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Protein

GTP-binding protein rhb1

Gene

rhb1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Regulates entry into stationary phase when extracellular nitrogen levels are adequate for growth.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi13 – 20GTPBy similarity8
Nucleotide bindingi60 – 64GTPBy similarity5
Nucleotide bindingi119 – 122GTPBy similarity4

GO - Molecular functioni

  • GDP binding Source: PomBase
  • GTPase activity Source: UniProtKB
  • GTP binding Source: UniProtKB

GO - Biological processi

  • mitotic G1 cell cycle arrest in response to nitrogen starvation Source: PomBase
  • positive regulation of L-arginine import across plasma membrane Source: PomBase
  • small GTPase mediated signal transduction Source: PomBase

Keywordsi

LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-SPO-165159 mTOR signalling

Names & Taxonomyi

Protein namesi
Recommended name:
GTP-binding protein rhb1
Alternative name(s):
GTP-binding protein Rheb homolog
Gene namesi
Name:rhb1
ORF Names:SPBC428.16c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC428.16c
PomBaseiSPBC428.16c rhb1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000827121 – 182GTP-binding protein rhb1Add BLAST182
PropeptideiPRO_0000281369183 – 185Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei182Cysteine methyl esterBy similarity1
Lipidationi182S-farnesyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

MaxQBiO94363
PaxDbiO94363
PRIDEiO94363

PTM databases

iPTMnetiO94363

Interactioni

Protein-protein interaction databases

BioGridi277370, 12 interactors
STRINGi4896.SPBC428.16c.1

Structurei

3D structure databases

ProteinModelPortaliO94363
SMRiO94363
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi35 – 43Effector region9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rheb family.Curated

Phylogenomic databases

HOGENOMiHOG000233973
InParanoidiO94363
KOiK07208
OMAiFIENHFV
OrthoDBiEOG092C513S
PhylomeDBiO94363

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
IPR020849 Small_GTPase_Ras-type
PANTHERiPTHR24070 PTHR24070, 1 hit
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51421 RAS, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O94363-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPIKSRRIA VLGSRSVGKS SLTVQYVENH FVESYYPTIE NTFSKNIKYK
60 70 80 90 100
GQEFATEIID TAGQDEYSIL NSKHSIGIHG YVLVYSITSK SSFEMVKIVR
110 120 130 140 150
DKILNHTGTE WVPIVVVGNK SDLHMQRAVT AEEGKALANE WKCAWTEASA
160 170 180
RHNENVARAF ELIISEIEKQ ANPSPPGDGK GCVIA
Length:185
Mass (Da):20,515
Last modified:May 1, 1999 - v1
Checksum:i3DBC3E352C122C71
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA Translation: CAA22291.1
PIRiT40468
RefSeqiNP_595194.1, NM_001021101.2

Genome annotation databases

EnsemblFungiiSPBC428.16c.1; SPBC428.16c.1:pep; SPBC428.16c
GeneIDi2540853
KEGGispo:SPBC428.16c

Similar proteinsi

Entry informationi

Entry nameiRHB1_SCHPO
AccessioniPrimary (citable) accession number: O94363
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 1999
Last modified: May 23, 2018
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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