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O94412

- PGTA_SCHPO

UniProt

O94412 - PGTA_SCHPO

Protein

Geranylgeranyl transferase type-2 subunit alpha

Gene

bet4

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to proteins having the C-terminal-XCC or -XCXC, where both cysteines may become modified.By similarity

    Catalytic activityi

    Geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate.

    GO - Molecular functioni

    1. Rab geranylgeranyltransferase activity Source: UniProtKB
    2. Rab GTPase binding Source: UniProtKB

    GO - Biological processi

    1. ER to Golgi vesicle-mediated transport Source: PomBase
    2. protein geranylgeranylation Source: UniProtKB
    3. protein targeting to membrane Source: PomBase

    Keywords - Molecular functioni

    Prenyltransferase, Transferase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Geranylgeranyl transferase type-2 subunit alpha (EC:2.5.1.60)
    Alternative name(s):
    GGTase-II-alpha
    Geranylgeranyl transferase type II subunit alpha
    PGGT
    Type II protein geranyl-geranyltransferase subunit alpha
    Gene namesi
    Name:bet4
    ORF Names:SPCC1620.05
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome III

    Organism-specific databases

    PomBaseiSPCC1620.05.

    Subcellular locationi

    GO - Cellular componenti

    1. cell division site Source: PomBase
    2. cytosol Source: PomBase
    3. mitotic spindle pole body Source: PomBase
    4. nucleus Source: PomBase
    5. Rab-protein geranylgeranyltransferase complex Source: UniProtKB

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 344344Geranylgeranyl transferase type-2 subunit alphaPRO_0000314652Add
    BLAST

    Proteomic databases

    MaxQBiO94412.

    Interactioni

    Subunit structurei

    Heterodimer of an alpha and a beta subunit.By similarity

    Protein-protein interaction databases

    MINTiMINT-4683931.
    STRINGi4896.SPCC1620.05-1.

    Structurei

    3D structure databases

    ProteinModelPortaliO94412.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati44 – 7835PFTA 1Add
    BLAST
    Repeati89 – 12335PFTA 2Add
    BLAST
    Repeati125 – 15935PFTA 3Add
    BLAST
    Repeati165 – 19935PFTA 4Add
    BLAST
    Repeati214 – 24835PFTA 5Add
    BLAST
    Repeati266 – 29328PFTA 6Add
    BLAST

    Sequence similaritiesi

    Contains 6 PFTA repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG5536.
    HOGENOMiHOG000190796.
    KOiK14050.
    OMAiAWNYRRY.
    OrthoDBiEOG77Q569.
    PhylomeDBiO94412.

    Family and domain databases

    InterProiIPR002088. Prenyl_trans_a.
    [Graphical view]
    PfamiPF01239. PPTA. 5 hits.
    [Graphical view]
    PROSITEiPS51147. PFTA. 6 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O94412-1 [UniParc]FASTAAdd to Basket

    « Hide

    MHGILRVKLS EEQRKLKAEK ERAKIEEYRG LVSRFQEARK RKDYSEGNLK    50
    LTTELLDWNP ETYSVWNYRR EILLNDVFPK ISLNEKQDLL DNELKYVLSK 100
    MKVFPKVYWI FNHRRWCLEN APYPNWNYEM MITEKLLSAD ARNFHGWHYR 150
    RYVVSQIERA GNCSLAKKEM EYTTSAIATN FSNFSALHNR TKLIETILNL 200
    EADPNSQKAL AKQILEQELD MIHQAVFTDP DDSSVWIYHR WLMGHCNPNS 250
    MTPLISMITI EERIQYLQKE IELIQELHEM EPENRWCCES LVNYEALCKT 300
    LEKQKPTEAD IKRWTLLVDK MIKVDPQRRG RYRTLQEKIN NLNK 344
    Length:344
    Mass (Da):41,194
    Last modified:May 1, 1999 - v1
    Checksum:i6801D2872013427F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329672 Genomic DNA. Translation: CAA22489.1.
    PIRiT41035.
    RefSeqiNP_588463.1. NM_001023454.2.

    Genome annotation databases

    EnsemblFungiiSPCC1620.05.1; SPCC1620.05.1:pep; SPCC1620.05.
    GeneIDi2539343.
    KEGGispo:SPCC1620.05.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329672 Genomic DNA. Translation: CAA22489.1 .
    PIRi T41035.
    RefSeqi NP_588463.1. NM_001023454.2.

    3D structure databases

    ProteinModelPortali O94412.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-4683931.
    STRINGi 4896.SPCC1620.05-1.

    Proteomic databases

    MaxQBi O94412.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPCC1620.05.1 ; SPCC1620.05.1:pep ; SPCC1620.05 .
    GeneIDi 2539343.
    KEGGi spo:SPCC1620.05.

    Organism-specific databases

    PomBasei SPCC1620.05.

    Phylogenomic databases

    eggNOGi COG5536.
    HOGENOMi HOG000190796.
    KOi K14050.
    OMAi AWNYRRY.
    OrthoDBi EOG77Q569.
    PhylomeDBi O94412.

    Miscellaneous databases

    NextBioi 20800508.
    PROi O94412.

    Family and domain databases

    InterProi IPR002088. Prenyl_trans_a.
    [Graphical view ]
    Pfami PF01239. PPTA. 5 hits.
    [Graphical view ]
    PROSITEi PS51147. PFTA. 6 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.

    Entry informationi

    Entry nameiPGTA_SCHPO
    AccessioniPrimary (citable) accession number: O94412
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 81 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3