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O94376

- MED21_SCHPO

UniProt

O94376 - MED21_SCHPO

Protein

Mediator of RNA polymerase II transcription subunit 21

Gene

med21

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

    GO - Molecular functioni

    1. RNA polymerase II transcription cofactor activity Source: PomBase

    GO - Biological processi

    1. regulation of transcription from RNA polymerase II promoter Source: GOC
    2. transcription from RNA polymerase II promoter Source: PomBase

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mediator of RNA polymerase II transcription subunit 21
    Alternative name(s):
    Mediator complex subunit 21
    Suppressor of RNA polymerase B 7
    Gene namesi
    Name:med21
    Synonyms:srb7
    ORF Names:SPBC1604.10
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome II

    Organism-specific databases

    PomBaseiSPBC1604.10.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. cytosol Source: PomBase
    2. mediator complex Source: PomBase
    3. nucleus Source: PomBase

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 138138Mediator of RNA polymerase II transcription subunit 21PRO_0000096376Add
    BLAST

    Proteomic databases

    MaxQBiO94376.

    Interactioni

    Subunit structurei

    Component of the Mediator complex.1 Publication

    Protein-protein interaction databases

    BioGridi276742. 9 interactions.
    IntActiO94376. 1 interaction.
    MINTiMINT-4683620.
    STRINGi4896.SPBC1604.10-1.

    Structurei

    3D structure databases

    ProteinModelPortaliO94376.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili87 – 12842Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the Mediator complex subunit 21 family.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG247021.
    HOGENOMiHOG000001051.
    KOiK15152.
    OMAiAQQFVAC.
    OrthoDBiEOG7BCNQR.
    PhylomeDBiO94376.

    Family and domain databases

    InterProiIPR021384. Mediator_Med21.
    [Graphical view]
    PfamiPF11221. Med21. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O94376-1 [UniParc]FASTAAdd to Basket

    « Hide

    MACRCTQLQD TIDEVATQFY SSIHYLSSHH DFVPLPGQEK VSDSKVNPIS    50
    AEELQFAQRD LAKDLVTKFM QIDTLINQLP GISTAPKHQL EKIKKLQNSI 100
    EEKQLERKSL ESENEDLKLQ LAKRIETFGR LSCVLFQP 138
    Length:138
    Mass (Da):15,800
    Last modified:May 1, 1999 - v1
    Checksum:i5A7C236108C09AF9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329671 Genomic DNA. Translation: CAA22343.1.
    PIRiT39504.
    RefSeqiNP_596630.1. NM_001022551.2.

    Genome annotation databases

    EnsemblFungiiSPBC1604.10.1; SPBC1604.10.1:pep; SPBC1604.10.
    GeneIDi2540209.
    KEGGispo:SPBC1604.10.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329671 Genomic DNA. Translation: CAA22343.1 .
    PIRi T39504.
    RefSeqi NP_596630.1. NM_001022551.2.

    3D structure databases

    ProteinModelPortali O94376.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 276742. 9 interactions.
    IntActi O94376. 1 interaction.
    MINTi MINT-4683620.
    STRINGi 4896.SPBC1604.10-1.

    Proteomic databases

    MaxQBi O94376.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPBC1604.10.1 ; SPBC1604.10.1:pep ; SPBC1604.10 .
    GeneIDi 2540209.
    KEGGi spo:SPBC1604.10.

    Organism-specific databases

    PomBasei SPBC1604.10.

    Phylogenomic databases

    eggNOGi NOG247021.
    HOGENOMi HOG000001051.
    KOi K15152.
    OMAi AQQFVAC.
    OrthoDBi EOG7BCNQR.
    PhylomeDBi O94376.

    Miscellaneous databases

    NextBioi 20801341.

    Family and domain databases

    InterProi IPR021384. Mediator_Med21.
    [Graphical view ]
    Pfami PF11221. Med21. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.
    2. "Analysis of Schizosaccharomyces pombe mediator reveals a set of essential subunits conserved between yeast and metazoan cells."
      Spaehr H., Samuelsen C.O., Baraznenok V., Ernest I., Huylebroeck D., Remacle J.E., Samuelsson T., Kieselbach T., Holmberg S., Gustafsson C.M.
      Proc. Natl. Acad. Sci. U.S.A. 98:11985-11990(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN THE MEDIATOR COMPLEX.

    Entry informationi

    Entry nameiMED21_SCHPO
    AccessioniPrimary (citable) accession number: O94376
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 6, 2002
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 80 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3