
OrthoDBi EOG7M3J8B.
PhylomeDBi O94500.

Miscellaneous databases

NextBioi 20801862.
PROi O94500.

Family and domain databases

InterProi IPR019575. NADH-UbQ_OxRdtase_Fsu_4Fe4S-bd.
IPR011538. NADH_UbQ_OxRdtase_51kDa_su.
IPR019554. Soluble_ligand-bd.
[Graphical view ]
Pfami PF01512. Complex1_51K. 1 hit.
PF10531. SLBB. 1 hit.
[Graphical view ]
SMARTi SM00928. NADH_4Fe-4S. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
    Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
    Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiNDUV1_SCHPO
AccessioniPrimary (citable) accession number: O94500
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: May 1, 1999
Last modified: October 29, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3