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O94297

- OXSM_SCHPO

UniProt

O94297 - OXSM_SCHPO

Protein

Putative 3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial

Gene

SPBC887.13c

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    May play a role in the biosynthesis of lipoic acid as well as longer chain fatty acids required for optimal mitochondrial function.By similarity

    Catalytic activityi

    Acyl-[acyl-carrier-protein] + malonyl-[acyl-carrier-protein] = 3-oxoacyl-[acyl-carrier-protein] + CO2 + [acyl-carrier-protein].

    Pathwayi

    GO - Molecular functioni

    1. 3-oxoacyl-[acyl-carrier-protein] synthase activity Source: PomBase

    GO - Biological processi

    1. fatty acid biosynthetic process Source: PomBase
    2. generation of precursor metabolites and energy Source: PomBase

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Keywords - Biological processi

    Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

    Enzyme and pathway databases

    UniPathwayiUPA00094.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative 3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial (EC:2.3.1.41)
    Alternative name(s):
    Beta-ketoacyl-ACP synthase
    mtKAS
    Gene namesi
    ORF Names:SPBC887.13c
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome II

    Organism-specific databases

    PomBaseiSPBC887.13c.

    Subcellular locationi

    Mitochondrion By similarity

    GO - Cellular componenti

    1. mitochondrion Source: PomBase
    2. nucleus Source: PomBase

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 1818MitochondrionSequence AnalysisAdd
    BLAST
    Chaini19 – 426408Putative 3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrialPRO_0000310303Add
    BLAST

    Proteomic databases

    MaxQBiO94297.

    Interactioni

    Protein-protein interaction databases

    MINTiMINT-4682980.
    STRINGi4896.SPBC887.13c-1.

    Structurei

    3D structure databases

    ProteinModelPortaliO94297.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the beta-ketoacyl-ACP synthases family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0304.
    HOGENOMiHOG000060166.
    KOiK09458.
    OMAiKDSGWYP.
    OrthoDBiEOG7T1RN8.
    PhylomeDBiO94297.

    Family and domain databases

    Gene3Di3.40.47.10. 2 hits.
    InterProiIPR017568. 3-oxoacyl-ACP_synth-2.
    IPR014031. Ketoacyl_synth_C.
    IPR014030. Ketoacyl_synth_N.
    IPR016039. Thiolase-like.
    IPR016038. Thiolase-like_subgr.
    [Graphical view]
    PfamiPF00109. ketoacyl-synt. 1 hit.
    PF02801. Ketoacyl-synt_C. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000447. KAS_II. 1 hit.
    SUPFAMiSSF53901. SSF53901. 2 hits.
    TIGRFAMsiTIGR03150. fabF. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O94297-1 [UniParc]FASTAAdd to Basket

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    MKRVVITGLG AVTPLGNGVK TNWRNLIQGK SGIVSLKGFP EYEQIPSKVA    50
    GVIPRGKEKE EWNVLDYVDQ GKLREVATFT QLALTSAAEA LKDARWIDID 100
    EQEKLATGVC FGTGIGNLDD ALNENGVLNK AGIRKVSPRV ISKILINMPA 150
    GYISQRYGFT ALNHTTTTAC AAGCHAIGDA FNFIKLGHAD VIIAGGSESC 200
    INPLTVAGFS KARSLSTKFN DNPKAASRPF DANRDGFVIG EGSAALVLEE 250
    LEHAKNRNAH IYAEIVGYGL ASDSYHITAP NPNGDAAYYA MKRSLKQAGL 300
    SASQLDYINA HATSTKLGDV AESIAITRLL CDVNRNPEAF PVSSSKGSIG 350
    HLLGAAGAIE SVYTVLTVQK GVLPPTLNFE YSDIPQQFQC DYVPNVAKES 400
    RINVALSNSF GFGGTNASLC FKKFLQ 426
    Length:426
    Mass (Da):45,489
    Last modified:May 1, 1999 - v1
    Checksum:iA7C6EA9264C7DE48
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329671 Genomic DNA. Translation: CAA21898.1.
    PIRiT40738.
    RefSeqiNP_596487.1. NM_001022407.2.

    Genome annotation databases

    EnsemblFungiiSPBC887.13c.1; SPBC887.13c.1:pep; SPBC887.13c.
    GeneIDi2541226.
    KEGGispo:SPBC887.13c.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329671 Genomic DNA. Translation: CAA21898.1 .
    PIRi T40738.
    RefSeqi NP_596487.1. NM_001022407.2.

    3D structure databases

    ProteinModelPortali O94297.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-4682980.
    STRINGi 4896.SPBC887.13c-1.

    Proteomic databases

    MaxQBi O94297.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPBC887.13c.1 ; SPBC887.13c.1:pep ; SPBC887.13c .
    GeneIDi 2541226.
    KEGGi spo:SPBC887.13c.

    Organism-specific databases

    PomBasei SPBC887.13c.

    Phylogenomic databases

    eggNOGi COG0304.
    HOGENOMi HOG000060166.
    KOi K09458.
    OMAi KDSGWYP.
    OrthoDBi EOG7T1RN8.
    PhylomeDBi O94297.

    Enzyme and pathway databases

    UniPathwayi UPA00094 .

    Miscellaneous databases

    NextBioi 20802338.
    PROi O94297.

    Family and domain databases

    Gene3Di 3.40.47.10. 2 hits.
    InterProi IPR017568. 3-oxoacyl-ACP_synth-2.
    IPR014031. Ketoacyl_synth_C.
    IPR014030. Ketoacyl_synth_N.
    IPR016039. Thiolase-like.
    IPR016038. Thiolase-like_subgr.
    [Graphical view ]
    Pfami PF00109. ketoacyl-synt. 1 hit.
    PF02801. Ketoacyl-synt_C. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000447. KAS_II. 1 hit.
    SUPFAMi SSF53901. SSF53901. 2 hits.
    TIGRFAMsi TIGR03150. fabF. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.

    Entry informationi

    Entry nameiOXSM_SCHPO
    AccessioniPrimary (citable) accession number: O94297
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 13, 2007
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 84 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3