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Protein

SWI/SNF chromatin-remodeling complex subunit snf22

Gene

snf22

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Helicase. Component of the SWI/SNF complex, an ATP-dependent chromatin remodeling complex, required for the positive and negative regulation of gene expression of a large number of genes. It changes chromatin structure by altering DNA-histone contacts within a nucleosome, leading eventually to a change in nucleosome position, thus facilitating or repressing binding of gene-specific transcription factors.2 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi894 – 9018ATPPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

  • chromatin remodeling Source: PomBase
  • DNA duplex unwinding Source: GOC
  • regulation of iron ion import by regulation of transcription from RNA polymerase II promoter Source: PomBase
  • regulation of transcription from RNA polymerase II promoter Source: PomBase
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Helicase, Hydrolase

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
SWI/SNF chromatin-remodeling complex subunit snf22 (EC:3.6.4.-)
Alternative name(s):
ATP-dependent helicase snf22
SWI/SNF complex subunit snf22
Gene namesi
Name:snf22
ORF Names:SPCC1620.14c, SPCC830.01c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:SPCC1620.14c.
PomBaseiSPCC1620.14c. snf22.

Subcellular locationi

GO - Cellular componenti

  • mitotic spindle Source: PomBase
  • nuclear chromatin Source: PomBase
  • nucleus Source: PomBase
  • SWI/SNF complex Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 16801680SWI/SNF chromatin-remodeling complex subunit snf22PRO_0000074360Add
BLAST

Proteomic databases

MaxQBiO94421.

Interactioni

Subunit structurei

Component of the SWI/SNF global transcription activator complex composed of at least arp9, arp42, snf5, snf22, snf30, sbf59, sol1, ssr1, ssr2, ssr3, ssr4 and tfg3.1 Publication

Protein-protein interaction databases

BioGridi275460. 16 interactions.
DIPiDIP-48377N.
MINTiMINT-4684013.

Structurei

3D structure databases

ProteinModelPortaliO94421.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini429 – 46537QLQPROSITE-ProRule annotationAdd
BLAST
Domaini704 – 77673HSAPROSITE-ProRule annotationAdd
BLAST
Domaini881 – 1046166Helicase ATP-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini1191 – 1354164Helicase C-terminalPROSITE-ProRule annotationAdd
BLAST
Domaini1536 – 160671BromoPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi996 – 9994DEGH box

Sequence similaritiesi

Belongs to the SNF2/RAD54 helicase family.Curated
Contains 1 bromo domain.PROSITE-ProRule annotation
Contains 1 helicase ATP-binding domain.PROSITE-ProRule annotation
Contains 1 helicase C-terminal domain.PROSITE-ProRule annotation
Contains 1 HSA domain.PROSITE-ProRule annotation
Contains 1 QLQ domain.PROSITE-ProRule annotation

Keywords - Domaini

Bromodomain

Phylogenomic databases

HOGENOMiHOG000172362.
InParanoidiO94421.
KOiK11786.
OrthoDBiEOG7M98QM.
PhylomeDBiO94421.

Family and domain databases

Gene3Di1.20.920.10. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR001487. Bromodomain.
IPR018359. Bromodomain_CS.
IPR014978. Gln-Leu-Gln_QLQ.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR014012. HSA_dom.
IPR027417. P-loop_NTPase.
IPR029295. SnAC.
IPR000330. SNF2_N.
[Graphical view]
PfamiPF00439. Bromodomain. 1 hit.
PF00271. Helicase_C. 1 hit.
PF08880. QLQ. 1 hit.
PF14619. SnAC. 1 hit.
PF00176. SNF2_N. 1 hit.
[Graphical view]
PRINTSiPR00503. BROMODOMAIN.
SMARTiSM00297. BROMO. 1 hit.
SM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
SM00951. QLQ. 1 hit.
SM01314. SnAC. 1 hit.
[Graphical view]
SUPFAMiSSF47370. SSF47370. 1 hit.
SSF52540. SSF52540. 2 hits.
PROSITEiPS00633. BROMODOMAIN_1. 1 hit.
PS50014. BROMODOMAIN_2. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS51204. HSA. 1 hit.
PS51666. QLQ. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O94421-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFAVQGNQKF PKGLTKDNIQ SLYQQWQVMR NQGATEENNP EFAQISSILR
60 70 80 90 100
MVQRAHYARM QQMRNQSSEF PDAENTNLRK QQDTLPTTGF NNLPEGKAGM
110 120 130 140 150
QTLPGRPASN GPTPPNPGNG NVGLNNPSYM NSQASPNIMN APLQRDTSVP
160 170 180 190 200
PAPSMVHPHT NTNANSNNLK VYANQLSQQN TSNPTYHNAY DMASMMKNGS
210 220 230 240 250
RMNNSFPPTT PYPPANDTTV NSSLPHSFAS PSSTFEQPHT VQSRAPSVDT
260 270 280 290 300
TSSSHSFSAR NIPANVSMQQ QMGRRGSIPV NPSTFSASSP PSGSMLASPY
310 320 330 340 350
NGYQNDAASF AHSKLPSSAN PNTPFNSTAT VDVGAAGSHF PYPQPSNLDA
360 370 380 390 400
INAKTYFQSS SNSPAPYVYR NNLPPSATSF QPSSSRSPSV DPNTVKSAQH
410 420 430 440 450
IPRMSPSPSA SALKTQSHVP SAKVPPTSKL NHAQLAMLKS QIVAYNCLNS
460 470 480 490 500
PNGQVPPAVQ QAIFGRVYGA SNEVSPSMPF QQNVPQMSSV KKDTPTRDAN
510 520 530 540 550
MRTSKAPYIQ NIPNQFQRRA YSATIPVKNE SLAKPSVSPM PLQQSTGKTE
560 570 580 590 600
VAKRAQFPTN VNYSSCVDPR TYVKTPIPFS KFSSSENLSL IPSLLPPSIS
610 620 630 640 650
WDDVFLSSEI AIACSIANRI DFLEKENRPK SVNKKILQQD KSKSMIELRC
660 670 680 690 700
LRLLEKQRSL RETINSVIPH SDSLAAGNLR LMFRNVKRQT MQEANLVLAL
710 720 730 740 750
AEKQKTEHAM RQKEKLLTHL RSIMLHRKSI VTKVDKQNKA KTQRCKDIIN
760 770 780 790 800
FHAHLEKEEK KRIERSARQR LQALRADDEA AYLQLLDKAK DTRITHLLKQ
810 820 830 840 850
TDQYLENLTR AVRIQQSNIH SGNTSGKGSN SAELEAPISE EDKNLDYFKV
860 870 880 890 900
AHRIHEEVEQ PKIFVGGTLK DYQLKGLEWM LSLYNNNLNG ILADEMGLGK
910 920 930 940 950
TIQTIAFITY LIEKKNQQGP FLIIVPLSTL TNWIMEFEKW APSVKKIAYK
960 970 980 990 1000
GPPQLRKTLQ SQIRSSNFNV LLTTFEYIIK DRPLLSRIKW VHMIIDEGHR
1010 1020 1030 1040 1050
IKNTQSKLTS TLSTYYHSQY RLILTGTPLQ NNLPELWALL NFVLPKIFNS
1060 1070 1080 1090 1100
IKSFDEWFNT PFANTGGQDK IGLNEEEALL IIKRLHKVLR PFLFRRLKKD
1110 1120 1130 1140 1150
VEKELPDKVE KVIKCPLSGL QLKLYQQMKK HGMLFVDGEK GKTGIKGLQN
1160 1170 1180 1190 1200
TVMQLKKICN HPFIFEDVER AIDPSGTNVD LLWRAAGKFE LLDRILPKLF
1210 1220 1230 1240 1250
LTGHKTLMFF QMTQIMTIME DYLRSKNWKY LRLDGSTKSD DRCSLLAQFN
1260 1270 1280 1290 1300
DPKSDVYIFM LSTRAGGLGL NLQTADTVII FDTDWNPHQD LQAQDRAHRI
1310 1320 1330 1340 1350
GQTKEVRILR LITEKSIEEN ILSRAQYKLD LDGKVIQAGK FDNKSTPEER
1360 1370 1380 1390 1400
EAFLRSLLEH DGDDDHDLTY GELQDDELNE LISRTDEELV LFKKLDKERA
1410 1420 1430 1440 1450
ATDIYGKGKP LERLLTVNEL PDFYKVEVDS FAVQSSSELE DQYLERKRRR
1460 1470 1480 1490 1500
RNSISYTELT LDELNTVDDP SSTLMPRKRG RPRKKTNSGS SLSTPLSQES
1510 1520 1530 1540 1550
SLARSGRKNT PSYKQKALRR YCMEIFERLY NLQSEDGRFV NGLFLYPPNR
1560 1570 1580 1590 1600
KLYPDYYIII KRPIALGKIK RNIKNDRYGD VGELIADFML MFNNAYTYNE
1610 1620 1630 1640 1650
EHSIVYEDAK LMEKTLKEVI EDLEKNNSLH AYEEEALNEE QASLVFLENS
1660 1670 1680
EAELPLDSGI VSAEDDKVIT YEDSSSSYSE
Length:1,680
Mass (Da):189,913
Last modified:April 13, 2004 - v2
Checksum:i8D0B978979768775
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB162437 Genomic DNA. Translation: BAD11104.1.
CU329672 Genomic DNA. Translation: CAA22498.1.
PIRiT41628.
RefSeqiNP_588472.2. NM_001023463.2.

Genome annotation databases

EnsemblFungiiSPCC1620.14c.1; SPCC1620.14c.1:pep; SPCC1620.14c.
GeneIDi2538881.
KEGGispo:SPCC1620.14c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB162437 Genomic DNA. Translation: BAD11104.1.
CU329672 Genomic DNA. Translation: CAA22498.1.
PIRiT41628.
RefSeqiNP_588472.2. NM_001023463.2.

3D structure databases

ProteinModelPortaliO94421.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi275460. 16 interactions.
DIPiDIP-48377N.
MINTiMINT-4684013.

Proteomic databases

MaxQBiO94421.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPCC1620.14c.1; SPCC1620.14c.1:pep; SPCC1620.14c.
GeneIDi2538881.
KEGGispo:SPCC1620.14c.

Organism-specific databases

EuPathDBiFungiDB:SPCC1620.14c.
PomBaseiSPCC1620.14c. snf22.

Phylogenomic databases

HOGENOMiHOG000172362.
InParanoidiO94421.
KOiK11786.
OrthoDBiEOG7M98QM.
PhylomeDBiO94421.

Miscellaneous databases

PROiO94421.

Family and domain databases

Gene3Di1.20.920.10. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR001487. Bromodomain.
IPR018359. Bromodomain_CS.
IPR014978. Gln-Leu-Gln_QLQ.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR014012. HSA_dom.
IPR027417. P-loop_NTPase.
IPR029295. SnAC.
IPR000330. SNF2_N.
[Graphical view]
PfamiPF00439. Bromodomain. 1 hit.
PF00271. Helicase_C. 1 hit.
PF08880. QLQ. 1 hit.
PF14619. SnAC. 1 hit.
PF00176. SNF2_N. 1 hit.
[Graphical view]
PRINTSiPR00503. BROMODOMAIN.
SMARTiSM00297. BROMO. 1 hit.
SM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
SM00951. QLQ. 1 hit.
SM01314. SnAC. 1 hit.
[Graphical view]
SUPFAMiSSF47370. SSF47370. 1 hit.
SSF52540. SSF52540. 2 hits.
PROSITEiPS00633. BROMODOMAIN_1. 1 hit.
PS50014. BROMODOMAIN_2. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS51204. HSA. 1 hit.
PS51666. QLQ. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Roles of histone acetylation and chromatin remodeling factor in a meiotic recombination hotspot."
    Yamada T., Mizuno K., Hirota K., Kon N., Wahls W.P., Hartsuiker E., Murofushi H., Shibata T., Ohta K.
    EMBO J. 23:1792-1803(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION.
  2. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  3. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
    Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
    Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  4. "Fission yeast SWI/SNF and RSC complexes show compositional and functional differences from budding yeast."
    Monahan B.J., Villen J., Marguerat S., Baehler J., Gygi S.P., Winston F.
    Nat. Struct. Mol. Biol. 15:873-880(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE SWI/SNF COMPLEX, FUNCTION OF THE SWI/SNF COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiSNF22_SCHPO
AccessioniPrimary (citable) accession number: O94421
Secondary accession number(s): Q9UU97
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: April 13, 2004
Last modified: June 8, 2016
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.