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Protein

SWI/SNF chromatin-remodeling complex subunit snf22

Gene

snf22

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Helicase. Component of the SWI/SNF complex, an ATP-dependent chromatin remodeling complex, required for the positive and negative regulation of gene expression of a large number of genes. It changes chromatin structure by altering DNA-histone contacts within a nucleosome, leading eventually to a change in nucleosome position, thus facilitating or repressing binding of gene-specific transcription factors.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi894 – 901ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

  • chromatin remodeling Source: PomBase
  • regulation of iron ion import by regulation of transcription from RNA polymerase II promoter Source: PomBase
  • regulation of transcription by RNA polymerase II Source: PomBase
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionChromatin regulator, Helicase, Hydrolase
Biological processTranscription, Transcription regulation
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
SWI/SNF chromatin-remodeling complex subunit snf22 (EC:3.6.4.-)
Alternative name(s):
ATP-dependent helicase snf22
SWI/SNF complex subunit snf22
Gene namesi
Name:snf22
ORF Names:SPCC1620.14c, SPCC830.01c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:SPCC1620.14c
PomBaseiSPCC1620.14c snf22

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000743601 – 1680SWI/SNF chromatin-remodeling complex subunit snf22Add BLAST1680

Proteomic databases

MaxQBiO94421
PaxDbiO94421
PRIDEiO94421

PTM databases

iPTMnetiO94421

Interactioni

Subunit structurei

Component of the SWI/SNF global transcription activator complex composed of at least arp9, arp42, snf5, snf22, snf30, sbf59, sol1, ssr1, ssr2, ssr3, ssr4 and tfg3.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi275460, 16 interactors
DIPiDIP-48377N
IntActiO94421, 11 interactors
STRINGi4896.SPCC1620.14c.1

Structurei

3D structure databases

ProteinModelPortaliO94421
SMRiO94421
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini429 – 465QLQPROSITE-ProRule annotationAdd BLAST37
Domaini704 – 776HSAPROSITE-ProRule annotationAdd BLAST73
Domaini881 – 1046Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST166
Domaini1191 – 1354Helicase C-terminalPROSITE-ProRule annotationAdd BLAST164
Domaini1536 – 1606BromoPROSITE-ProRule annotationAdd BLAST71

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi996 – 999DEGH box4

Sequence similaritiesi

Belongs to the SNF2/RAD54 helicase family.Curated

Keywords - Domaini

Bromodomain

Phylogenomic databases

HOGENOMiHOG000172362
InParanoidiO94421
KOiK11786
OrthoDBiEOG092C1YH4
PhylomeDBiO94421

Family and domain databases

CDDicd00079 HELICc, 1 hit
Gene3Di1.20.920.10, 1 hit
3.40.50.10810, 1 hit
InterProiView protein in InterPro
IPR001487 Bromodomain
IPR036427 Bromodomain-like_sf
IPR018359 Bromodomain_CS
IPR014978 Gln-Leu-Gln_QLQ
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR014012 HSA_dom
IPR027417 P-loop_NTPase
IPR029295 SnAC
IPR038718 SNF2-like_sf
IPR000330 SNF2_N
PfamiView protein in Pfam
PF00439 Bromodomain, 1 hit
PF00271 Helicase_C, 1 hit
PF08880 QLQ, 1 hit
PF14619 SnAC, 1 hit
PF00176 SNF2_N, 1 hit
PRINTSiPR00503 BROMODOMAIN
SMARTiView protein in SMART
SM00297 BROMO, 1 hit
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit
SM00951 QLQ, 1 hit
SM01314 SnAC, 1 hit
SUPFAMiSSF47370 SSF47370, 1 hit
SSF52540 SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS00633 BROMODOMAIN_1, 1 hit
PS50014 BROMODOMAIN_2, 1 hit
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS51204 HSA, 1 hit
PS51666 QLQ, 1 hit

Sequencei

Sequence statusi: Complete.

O94421-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFAVQGNQKF PKGLTKDNIQ SLYQQWQVMR NQGATEENNP EFAQISSILR
60 70 80 90 100
MVQRAHYARM QQMRNQSSEF PDAENTNLRK QQDTLPTTGF NNLPEGKAGM
110 120 130 140 150
QTLPGRPASN GPTPPNPGNG NVGLNNPSYM NSQASPNIMN APLQRDTSVP
160 170 180 190 200
PAPSMVHPHT NTNANSNNLK VYANQLSQQN TSNPTYHNAY DMASMMKNGS
210 220 230 240 250
RMNNSFPPTT PYPPANDTTV NSSLPHSFAS PSSTFEQPHT VQSRAPSVDT
260 270 280 290 300
TSSSHSFSAR NIPANVSMQQ QMGRRGSIPV NPSTFSASSP PSGSMLASPY
310 320 330 340 350
NGYQNDAASF AHSKLPSSAN PNTPFNSTAT VDVGAAGSHF PYPQPSNLDA
360 370 380 390 400
INAKTYFQSS SNSPAPYVYR NNLPPSATSF QPSSSRSPSV DPNTVKSAQH
410 420 430 440 450
IPRMSPSPSA SALKTQSHVP SAKVPPTSKL NHAQLAMLKS QIVAYNCLNS
460 470 480 490 500
PNGQVPPAVQ QAIFGRVYGA SNEVSPSMPF QQNVPQMSSV KKDTPTRDAN
510 520 530 540 550
MRTSKAPYIQ NIPNQFQRRA YSATIPVKNE SLAKPSVSPM PLQQSTGKTE
560 570 580 590 600
VAKRAQFPTN VNYSSCVDPR TYVKTPIPFS KFSSSENLSL IPSLLPPSIS
610 620 630 640 650
WDDVFLSSEI AIACSIANRI DFLEKENRPK SVNKKILQQD KSKSMIELRC
660 670 680 690 700
LRLLEKQRSL RETINSVIPH SDSLAAGNLR LMFRNVKRQT MQEANLVLAL
710 720 730 740 750
AEKQKTEHAM RQKEKLLTHL RSIMLHRKSI VTKVDKQNKA KTQRCKDIIN
760 770 780 790 800
FHAHLEKEEK KRIERSARQR LQALRADDEA AYLQLLDKAK DTRITHLLKQ
810 820 830 840 850
TDQYLENLTR AVRIQQSNIH SGNTSGKGSN SAELEAPISE EDKNLDYFKV
860 870 880 890 900
AHRIHEEVEQ PKIFVGGTLK DYQLKGLEWM LSLYNNNLNG ILADEMGLGK
910 920 930 940 950
TIQTIAFITY LIEKKNQQGP FLIIVPLSTL TNWIMEFEKW APSVKKIAYK
960 970 980 990 1000
GPPQLRKTLQ SQIRSSNFNV LLTTFEYIIK DRPLLSRIKW VHMIIDEGHR
1010 1020 1030 1040 1050
IKNTQSKLTS TLSTYYHSQY RLILTGTPLQ NNLPELWALL NFVLPKIFNS
1060 1070 1080 1090 1100
IKSFDEWFNT PFANTGGQDK IGLNEEEALL IIKRLHKVLR PFLFRRLKKD
1110 1120 1130 1140 1150
VEKELPDKVE KVIKCPLSGL QLKLYQQMKK HGMLFVDGEK GKTGIKGLQN
1160 1170 1180 1190 1200
TVMQLKKICN HPFIFEDVER AIDPSGTNVD LLWRAAGKFE LLDRILPKLF
1210 1220 1230 1240 1250
LTGHKTLMFF QMTQIMTIME DYLRSKNWKY LRLDGSTKSD DRCSLLAQFN
1260 1270 1280 1290 1300
DPKSDVYIFM LSTRAGGLGL NLQTADTVII FDTDWNPHQD LQAQDRAHRI
1310 1320 1330 1340 1350
GQTKEVRILR LITEKSIEEN ILSRAQYKLD LDGKVIQAGK FDNKSTPEER
1360 1370 1380 1390 1400
EAFLRSLLEH DGDDDHDLTY GELQDDELNE LISRTDEELV LFKKLDKERA
1410 1420 1430 1440 1450
ATDIYGKGKP LERLLTVNEL PDFYKVEVDS FAVQSSSELE DQYLERKRRR
1460 1470 1480 1490 1500
RNSISYTELT LDELNTVDDP SSTLMPRKRG RPRKKTNSGS SLSTPLSQES
1510 1520 1530 1540 1550
SLARSGRKNT PSYKQKALRR YCMEIFERLY NLQSEDGRFV NGLFLYPPNR
1560 1570 1580 1590 1600
KLYPDYYIII KRPIALGKIK RNIKNDRYGD VGELIADFML MFNNAYTYNE
1610 1620 1630 1640 1650
EHSIVYEDAK LMEKTLKEVI EDLEKNNSLH AYEEEALNEE QASLVFLENS
1660 1670 1680
EAELPLDSGI VSAEDDKVIT YEDSSSSYSE
Length:1,680
Mass (Da):189,913
Last modified:April 13, 2004 - v2
Checksum:i8D0B978979768775
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB162437 Genomic DNA Translation: BAD11104.1
CU329672 Genomic DNA Translation: CAA22498.1
PIRiT41628
RefSeqiNP_588472.2, NM_001023463.2

Genome annotation databases

EnsemblFungiiSPCC1620.14c.1; SPCC1620.14c.1:pep; SPCC1620.14c
GeneIDi2538881
KEGGispo:SPCC1620.14c

Similar proteinsi

Entry informationi

Entry nameiSNF22_SCHPO
AccessioniPrimary (citable) accession number: O94421
Secondary accession number(s): Q9UU97
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: April 13, 2004
Last modified: May 23, 2018
This is version 137 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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