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Protein

Sorting nexin-3

Gene

snx3

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Required for retention of late Golgi membrane proteins. Component of the retrieval machinery that functions by direct interaction with the cytosolic tails of certain TGN membrane proteins during the sorting/budding process at the prevacuolar compartment. Binds phosphatidylinositol 3-phosphate (PtdIns(P3)) (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei66Phosphatidylinositol 3-phosphateBy similarity1
Binding sitei68Phosphatidylinositol 3-phosphate; via amide nitrogen and carbonyl oxygenBy similarity1
Binding sitei92Phosphatidylinositol 3-phosphateBy similarity1
Binding sitei97Phosphatidylinositol 3-phosphateBy similarity1
Binding sitei106Phosphatidylinositol 3-phosphateBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

Lipid-binding

Enzyme and pathway databases

ReactomeiR-SPO-3238698. WNT ligand biogenesis and trafficking.
R-SPO-5689880. Ub-specific processing proteases.

Names & Taxonomyi

Protein namesi
Recommended name:
Sorting nexin-3
Gene namesi
Name:snx3
Synonyms:grd19
ORF Names:SPBC887.06c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC887.06c.
PomBaseiSPBC887.06c. snx3.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: PomBase
  • endosome Source: PomBase
  • extrinsic component of membrane Source: GO_Central
  • Golgi membrane Source: UniProtKB-SubCell
  • late endosome membrane Source: UniProtKB-SubCell
  • nucleus Source: PomBase
  • pre-autophagosomal structure Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002385901 – 143Sorting nexin-3Add BLAST143

Proteomic databases

PRIDEiO94291.

Interactioni

Protein-protein interaction databases

BioGridi277724. 2 interactors.
MINTiMINT-4682923.

Structurei

3D structure databases

ProteinModelPortaliO94291.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 140PXPROSITE-ProRule annotationAdd BLAST118

Domaini

The PX domain binds phosphatidylinositol 3-phosphate which is necessary for peripheral membrane localization.By similarity

Sequence similaritiesi

Belongs to the sorting nexin family.Curated
Contains 1 PX (phox homology) domain.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000234882.
InParanoidiO94291.
KOiK17918.
OMAiILCRTNI.
OrthoDBiEOG092C4ZGK.
PhylomeDBiO94291.

Family and domain databases

Gene3Di3.30.1520.10. 1 hit.
InterProiIPR001683. Phox.
[Graphical view]
PfamiPF00787. PX. 1 hit.
[Graphical view]
SMARTiSM00312. PX. 1 hit.
[Graphical view]
SUPFAMiSSF64268. SSF64268. 1 hit.
PROSITEiPS50195. PX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O94291-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDKLSRPEIR QQTTQQMYDV PENILEIDVI NPQTHGIGRN MFTTYEIVCR
60 70 80 90 100
TNMPYFRLHN SSVRRRYSEF EKFHDMLERE SGRVSIPPLP GKIFTQRFRD
110 120 130 140
DVIEERRQGL ENFLRLVAGH PLIQTHSRVL SSFLQSPEFK PTP
Length:143
Mass (Da):16,961
Last modified:May 1, 1999 - v1
Checksum:iB688DD1A342A8D2A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA21891.1.
PIRiT40731.
RefSeqiNP_596480.1. NM_001022400.2.

Genome annotation databases

EnsemblFungiiSPBC887.06c.1; SPBC887.06c.1:pep; SPBC887.06c.
GeneIDi2541210.
KEGGispo:SPBC887.06c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA21891.1.
PIRiT40731.
RefSeqiNP_596480.1. NM_001022400.2.

3D structure databases

ProteinModelPortaliO94291.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi277724. 2 interactors.
MINTiMINT-4682923.

Proteomic databases

PRIDEiO94291.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC887.06c.1; SPBC887.06c.1:pep; SPBC887.06c.
GeneIDi2541210.
KEGGispo:SPBC887.06c.

Organism-specific databases

EuPathDBiFungiDB:SPBC887.06c.
PomBaseiSPBC887.06c. snx3.

Phylogenomic databases

HOGENOMiHOG000234882.
InParanoidiO94291.
KOiK17918.
OMAiILCRTNI.
OrthoDBiEOG092C4ZGK.
PhylomeDBiO94291.

Enzyme and pathway databases

ReactomeiR-SPO-3238698. WNT ligand biogenesis and trafficking.
R-SPO-5689880. Ub-specific processing proteases.

Miscellaneous databases

PROiO94291.

Family and domain databases

Gene3Di3.30.1520.10. 1 hit.
InterProiIPR001683. Phox.
[Graphical view]
PfamiPF00787. PX. 1 hit.
[Graphical view]
SMARTiSM00312. PX. 1 hit.
[Graphical view]
SUPFAMiSSF64268. SSF64268. 1 hit.
PROSITEiPS50195. PX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSNX3_SCHPO
AccessioniPrimary (citable) accession number: O94291
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: May 1, 1999
Last modified: November 30, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.