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O94374

- IMA2_SCHPO

UniProt

O94374 - IMA2_SCHPO

Protein

Importin subunit alpha-2

Gene

imp1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. Active directional transport is assured by both, a Phe-Gly (FG) repeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope. Involved in nuclear protein import. Required for efficient nuclera import of both an SV40 nuclear localization signal-containing reporter protein and the pap1 component of the stress response MAP kinase pathway. Required for proper mitotic progression.3 Publications

    GO - Molecular functioni

    1. GTP binding Source: PomBase
    2. protein binding Source: PomBase
    3. protein transporter activity Source: InterPro

    GO - Biological processi

    1. mitotic nuclear division Source: UniProtKB-KW
    2. NLS-bearing protein import into nucleus Source: PomBase
    3. nucleocytoplasmic transport Source: PomBase

    Keywords - Biological processi

    Cell cycle, Cell division, Mitosis, Protein transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Importin subunit alpha-2
    Alternative name(s):
    Importin-1
    Karyopherin subunit alpha-2
    Gene namesi
    Name:imp1
    ORF Names:SPBC1604.08c
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome II

    Organism-specific databases

    PomBaseiSPBC1604.08c.

    Subcellular locationi

    Cytoplasm. Nucleusnucleolus
    Note: Nucleus; nucleolus; nuclear rim.

    GO - Cellular componenti

    1. cytosol Source: PomBase
    2. nuclear envelope Source: PomBase
    3. nuclear pore Source: PomBase
    4. nucleolus Source: PomBase
    5. nucleus Source: PomBase

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 539539Importin subunit alpha-2PRO_0000290665Add
    BLAST

    Proteomic databases

    MaxQBiO94374.
    PaxDbiO94374.

    Interactioni

    Subunit structurei

    Interacts with pap1.1 Publication

    Protein-protein interaction databases

    BioGridi276472. 66 interactions.
    IntActiO94374. 1 interaction.
    MINTiMINT-4683591.
    STRINGi4896.SPBC1604.08c-1.

    Structurei

    3D structure databases

    ProteinModelPortaliO94374.
    SMRiO94374. Positions 78-512.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 5757IBBPROSITE-ProRule annotationAdd
    BLAST
    Repeati110 – 14940ARM 1Add
    BLAST
    Repeati152 – 19140ARM 2Add
    BLAST
    Repeati194 – 23542ARM 3Add
    BLAST
    Repeati238 – 27740ARM 4Add
    BLAST
    Repeati280 – 31940ARM 5Add
    BLAST
    Repeati322 – 36140ARM 6Add
    BLAST
    Repeati364 – 40340ARM 7Add
    BLAST
    Repeati409 – 44840ARM 8Add
    BLAST

    Sequence similaritiesi

    Belongs to the importin alpha family.Curated
    Contains 8 ARM repeats.PROSITE-ProRule annotation
    Contains 1 IBB domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG5064.
    HOGENOMiHOG000167616.
    OMAiETENGAF.
    OrthoDBiEOG7DC2DF.
    PhylomeDBiO94374.

    Family and domain databases

    Gene3Di1.25.10.10. 1 hit.
    InterProiIPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR000225. Armadillo.
    IPR002652. Importin-a_IBB.
    IPR024931. Importing_su_alpha.
    [Graphical view]
    PfamiPF00514. Arm. 8 hits.
    PF01749. IBB. 1 hit.
    [Graphical view]
    PIRSFiPIRSF005673. Importin_alpha. 1 hit.
    SMARTiSM00185. ARM. 8 hits.
    [Graphical view]
    SUPFAMiSSF48371. SSF48371. 1 hit.
    PROSITEiPS50176. ARM_REPEAT. 4 hits.
    PS51214. IBB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O94374-1 [UniParc]FASTAAdd to Basket

    « Hide

    MESRYLSDRR SRFKSKGVFK ADELRRQREE QQIEIRKQKR EESLNKRRNL    50
    NAVLQNDIDV EEEADQSQVQ MEQQMKDEFP KLTADVMSDD IELQLGAVTK 100
    FRKYLSKETH PPIDQVIACG VVDRFVQFLE SEHHLLQFEA AWALTNIASG 150
    TTDQTRIVVD SGAVPRFIQL LSSPEKDVRE QVVWALGNIA GDSSACRDYV 200
    LGNGVLQPLL NILQSSASDV SMLRNATWTL SNLCRGKNPP PNWSTISVAV 250
    PILAKLLYSE DVEIIVDACW AISYLSDGPN EKIGAILDVG CAPRLVELLS 300
    SPSVNIQTPA LRSVGNIVTG TDAQTQIIID CGALNAFPSL LSHQKENIRK 350
    EACWTISNIT AGNTQQIQAI IESNLIPPLV HLLSYADYKT KKEACWAISN 400
    ATSGGLGQPD QIRYLVSQGV IKPLCDMLNG SDNKIIQVAL DAIENILKVG 450
    EMDRTMDLEN INQYAVYVEE AGGMDMIHDL QSSGNNDIYL KAYSIIEKYF 500
    SDEDAVEDLA PETENGAFTF GNGPQAQGEF KFDSQDMAM 539
    Length:539
    Mass (Da):59,853
    Last modified:May 1, 1999 - v1
    Checksum:iFFD4919E936E0941
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329671 Genomic DNA. Translation: CAA22341.1.
    PIRiT39506.
    RefSeqiNP_596632.1. NM_001022553.2.

    Genome annotation databases

    EnsemblFungiiSPBC1604.08c.1; SPBC1604.08c.1:pep; SPBC1604.08c.
    GeneIDi2539928.
    KEGGispo:SPBC1604.08c.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329671 Genomic DNA. Translation: CAA22341.1 .
    PIRi T39506.
    RefSeqi NP_596632.1. NM_001022553.2.

    3D structure databases

    ProteinModelPortali O94374.
    SMRi O94374. Positions 78-512.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 276472. 66 interactions.
    IntActi O94374. 1 interaction.
    MINTi MINT-4683591.
    STRINGi 4896.SPBC1604.08c-1.

    Proteomic databases

    MaxQBi O94374.
    PaxDbi O94374.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPBC1604.08c.1 ; SPBC1604.08c.1:pep ; SPBC1604.08c .
    GeneIDi 2539928.
    KEGGi spo:SPBC1604.08c.

    Organism-specific databases

    PomBasei SPBC1604.08c.

    Phylogenomic databases

    eggNOGi COG5064.
    HOGENOMi HOG000167616.
    OMAi ETENGAF.
    OrthoDBi EOG7DC2DF.
    PhylomeDBi O94374.

    Miscellaneous databases

    NextBioi 20801071.

    Family and domain databases

    Gene3Di 1.25.10.10. 1 hit.
    InterProi IPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR000225. Armadillo.
    IPR002652. Importin-a_IBB.
    IPR024931. Importing_su_alpha.
    [Graphical view ]
    Pfami PF00514. Arm. 8 hits.
    PF01749. IBB. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF005673. Importin_alpha. 1 hit.
    SMARTi SM00185. ARM. 8 hits.
    [Graphical view ]
    SUPFAMi SSF48371. SSF48371. 1 hit.
    PROSITEi PS50176. ARM_REPEAT. 4 hits.
    PS51214. IBB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.
    2. "Genome-wide search of Schizosaccharomyces pombe genes causing overexpression-mediated cell cycle defects."
      Tallada V.A., Daga R.R., Palomeque C., Garzon A., Jimenez J.
      Yeast 19:1139-1151(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
      Strain: 972 / ATCC 24843.
    3. "Identification of genes encoding putative nucleoporins and transport factors in the fission yeast Schizosaccharomyces pombe: a deletion analysis."
      Chen X.Q., Du X., Liu J., Balasubramanian M.K., Balasundaram D.
      Yeast 21:495-509(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.
    4. "The fission yeast Schizosaccharomyces pombe has two importin-alpha proteins, Imp1p and Cut15p, which have common and unique functions in nucleocytoplasmic transport and cell cycle progression."
      Umeda M., Izaddoost S., Cushman I., Moore M.S., Sazer S.
      Genetics 171:7-21(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH PAP1, SUBCELLULAR LOCATION.
    5. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
      Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
      Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiIMA2_SCHPO
    AccessioniPrimary (citable) accession number: O94374
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 12, 2007
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 98 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3