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O94412

- PGTA_SCHPO

UniProt

O94412 - PGTA_SCHPO

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Protein

Geranylgeranyl transferase type-2 subunit alpha

Gene
bet4, SPCC1620.05
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to proteins having the C-terminal-XCC or -XCXC, where both cysteines may become modified By similarity.

Catalytic activityi

Geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate.

GO - Molecular functioni

  1. Rab geranylgeranyltransferase activity Source: UniProtKB
  2. Rab GTPase binding Source: UniProtKB

GO - Biological processi

  1. ER to Golgi vesicle-mediated transport Source: PomBase
  2. protein geranylgeranylation Source: UniProtKB
  3. protein targeting to membrane Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Prenyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Geranylgeranyl transferase type-2 subunit alpha (EC:2.5.1.60)
Alternative name(s):
GGTase-II-alpha
Geranylgeranyl transferase type II subunit alpha
PGGT
Type II protein geranyl-geranyltransferase subunit alpha
Gene namesi
Name:bet4
ORF Names:SPCC1620.05
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome III

Organism-specific databases

PomBaseiSPCC1620.05.

Subcellular locationi

GO - Cellular componenti

  1. cell division site Source: PomBase
  2. cytosol Source: PomBase
  3. mitotic spindle pole body Source: PomBase
  4. nucleus Source: PomBase
  5. Rab-protein geranylgeranyltransferase complex Source: UniProtKB
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 344344Geranylgeranyl transferase type-2 subunit alphaPRO_0000314652Add
BLAST

Proteomic databases

MaxQBiO94412.

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit By similarity.

Protein-protein interaction databases

MINTiMINT-4683931.
STRINGi4896.SPCC1620.05-1.

Structurei

3D structure databases

ProteinModelPortaliO94412.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati44 – 7835PFTA 1Add
BLAST
Repeati89 – 12335PFTA 2Add
BLAST
Repeati125 – 15935PFTA 3Add
BLAST
Repeati165 – 19935PFTA 4Add
BLAST
Repeati214 – 24835PFTA 5Add
BLAST
Repeati266 – 29328PFTA 6Add
BLAST

Sequence similaritiesi

Contains 6 PFTA repeats.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG5536.
HOGENOMiHOG000190796.
KOiK14050.
OMAiAWNYRRY.
OrthoDBiEOG77Q569.
PhylomeDBiO94412.

Family and domain databases

InterProiIPR002088. Prenyl_trans_a.
[Graphical view]
PfamiPF01239. PPTA. 5 hits.
[Graphical view]
PROSITEiPS51147. PFTA. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O94412-1 [UniParc]FASTAAdd to Basket

« Hide

MHGILRVKLS EEQRKLKAEK ERAKIEEYRG LVSRFQEARK RKDYSEGNLK    50
LTTELLDWNP ETYSVWNYRR EILLNDVFPK ISLNEKQDLL DNELKYVLSK 100
MKVFPKVYWI FNHRRWCLEN APYPNWNYEM MITEKLLSAD ARNFHGWHYR 150
RYVVSQIERA GNCSLAKKEM EYTTSAIATN FSNFSALHNR TKLIETILNL 200
EADPNSQKAL AKQILEQELD MIHQAVFTDP DDSSVWIYHR WLMGHCNPNS 250
MTPLISMITI EERIQYLQKE IELIQELHEM EPENRWCCES LVNYEALCKT 300
LEKQKPTEAD IKRWTLLVDK MIKVDPQRRG RYRTLQEKIN NLNK 344
Length:344
Mass (Da):41,194
Last modified:May 1, 1999 - v1
Checksum:i6801D2872013427F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329672 Genomic DNA. Translation: CAA22489.1.
PIRiT41035.
RefSeqiNP_588463.1. NM_001023454.2.

Genome annotation databases

EnsemblFungiiSPCC1620.05.1; SPCC1620.05.1:pep; SPCC1620.05.
GeneIDi2539343.
KEGGispo:SPCC1620.05.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329672 Genomic DNA. Translation: CAA22489.1 .
PIRi T41035.
RefSeqi NP_588463.1. NM_001023454.2.

3D structure databases

ProteinModelPortali O94412.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-4683931.
STRINGi 4896.SPCC1620.05-1.

Proteomic databases

MaxQBi O94412.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPCC1620.05.1 ; SPCC1620.05.1:pep ; SPCC1620.05 .
GeneIDi 2539343.
KEGGi spo:SPCC1620.05.

Organism-specific databases

PomBasei SPCC1620.05.

Phylogenomic databases

eggNOGi COG5536.
HOGENOMi HOG000190796.
KOi K14050.
OMAi AWNYRRY.
OrthoDBi EOG77Q569.
PhylomeDBi O94412.

Miscellaneous databases

NextBioi 20800508.
PROi O94412.

Family and domain databases

InterProi IPR002088. Prenyl_trans_a.
[Graphical view ]
Pfami PF01239. PPTA. 5 hits.
[Graphical view ]
PROSITEi PS51147. PFTA. 6 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.

Entry informationi

Entry nameiPGTA_SCHPO
AccessioniPrimary (citable) accession number: O94412
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 1, 1999
Last modified: May 14, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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