Reviewed, UniProtKB/Swiss-Prot O94412 (PGTA_SCHPO)

Names and origin

Protein names

Recommended name:
    Geranylgeranyl transferase type-2 subunit alpha
    EC=2.5.1.60
Alternative name(s):
    Geranylgeranyl transferase type II subunit alpha
    Type II protein geranyl-geranyltransferase subunit alpha
    GGTase-II-alpha
    PGGT

Gene names

Name:	bet4
ORF Names:	SPCC1620.05

Organism

Schizosaccharomyces pombe (Fission yeast) [Complete proteome]

Taxonomic identifier

4896 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces

Protein attributes

Sequence length	344 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to proteins having the C-terminal-XCC or -XCXC, where both cysteines may become modified By similarity.
Catalytic activity	Geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate.
Subunit structure	Heterodimer of an alpha and a beta subunit By similarity.
Sequence similarities	Belongs to the protein prenyltransferase subunit alpha family. Contains 6 PFTA repeats.

Ontologies

Keywords
Domain	Repeat
Molecular function	Prenyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	protein amino acid prenylation Inferred from electronic annotation. Source: InterPro
Cellular component	cell division site Inferred from direct assay. Source: GeneDB_SPombe cytosol Inferred from direct assay. Source: GeneDB_SPombe nucleus Inferred from direct assay. Source: GeneDB_SPombe
Molecular function	Rab geranylgeranyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 344	344	Geranylgeranyl transferase type-2 subunit alpha		PRO_0000314652
Regions
	Repeat	44 – 78	35	PFTA 1
	Repeat	89 – 123	35	PFTA 2
	Repeat	125 – 159	35	PFTA 3
	Repeat	165 – 199	35	PFTA 4
	Repeat	214 – 248	35	PFTA 5
	Repeat	266 – 293	28	PFTA 6

Sequences

	Sequence		Length	Mass (Da)
	O94412-1 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: 6801D2872013427F	FASTA	344	41,194
	10 20 30 40 50 60 MHGILRVKLS EEQRKLKAEK ERAKIEEYRG LVSRFQEARK RKDYSEGNLK LTTELLDWNP 70 80 90 100 110 120 ETYSVWNYRR EILLNDVFPK ISLNEKQDLL DNELKYVLSK MKVFPKVYWI FNHRRWCLEN 130 140 150 160 170 180 APYPNWNYEM MITEKLLSAD ARNFHGWHYR RYVVSQIERA GNCSLAKKEM EYTTSAIATN 190 200 210 220 230 240 FSNFSALHNR TKLIETILNL EADPNSQKAL AKQILEQELD MIHQAVFTDP DDSSVWIYHR 250 260 270 280 290 300 WLMGHCNPNS MTPLISMITI EERIQYLQKE IELIQELHEM EPENRWCCES LVNYEALCKT 310 320 330 340 LEKQKPTEAD IKRWTLLVDK MIKVDPQRRG RYRTLQEKIN NLNK

References

[1]

"The genome sequence of Schizosaccharomyces pombe." Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P. Nature 415:871-880(2002) [PubMed: 11859360] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 38366 / 972.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CU329672 Genomic DNA. Translation: CAA22489.1.
PIR	T41035.
RefSeq	NP_588463.1.
3D structure databases
HSSP	HSSP built from PDB template 1LTX based on UniProtKB Q08602.
SMR	O94412. Positions 2-250, 24-339.
ModBase	Search...
Protein-protein interaction databases
STRING	O94412.
Genome annotation databases
GeneID	2539343.
GenomeReviews	Gene locus bet4 in contig CU329672_GR.
KEGG	spo:SPCC1620.05.
NMPDR	fig|4896.1.peg.801.
Organism-specific databases
GeneDB_Spombe	SPCC1620.05.
Phylogenomic databases
eggNOG	fuNOG09716.
HOGENOM	HBG464445.
OMA	WNYRRDI.
OrthoDB	EOG9CVHQ7.
PhylomeDB	O94412.
Enzyme and pathway databases
BRENDA	2.5.1.60. 653.
Gene expression databases
ArrayExpress	O94412.
Family and domain databases
InterPro	IPR002088. Prenyl_trans_a. IPR008940. Prenyltransferase. [Graphical view]
Gene3D	G3DSA:1.25.40.120. Prenyl_trans. 1 hit.
Pfam	PF01239. PPTA. 5 hits. [Graphical view]
PROSITE	PS51147. PFTA. 6 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PGTA_SCHPO

Accession

Primary (citable) accession number: O94412

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	May 1, 1999
Last modified:	January 19, 2010
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)