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Protein

Cystathionine beta-lyase

Gene

str3

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

L-cystathionine + H2O = L-homocysteine + NH3 + pyruvate.

Cofactori

Pathwayi: L-methionine biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes L-homocysteine from L-cystathionine.
Proteins known to be involved in this subpathway in this organism are:
  1. Cystathionine beta-lyase (str3)
This subpathway is part of the pathway L-methionine biosynthesis via de novo pathway, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-homocysteine from L-cystathionine, the pathway L-methionine biosynthesis via de novo pathway and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Amino-acid biosynthesis, Methionine biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

ReactomeiR-SPO-1614558. Degradation of cysteine and homocysteine.
R-SPO-1614603. Cysteine formation from homocysteine.
UniPathwayiUPA00051; UER00078.

Names & Taxonomyi

Protein namesi
Recommended name:
Cystathionine beta-lyase (EC:4.4.1.8)
Short name:
CBL
Alternative name(s):
Beta-cystathionase
Cysteine lyase
Gene namesi
Name:str3
ORF Names:SPCC11E10.01, SPCC61.06
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:SPCC11E10.01.
PomBaseiSPCC11E10.01.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003528101 – 390Cystathionine beta-lyaseAdd BLAST390

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei202N6-(pyridoxal phosphate)lysineBy similarity1

Proteomic databases

MaxQBiO94350.
PRIDEiO94350.

Structurei

3D structure databases

ProteinModelPortaliO94350.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the trans-sulfuration enzymes family.Curated

Phylogenomic databases

HOGENOMiHOG000246415.
KOiK01760.
OMAiHLAKIMN.
OrthoDBiEOG092C2AJE.
PhylomeDBiO94350.

Family and domain databases

CDDicd00614. CGS_like. 1 hit.
Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR000277. Cys/Met-Metab_PyrdxlP-dep_enz.
IPR006238. Cys_b_lyase_euk.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11808. PTHR11808. 1 hit.
PfamiPF01053. Cys_Met_Meta_PP. 1 hit.
[Graphical view]
PIRSFiPIRSF001434. CGS. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01329. cysta_beta_ly_E. 1 hit.
PROSITEiPS00868. CYS_MET_METAB_PP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O94350-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSDCKYSVD TELVHVEGNE DQYHASSVPI YQSATFKQPC LEHMGKFDYT
60 70 80 90 100
RSGNPTRSVL QVHLAKLMKA KHAFVTSNGM SALDMILRCC KSNSHVVAGH
110 120 130 140 150
DLYGGSDRLL SFNQRQYGFK VDNVDTSDLA AFEAALRPDT NLVLIESPTN
160 170 180 190 200
PRISICDIRA IVKITRSKAK DALLVMDNTM LSPVLCNPLD FGYDIVYESA
210 220 230 240 250
TKYLSGHHDL MGGVIATKSD EIAKSVFFNI NAMGAAMAPF ECFLLLRGIK
260 270 280 290 300
TMGLRVERAQ QNAIEIAKFL KSKGLQVNFP GLDPDAKSTA IFYSFARGPG
310 320 330 340 350
AVMSVFTGDV EVSKTIVNTT KLFEISVSFG AVNSLISMPA YMSHASIKKE
360 370 380 390
VRDARGLSED LIRICVGIEN VDDLKADLEN ALAQANFKQN
Length:390
Mass (Da):42,773
Last modified:August 21, 2007 - v4
Checksum:iFBC40B8CF2D1CD60
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA. Translation: CAA22275.2.
RefSeqiNP_588197.2. NM_001023187.2.

Genome annotation databases

EnsemblFungiiSPCC11E10.01.1; SPCC11E10.01.1:pep; SPCC11E10.01.
GeneIDi2539019.
KEGGispo:SPCC11E10.01.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA. Translation: CAA22275.2.
RefSeqiNP_588197.2. NM_001023187.2.

3D structure databases

ProteinModelPortaliO94350.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiO94350.
PRIDEiO94350.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPCC11E10.01.1; SPCC11E10.01.1:pep; SPCC11E10.01.
GeneIDi2539019.
KEGGispo:SPCC11E10.01.

Organism-specific databases

EuPathDBiFungiDB:SPCC11E10.01.
PomBaseiSPCC11E10.01.

Phylogenomic databases

HOGENOMiHOG000246415.
KOiK01760.
OMAiHLAKIMN.
OrthoDBiEOG092C2AJE.
PhylomeDBiO94350.

Enzyme and pathway databases

UniPathwayiUPA00051; UER00078.
ReactomeiR-SPO-1614558. Degradation of cysteine and homocysteine.
R-SPO-1614603. Cysteine formation from homocysteine.

Miscellaneous databases

PROiO94350.

Family and domain databases

CDDicd00614. CGS_like. 1 hit.
Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR000277. Cys/Met-Metab_PyrdxlP-dep_enz.
IPR006238. Cys_b_lyase_euk.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11808. PTHR11808. 1 hit.
PfamiPF01053. Cys_Met_Meta_PP. 1 hit.
[Graphical view]
PIRSFiPIRSF001434. CGS. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01329. cysta_beta_ly_E. 1 hit.
PROSITEiPS00868. CYS_MET_METAB_PP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCBL_SCHPO
AccessioniPrimary (citable) accession number: O94350
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 4, 2008
Last sequence update: August 21, 2007
Last modified: October 5, 2016
This is version 93 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.