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Protein

Mediator of RNA polymerase II transcription subunit 21

Gene

med21

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Mediator of RNA polymerase II transcription subunit 21
Alternative name(s):
Mediator complex subunit 21
Suppressor of RNA polymerase B 7
Gene namesi
Name:med21
Synonyms:srb7
ORF Names:SPBC1604.10
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC1604.10.
PomBaseiSPBC1604.10.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000963761 – 138Mediator of RNA polymerase II transcription subunit 21Add BLAST138

Proteomic databases

MaxQBiO94376.
PRIDEiO94376.

Interactioni

Subunit structurei

Component of the Mediator complex.1 Publication

Protein-protein interaction databases

BioGridi276742. 9 interactors.
IntActiO94376. 1 interactor.
MINTiMINT-4683620.
STRINGi4896.SPBC1604.10.1.

Structurei

Secondary structure

1138
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi4 – 28Combined sources25
Beta strandi35 – 37Combined sources3
Helixi43 – 46Combined sources4
Helixi51 – 78Combined sources28
Helixi87 – 136Combined sources50

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5N9JX-ray3.40D1-138[»]
5U0Pelectron microscopy4.40U1-138[»]
5U0Selectron microscopy7.80U1-138[»]
ProteinModelPortaliO94376.
SMRiO94376.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili87 – 128Sequence analysisAdd BLAST42

Sequence similaritiesi

Belongs to the Mediator complex subunit 21 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

HOGENOMiHOG000001051.
InParanoidiO94376.
KOiK15152.
OMAiMGDRLTQ.
OrthoDBiEOG092C5Z2L.
PhylomeDBiO94376.

Family and domain databases

InterProiView protein in InterPro
IPR037212. Med7/Med21-like.
IPR021384. Mediator_Med21.
PANTHERiPTHR13381. PTHR13381. 1 hit.
PfamiView protein in Pfam
PF11221. Med21. 1 hit.
SUPFAMiSSF140718. SSF140718. 1 hit.

Sequencei

Sequence statusi: Complete.

O94376-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MACRCTQLQD TIDEVATQFY SSIHYLSSHH DFVPLPGQEK VSDSKVNPIS
60 70 80 90 100
AEELQFAQRD LAKDLVTKFM QIDTLINQLP GISTAPKHQL EKIKKLQNSI
110 120 130
EEKQLERKSL ESENEDLKLQ LAKRIETFGR LSCVLFQP
Length:138
Mass (Da):15,800
Last modified:May 1, 1999 - v1
Checksum:i5A7C236108C09AF9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA22343.1.
PIRiT39504.
RefSeqiNP_596630.1. NM_001022551.2.

Genome annotation databases

EnsemblFungiiSPBC1604.10.1; SPBC1604.10.1:pep; SPBC1604.10.
GeneIDi2540209.
KEGGispo:SPBC1604.10.

Similar proteinsi

Entry informationi

Entry nameiMED21_SCHPO
AccessioniPrimary (citable) accession number: O94376
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: May 1, 1999
Last modified: October 25, 2017
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families