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Protein

Mediator of RNA polymerase II transcription subunit 21

Gene

med21

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Mediator of RNA polymerase II transcription subunit 21
Alternative name(s):
Mediator complex subunit 21
Suppressor of RNA polymerase B 7
Gene namesi
Name:med21
Synonyms:srb7
ORF Names:SPBC1604.10
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC1604.10.
PomBaseiSPBC1604.10.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: PomBase
  • mediator complex Source: PomBase
  • nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 138138Mediator of RNA polymerase II transcription subunit 21PRO_0000096376Add
BLAST

Proteomic databases

MaxQBiO94376.

Interactioni

Subunit structurei

Component of the Mediator complex.1 Publication

Protein-protein interaction databases

BioGridi276742. 9 interactions.
IntActiO94376. 1 interaction.
MINTiMINT-4683620.

Structurei

3D structure databases

ProteinModelPortaliO94376.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili87 – 12842Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the Mediator complex subunit 21 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG247021.
HOGENOMiHOG000001051.
InParanoidiO94376.
KOiK15152.
OMAiDKIREPK.
OrthoDBiEOG7BCNQR.
PhylomeDBiO94376.

Family and domain databases

InterProiIPR021384. Mediator_Med21.
[Graphical view]
PfamiPF11221. Med21. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O94376-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MACRCTQLQD TIDEVATQFY SSIHYLSSHH DFVPLPGQEK VSDSKVNPIS
60 70 80 90 100
AEELQFAQRD LAKDLVTKFM QIDTLINQLP GISTAPKHQL EKIKKLQNSI
110 120 130
EEKQLERKSL ESENEDLKLQ LAKRIETFGR LSCVLFQP
Length:138
Mass (Da):15,800
Last modified:May 1, 1999 - v1
Checksum:i5A7C236108C09AF9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA22343.1.
PIRiT39504.
RefSeqiNP_596630.1. NM_001022551.2.

Genome annotation databases

EnsemblFungiiSPBC1604.10.1; SPBC1604.10.1:pep; SPBC1604.10.
GeneIDi2540209.
KEGGispo:SPBC1604.10.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA22343.1.
PIRiT39504.
RefSeqiNP_596630.1. NM_001022551.2.

3D structure databases

ProteinModelPortaliO94376.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi276742. 9 interactions.
IntActiO94376. 1 interaction.
MINTiMINT-4683620.

Proteomic databases

MaxQBiO94376.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC1604.10.1; SPBC1604.10.1:pep; SPBC1604.10.
GeneIDi2540209.
KEGGispo:SPBC1604.10.

Organism-specific databases

EuPathDBiFungiDB:SPBC1604.10.
PomBaseiSPBC1604.10.

Phylogenomic databases

eggNOGiNOG247021.
HOGENOMiHOG000001051.
InParanoidiO94376.
KOiK15152.
OMAiDKIREPK.
OrthoDBiEOG7BCNQR.
PhylomeDBiO94376.

Miscellaneous databases

NextBioi20801341.
PROiO94376.

Family and domain databases

InterProiIPR021384. Mediator_Med21.
[Graphical view]
PfamiPF11221. Med21. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "Analysis of Schizosaccharomyces pombe mediator reveals a set of essential subunits conserved between yeast and metazoan cells."
    Spaehr H., Samuelsen C.O., Baraznenok V., Ernest I., Huylebroeck D., Remacle J.E., Samuelsson T., Kieselbach T., Holmberg S., Gustafsson C.M.
    Proc. Natl. Acad. Sci. U.S.A. 98:11985-11990(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN THE MEDIATOR COMPLEX.

Entry informationi

Entry nameiMED21_SCHPO
AccessioniPrimary (citable) accession number: O94376
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: May 1, 1999
Last modified: July 22, 2015
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.