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O94297 (OXSM_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative 3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial

EC=2.3.1.41
Alternative name(s):
Beta-ketoacyl-ACP synthase
mtKAS
Gene names
ORF Names:SPBC887.13c
OrganismSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) [Reference proteome]
Taxonomic identifier284812 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces

Protein attributes

Sequence length426 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

May play a role in the biosynthesis of lipoic acid as well as longer chain fatty acids required for optimal mitochondrial function By similarity.

Catalytic activity

Acyl-[acyl-carrier-protein] + malonyl-[acyl-carrier-protein] = 3-oxoacyl-[acyl-carrier-protein] + CO2 + [acyl-carrier-protein].

Pathway

Lipid metabolism; fatty acid biosynthesis.

Subcellular location

Mitochondrion By similarity.

Sequence similarities

Belongs to the beta-ketoacyl-ACP synthases family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 1818Mitochondrion Potential
Chain19 – 426408Putative 3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial
PRO_0000310303

Sequences

Sequence LengthMass (Da)Tools
O94297 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: A7C6EA9264C7DE48

FASTA42645,489
        10         20         30         40         50         60 
MKRVVITGLG AVTPLGNGVK TNWRNLIQGK SGIVSLKGFP EYEQIPSKVA GVIPRGKEKE 

        70         80         90        100        110        120 
EWNVLDYVDQ GKLREVATFT QLALTSAAEA LKDARWIDID EQEKLATGVC FGTGIGNLDD 

       130        140        150        160        170        180 
ALNENGVLNK AGIRKVSPRV ISKILINMPA GYISQRYGFT ALNHTTTTAC AAGCHAIGDA 

       190        200        210        220        230        240 
FNFIKLGHAD VIIAGGSESC INPLTVAGFS KARSLSTKFN DNPKAASRPF DANRDGFVIG 

       250        260        270        280        290        300 
EGSAALVLEE LEHAKNRNAH IYAEIVGYGL ASDSYHITAP NPNGDAAYYA MKRSLKQAGL 

       310        320        330        340        350        360 
SASQLDYINA HATSTKLGDV AESIAITRLL CDVNRNPEAF PVSSSKGSIG HLLGAAGAIE 

       370        380        390        400        410        420 
SVYTVLTVQK GVLPPTLNFE YSDIPQQFQC DYVPNVAKES RINVALSNSF GFGGTNASLC 


FKKFLQ 

« Hide

References

[1]"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. expand/collapse author list , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 972 / ATCC 24843.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CU329671 Genomic DNA. Translation: CAA21898.1.
PIRT40738.
RefSeqNP_596487.1. NM_001022407.2.

3D structure databases

ProteinModelPortalO94297.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

MINTMINT-4682980.
STRING4896.SPBC887.13c-1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiSPBC887.13c.1; SPBC887.13c.1:pep; SPBC887.13c.
GeneID2541226.
KEGGspo:SPBC887.13c.

Organism-specific databases

PomBaseSPBC887.13c.

Phylogenomic databases

eggNOGCOG0304.
HOGENOMHOG000060166.
KOK09458.
OMAWMEPKEQ.
OrthoDBEOG7T1RN8.
PhylomeDBO94297.

Enzyme and pathway databases

UniPathwayUPA00094.

Family and domain databases

Gene3D3.40.47.10. 2 hits.
InterProIPR017568. 3-oxoacyl-ACP_synth-2.
IPR014031. Ketoacyl_synth_C.
IPR014030. Ketoacyl_synth_N.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamPF00109. ketoacyl-synt. 1 hit.
PF02801. Ketoacyl-synt_C. 1 hit.
[Graphical view]
PIRSFPIRSF000447. KAS_II. 1 hit.
SUPFAMSSF53901. SSF53901. 2 hits.
TIGRFAMsTIGR03150. fabF. 1 hit.
ProtoNetSearch...

Other

NextBio20802338.
PROO94297.

Entry information

Entry nameOXSM_SCHPO
AccessionPrimary (citable) accession number: O94297
Entry history
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: May 1, 1999
Last modified: April 16, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways