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O94350 (CBL_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cystathionine beta-lyase
Short name=CBL
EC=4.4.1.8
Alternative name(s):
Beta-cystathionase
Cysteine lyase
Gene names
Name:str3
ORF Names:SPCC11E10.01, SPCC61.06
OrganismSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifier284812 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces

Protein attributes

Sequence length390 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

L-cystathionine + H2O = L-homocysteine + NH3 + pyruvate.

Cofactor

Pyridoxal phosphate By similarity.

Pathway

Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homocysteine from L-cystathionine: step 1/1.

Subcellular location

Cytoplasm By similarity. Nucleus By similarity.

Sequence similarities

Belongs to the trans-sulfuration enzymes family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Methionine biosynthesis
   Cellular componentCytoplasm
Nucleus
   LigandPyridoxal phosphate
   Molecular functionLyase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processL-methionine biosynthetic process from L-homoserine via cystathionine

Inferred by curator. Source: GeneDB_Spombe

   Cellular componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

peroxisome

Inferred from sequence or structural similarity. Source: GeneDB_Spombe

   Molecular functioncystathionine beta-lyase activity

Inferred from sequence or structural similarity. Source: GeneDB_Spombe

pyridoxal phosphate binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 390390Cystathionine beta-lyase
PRO_0000352810

Amino acid modifications

Modified residue2021N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
O94350 [UniParc].

Last modified August 21, 2007. Version 4.
Checksum: FBC40B8CF2D1CD60

FASTA39042,773
        10         20         30         40         50         60 
MPSDCKYSVD TELVHVEGNE DQYHASSVPI YQSATFKQPC LEHMGKFDYT RSGNPTRSVL 

        70         80         90        100        110        120 
QVHLAKLMKA KHAFVTSNGM SALDMILRCC KSNSHVVAGH DLYGGSDRLL SFNQRQYGFK 

       130        140        150        160        170        180 
VDNVDTSDLA AFEAALRPDT NLVLIESPTN PRISICDIRA IVKITRSKAK DALLVMDNTM 

       190        200        210        220        230        240 
LSPVLCNPLD FGYDIVYESA TKYLSGHHDL MGGVIATKSD EIAKSVFFNI NAMGAAMAPF 

       250        260        270        280        290        300 
ECFLLLRGIK TMGLRVERAQ QNAIEIAKFL KSKGLQVNFP GLDPDAKSTA IFYSFARGPG 

       310        320        330        340        350        360 
AVMSVFTGDV EVSKTIVNTT KLFEISVSFG AVNSLISMPA YMSHASIKKE VRDARGLSED 

       370        380        390 
LIRICVGIEN VDDLKADLEN ALAQANFKQN

« Hide

References

[1]"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. expand/collapse author list , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
Nature 415:871-880(2002) [PubMed: 11859360] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 972 / ATCC 24843.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CU329672 Genomic DNA. Translation: CAA22275.2.
RefSeqNP_588197.2. NM_001023187.1.

3D structure databases

HSSPHSSP built from PDB template 1IBJ based on UniProtKB P53780.
ProteinModelPortalO94350.
SMRO94350. Positions 8-384.
ModBaseSearch...

Protein-protein interaction databases

STRINGO94350.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiSPCC11E10.01.1; SPCC11E10.01.1:pep; SPCC11E10.01.
GeneID2539019.
GenomeReviewsGene locus str3 in contig CU329672_GR.
KEGGspo:SPCC11E10.01.

Organism-specific databases

GeneDB_SpombeSPCC11E10.01.

Phylogenomic databases

eggNOGfuNOG05348.
GeneTreeEFGT00050000003425.
HOGENOMHBG754729.
OMAESATKYL.
OrthoDBEOG4Z9256.

Gene expression databases

ArrayExpressO94350.

Family and domain databases

InterProIPR000277. Cys/Met-Metab_PyrdxlP-dep_enz.
IPR006238. Cys_b_lyase_euk.
IPR015424. PyrdxlP-dep_Trfase_major_dom.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
Gene3DG3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit.
G3DSA:3.90.1150.10. PyrdxlP-dep_Trfase_major_sub2. 1 hit.
KOK01760.
PANTHERPTHR11808. Cys_Met_Meta_PP. 1 hit.
PTHR11808:SF18. PTHR11808:SF18. 1 hit.
PfamPF01053. Cys_Met_Meta_PP. 1 hit.
[Graphical view]
PIRSFPIRSF001434. CGS. 1 hit.
SUPFAMSSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
TIGRFAMsTIGR01329. Cysta_beta_ly_E. 1 hit.
PROSITEPS00868. CYS_MET_METAB_PP. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCBL_SCHPO
AccessionPrimary (citable) accession number: O94350
Entry history
Integrated into UniProtKB/Swiss-Prot: November 4, 2008
Last sequence update: August 21, 2007
Last modified: November 16, 2011
This is version 64 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents