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O94320 (AATM_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Aspartate aminotransferase, mitochondrial
EC=2.6.1.1
Alternative name(s):
Transaminase A
Gene names
Name:aat1
ORF Names:SPBC725.01
OrganismSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifier284812 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces

Protein attributes

Sequence length437 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol By similarity.

Catalytic activity

L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate. UniProtKB Q01802

Cofactor

Pyridoxal phosphate By similarity. UniProtKB Q01802

Subunit structure

Homodimer By similarity. UniProtKB Q01802

Subcellular location

Mitochondrion matrix Ref.2.

Miscellaneous

In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.

Sequence similarities

Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – ?Mitochondrion Potential UniProtKB Q01802
Chain? – 437Aspartate aminotransferase, mitochondrial UniProtKB Q01802PRO_0000309452

Sites

Binding site721Aspartate; via amide nitrogen By similarity
Binding site1671Aspartate By similarity
Binding site2201Aspartate By similarity
Binding site4131Aspartate By similarity

Amino acid modifications

Modified residue2841N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
O94320 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: 991D245BB1047A63

FASTA43748,243
        10         20         30         40         50         60 
MLARNLRCLH PNTFASLKTN VSYHGVKCLA SQSKRGFKVW ADVPMGPPDP IFGITEAYKK 

        70         80         90        100        110        120 
DGDVKKMNLG AGTYRDDAGK PYVLPSVRQA ETELLSQKLD KEYAPITGIP SFRVQATKLA 

       130        140        150        160        170        180 
YGDVYESIKD RLVSAQSISG TGALCIAANF LASFYPSKTI YVSDPTWGNH KNVFSRAGLT 

       190        200        210        220        230        240 
VKSYKYYDPA TRGLDIKGML SDLTSAPDGS IILLHACAHN PTGVDPTKAQ WDDILKTMQK 

       250        260        270        280        290        300 
KNHFALLDMA YQGFASGDFA RDAYATRLFA SSNVPMLLCQ SFAKNMGLYG ERAGCFSILA 

       310        320        330        340        350        360 
NDAEEAARIE SQTKILIRAL YSNPPVNGAR IANHILSNPA LREQWAGEVV GMSERLKSMR 

       370        380        390        400        410        420 
KALRNILEKD LKNKHSWKHI TDQIGMFCYT GLNPQQVDVL AKQYHIYLTK NGRISISGLN 

       430 
TSNVRYFAEA INAVTSN

« Hide

References

[1]"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. expand/collapse author list , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
Nature 415:871-880(2002) [PubMed: 11859360] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 972 / ATCC 24843.
[2]"ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
Nat. Biotechnol. 24:841-847(2006) [PubMed: 16823372] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CU329671 Genomic DNA. Translation: CAA22173.1.
PIRT40653.
RefSeqNP_595481.1. NM_001021392.1.

3D structure databases

HSSPHSSP built from PDB template 7AAT based on UniProtKB P00508.
ProteinModelPortalO94320.
SMRO94320. Positions 39-435.
ModBaseSearch...

Protein-protein interaction databases

STRINGO94320.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiSPBC725.01.1; SPBC725.01.1:pep; SPBC725.01.
GeneID2541186.
GenomeReviewsGene locus aat1 in contig CU329671_GR.
KEGGspo:SPBC725.01.
NMPDRfig|4896.1.peg.1347.

Organism-specific databases

GeneDB_SpombeSPBC725.01.

Phylogenomic databases

eggNOGfuNOG05116.
GeneTreeEFGT00050000000248.
HOGENOMHBG446828.
OMAAYRDDNT.
OrthoDBEOG4R7ZKM.

Gene expression databases

ArrayExpressO94320.

Family and domain databases

InterProIPR004839. Aminotransferase_I/II.
IPR000796. Asp_trans.
IPR004838. NHTrfase_class1_PyrdxlP-BS.
IPR015424. PyrdxlP-dep_Trfase_major_dom.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
Gene3DG3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit.
KOK14455.
PANTHERPTHR11879. Asp_trans. 1 hit.
PfamPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
PRINTSPR00799. TRANSAMINASE.
SUPFAMSSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
PROSITEPS00105. AA_TRANSFER_CLASS_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameAATM_SCHPO
AccessionPrimary (citable) accession number: O94320
Entry history
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: May 1, 1999
Last modified: December 14, 2011
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents