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Protein

Structural maintenance of chromosomes protein 1

Gene

psm1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in chromosome cohesion during cell cycle and in DNA repair. Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi32 – 39ATPCurated8

GO - Molecular functioni

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • mitotic cohesin loading Source: PomBase
  • mitotic sister chromatid cohesion Source: UniProtKB

Keywordsi

Biological processCell cycle, Cell division, Mitosis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-SPO-2500257 Resolution of Sister Chromatid Cohesion

Names & Taxonomyi

Protein namesi
Recommended name:
Structural maintenance of chromosomes protein 1
Alternative name(s):
Chromosome segregation protein smc1
Cohesin complex subunit psm1
Gene namesi
Name:psm1
Synonyms:smc1
ORF Names:SPBC29A10.04
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC29A10.04
PomBaseiSPBC29A10.04 psm1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001190101 – 1228Structural maintenance of chromosomes protein 1Add BLAST1228

Proteomic databases

MaxQBiO94383
PaxDbiO94383
PRIDEiO94383

PTM databases

iPTMnetiO94383

Interactioni

Subunit structurei

Cohesin complexes are composed of the psm1/smc1 and psm3/smc3 heterodimer attached via their hinge domain, rad21/scc1 which link them, and psc3/scc3, which interacts with rad21.

Binary interactionsi

WithEntry#Exp.IntActNotes
psm3O426493EBI-1151900,EBI-1151879

GO - Molecular functioni

Protein-protein interaction databases

BioGridi277084, 11 interactors
IntActiO94383, 2 interactors
STRINGi4896.SPBC29A10.04.1

Structurei

3D structure databases

SMRiO94383
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni511 – 709Flexible hingeAdd BLAST199

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili197 – 510Sequence analysisAdd BLAST314
Coiled coili710 – 783Sequence analysisAdd BLAST74
Coiled coili814 – 926Sequence analysisAdd BLAST113
Coiled coili984 – 1068Sequence analysisAdd BLAST85

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1132 – 1167Ala/Asp-rich (DA-box)Add BLAST36

Domaini

The flexible hinge domain, which separates the large intramolecular coiled coil regions, allows the heterotypic interaction with the corresponding domain of psm3, forming a V-shaped heterodimer. The two heads of the heterodimer are then connected by different ends of the cleavable rad21 protein, forming a ring structure (By similarity).By similarity

Sequence similaritiesi

Belongs to the SMC family. SMC1 subfamily.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

HOGENOMiHOG000195481
InParanoidiO94383
KOiK06636
OMAiFNFKSYK
OrthoDBiEOG092C0XGI

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR003395 RecF/RecN/SMC_N
IPR024704 SMC
IPR028468 Smc1
IPR010935 SMC_hinge
IPR036277 SMC_hinge_sf
PANTHERiPTHR18937:SF12 PTHR18937:SF12, 1 hit
PfamiView protein in Pfam
PF06470 SMC_hinge, 1 hit
PF02463 SMC_N, 1 hit
PIRSFiPIRSF005719 SMC, 1 hit
SMARTiView protein in SMART
SM00968 SMC_hinge, 1 hit
SUPFAMiSSF52540 SSF52540, 2 hits
SSF75553 SSF75553, 1 hit

Sequencei

Sequence statusi: Complete.

O94383-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGRLLRLEVE NFKSYRGHQI IGPFEDFTSI IGPNGAGKSN LMDAISFVLG
60 70 80 90 100
VKSSHLRSTN VKELIYRGKI LQRDNTDFTD SSNPTTAYVK LMYELDNGEQ
110 120 130 140 150
REYKRAITPS GATEYKIDEE IVTFSEYCGS LQKENILVRA RNFLVFQGDV
160 170 180 190 200
ETIASQSPLE LSKLVEQISG SLEYKSEYDK SKDEQDKAVN LSAHSFNKKR
210 220 230 240 250
GINAELRQYQ EQKTEAERYQ SQKEKRDSAQ LVYLLWKLFH LEKSISSNMA
260 270 280 290 300
EVTRLKADSI QLIERRDENT KEIEKLKEKE GSIRRNLLAF DRKVRKQEKL
310 320 330 340 350
IASKRPELIS IAEKALESKS NLRKIQRKAA EIEKDYSDQA STLQVLENQL
360 370 380 390 400
TSLSAAEKEF LKDMQEKEQL KGLRLLPEDK EEYEGLRSEA DKLNSNLLFK
410 420 430 440 450
LQTLNRNIKV TSQSKDSLTS IVGDLESKIK SLHESVSSLD TERADLLAKI
460 470 480 490 500
NEKIESLELE KHDQQKKRLT YSELFHKTQE LNEELQSCLQ KILEASADRN
510 520 530 540 550
ESKQDAKKRE ALYALKRIYP EVKGRIIDLC TPTQKKYESA IAAALGKNFD
560 570 580 590 600
AIVVETQAVA KECIDYIKEQ RIGIMTFFPM DTIAASPVNQ KFRGTHKGAR
610 620 630 640 650
LAIDVLNFES EYERVMISAV GNTLICDSMT VARDLSYNKR LNAKTVTLEG
660 670 680 690 700
TVIHKTGLIT GGSSNNRSAK HWDDHDFDLL TQTKDRLMHQ IGEIEYQKSS
710 720 730 740 750
CVITESDTVK LHSLESEISL LKDKYTVVSR SVEDKKKEIG HYESLIKEKQ
760 770 780 790 800
PHLSELEMEL RNFVKSRDEL QIQVEKVEEK IFSGFCKRIG ISDIHTYDEI
810 820 830 840 850
HRTFTQSFTQ KQLEFTKQKS LLENRISFEK QRVSDTRLRL ERMHKFIEKD
860 870 880 890 900
QESIDNYEQN REALESEVAT AEAELELLKE DFASENSKTE KILLAASEKK
910 920 930 940 950
LVGKRLVSEL TKLSGNITLL ESEIDRYVSE WHAILRKCKL EDIDVPLREG
960 970 980 990 1000
SLTSIPIDDV SNSGDITMGE EPSEPVINFE KFGVEVDYDE LDEELRNDGS
1010 1020 1030 1040 1050
ESMASVLQEK LREYSEELDQ MSPNLRAIER LETVETRLAK LDEEFAAARK
1060 1070 1080 1090 1100
AAKNAKERFN AVKQKRLQKF QAAFSHISEQ IDPIYKELTK SPAFPLGGTA
1110 1120 1130 1140 1150
YLTLDDLDEP YLGGIKFHAM PPMKRFRDMD QLSGGEKTMA ALALLFAIHS
1160 1170 1180 1190 1200
YQPSPFFVLD EIDAALDQTN VTKIANYIRQ HASSGFQFVV ISLKNQLFSK
1210 1220
SEALVGIYRD QQENSSRTLS INLEGYVE
Length:1,228
Mass (Da):140,522
Last modified:October 3, 2012 - v2
Checksum:i915817D9AF404CEC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA Translation: CAA22432.2
PIRiT40059
RefSeqiNP_596049.2, NM_001021960.2

Genome annotation databases

EnsemblFungiiSPBC29A10.04.1; SPBC29A10.04.1:pep; SPBC29A10.04
GeneIDi2540557
KEGGispo:SPBC29A10.04

Similar proteinsi

Entry informationi

Entry nameiSMC1_SCHPO
AccessioniPrimary (citable) accession number: O94383
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: October 3, 2012
Last modified: March 28, 2018
This is version 133 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health