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Protein

U3 small nucleolar RNA-associated protein 15

Gene

utp15

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I together with a subset of U3 proteins required for transcription (t-UTPs) (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein

Keywords - Biological processi

Ribosome biogenesis, rRNA processing, Transcription

Enzyme and pathway databases

ReactomeiR-SPO-6791226. Major pathway of rRNA processing in the nucleolus.

Names & Taxonomyi

Protein namesi
Recommended name:
U3 small nucleolar RNA-associated protein 15
Short name:
U3 snoRNA-associated protein 15
Alternative name(s):
U3 protein 15 required for transcription
Gene namesi
Name:utp15
ORF Names:SPBC428.19c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC428.19c.
PomBaseiSPBC428.19c. utp15.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: PomBase
  • mitotic spindle Source: PomBase
  • nucleolus Source: PomBase
  • small-subunit processome Source: PomBase
  • t-UTP complex Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 494494U3 small nucleolar RNA-associated protein 15PRO_0000307922Add
BLAST

Proteomic databases

MaxQBiO94365.

Interactioni

Subunit structurei

Component of the ribosomal small subunit (SSU) processome.By similarity

Protein-protein interaction databases

BioGridi277375. 1 interaction.
MINTiMINT-4683550.

Structurei

3D structure databases

ProteinModelPortaliO94365.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati37 – 7640WD 1Sequence analysisAdd
BLAST
Repeati79 – 11840WD 2Sequence analysisAdd
BLAST
Repeati121 – 16141WD 3Sequence analysisAdd
BLAST
Repeati164 – 20239WD 4Sequence analysisAdd
BLAST
Repeati205 – 24339WD 5Sequence analysisAdd
BLAST
Repeati248 – 28740WD 6Sequence analysisAdd
BLAST
Repeati289 – 32840WD 7Sequence analysisAdd
BLAST

Sequence similaritiesi

Contains 7 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

HOGENOMiHOG000185028.
InParanoidiO94365.
KOiK14549.
OMAiLTFKEHS.
OrthoDBiEOG7K6Q48.
PhylomeDBiO94365.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR018983. U3_snoRNA-assocProt_15_C.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF09384. UTP15_C. 1 hit.
PF00400. WD40. 3 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O94365-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAPAGRLQP QRFAALPNPV TAENKFWRSF KVPVVAKEYS AITSIHFSAE
60 70 80 90 100
SPYDFAVTSG ARVQIYGASS RSVKKTIARF KDTAYSGNIR KDGKLLLAGD
110 120 130 140 150
ATGLVQIFDL STRSILRALD AHQFPVHVTQ FCPYANTTFL SGSDDKTVKV
160 170 180 190 200
WDLSTGAVQY DLSGHEDYVR TASWMSATRL VSGGYDGTIR LWDTRIADPE
210 220 230 240 250
VMSFSHGEAI DVVLPMQSGS TVISAGGPSI KVWDLVAGRQ TPTKKLSNHQ
260 270 280 290 300
KSITCLAMNS ENTRLLSGGL DGHVKIYNIS DWKVVHGMKY SGPILSMGLS
310 320 330 340 350
PDSCNLVVGM SNGTLSQRTR RITKQTSSKT PFLGGVGSAF GVVGKKKQIY
360 370 380 390 400
KGENDEFYVE EARRKRLRPF DKALKSFCYS DALDMVLENG SPVLIITMLI
410 420 430 440 450
ELLHVGGLRI ALSNRDDLSL TPLINFLRKY IRDPRFSETL CIVTSTILDI
460 470 480 490
YGAALGGSVM VENAISKLRE KVEQEVAVTQ RANELVGMLQ MLSA
Length:494
Mass (Da):54,112
Last modified:May 1, 1999 - v1
Checksum:i3D3C484C12950B31
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA22294.1.
PIRiT40471.
RefSeqiNP_595197.1. NM_001021104.2.

Genome annotation databases

EnsemblFungiiSPBC428.19c.1; SPBC428.19c.1:pep; SPBC428.19c.
GeneIDi2540858.
KEGGispo:SPBC428.19c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA22294.1.
PIRiT40471.
RefSeqiNP_595197.1. NM_001021104.2.

3D structure databases

ProteinModelPortaliO94365.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi277375. 1 interaction.
MINTiMINT-4683550.

Proteomic databases

MaxQBiO94365.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC428.19c.1; SPBC428.19c.1:pep; SPBC428.19c.
GeneIDi2540858.
KEGGispo:SPBC428.19c.

Organism-specific databases

EuPathDBiFungiDB:SPBC428.19c.
PomBaseiSPBC428.19c. utp15.

Phylogenomic databases

HOGENOMiHOG000185028.
InParanoidiO94365.
KOiK14549.
OMAiLTFKEHS.
OrthoDBiEOG7K6Q48.
PhylomeDBiO94365.

Enzyme and pathway databases

ReactomeiR-SPO-6791226. Major pathway of rRNA processing in the nucleolus.

Miscellaneous databases

PROiO94365.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR018983. U3_snoRNA-assocProt_15_C.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF09384. UTP15_C. 1 hit.
PF00400. WD40. 3 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
    Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
    Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiUTP15_SCHPO
AccessioniPrimary (citable) accession number: O94365
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: May 1, 1999
Last modified: June 8, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.