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Protein

Multistep phosphorelay regulator 1

Gene

mpr1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Binds to the msc4 response regulator which is part of a multistep phosphorelay system that transmits oxidative stress signals to the spc1 MAPK cascade.1 Publication

GO - Molecular functioni

  • histidine phosphotransfer kinase activity Source: PomBase
  • protein histidine kinase binding Source: GO_Central

GO - Biological processi

  • cellular response to oxidative stress Source: PomBase
  • negative regulation of G2/M transition of mitotic cell cycle Source: PomBase
  • osmosensory signaling via phosphorelay pathway Source: PomBase
  • phosphorelay signal transduction system Source: PomBase
  • positive regulation of stress-activated MAPK cascade Source: PomBase
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Multistep phosphorelay regulator 1
Gene namesi
Name:mpr1
Synonyms:spy1
ORF Names:SPBC725.02
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC725.02.
PomBaseiSPBC725.02. mpr1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: GO_Central
  • cytosol Source: PomBase
  • nucleus Source: PomBase
Complete GO annotation...

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi221H → Q: Oxidative stress signaling to spc1 did not occur. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000965581 – 295Multistep phosphorelay regulator 1Add BLAST295

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei221PhosphohistidinePROSITE-ProRule annotation1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO94321.
PRIDEiO94321.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi277692. 192 interactors.
MINTiMINT-4683206.

Structurei

3D structure databases

ProteinModelPortaliO94321.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini182 – 284HPtPROSITE-ProRule annotationAdd BLAST103

Sequence similaritiesi

Contains 1 HPt domain.PROSITE-ProRule annotation

Phylogenomic databases

InParanoidiO94321.
KOiK11232.
OrthoDBiEOG092C5IZ3.

Family and domain databases

Gene3Di1.20.120.160. 1 hit.
InterProiIPR008207. Sig_transdc_His_kin_Hpt_dom.
[Graphical view]
PfamiPF01627. Hpt. 1 hit.
[Graphical view]
SMARTiSM00073. HPT. 1 hit.
[Graphical view]
SUPFAMiSSF47226. SSF47226. 1 hit.
PROSITEiPS50894. HPT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O94321-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVYRDNMYM KYDRNFENRV ARRNGQARNA SLAKTLHDSG IAERARSPSG
60 70 80 90 100
SAIPHAYRVM NGSGANDTSL PLTSNPAYVA LTSRISSSKS ENNQQLAANE
110 120 130 140 150
TAGAPEGTEE TVDISNSISD DHANAKNLPA ASVKALVGAG VLSDELSVIA
160 170 180 190 200
YDMSFEDELI QDKQLIDHSV FDQLLEMDDD DEHEFSKSIV WNYFEQAETT
210 220 230 240 250
IADLQKALEA KDLKKLSSLG HFLKGSSAVL GLTKMRKVCE RIQNYGSLRS
260 270 280 290
RDGVMKLPSE EIALDLISKS LSVVNDFYKD ARAYLLDFYE KNSST
Length:295
Mass (Da):32,550
Last modified:May 1, 1999 - v1
Checksum:i99207DA474E4F9E9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA22174.1.
PIRiT40654.
RefSeqiNP_595482.1. NM_001021393.2.

Genome annotation databases

EnsemblFungiiSPBC725.02.1; SPBC725.02.1:pep; SPBC725.02.
GeneIDi2541178.
KEGGispo:SPBC725.02.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA22174.1.
PIRiT40654.
RefSeqiNP_595482.1. NM_001021393.2.

3D structure databases

ProteinModelPortaliO94321.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi277692. 192 interactors.
MINTiMINT-4683206.

Proteomic databases

MaxQBiO94321.
PRIDEiO94321.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC725.02.1; SPBC725.02.1:pep; SPBC725.02.
GeneIDi2541178.
KEGGispo:SPBC725.02.

Organism-specific databases

EuPathDBiFungiDB:SPBC725.02.
PomBaseiSPBC725.02. mpr1.

Phylogenomic databases

InParanoidiO94321.
KOiK11232.
OrthoDBiEOG092C5IZ3.

Miscellaneous databases

PROiO94321.

Family and domain databases

Gene3Di1.20.120.160. 1 hit.
InterProiIPR008207. Sig_transdc_His_kin_Hpt_dom.
[Graphical view]
PfamiPF01627. Hpt. 1 hit.
[Graphical view]
SMARTiSM00073. HPT. 1 hit.
[Graphical view]
SUPFAMiSSF47226. SSF47226. 1 hit.
PROSITEiPS50894. HPT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMPR1_SCHPO
AccessioniPrimary (citable) accession number: O94321
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: May 1, 1999
Last modified: October 5, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.