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Protein

Geranylgeranyl transferase type-2 subunit alpha

Gene

bet4

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to proteins having the C-terminal-XCC or -XCXC, where both cysteines may become modified.By similarity

Catalytic activityi

Geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Prenyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Geranylgeranyl transferase type-2 subunit alpha (EC:2.5.1.60)
Alternative name(s):
GGTase-II-alpha
Geranylgeranyl transferase type II subunit alpha
PGGT
Type II protein geranyl-geranyltransferase subunit alpha
Gene namesi
Name:bet4
ORF Names:SPCC1620.05
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:SPCC1620.05.
PomBaseiSPCC1620.05.

Subcellular locationi

GO - Cellular componenti

  • cell division site Source: PomBase
  • cytosol Source: PomBase
  • mitotic spindle pole body Source: PomBase
  • nucleus Source: PomBase
  • Rab-protein geranylgeranyltransferase complex Source: UniProtKB
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 344344Geranylgeranyl transferase type-2 subunit alphaPRO_0000314652Add
BLAST

Proteomic databases

MaxQBiO94412.

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit.By similarity

Protein-protein interaction databases

MINTiMINT-4683931.

Structurei

3D structure databases

ProteinModelPortaliO94412.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati44 – 7835PFTA 1Add
BLAST
Repeati89 – 12335PFTA 2Add
BLAST
Repeati125 – 15935PFTA 3Add
BLAST
Repeati165 – 19935PFTA 4Add
BLAST
Repeati214 – 24835PFTA 5Add
BLAST
Repeati266 – 29328PFTA 6Add
BLAST

Sequence similaritiesi

Contains 6 PFTA repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG5536.
HOGENOMiHOG000190796.
InParanoidiO94412.
KOiK14050.
OMAiAWNYRRY.
OrthoDBiEOG77Q569.
PhylomeDBiO94412.

Family and domain databases

InterProiIPR002088. Prenyl_trans_a.
[Graphical view]
PfamiPF01239. PPTA. 5 hits.
[Graphical view]
PROSITEiPS51147. PFTA. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O94412-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHGILRVKLS EEQRKLKAEK ERAKIEEYRG LVSRFQEARK RKDYSEGNLK
60 70 80 90 100
LTTELLDWNP ETYSVWNYRR EILLNDVFPK ISLNEKQDLL DNELKYVLSK
110 120 130 140 150
MKVFPKVYWI FNHRRWCLEN APYPNWNYEM MITEKLLSAD ARNFHGWHYR
160 170 180 190 200
RYVVSQIERA GNCSLAKKEM EYTTSAIATN FSNFSALHNR TKLIETILNL
210 220 230 240 250
EADPNSQKAL AKQILEQELD MIHQAVFTDP DDSSVWIYHR WLMGHCNPNS
260 270 280 290 300
MTPLISMITI EERIQYLQKE IELIQELHEM EPENRWCCES LVNYEALCKT
310 320 330 340
LEKQKPTEAD IKRWTLLVDK MIKVDPQRRG RYRTLQEKIN NLNK
Length:344
Mass (Da):41,194
Last modified:May 1, 1999 - v1
Checksum:i6801D2872013427F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA. Translation: CAA22489.1.
PIRiT41035.
RefSeqiNP_588463.1. NM_001023454.2.

Genome annotation databases

EnsemblFungiiSPCC1620.05.1; SPCC1620.05.1:pep; SPCC1620.05.
GeneIDi2539343.
KEGGispo:SPCC1620.05.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA. Translation: CAA22489.1.
PIRiT41035.
RefSeqiNP_588463.1. NM_001023454.2.

3D structure databases

ProteinModelPortaliO94412.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4683931.

Proteomic databases

MaxQBiO94412.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPCC1620.05.1; SPCC1620.05.1:pep; SPCC1620.05.
GeneIDi2539343.
KEGGispo:SPCC1620.05.

Organism-specific databases

EuPathDBiFungiDB:SPCC1620.05.
PomBaseiSPCC1620.05.

Phylogenomic databases

eggNOGiCOG5536.
HOGENOMiHOG000190796.
InParanoidiO94412.
KOiK14050.
OMAiAWNYRRY.
OrthoDBiEOG77Q569.
PhylomeDBiO94412.

Miscellaneous databases

NextBioi20800508.
PROiO94412.

Family and domain databases

InterProiIPR002088. Prenyl_trans_a.
[Graphical view]
PfamiPF01239. PPTA. 5 hits.
[Graphical view]
PROSITEiPS51147. PFTA. 6 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.

Entry informationi

Entry nameiPGTA_SCHPO
AccessioniPrimary (citable) accession number: O94412
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 1, 1999
Last modified: July 22, 2015
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.