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O94412 (PGTA_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Geranylgeranyl transferase type-2 subunit alpha
EC=2.5.1.60
Alternative name(s):
GGTase-II-alpha
Geranylgeranyl transferase type II subunit alpha
PGGT
Type II protein geranyl-geranyltransferase subunit alpha
Gene names
Name:bet4
ORF Names:SPCC1620.05
OrganismSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifier284812 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces

Protein attributes

Sequence length344 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to proteins having the C-terminal-XCC or -XCXC, where both cysteines may become modified By similarity.

Catalytic activity

Geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate.

Subunit structure

Heterodimer of an alpha and a beta subunit By similarity.

Sequence similarities

Belongs to the protein prenyltransferase subunit alpha family.

Contains 6 PFTA repeats.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 344344Geranylgeranyl transferase type-2 subunit alpha
PRO_0000314652

Regions

Repeat44 – 7835PFTA 1
Repeat89 – 12335PFTA 2
Repeat125 – 15935PFTA 3
Repeat165 – 19935PFTA 4
Repeat214 – 24835PFTA 5
Repeat266 – 29328PFTA 6

Sequences

Sequence LengthMass (Da)Tools
O94412 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: 6801D2872013427F

FASTA34441,194
        10         20         30         40         50         60 
MHGILRVKLS EEQRKLKAEK ERAKIEEYRG LVSRFQEARK RKDYSEGNLK LTTELLDWNP 

        70         80         90        100        110        120 
ETYSVWNYRR EILLNDVFPK ISLNEKQDLL DNELKYVLSK MKVFPKVYWI FNHRRWCLEN 

       130        140        150        160        170        180 
APYPNWNYEM MITEKLLSAD ARNFHGWHYR RYVVSQIERA GNCSLAKKEM EYTTSAIATN 

       190        200        210        220        230        240 
FSNFSALHNR TKLIETILNL EADPNSQKAL AKQILEQELD MIHQAVFTDP DDSSVWIYHR 

       250        260        270        280        290        300 
WLMGHCNPNS MTPLISMITI EERIQYLQKE IELIQELHEM EPENRWCCES LVNYEALCKT 

       310        320        330        340 
LEKQKPTEAD IKRWTLLVDK MIKVDPQRRG RYRTLQEKIN NLNK

« Hide

References

[1]"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. expand/collapse author list , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
Nature 415:871-880(2002) [PubMed: 11859360] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 972 / ATCC 24843.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CU329672 Genomic DNA. Translation: CAA22489.1.
PIRT41035.
RefSeqNP_588463.1. NM_001023454.1.

3D structure databases

HSSPHSSP built from PDB template 1LTX based on UniProtKB Q08602.
ProteinModelPortalO94412.
ModBaseSearch...

Protein-protein interaction databases

STRINGO94412.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiSPCC1620.05.1; SPCC1620.05.1:pep; SPCC1620.05.
GeneID2539343.
GenomeReviewsGene locus bet4 in contig CU329672_GR.
KEGGspo:SPCC1620.05.
NMPDRfig|4896.1.peg.801.

Organism-specific databases

GeneDB_SpombeSPCC1620.05.

Phylogenomic databases

eggNOGfuNOG09716.
GeneTreeEFGT00050000004024.
HOGENOMHBG464445.
OMASAWHYRT.
OrthoDBEOG454D7T.

Gene expression databases

ArrayExpressO94412.

Family and domain databases

InterProIPR002088. Prenyl_trans_a.
IPR008940. Prenyltransferase.
[Graphical view]
Gene3DG3DSA:1.25.40.120. Prenyl_trans. 1 hit.
KOK14050.
PfamPF01239. PPTA. 5 hits.
[Graphical view]
PROSITEPS51147. PFTA. 6 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePGTA_SCHPO
AccessionPrimary (citable) accession number: O94412
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 1, 1999
Last modified: December 14, 2011
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents