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O94374

- IMA2_SCHPO

UniProt

O94374 - IMA2_SCHPO

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Protein

Importin subunit alpha-2

Gene

imp1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. Active directional transport is assured by both, a Phe-Gly (FG) repeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope. Involved in nuclear protein import. Required for efficient nuclera import of both an SV40 nuclear localization signal-containing reporter protein and the pap1 component of the stress response MAP kinase pathway. Required for proper mitotic progression.3 Publications

GO - Molecular functioni

  1. GTP binding Source: PomBase
  2. protein transporter activity Source: InterPro

GO - Biological processi

  1. mitotic nuclear division Source: UniProtKB-KW
  2. NLS-bearing protein import into nucleus Source: PomBase
  3. nucleocytoplasmic transport Source: PomBase
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Mitosis, Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Importin subunit alpha-2
Alternative name(s):
Importin-1
Karyopherin subunit alpha-2
Gene namesi
Name:imp1
ORF Names:SPBC1604.08c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome II

Organism-specific databases

PomBaseiSPBC1604.08c.

Subcellular locationi

Cytoplasm. Nucleusnucleolus
Note: Nucleus; nucleolus; nuclear rim.

GO - Cellular componenti

  1. cytosol Source: PomBase
  2. nuclear envelope Source: PomBase
  3. nuclear pore Source: PomBase
  4. nucleolus Source: PomBase
  5. nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 539539Importin subunit alpha-2PRO_0000290665Add
BLAST

Proteomic databases

MaxQBiO94374.
PaxDbiO94374.

Interactioni

Subunit structurei

Interacts with pap1.1 Publication

Protein-protein interaction databases

BioGridi276472. 66 interactions.
IntActiO94374. 1 interaction.
MINTiMINT-4683591.
STRINGi4896.SPBC1604.08c-1.

Structurei

3D structure databases

ProteinModelPortaliO94374.
SMRiO94374. Positions 78-512.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 5757IBBPROSITE-ProRule annotationAdd
BLAST
Repeati110 – 14940ARM 1Add
BLAST
Repeati152 – 19140ARM 2Add
BLAST
Repeati194 – 23542ARM 3Add
BLAST
Repeati238 – 27740ARM 4Add
BLAST
Repeati280 – 31940ARM 5Add
BLAST
Repeati322 – 36140ARM 6Add
BLAST
Repeati364 – 40340ARM 7Add
BLAST
Repeati409 – 44840ARM 8Add
BLAST

Sequence similaritiesi

Belongs to the importin alpha family.Curated
Contains 8 ARM repeats.PROSITE-ProRule annotation
Contains 1 IBB domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG5064.
HOGENOMiHOG000167616.
InParanoidiO94374.
OMAiETENGAF.
OrthoDBiEOG7DC2DF.
PhylomeDBiO94374.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
IPR002652. Importin-a_IBB.
IPR024931. Importing_su_alpha.
[Graphical view]
PfamiPF00514. Arm. 8 hits.
PF01749. IBB. 1 hit.
[Graphical view]
PIRSFiPIRSF005673. Importin_alpha. 1 hit.
SMARTiSM00185. ARM. 8 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS50176. ARM_REPEAT. 4 hits.
PS51214. IBB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O94374 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MESRYLSDRR SRFKSKGVFK ADELRRQREE QQIEIRKQKR EESLNKRRNL
60 70 80 90 100
NAVLQNDIDV EEEADQSQVQ MEQQMKDEFP KLTADVMSDD IELQLGAVTK
110 120 130 140 150
FRKYLSKETH PPIDQVIACG VVDRFVQFLE SEHHLLQFEA AWALTNIASG
160 170 180 190 200
TTDQTRIVVD SGAVPRFIQL LSSPEKDVRE QVVWALGNIA GDSSACRDYV
210 220 230 240 250
LGNGVLQPLL NILQSSASDV SMLRNATWTL SNLCRGKNPP PNWSTISVAV
260 270 280 290 300
PILAKLLYSE DVEIIVDACW AISYLSDGPN EKIGAILDVG CAPRLVELLS
310 320 330 340 350
SPSVNIQTPA LRSVGNIVTG TDAQTQIIID CGALNAFPSL LSHQKENIRK
360 370 380 390 400
EACWTISNIT AGNTQQIQAI IESNLIPPLV HLLSYADYKT KKEACWAISN
410 420 430 440 450
ATSGGLGQPD QIRYLVSQGV IKPLCDMLNG SDNKIIQVAL DAIENILKVG
460 470 480 490 500
EMDRTMDLEN INQYAVYVEE AGGMDMIHDL QSSGNNDIYL KAYSIIEKYF
510 520 530
SDEDAVEDLA PETENGAFTF GNGPQAQGEF KFDSQDMAM
Length:539
Mass (Da):59,853
Last modified:May 1, 1999 - v1
Checksum:iFFD4919E936E0941
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329671 Genomic DNA. Translation: CAA22341.1.
PIRiT39506.
RefSeqiNP_596632.1. NM_001022553.2.

Genome annotation databases

EnsemblFungiiSPBC1604.08c.1; SPBC1604.08c.1:pep; SPBC1604.08c.
GeneIDi2539928.
KEGGispo:SPBC1604.08c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329671 Genomic DNA. Translation: CAA22341.1 .
PIRi T39506.
RefSeqi NP_596632.1. NM_001022553.2.

3D structure databases

ProteinModelPortali O94374.
SMRi O94374. Positions 78-512.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 276472. 66 interactions.
IntActi O94374. 1 interaction.
MINTi MINT-4683591.
STRINGi 4896.SPBC1604.08c-1.

Proteomic databases

MaxQBi O94374.
PaxDbi O94374.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPBC1604.08c.1 ; SPBC1604.08c.1:pep ; SPBC1604.08c .
GeneIDi 2539928.
KEGGi spo:SPBC1604.08c.

Organism-specific databases

PomBasei SPBC1604.08c.

Phylogenomic databases

eggNOGi COG5064.
HOGENOMi HOG000167616.
InParanoidi O94374.
OMAi ETENGAF.
OrthoDBi EOG7DC2DF.
PhylomeDBi O94374.

Miscellaneous databases

NextBioi 20801071.

Family and domain databases

Gene3Di 1.25.10.10. 1 hit.
InterProi IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
IPR002652. Importin-a_IBB.
IPR024931. Importing_su_alpha.
[Graphical view ]
Pfami PF00514. Arm. 8 hits.
PF01749. IBB. 1 hit.
[Graphical view ]
PIRSFi PIRSF005673. Importin_alpha. 1 hit.
SMARTi SM00185. ARM. 8 hits.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 1 hit.
PROSITEi PS50176. ARM_REPEAT. 4 hits.
PS51214. IBB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "Genome-wide search of Schizosaccharomyces pombe genes causing overexpression-mediated cell cycle defects."
    Tallada V.A., Daga R.R., Palomeque C., Garzon A., Jimenez J.
    Yeast 19:1139-1151(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
    Strain: 972 / ATCC 24843.
  3. "Identification of genes encoding putative nucleoporins and transport factors in the fission yeast Schizosaccharomyces pombe: a deletion analysis."
    Chen X.Q., Du X., Liu J., Balasubramanian M.K., Balasundaram D.
    Yeast 21:495-509(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  4. "The fission yeast Schizosaccharomyces pombe has two importin-alpha proteins, Imp1p and Cut15p, which have common and unique functions in nucleocytoplasmic transport and cell cycle progression."
    Umeda M., Izaddoost S., Cushman I., Moore M.S., Sazer S.
    Genetics 171:7-21(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH PAP1, SUBCELLULAR LOCATION.
  5. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
    Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
    Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiIMA2_SCHPO
AccessioniPrimary (citable) accession number: O94374
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: May 1, 1999
Last modified: October 29, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3