Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

O94412 (PGTA_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Geranylgeranyl transferase type-2 subunit alpha

EC=2.5.1.60
Alternative name(s):
GGTase-II-alpha
Geranylgeranyl transferase type II subunit alpha
PGGT
Type II protein geranyl-geranyltransferase subunit alpha
Gene names
Name:bet4
ORF Names:SPCC1620.05
OrganismSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) [Reference proteome]
Taxonomic identifier284812 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces

Protein attributes

Sequence length344 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to proteins having the C-terminal-XCC or -XCXC, where both cysteines may become modified By similarity.

Catalytic activity

Geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate.

Subunit structure

Heterodimer of an alpha and a beta subunit By similarity.

Sequence similarities

Belongs to the protein prenyltransferase subunit alpha family.

Contains 6 PFTA repeats.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 344344Geranylgeranyl transferase type-2 subunit alpha
PRO_0000314652

Regions

Repeat44 – 7835PFTA 1
Repeat89 – 12335PFTA 2
Repeat125 – 15935PFTA 3
Repeat165 – 19935PFTA 4
Repeat214 – 24835PFTA 5
Repeat266 – 29328PFTA 6

Sequences

Sequence LengthMass (Da)Tools
O94412 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: 6801D2872013427F

FASTA34441,194
        10         20         30         40         50         60 
MHGILRVKLS EEQRKLKAEK ERAKIEEYRG LVSRFQEARK RKDYSEGNLK LTTELLDWNP 

        70         80         90        100        110        120 
ETYSVWNYRR EILLNDVFPK ISLNEKQDLL DNELKYVLSK MKVFPKVYWI FNHRRWCLEN 

       130        140        150        160        170        180 
APYPNWNYEM MITEKLLSAD ARNFHGWHYR RYVVSQIERA GNCSLAKKEM EYTTSAIATN 

       190        200        210        220        230        240 
FSNFSALHNR TKLIETILNL EADPNSQKAL AKQILEQELD MIHQAVFTDP DDSSVWIYHR 

       250        260        270        280        290        300 
WLMGHCNPNS MTPLISMITI EERIQYLQKE IELIQELHEM EPENRWCCES LVNYEALCKT 

       310        320        330        340 
LEKQKPTEAD IKRWTLLVDK MIKVDPQRRG RYRTLQEKIN NLNK 

« Hide

References

[1]"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. expand/collapse author list , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 972 / ATCC 24843.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CU329672 Genomic DNA. Translation: CAA22489.1.
PIRT41035.
RefSeqNP_588463.1. NM_001023454.2.

3D structure databases

ProteinModelPortalO94412.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

MINTMINT-4683931.
STRING4896.SPCC1620.05-1.

Proteomic databases

MaxQBO94412.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiSPCC1620.05.1; SPCC1620.05.1:pep; SPCC1620.05.
GeneID2539343.
KEGGspo:SPCC1620.05.

Organism-specific databases

PomBaseSPCC1620.05.

Phylogenomic databases

eggNOGCOG5536.
HOGENOMHOG000190796.
KOK14050.
OMAAWNYRRY.
OrthoDBEOG77Q569.
PhylomeDBO94412.

Family and domain databases

InterProIPR002088. Prenyl_trans_a.
[Graphical view]
PfamPF01239. PPTA. 5 hits.
[Graphical view]
PROSITEPS51147. PFTA. 6 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio20800508.
PROO94412.

Entry information

Entry namePGTA_SCHPO
AccessionPrimary (citable) accession number: O94412
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 1, 1999
Last modified: May 14, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names