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Protein

Probable succinyl-CoA ligase [GDP-forming] subunit beta, mitochondrial

Gene

SPCC1620.08

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

GTP + succinate + CoA = GDP + phosphate + succinyl-CoA.

Pathwayi: tricarboxylic acid cycle

This protein is involved in the pathway tricarboxylic acid cycle, which is part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-SPO-71403. Citric acid cycle (TCA cycle).
UniPathwayiUPA00223.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable succinyl-CoA ligase [GDP-forming] subunit beta, mitochondrial (EC:6.2.1.4)
Alternative name(s):
Succinyl-CoA synthetase beta chain
Short name:
SCS-beta
Gene namesi
ORF Names:SPCC1620.08
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:SPCC1620.08.
PomBaseiSPCC1620.08.

Subcellular locationi

GO - Cellular componenti

  • mitochondrion Source: PomBase
  • succinate-CoA ligase complex Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 433Probable succinyl-CoA ligase [GDP-forming] subunit beta, mitochondrialPRO_0000033364
Transit peptidei1 – ?MitochondrionSequence analysis

Proteomic databases

MaxQBiO94415.
PRIDEiO94415.

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit.By similarity

Protein-protein interaction databases

BioGridi275739. 10 interactions.
MINTiMINT-4683958.

Structurei

3D structure databases

ProteinModelPortaliO94415.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini31 – 256226ATP-graspAdd
BLAST

Sequence similaritiesi

Contains 1 ATP-grasp domain.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOGENOMiHOG000007059.
InParanoidiO94415.
KOiK01900.
OMAiYIESGCD.
OrthoDBiEOG7DJSWM.
PhylomeDBiO94415.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.261. 1 hit.
InterProiIPR013650. ATP-grasp_succ-CoA_synth-type.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR005811. CoA_ligase.
IPR017866. Succ-CoA_synthase_bsu_CS.
IPR005809. Succ_CoA_synthase_bsu.
IPR016102. Succinyl-CoA_synth-like.
[Graphical view]
PANTHERiPTHR11815. PTHR11815. 1 hit.
PfamiPF08442. ATP-grasp_2. 1 hit.
PF00549. Ligase_CoA. 1 hit.
[Graphical view]
PIRSFiPIRSF001554. SucCS_beta. 1 hit.
SUPFAMiSSF52210. SSF52210. 1 hit.
TIGRFAMsiTIGR01016. sucCoAbeta. 1 hit.
PROSITEiPS01217. SUCCINYL_COA_LIG_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O94415-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLTRSVLRKA PRAFSPFLQK RNLALHEYIS HDILRKFGVD VPRGAPARSG
60 70 80 90 100
EEAEKVARDL KVTDLVVKAQ VLAGGRGKGQ FDSGLRGGVR PVYDATEARM
110 120 130 140 150
FAEQMIGHKL ITRQTGPAGK ICNVVYVCER KFIRKEYYFA ILMDRENQCP
160 170 180 190 200
MIVASDQGGV DIETVAAENP SAIIKRSLPN SPNLDPHIAE ELVDKLGFSS
210 220 230 240 250
SSKPKAVDAI VKLYKVFNDC DATQVEINPL AETTDHKVLC MDAKLNFDDN
260 270 280 290 300
AEFRHSNIFV LRDISQEDPD EARAAKVGLN FIKLDGNIGC LVNGAGLAMA
310 320 330 340 350
TMDIIKLHGG EPANFLDVGG NANAEAIREA FSLITNDPKT TAIFVNIFGG
360 370 380 390 400
IVRCDVIAKG LISVVSALNL NIPIICRLQG TNQGAAKEVI NNSGLRIFSF
410 420 430
DDLDEAAKKA CRFSRVVEMA READVNVSFE LPL
Length:433
Mass (Da):47,287
Last modified:May 1, 1999 - v1
Checksum:iB2357DBDFA0A430F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA. Translation: CAA22492.1.
PIRiT41038.
RefSeqiNP_588466.1. NM_001023457.2.

Genome annotation databases

EnsemblFungiiSPCC1620.08.1; SPCC1620.08.1:pep; SPCC1620.08.
GeneIDi2539168.
KEGGispo:SPCC1620.08.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA. Translation: CAA22492.1.
PIRiT41038.
RefSeqiNP_588466.1. NM_001023457.2.

3D structure databases

ProteinModelPortaliO94415.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi275739. 10 interactions.
MINTiMINT-4683958.

Proteomic databases

MaxQBiO94415.
PRIDEiO94415.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPCC1620.08.1; SPCC1620.08.1:pep; SPCC1620.08.
GeneIDi2539168.
KEGGispo:SPCC1620.08.

Organism-specific databases

EuPathDBiFungiDB:SPCC1620.08.
PomBaseiSPCC1620.08.

Phylogenomic databases

HOGENOMiHOG000007059.
InParanoidiO94415.
KOiK01900.
OMAiYIESGCD.
OrthoDBiEOG7DJSWM.
PhylomeDBiO94415.

Enzyme and pathway databases

UniPathwayiUPA00223.
ReactomeiR-SPO-71403. Citric acid cycle (TCA cycle).

Miscellaneous databases

PROiO94415.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.261. 1 hit.
InterProiIPR013650. ATP-grasp_succ-CoA_synth-type.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR005811. CoA_ligase.
IPR017866. Succ-CoA_synthase_bsu_CS.
IPR005809. Succ_CoA_synthase_bsu.
IPR016102. Succinyl-CoA_synth-like.
[Graphical view]
PANTHERiPTHR11815. PTHR11815. 1 hit.
PfamiPF08442. ATP-grasp_2. 1 hit.
PF00549. Ligase_CoA. 1 hit.
[Graphical view]
PIRSFiPIRSF001554. SucCS_beta. 1 hit.
SUPFAMiSSF52210. SSF52210. 1 hit.
TIGRFAMsiTIGR01016. sucCoAbeta. 1 hit.
PROSITEiPS01217. SUCCINYL_COA_LIG_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.

Entry informationi

Entry nameiSUCB_SCHPO
AccessioniPrimary (citable) accession number: O94415
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: May 1, 1999
Last modified: June 8, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.