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Protein

GTP-binding protein rhb1

Gene

rhb1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

Regulates entry into stationary phase when extracellular nitrogen levels are adequate for growth.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi13 – 208GTPBy similarity
Nucleotide bindingi60 – 645GTPBy similarity
Nucleotide bindingi119 – 1224GTPBy similarity

GO - Molecular functioni

  • GDP binding Source: PomBase
  • GTPase activity Source: UniProtKB
  • GTP binding Source: UniProtKB

GO - Biological processi

  • mitotic G1 cell cycle arrest in response to nitrogen starvation Source: PomBase
  • protein transport Source: InterPro
  • regulation of L-arginine import Source: PomBase
  • signal transduction Source: PomBase
  • small GTPase mediated signal transduction Source: PomBase
Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-SPO-165159. mTOR signalling.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP-binding protein rhb1
Alternative name(s):
GTP-binding protein Rheb homolog
Gene namesi
Name:rhb1
ORF Names:SPBC428.16c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC428.16c.
PomBaseiSPBC428.16c. rhb1.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: PomBase
  • nucleus Source: PomBase
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 182182GTP-binding protein rhb1PRO_0000082712Add
BLAST
Propeptidei183 – 1853Removed in mature formBy similarityPRO_0000281369

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei182 – 1821Cysteine methyl esterBy similarity
Lipidationi182 – 1821S-farnesyl cysteineBy similarity

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

MaxQBiO94363.

Interactioni

Protein-protein interaction databases

BioGridi277370. 12 interactions.
MINTiMINT-4683520.

Structurei

3D structure databases

ProteinModelPortaliO94363.
SMRiO94363. Positions 5-170.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi35 – 439Effector region

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rheb family.Curated

Phylogenomic databases

HOGENOMiHOG000233973.
InParanoidiO94363.
KOiK07208.
OMAiTILNSKH.
OrthoDBiEOG7H1JXN.
PhylomeDBiO94363.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERiPTHR24070. PTHR24070. 1 hit.
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51421. RAS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O94363-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPIKSRRIA VLGSRSVGKS SLTVQYVENH FVESYYPTIE NTFSKNIKYK
60 70 80 90 100
GQEFATEIID TAGQDEYSIL NSKHSIGIHG YVLVYSITSK SSFEMVKIVR
110 120 130 140 150
DKILNHTGTE WVPIVVVGNK SDLHMQRAVT AEEGKALANE WKCAWTEASA
160 170 180
RHNENVARAF ELIISEIEKQ ANPSPPGDGK GCVIA
Length:185
Mass (Da):20,515
Last modified:May 1, 1999 - v1
Checksum:i3DBC3E352C122C71
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA22291.1.
PIRiT40468.
RefSeqiNP_595194.1. NM_001021101.2.

Genome annotation databases

EnsemblFungiiSPBC428.16c.1; SPBC428.16c.1:pep; SPBC428.16c.
GeneIDi2540853.
KEGGispo:SPBC428.16c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA22291.1.
PIRiT40468.
RefSeqiNP_595194.1. NM_001021101.2.

3D structure databases

ProteinModelPortaliO94363.
SMRiO94363. Positions 5-170.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi277370. 12 interactions.
MINTiMINT-4683520.

Proteomic databases

MaxQBiO94363.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC428.16c.1; SPBC428.16c.1:pep; SPBC428.16c.
GeneIDi2540853.
KEGGispo:SPBC428.16c.

Organism-specific databases

EuPathDBiFungiDB:SPBC428.16c.
PomBaseiSPBC428.16c. rhb1.

Phylogenomic databases

HOGENOMiHOG000233973.
InParanoidiO94363.
KOiK07208.
OMAiTILNSKH.
OrthoDBiEOG7H1JXN.
PhylomeDBiO94363.

Enzyme and pathway databases

ReactomeiR-SPO-165159. mTOR signalling.

Miscellaneous databases

PROiO94363.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERiPTHR24070. PTHR24070. 1 hit.
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51421. RAS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "Loss of Rhb1, a Rheb-related GTPase in fission yeast, causes growth arrest with a terminal phenotype similar to that caused by nitrogen starvation."
    Mach K.E., Furge K.A., Albright C.F.
    Genetics 155:611-622(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiRHB1_SCHPO
AccessioniPrimary (citable) accession number: O94363
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 1999
Last modified: June 8, 2016
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.