Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Sulfide:quinone oxidoreductase, mitochondrial

Gene

hmt2

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the oxidation of hydrogen sulfide, with the help of a quinone.1 Publication

Cofactori

FAD1 PublicationNote: Binds 1 FAD per subunit.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei204 – 2041Cysteine persulfide intermediateBy similarity
Active sitei383 – 3831Cysteine persulfide intermediateBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi35 – 395FADBy similarity

GO - Molecular functioni

  • FAD binding Source: PomBase
  • quinone binding Source: UniProtKB-KW
  • sulfide:quinone oxidoreductase activity Source: PomBase

GO - Biological processi

  • cellular detoxification of cadmium ion Source: PomBase
  • cellular response to cadmium ion Source: PomBase
  • cellular sulfide ion homeostasis Source: PomBase
  • glutathione biosynthetic process Source: PomBase
  • phytochelatin biosynthetic process Source: PomBase
  • regulation of sulfur metabolic process Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Cadmium, FAD, Flavoprotein

Enzyme and pathway databases

BRENDAi1.8.5.4. 5613.

Names & Taxonomyi

Protein namesi
Recommended name:
Sulfide:quinone oxidoreductase, mitochondrial (EC:1.8.5.-1 Publication)
Alternative name(s):
Cadmium resistance protein 1
Heavy metal tolerance protein 2
Gene namesi
Name:hmt2
Synonyms:cad1
ORF Names:SPBC2G5.06c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC2G5.06c.
PomBaseiSPBC2G5.06c. hmt2.

Subcellular locationi

GO - Cellular componenti

  • mitochondrion Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2424MitochondrionSequence analysisAdd
BLAST
Chaini25 – 459435Sulfide:quinone oxidoreductase, mitochondrialPRO_0000021446Add
BLAST

Keywords - PTMi

Quinone

Proteomic databases

MaxQBiO94284.

Interactioni

Protein-protein interaction databases

BioGridi276856. 78 interactions.
MINTiMINT-4682860.

Structurei

3D structure databases

ProteinModelPortaliO94284.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SQRD family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOGENOMiHOG000249874.
InParanoidiO94284.
KOiK17218.
OMAiWMAWDRY.
OrthoDBiEOG092C2TWU.
PhylomeDBiO94284.

Family and domain databases

Gene3Di3.50.50.60. 2 hits.
InterProiIPR023753. FAD/NAD-binding_dom.
[Graphical view]
SUPFAMiSSF51905. SSF51905. 3 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O94284-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLTLNSTIKS VTGSFQSASM LARFASTHHK VLVVGGGSAG ISVAHQIYNK
60 70 80 90 100
FSKYRFANDQ GKDTSLKPGE IGIVDGAKYH YYQPGWTLTG AGLSSVAKTR
110 120 130 140 150
RELASLVPAD KFKLHPEFVK SLHPRENKIV TQSGQEISYD YLVMAAGIYT
160 170 180 190 200
DFGRIKGLTE ALDDPNTPVV TIYSEKYADA VYPWIEKTKS GNAIFTQPSG
210 220 230 240 250
VLKCAGAPQK IMWMAEDYWR RHKVRSNIDV SFYTGMPTLF SVKRYSDALL
260 270 280 290 300
RQNEQLHRNV KINYKDELVE VKGSERKAVF KNLNDGSLFE RPFDLLHAVP
310 320 330 340 350
SMRSHEFIAK SDLADKSGFV AVDQSTTQST KFPNVFAIGD CSGLPTSKTY
360 370 380 390 400
AAITAQAPVM VHNLWSFVNG KNLTASYNGY TSCPLLTGYG KLILAEFLYK
410 420 430 440 450
QEPKESFGRF SRFLDQTVPR RMFYHLKKDF FPFVYWNFAV RNGKWYGSRG

LIPPHFPVN
Length:459
Mass (Da):51,575
Last modified:May 1, 1999 - v1
Checksum:i121F06DCC9579C04
GO

Sequence cautioni

The sequence BAA22793 differs from that shown.Sequencing errors.Curated
The sequence BAA22793 differs from that shown. Reason: Frameshift at several positions. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti396 – 3961E → K in cadmium sensitive strain. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF042283 Genomic DNA. Translation: AAD41159.1.
AB007905 Genomic DNA. Translation: BAA22793.1. Sequence problems.
CU329671 Genomic DNA. Translation: CAA21882.1.
PIRiT43278.
T43558.
RefSeqiNP_596067.1. NM_001021978.2.

Genome annotation databases

EnsemblFungiiSPBC2G5.06c.1; SPBC2G5.06c.1:pep; SPBC2G5.06c.
GeneIDi2540326.
KEGGispo:SPBC2G5.06c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF042283 Genomic DNA. Translation: AAD41159.1.
AB007905 Genomic DNA. Translation: BAA22793.1. Sequence problems.
CU329671 Genomic DNA. Translation: CAA21882.1.
PIRiT43278.
T43558.
RefSeqiNP_596067.1. NM_001021978.2.

3D structure databases

ProteinModelPortaliO94284.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi276856. 78 interactions.
MINTiMINT-4682860.

Proteomic databases

MaxQBiO94284.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC2G5.06c.1; SPBC2G5.06c.1:pep; SPBC2G5.06c.
GeneIDi2540326.
KEGGispo:SPBC2G5.06c.

Organism-specific databases

EuPathDBiFungiDB:SPBC2G5.06c.
PomBaseiSPBC2G5.06c. hmt2.

Phylogenomic databases

HOGENOMiHOG000249874.
InParanoidiO94284.
KOiK17218.
OMAiWMAWDRY.
OrthoDBiEOG092C2TWU.
PhylomeDBiO94284.

Enzyme and pathway databases

BRENDAi1.8.5.4. 5613.

Miscellaneous databases

PROiO94284.

Family and domain databases

Gene3Di3.50.50.60. 2 hits.
InterProiIPR023753. FAD/NAD-binding_dom.
[Graphical view]
SUPFAMiSSF51905. SSF51905. 3 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiHMT2_SCHPO
AccessioniPrimary (citable) accession number: O94284
Secondary accession number(s): O13293
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 13, 2002
Last sequence update: May 1, 1999
Last modified: September 7, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.