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Protein

26S proteasome regulatory subunit rpn10

Gene

rpn10

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Protects ubiquitin chains against dissambly by deubiquitinating enzymes thereby promoting protein degradation.2 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

ReactomeiR-SPO-1236978 Cross-presentation of soluble exogenous antigens (endosomes)
R-SPO-174113 SCF-beta-TrCP mediated degradation of Emi1
R-SPO-382556 ABC-family proteins mediated transport
R-SPO-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA
R-SPO-5689603 UCH proteinases
R-SPO-5689880 Ub-specific processing proteases
R-SPO-68949 Orc1 removal from chromatin
R-SPO-69017 CDK-mediated phosphorylation and removal of Cdc6
R-SPO-69601 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
R-SPO-983168 Antigen processing: Ubiquitination & Proteasome degradation

Names & Taxonomyi

Protein namesi
Recommended name:
26S proteasome regulatory subunit rpn10
Gene namesi
Name:rpn10
Synonyms:pus1
ORF Names:SPAC637.10c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC637.10c
PomBaseiSPAC637.10c rpn10

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus, Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001738331 – 24326S proteasome regulatory subunit rpn10Add BLAST243

Proteomic databases

MaxQBiO94444
PaxDbiO94444
PRIDEiO94444

PTM databases

iPTMnetiO94444

Interactioni

Subunit structurei

The 26S proteasome is composed of a core protease, known as the 20S proteasome, capped at one or both ends by the 19S regulatory complex (RC). The RC is composed of at least 18 different subunits in two subcomplexes, the base and the lid, which form the portions proximal and distal to the 20S proteolytic core, respectively (By similarity). Interacts with uch2.By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi280096, 23 interactors
IntActiO94444, 1 interactor
STRINGi4896.SPAC637.10c.1

Structurei

Secondary structure

1243
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi4 – 10Combined sources7
Helixi14 – 17Combined sources4
Beta strandi21 – 23Combined sources3
Helixi25 – 43Combined sources19
Beta strandi48 – 53Combined sources6
Beta strandi61 – 67Combined sources7
Helixi69 – 76Combined sources8
Helixi87 – 99Combined sources13
Beta strandi106 – 114Combined sources9
Helixi122 – 134Combined sources13
Beta strandi137 – 145Combined sources9
Helixi152 – 160Combined sources9
Beta strandi167 – 171Combined sources5
Helixi178 – 183Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2X5NX-ray1.30A2-193[»]
ProteinModelPortaliO94444
SMRiO94444
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 185VWFAPROSITE-ProRule annotationAdd BLAST181
Domaini205 – 224UIMPROSITE-ProRule annotationAdd BLAST20

Sequence similaritiesi

Belongs to the proteasome subunit S5A family.Curated

Phylogenomic databases

HOGENOMiHOG000165630
InParanoidiO94444
KOiK03029
OMAiMGGKGPE
OrthoDBiEOG092C5246
PhylomeDBiO94444

Family and domain databases

Gene3Di3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR027040 Proteasome_su_Rpn10
IPR003903 UIM_dom
IPR002035 VWF_A
IPR036465 vWFA_dom_sf
PANTHERiPTHR10223:SF0 PTHR10223:SF0, 1 hit
PfamiView protein in Pfam
PF13519 VWA_2, 1 hit
SMARTiView protein in SMART
SM00327 VWA, 1 hit
SUPFAMiSSF53300 SSF53300, 1 hit
PROSITEiView protein in PROSITE
PS50330 UIM, 1 hit
PS50234 VWFA, 1 hit

Sequencei

Sequence statusi: Complete.

O94444-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLEATMILI DNSEWMINGD YIPTRFEAQK DTVHMIFNQK INDNPENMCG
60 70 80 90 100
LMTIGDNSPQ VLSTLTRDYG KFLSAMHDLP VRGNAKFGDG IQIAQLALKH
110 120 130 140 150
RENKIQRQRI VAFVGSPIVE DEKNLIRLAK RMKKNNVAID IIHIGELQNE
160 170 180 190 200
SALQHFIDAA NSSDSCHLVS IPPSPQLLSD LVNQSPIGQG VVASQNQFEY
210 220 230 240
GVDPNLDVEL ALALELSMAE ERARQEVAAQ KSSEETEDKK MQE
Length:243
Mass (Da):27,140
Last modified:May 1, 1999 - v1
Checksum:i9ED58AE82687F79E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAA22589.1
PIRiT39002
RefSeqiNP_594628.1, NM_001020056.2

Genome annotation databases

EnsemblFungiiSPAC637.10c.1; SPAC637.10c.1:pep; SPAC637.10c
GeneIDi2543682
KEGGispo:SPAC637.10c

Similar proteinsi

Entry informationi

Entry nameiRPN10_SCHPO
AccessioniPrimary (citable) accession number: O94444
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: May 1, 1999
Last modified: May 23, 2018
This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health