O94320 (AATM_SCHPO) Reviewed, UniProtKB/Swiss-Prot
Last modified
December 14, 2011.
Version 67.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Aspartate aminotransferase, mitochondrial EC=2.6.1.1 Alternative name(s): Transaminase A | ||||
| Gene names |
| ||||
| Organism | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) | ||||
| Taxonomic identifier | 284812 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces |
Protein attributes
| Sequence length | 437 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at transcript level |
General annotation (Comments)
| Function | Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol By similarity. |
| Catalytic activity | L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate. UniProtKB Q01802 |
| Cofactor | Pyridoxal phosphate By similarity. UniProtKB Q01802 |
| Subunit structure | Homodimer By similarity. UniProtKB Q01802 |
| Subcellular location | |
| Miscellaneous | In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes. |
| Sequence similarities | Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. |
Ontologies
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Transit peptide | 1 – ? | Mitochondrion Potential UniProtKB Q01802 | |||||||
| Chain | ? – 437 | Aspartate aminotransferase, mitochondrial UniProtKB Q01802 | PRO_0000309452 | ||||||
Sites | |||||||||
| Binding site | 72 | 1 | Aspartate; via amide nitrogen By similarity | ||||||
| Binding site | 167 | 1 | Aspartate By similarity | ||||||
| Binding site | 220 | 1 | Aspartate By similarity | ||||||
| Binding site | 413 | 1 | Aspartate By similarity | ||||||
Amino acid modifications | |||||||||
| Modified residue | 284 | 1 | N6-(pyridoxal phosphate)lysine By similarity | ||||||
Sequences
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References
| [1] | "The genome sequence of Schizosaccharomyces pombe." Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. Nurse P.Nature 415:871-880(2002) [PubMed: 11859360] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 972 / ATCC 24843. |
| [2] | "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe." Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M. Nat. Biotechnol. 24:841-847(2006) [PubMed: 16823372] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS]. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | CU329671 Genomic DNA. Translation: CAA22173.1. |
| PIR | T40653. |
| RefSeq | NP_595481.1. NM_001021392.1. |
3D structure databases | |
| HSSP | HSSP built from PDB template 7AAT based on UniProtKB P00508. |
| ProteinModelPortal | O94320. |
| SMR | O94320. Positions 39-435. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | O94320. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| EnsemblFungi | SPBC725.01.1; SPBC725.01.1:pep; SPBC725.01. |
| GeneID | 2541186. |
| GenomeReviews | Gene locus aat1 in contig CU329671_GR. |
| KEGG | spo:SPBC725.01. |
| NMPDR | fig|4896.1.peg.1347. |
Organism-specific databases | |
| GeneDB_Spombe | SPBC725.01. |
Phylogenomic databases | |
| eggNOG | fuNOG05116. |
| GeneTree | EFGT00050000000248. |
| HOGENOM | HBG446828. |
| OMA | AYRDDNT. |
| OrthoDB | EOG4R7ZKM. |
Gene expression databases | |
| ArrayExpress | O94320. |
Family and domain databases | |
| InterPro | IPR004839. Aminotransferase_I/II. IPR000796. Asp_trans. IPR004838. NHTrfase_class1_PyrdxlP-BS. IPR015424. PyrdxlP-dep_Trfase_major_dom. IPR015421. PyrdxlP-dep_Trfase_major_sub1. [Graphical view] |
| Gene3D | G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit. |
| KO | K14455. |
| PANTHER | PTHR11879. Asp_trans. 1 hit. |
| Pfam | PF00155. Aminotran_1_2. 1 hit. [Graphical view] |
| PRINTS | PR00799. TRANSAMINASE. |
| SUPFAM | SSF53383. PyrdxlP-dep_Trfase_major. 1 hit. |
| PROSITE | PS00105. AA_TRANSFER_CLASS_1. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | AATM_SCHPO | ||||||||
| Accession | Primary (citable) accession number: O94320 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Fungal Protein Annotation Program | ||||||||
Relevant documents
| Schizosaccharomyces pombe Schizosaccharomyces pombe: entries and gene names |
| SIMILARITY comments Index of protein domains and families |

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