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Protein

Putative monoglyceride lipase

Gene

SPCC5E4.05c

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Converts monoacylglycerides (MAG) to free fatty acids and glycerol. Required for efficient degradation of MAG, short-lived intermediates of glycerolipid metabolism which may also function as lipid signaling molecules.By similarity

Catalytic activityi

Hydrolyzes glycerol monoesters of long-chain fatty acids.By similarity

Pathwayi: triacylglycerol degradation

This protein is involved in the pathway triacylglycerol degradation, which is part of Glycerolipid metabolism.By similarity
View all proteins of this organism that are known to be involved in the pathway triacylglycerol degradation and in Glycerolipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei99NucleophileBy similarity1
Active sitei219Charge relay systemBy similarity1
Active sitei249Charge relay systemBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

ReactomeiR-SPO-1482883. Acyl chain remodeling of DAG and TAG.
R-SPO-426048. Arachidonate production from DAG.
UniPathwayiUPA00256.

Protein family/group databases

ESTHERischpo-SPCC5E4.05C. Monoglyceridelipase_lysophospholip.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative monoglyceride lipaseCurated (EC:3.1.1.23By similarity)
Short name:
MGL
Alternative name(s):
Monoacylglycerol hydrolase
Short name:
MAG hydrolase
Short name:
MGH
Monoacylglycerol lipase
Short name:
MAG lipase
Short name:
MAGL
Gene namesi
ORF Names:SPCC5E4.05c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:SPCC5E4.05c.
PomBaseiSPCC5E4.05c.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: PomBase
  • endoplasmic reticulum Source: UniProtKB-SubCell
  • lipid particle Source: UniProtKB-SubCell
  • membrane Source: GO_Central
  • mitochondrial outer membrane Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Lipid droplet, Membrane, Mitochondrion, Mitochondrion outer membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003126561 – 378Putative monoglyceride lipaseAdd BLAST378

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei301Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO94305.
PRIDEiO94305.

PTM databases

iPTMnetiO94305.

Interactioni

Protein-protein interaction databases

IntActiO94305. 1 interactor.
MINTiMINT-4683043.

Structurei

3D structure databases

ProteinModelPortaliO94305.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

InParanoidiO94305.
KOiK01054.
OMAiQHITRDE.
OrthoDBiEOG092C4I0R.
PhylomeDBiO94305.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
IPR022742. Hydrolase_4.
[Graphical view]
PfamiPF12146. Hydrolase_4. 1 hit.
[Graphical view]
PRINTSiPR00111. ABHYDROLASE.
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

O94305-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADLYTKDWT DVKDKPVARV VFIHGFGEHV NAYPEFFEAL NERNIEVYTF
60 70 80 90 100
DQRGFGHSRK GGPKKQGCTG GWSLVFPDLD YQILRASDTE LPLFLWGHSM
110 120 130 140 150
GGGLALRYGI SGTHRHKLAG VIAQAPMLRC HPDTEPNFLL RKALTLVSKV
160 170 180 190 200
HPNFLFDSDV QSQHITRDEA VNQRLQDDPL VSSVGSLQVF SDMLNRGTKT
210 220 230 240 250
IELAPQFFLP LLITHGTDDN VTCSDSSKEF YENAGTKDKT YQSYPGFYHS
260 270 280 290 300
LHIEKKPEVY EYLDKVAAWI YEHSKPSETV KSEQETAVEH PKPTATTSAP
310 320 330 340 350
SASPTGVPVE EESHKATSDA VPPAEAKPEP VPASAAERAP TSESTTVPET
360 370
IVASTTKVIS EPAPRVTTAA TADIVTNK
Length:378
Mass (Da):41,624
Last modified:May 1, 1999 - v1
Checksum:iBFB219E181B04259
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA. Translation: CAA21960.1.
PIRiT41456.
RefSeqiNP_587904.1. NM_001022896.2.

Genome annotation databases

EnsemblFungiiSPCC5E4.05c.1; SPCC5E4.05c.1:pep; SPCC5E4.05c.
GeneIDi2538799.
KEGGispo:SPCC5E4.05c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA. Translation: CAA21960.1.
PIRiT41456.
RefSeqiNP_587904.1. NM_001022896.2.

3D structure databases

ProteinModelPortaliO94305.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO94305. 1 interactor.
MINTiMINT-4683043.

Protein family/group databases

ESTHERischpo-SPCC5E4.05C. Monoglyceridelipase_lysophospholip.

PTM databases

iPTMnetiO94305.

Proteomic databases

MaxQBiO94305.
PRIDEiO94305.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPCC5E4.05c.1; SPCC5E4.05c.1:pep; SPCC5E4.05c.
GeneIDi2538799.
KEGGispo:SPCC5E4.05c.

Organism-specific databases

EuPathDBiFungiDB:SPCC5E4.05c.
PomBaseiSPCC5E4.05c.

Phylogenomic databases

InParanoidiO94305.
KOiK01054.
OMAiQHITRDE.
OrthoDBiEOG092C4I0R.
PhylomeDBiO94305.

Enzyme and pathway databases

UniPathwayiUPA00256.
ReactomeiR-SPO-1482883. Acyl chain remodeling of DAG and TAG.
R-SPO-426048. Arachidonate production from DAG.

Miscellaneous databases

PROiO94305.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
IPR022742. Hydrolase_4.
[Graphical view]
PfamiPF12146. Hydrolase_4. 1 hit.
[Graphical view]
PRINTSiPR00111. ABHYDROLASE.
SUPFAMiSSF53474. SSF53474. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMGLL_SCHPO
AccessioniPrimary (citable) accession number: O94305
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: May 1, 1999
Last modified: November 30, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.