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Protein

U3 small nucleolar RNA-associated protein 15

Gene

utp15

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I together with a subset of U3 proteins required for transcription (t-UTPs) (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein

Keywords - Biological processi

Ribosome biogenesis, rRNA processing, Transcription

Enzyme and pathway databases

ReactomeiR-SPO-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.

Names & Taxonomyi

Protein namesi
Recommended name:
U3 small nucleolar RNA-associated protein 15
Short name:
U3 snoRNA-associated protein 15
Alternative name(s):
U3 protein 15 required for transcription
Gene namesi
Name:utp15
ORF Names:SPBC428.19c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC428.19c.
PomBaseiSPBC428.19c. utp15.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: PomBase
  • mitotic spindle Source: PomBase
  • nucleolus Source: PomBase
  • small-subunit processome Source: PomBase
  • t-UTP complex Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003079221 – 494U3 small nucleolar RNA-associated protein 15Add BLAST494

Proteomic databases

MaxQBiO94365.
PRIDEiO94365.

Interactioni

Subunit structurei

Component of the ribosomal small subunit (SSU) processome.By similarity

Protein-protein interaction databases

BioGridi277375. 1 interactor.
MINTiMINT-4683550.

Structurei

3D structure databases

ProteinModelPortaliO94365.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati37 – 76WD 1Sequence analysisAdd BLAST40
Repeati79 – 118WD 2Sequence analysisAdd BLAST40
Repeati121 – 161WD 3Sequence analysisAdd BLAST41
Repeati164 – 202WD 4Sequence analysisAdd BLAST39
Repeati205 – 243WD 5Sequence analysisAdd BLAST39
Repeati248 – 287WD 6Sequence analysisAdd BLAST40
Repeati289 – 328WD 7Sequence analysisAdd BLAST40

Sequence similaritiesi

Contains 7 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

HOGENOMiHOG000185028.
InParanoidiO94365.
KOiK14549.
OMAiDILINRP.
OrthoDBiEOG092C1VIW.
PhylomeDBiO94365.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR018983. U3_snoRNA-assocProt_15_C.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF09384. UTP15_C. 1 hit.
PF00400. WD40. 3 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O94365-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAPAGRLQP QRFAALPNPV TAENKFWRSF KVPVVAKEYS AITSIHFSAE
60 70 80 90 100
SPYDFAVTSG ARVQIYGASS RSVKKTIARF KDTAYSGNIR KDGKLLLAGD
110 120 130 140 150
ATGLVQIFDL STRSILRALD AHQFPVHVTQ FCPYANTTFL SGSDDKTVKV
160 170 180 190 200
WDLSTGAVQY DLSGHEDYVR TASWMSATRL VSGGYDGTIR LWDTRIADPE
210 220 230 240 250
VMSFSHGEAI DVVLPMQSGS TVISAGGPSI KVWDLVAGRQ TPTKKLSNHQ
260 270 280 290 300
KSITCLAMNS ENTRLLSGGL DGHVKIYNIS DWKVVHGMKY SGPILSMGLS
310 320 330 340 350
PDSCNLVVGM SNGTLSQRTR RITKQTSSKT PFLGGVGSAF GVVGKKKQIY
360 370 380 390 400
KGENDEFYVE EARRKRLRPF DKALKSFCYS DALDMVLENG SPVLIITMLI
410 420 430 440 450
ELLHVGGLRI ALSNRDDLSL TPLINFLRKY IRDPRFSETL CIVTSTILDI
460 470 480 490
YGAALGGSVM VENAISKLRE KVEQEVAVTQ RANELVGMLQ MLSA
Length:494
Mass (Da):54,112
Last modified:May 1, 1999 - v1
Checksum:i3D3C484C12950B31
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA22294.1.
PIRiT40471.
RefSeqiNP_595197.1. NM_001021104.2.

Genome annotation databases

EnsemblFungiiSPBC428.19c.1; SPBC428.19c.1:pep; SPBC428.19c.
GeneIDi2540858.
KEGGispo:SPBC428.19c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA22294.1.
PIRiT40471.
RefSeqiNP_595197.1. NM_001021104.2.

3D structure databases

ProteinModelPortaliO94365.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi277375. 1 interactor.
MINTiMINT-4683550.

Proteomic databases

MaxQBiO94365.
PRIDEiO94365.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC428.19c.1; SPBC428.19c.1:pep; SPBC428.19c.
GeneIDi2540858.
KEGGispo:SPBC428.19c.

Organism-specific databases

EuPathDBiFungiDB:SPBC428.19c.
PomBaseiSPBC428.19c. utp15.

Phylogenomic databases

HOGENOMiHOG000185028.
InParanoidiO94365.
KOiK14549.
OMAiDILINRP.
OrthoDBiEOG092C1VIW.
PhylomeDBiO94365.

Enzyme and pathway databases

ReactomeiR-SPO-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.

Miscellaneous databases

PROiO94365.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR018983. U3_snoRNA-assocProt_15_C.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF09384. UTP15_C. 1 hit.
PF00400. WD40. 3 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiUTP15_SCHPO
AccessioniPrimary (citable) accession number: O94365
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: May 1, 1999
Last modified: November 30, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.