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Protein

Ribose-phosphate pyrophosphokinase 2

Gene

SPCC1620.06c

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

5-phosphoribose 1-diphosphate synthase involved in nucleotide, histidine, and tryptophan biosynthesis. Active in heteromultimeric complexes with other 5-phosphoribose 1-diphosphate synthases (By similarity).By similarity

Catalytic activityi

ATP + D-ribose 5-phosphate = AMP + 5-phospho-alpha-D-ribose 1-diphosphate.By similarity

Pathwayi: 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I).By similarity
Proteins known to be involved in this subpathway in this organism are:
  1. Ribose-phosphate pyrophosphokinase 2 (SPCC1620.06c), Ribose-phosphate pyrophosphokinase 1 (SPAC4A8.14), Ribose-phosphate pyrophosphokinase 5 (SPBC3D6.06c)
This subpathway is part of the pathway 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I), the pathway 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis and in Metabolic intermediate biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi130MagnesiumSequence analysisBy similarity1
Metal bindingi132MagnesiumSequence analysisBy similarity1
Metal bindingi145MagnesiumSequence analysisBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Nucleotide biosynthesis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-SPO-73843. 5-Phosphoribose 1-diphosphate biosynthesis.
UniPathwayiUPA00087; UER00172.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribose-phosphate pyrophosphokinase 2 (EC:2.7.6.1)
Alternative name(s):
Phosphoribosyl pyrophosphate synthase 2
Gene namesi
ORF Names:SPCC1620.06c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:SPCC1620.06c.
PomBaseiSPCC1620.06c.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: PomBase
  • cytosol Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003094631 – 321Ribose-phosphate pyrophosphokinase 2Add BLAST321

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei172Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO94413.
PRIDEiO94413.

PTM databases

iPTMnetiO94413.

Interactioni

Protein-protein interaction databases

BioGridi275501. 1 interactor.
MINTiMINT-4683942.

Structurei

3D structure databases

ProteinModelPortaliO94413.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribose-phosphate pyrophosphokinase family.Sequence analysis

Phylogenomic databases

HOGENOMiHOG000210451.
InParanoidiO94413.
KOiK00948.
OMAiLCLAAQH.
OrthoDBiEOG092C2PL8.
PhylomeDBiO94413.

Family and domain databases

CDDicd06223. PRTases_typeI. 1 hit.
Gene3Di3.40.50.2020. 2 hits.
InterProiIPR000842. PRib_PP_synth_CS.
IPR029099. Pribosyltran_N.
IPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
IPR005946. Rib-P_diPkinase.
[Graphical view]
PfamiPF14572. Pribosyl_synth. 1 hit.
PF13793. Pribosyltran_N. 1 hit.
[Graphical view]
SUPFAMiSSF53271. SSF53271. 1 hit.
TIGRFAMsiTIGR01251. ribP_PPkin. 1 hit.
PROSITEiPS00114. PRPP_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O94413-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASNSIKIFA GNSHPELAEK VARRIGLSLG KVAVVQYSNR ETSVTIGESV
60 70 80 90 100
RDEDVFILQT GCGSINDHLM ELLIMINACR SASARRITAI IPCFPYARQD
110 120 130 140 150
KKDKSRAPIT ARLVANMLQT AGCNHIITMD LHASQIQGFF NVPVDNLYAE
160 170 180 190 200
PSVLRYIREN IDTTVNPTVI VSPDAGGAKR ATALADRLDL DFALIHKERQ
210 220 230 240 250
KANEVSRMVL VGDVRDKLAI LVDDMADTCG TLGLAAKTLK DNGAKAVYAI
260 270 280 290 300
VTHGILSGKA IKVINESALE KVIVTNTIPH DDKRSLCSKI ETIDISGVLA
310 320
ECIRRIHHGE SVSVLFSVAP A
Length:321
Mass (Da):34,779
Last modified:May 1, 1999 - v1
Checksum:i584DFE1EC5C36DD5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA. Translation: CAA22490.1.
PIRiT41036.
RefSeqiNP_588464.1. NM_001023455.2.

Genome annotation databases

EnsemblFungiiSPCC1620.06c.1; SPCC1620.06c.1:pep; SPCC1620.06c.
GeneIDi2538924.
KEGGispo:SPCC1620.06c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA. Translation: CAA22490.1.
PIRiT41036.
RefSeqiNP_588464.1. NM_001023455.2.

3D structure databases

ProteinModelPortaliO94413.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi275501. 1 interactor.
MINTiMINT-4683942.

PTM databases

iPTMnetiO94413.

Proteomic databases

MaxQBiO94413.
PRIDEiO94413.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPCC1620.06c.1; SPCC1620.06c.1:pep; SPCC1620.06c.
GeneIDi2538924.
KEGGispo:SPCC1620.06c.

Organism-specific databases

EuPathDBiFungiDB:SPCC1620.06c.
PomBaseiSPCC1620.06c.

Phylogenomic databases

HOGENOMiHOG000210451.
InParanoidiO94413.
KOiK00948.
OMAiLCLAAQH.
OrthoDBiEOG092C2PL8.
PhylomeDBiO94413.

Enzyme and pathway databases

UniPathwayiUPA00087; UER00172.
ReactomeiR-SPO-73843. 5-Phosphoribose 1-diphosphate biosynthesis.

Miscellaneous databases

PROiO94413.

Family and domain databases

CDDicd06223. PRTases_typeI. 1 hit.
Gene3Di3.40.50.2020. 2 hits.
InterProiIPR000842. PRib_PP_synth_CS.
IPR029099. Pribosyltran_N.
IPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
IPR005946. Rib-P_diPkinase.
[Graphical view]
PfamiPF14572. Pribosyl_synth. 1 hit.
PF13793. Pribosyltran_N. 1 hit.
[Graphical view]
SUPFAMiSSF53271. SSF53271. 1 hit.
TIGRFAMsiTIGR01251. ribP_PPkin. 1 hit.
PROSITEiPS00114. PRPP_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKPR2_SCHPO
AccessioniPrimary (citable) accession number: O94413
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: May 1, 1999
Last modified: November 30, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.