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Protein

Sulfide:quinone oxidoreductase, mitochondrial

Gene

hmt2

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the oxidation of hydrogen sulfide, with the help of a quinone.1 Publication

Cofactori

FAD1 PublicationNote: Binds 1 FAD per subunit.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei204Cysteine persulfide intermediateBy similarity1
Active sitei383Cysteine persulfide intermediateBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi35 – 39FADBy similarity5

GO - Molecular functioni

  • FAD binding Source: PomBase
  • quinone binding Source: UniProtKB-KW
  • sulfide:quinone oxidoreductase activity Source: PomBase

GO - Biological processi

  • cellular detoxification of cadmium ion Source: PomBase
  • cellular response to cadmium ion Source: PomBase
  • cellular sulfide ion homeostasis Source: PomBase
  • glutathione biosynthetic process Source: PomBase
  • phytochelatin biosynthetic process Source: PomBase
  • regulation of sulfur metabolic process Source: PomBase

Keywordsi

Molecular functionOxidoreductase
LigandCadmium, FAD, Flavoprotein

Enzyme and pathway databases

BRENDAi1.8.5.4 5613

Names & Taxonomyi

Protein namesi
Recommended name:
Sulfide:quinone oxidoreductase, mitochondrial (EC:1.8.5.-1 Publication)
Alternative name(s):
Cadmium resistance protein 1
Heavy metal tolerance protein 2
Gene namesi
Name:hmt2
Synonyms:cad1
ORF Names:SPBC2G5.06c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC2G5.06c
PomBaseiSPBC2G5.06c hmt2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 24MitochondrionSequence analysisAdd BLAST24
ChainiPRO_000002144625 – 459Sulfide:quinone oxidoreductase, mitochondrialAdd BLAST435

Keywords - PTMi

Quinone

Proteomic databases

MaxQBiO94284
PaxDbiO94284
PRIDEiO94284

PTM databases

iPTMnetiO94284

Interactioni

Protein-protein interaction databases

BioGridi276856, 80 interactors
STRINGi4896.SPBC2G5.06c.1

Structurei

3D structure databases

ProteinModelPortaliO94284
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SQRD family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOGENOMiHOG000249874
InParanoidiO94284
KOiK22470
OMAiYQPMFTL
OrthoDBiEOG092C2TWU
PhylomeDBiO94284

Family and domain databases

Gene3Di3.50.50.60, 3 hits
InterProiView protein in InterPro
IPR036188 FAD/NAD-bd_sf
IPR015904 Sulphide_quinone_reductase
PANTHERiPTHR10632 PTHR10632, 1 hit
SUPFAMiSSF51905 SSF51905, 3 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O94284-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLTLNSTIKS VTGSFQSASM LARFASTHHK VLVVGGGSAG ISVAHQIYNK
60 70 80 90 100
FSKYRFANDQ GKDTSLKPGE IGIVDGAKYH YYQPGWTLTG AGLSSVAKTR
110 120 130 140 150
RELASLVPAD KFKLHPEFVK SLHPRENKIV TQSGQEISYD YLVMAAGIYT
160 170 180 190 200
DFGRIKGLTE ALDDPNTPVV TIYSEKYADA VYPWIEKTKS GNAIFTQPSG
210 220 230 240 250
VLKCAGAPQK IMWMAEDYWR RHKVRSNIDV SFYTGMPTLF SVKRYSDALL
260 270 280 290 300
RQNEQLHRNV KINYKDELVE VKGSERKAVF KNLNDGSLFE RPFDLLHAVP
310 320 330 340 350
SMRSHEFIAK SDLADKSGFV AVDQSTTQST KFPNVFAIGD CSGLPTSKTY
360 370 380 390 400
AAITAQAPVM VHNLWSFVNG KNLTASYNGY TSCPLLTGYG KLILAEFLYK
410 420 430 440 450
QEPKESFGRF SRFLDQTVPR RMFYHLKKDF FPFVYWNFAV RNGKWYGSRG

LIPPHFPVN
Length:459
Mass (Da):51,575
Last modified:May 1, 1999 - v1
Checksum:i121F06DCC9579C04
GO

Sequence cautioni

The sequence BAA22793 differs from that shown. Sequencing errors.Curated
The sequence BAA22793 differs from that shown. Reason: Frameshift at several positions.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti396E → K in cadmium sensitive strain. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF042283 Genomic DNA Translation: AAD41159.1
AB007905 Genomic DNA Translation: BAA22793.1 Sequence problems.
CU329671 Genomic DNA Translation: CAA21882.1
PIRiT43278
T43558
RefSeqiNP_596067.1, NM_001021978.2

Genome annotation databases

EnsemblFungiiSPBC2G5.06c.1; SPBC2G5.06c.1:pep; SPBC2G5.06c
GeneIDi2540326
KEGGispo:SPBC2G5.06c

Similar proteinsi

Entry informationi

Entry nameiHMT2_SCHPO
AccessioniPrimary (citable) accession number: O94284
Secondary accession number(s): O13293
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 13, 2002
Last sequence update: May 1, 1999
Last modified: April 25, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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