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O94446 (ESA1_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Histone acetyltransferase mst1

EC=2.3.1.48
Gene names
Name:mst1
Synonyms:esa1
ORF Names:SPAC637.12c
OrganismSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) [Reference proteome]
Taxonomic identifier284812 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces

Protein attributes

Sequence length463 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Catalytic component of the NuA4 histone acetyltransferase (HAT) complex which is involved in epigenetic transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4, H3, H2B, H2A and H2A variant H2A.Z. Acetylates histone H4 to form H4K5ac, H4K8ac, H4K12ac and H4K16ac, histone H3 to form H3K14ac, and histone H2A to form H2AK4ac and H2AK7ac. Acetylation of histone H4 is essential for DNA double-strand break repair through homologous recombination. Involved in cell cycle progression. Recruitment to promoters depends on H3K4me By similarity. Ref.4

Catalytic activity

Acetyl-CoA + [histone] = CoA + acetyl-[histone].

Subunit structure

Component of the NuA4 histone acetyltransferase complex By similarity. Interacts with arp4. Ref.3

Subcellular location

Nucleus Ref.2 Ref.4.

Domain

The ESA1-RPD3 motif is common to ESA1 and RPD3 and is required for ESA1 histone acetyl-transferase (HAT) activity and RPD3 histone deacetylase (HDAC) activity.

Post-translational modification

Autoacetylation at Lys-279 is required for proper function By similarity.

Sequence similarities

Belongs to the MYST (SAS/MOZ) family.

Contains 1 chromo domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 463463Histone acetyltransferase mst1
PRO_0000051564

Regions

Domain33 – 8957Chromo
Region329 – 3357Acetyl-CoA binding By similarity
Motif262 – 28322ESA1-RPD3 motif

Sites

Active site2791 By similarity
Active site3211Nucleophile By similarity
Binding site3241Acetyl-CoA By similarity
Binding site3591Acetyl-CoA By similarity

Amino acid modifications

Modified residue2791N6-acetyllysine; by autocatalysis By similarity

Sequences

Sequence LengthMass (Da)Tools
O94446 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: A5C6A4AEA1207902

FASTA46354,390
        10         20         30         40         50         60 
MSNDVDDESK IETKSYEAKD IVYKSKVFAF KDGEYRKAEI LMIQKRTRGV VYYVHYNDYN 

        70         80         90        100        110        120 
KRLDEWITID NIDLSKGIEY PPPEKPKKAH GKGKSSKRPK AVDRRRSITA PSKTEPSTPS 

       130        140        150        160        170        180 
TEKPEPSTPS GESDHGSNAG NESLPLLEED HKPESLSKEQ EVERLRFSGS MVQNPHEIAR 

       190        200        210        220        230        240 
IRNINKICIG DHEIEPWYFS PYPKEFSEVD IVYICSFCFC YYGSERQFQR HREKCTLQHP 

       250        260        270        280        290        300 
PGNEIYRDDY ISFFEIDGRK QRTWCRNICL LSKLFLDHKM LYYDVDPFLF YCMCRRDEYG 

       310        320        330        340        350        360 
CHLVGYFSKE KESSENYNLA CILTLPQYQR HGYGKLLIQF SYELTKREHK HGSPEKPLSD 

       370        380        390        400        410        420 
LGLISYRAYW AEQIINLVLG MRTETTIDEL ANKTSMTTND VLHTLQALNM LKYYKGQFII 

       430        440        450        460 
CISDGIEQQY ERLKNKKRRR INGDLLADWQ PPVFHPSQLR FGW 

« Hide

References

« Hide 'large scale' references
[1]"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. expand/collapse author list , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 972 / ATCC 24843.
[2]"Large-scale screening of intracellular protein localization in living fission yeast cells by the use of a GFP-fusion genomic DNA library."
Ding D.-Q., Tomita Y., Yamamoto A., Chikashige Y., Haraguchi T., Hiraoka Y.
Genes Cells 5:169-190(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] OF 263-441, SUBCELLULAR LOCATION.
Strain: ATCC 38364 / 968.
[3]"BAF53/Arp4 homolog Alp5 in fission yeast is required for histone H4 acetylation, kinetochore-spindle attachment, and gene silencing at centromere."
Minoda A., Saitoh S., Takahashi K., Toda T.
Mol. Biol. Cell 16:316-327(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH ARP4.
[4]"Schizosaccharomyces pombe mst2+ encodes a MYST family histone acetyltransferase that negatively regulates telomere silencing."
Gomez E.B., Espinosa J.M., Forsburg S.L.
Mol. Cell. Biol. 25:8887-8903(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CU329670 Genomic DNA. Translation: CAA22591.1.
AB027858 Genomic DNA. Translation: BAA87162.1.
PIRT39004.
RefSeqNP_594630.1. NM_001020058.2.

3D structure databases

ProteinModelPortalO94446.
SMRO94446. Positions 179-452.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid279924. 29 interactions.
IntActO94446. 1 interaction.
MINTMINT-8210884.
STRING4896.SPAC637.12c-1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiSPAC637.12c.1; SPAC637.12c.1:pep; SPAC637.12c.
GeneID2543506.
KEGGspo:SPAC637.12c.

Organism-specific databases

PomBaseSPAC637.12c.

Phylogenomic databases

eggNOGCOG5027.
HOGENOMHOG000182457.
KOK11304.
OMANIYSICM.
OrthoDBEOG7RFTRR.
PhylomeDBO94446.

Family and domain databases

Gene3D3.40.630.30. 1 hit.
InterProIPR016181. Acyl_CoA_acyltransferase.
IPR000953. Chromo_domain/shadow.
IPR016197. Chromodomain-like.
IPR002717. MOZ_SAS.
IPR025995. Tudor-knot.
[Graphical view]
PfamPF01853. MOZ_SAS. 1 hit.
PF11717. Tudor-knot. 1 hit.
[Graphical view]
SMARTSM00298. CHROMO. 1 hit.
[Graphical view]
SUPFAMSSF54160. SSF54160. 1 hit.
SSF55729. SSF55729. 1 hit.
ProtoNetSearch...

Other

NextBio20804516.
PROO94446.

Entry information

Entry nameESA1_SCHPO
AccessionPrimary (citable) accession number: O94446
Secondary accession number(s): Q9USC8
Entry history
Integrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: May 1, 1999
Last modified: April 16, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names