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Protein

Eukaryotic translation initiation factor 6

Gene

tif6

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionInitiation factor
Biological processProtein biosynthesis, Ribosome biogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation initiation factor 6UniRule annotation
Short name:
eIF-6UniRule annotation
Gene namesi
Name:tif6
ORF Names:SPCC1919.09
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:SPCC1919.09
PomBaseiSPCC1919.09 tif6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001537411 – 244Eukaryotic translation initiation factor 6Add BLAST244

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei174Phosphoserine; by CK1UniRule annotation1
Modified residuei175Phosphoserine; by CK1UniRule annotation1

Post-translational modificationi

Phosphorylation at Ser-174 and Ser-175 promotes nuclear export.UniRule annotation

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO94476
PaxDbiO94476
PRIDEiO94476

PTM databases

iPTMnetiO94476

Interactioni

Subunit structurei

Monomer. Associates with the 60S ribosomal subunit.UniRule annotation

Protein-protein interaction databases

BioGridi275698, 2 interactors
STRINGi4896.SPCC1919.09.1

Structurei

3D structure databases

ProteinModelPortaliO94476
SMRiO94476
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the eIF-6 family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000230605
InParanoidiO94476
KOiK03264
OMAiNDWCAFT
OrthoDBiEOG092C4BDP
PhylomeDBiO94476

Family and domain databases

CDDicd00527 IF6, 1 hit
HAMAPiMF_00032 eIF_6, 1 hit
InterProiView protein in InterPro
IPR002769 eIF6
PANTHERiPTHR10784 PTHR10784, 1 hit
PfamiView protein in Pfam
PF01912 eIF-6, 1 hit
PIRSFiPIRSF006413 IF-6, 1 hit
SMARTiView protein in SMART
SM00654 eIF6, 1 hit
TIGRFAMsiTIGR00323 eIF-6, 1 hit

Sequencei

Sequence statusi: Complete.

O94476-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALRAQFENS NEIGVFSNLT NSYALVALGG SENFYSVFEA ELGDVVPVVH
60 70 80 90 100
TTIGGTRIIG RLTCGNRKGL LVPSSTTDNE LQHLRNSLPD PVKIQRVDER
110 120 130 140 150
LSALGNIVAC NDYVALVHPD IERETEEIIA DVLDVEVFRQ TVAGNVLTGS
160 170 180 190 200
YCALSNQGAL VHPRTSIQEQ DELSSLLQVP LVAGTINRGS DVIGAGLVVN
210 220 230 240
DWCAFAGLDT TATELAVCES IFKLQDAQPS AIISNRDTLV ESYT
Length:244
Mass (Da):26,232
Last modified:May 1, 1999 - v1
Checksum:i388F52C670F25A3C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA Translation: CAA22640.1
PIRiT41234
RefSeqiNP_588491.1, NM_001023481.2

Genome annotation databases

EnsemblFungiiSPCC1919.09.1; SPCC1919.09.1:pep; SPCC1919.09
GeneIDi2539126
KEGGispo:SPCC1919.09

Similar proteinsi

Entry informationi

Entry nameiIF6_SCHPO
AccessioniPrimary (citable) accession number: O94476
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: March 28, 2018
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Translation initiation factors
    List of translation initiation factor entries
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

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