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O94279

- MGDP1_SCHPO

UniProt

O94279 - MGDP1_SCHPO

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Protein

Putative magnesium-dependent phosphatase P8B7.31

Gene

SPBP8B7.31

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Magnesium-dependent phosphatase which may act as a tyrosine phosphatase.By similarity

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei14 – 141NucleophileBy similarity
Metal bindingi14 – 141MagnesiumBy similarity
Binding sitei15 – 151Phosphate; via amide nitrogenBy similarity
Active sitei16 – 161Proton donorBy similarity
Metal bindingi16 – 161MagnesiumBy similarity
Binding sitei16 – 161Phosphate; via amide nitrogenBy similarity
Binding sitei23 – 231SubstrateBy similarity
Binding sitei74 – 741PhosphateBy similarity
Binding sitei75 – 751PhosphateBy similarity
Binding sitei75 – 751SubstrateBy similarity
Binding sitei114 – 1141PhosphateBy similarity
Metal bindingi137 – 1371MagnesiumBy similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. protein tyrosine phosphatase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Magnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Putative magnesium-dependent phosphatase P8B7.31 (EC:3.1.3.48)
Gene namesi
ORF Names:SPBP8B7.31
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome II

Organism-specific databases

PomBaseiSPBP8B7.31.

Subcellular locationi

Cytoplasm 1 Publication. Nucleus 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: PomBase
  2. cytosol Source: PomBase
  3. nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 172172Putative magnesium-dependent phosphatase P8B7.31PRO_0000352835Add
BLAST

Proteomic databases

MaxQBiO94279.

Interactioni

Protein-protein interaction databases

BioGridi277886. 12 interactions.
MINTiMINT-4682827.
STRINGi4896.SPBP8B7.31-1.

Structurei

3D structure databases

ProteinModelPortaliO94279.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the HAD-like hydrolase superfamily.Curated

Phylogenomic databases

eggNOGiNOG279690.
HOGENOMiHOG000216653.
InParanoidiO94279.
KOiK17619.
OrthoDBiEOG718KQX.

Family and domain databases

Gene3Di3.40.50.1000. 1 hit.
InterProiIPR023214. HAD-like_dom.
IPR010033. HAD_SF_ppase_IIIC.
IPR024734. MDP_1_eu.
IPR010036. MDP_1_eu_arc.
[Graphical view]
PANTHERiPTHR17901. PTHR17901. 1 hit.
PfamiPF12689. Acid_PPase. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR01681. HAD-SF-IIIC. 1 hit.
TIGR01685. MDP-1. 1 hit.

Sequencei

Sequence statusi: Complete.

O94279-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVKNIEFPKC VVFDLDYTLW PLWIDTHVTA PFKPSKNDPG VLIDKYGTEI
60 70 80 90 100
CFYSDITGIL QELRNQKVTL CVASRTCAPK YAKQALNLMK VPIDGSLKPA
110 120 130 140 150
IEFFTYVKAW PGSKMDHFKE IHNESGIDYR EMVFFDDESR NREVERLGVT
160 170
FLEKIKKNSL NILSFLKNHM HG
Length:172
Mass (Da):19,909
Last modified:February 22, 2012 - v2
Checksum:i2FFB1F981F7F5EBF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329671 Genomic DNA. Translation: CAA21816.2.
PIRiT40825.
RefSeqiNP_596538.2. NM_001022459.2.

Genome annotation databases

EnsemblFungiiSPBP8B7.31.1; SPBP8B7.31.1:pep; SPBP8B7.31.
GeneIDi2541375.
KEGGispo:SPBP8B7.31.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329671 Genomic DNA. Translation: CAA21816.2 .
PIRi T40825.
RefSeqi NP_596538.2. NM_001022459.2.

3D structure databases

ProteinModelPortali O94279.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 277886. 12 interactions.
MINTi MINT-4682827.
STRINGi 4896.SPBP8B7.31-1.

Proteomic databases

MaxQBi O94279.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPBP8B7.31.1 ; SPBP8B7.31.1:pep ; SPBP8B7.31 .
GeneIDi 2541375.
KEGGi spo:SPBP8B7.31.

Organism-specific databases

PomBasei SPBP8B7.31.

Phylogenomic databases

eggNOGi NOG279690.
HOGENOMi HOG000216653.
InParanoidi O94279.
KOi K17619.
OrthoDBi EOG718KQX.

Miscellaneous databases

NextBioi 20802484.

Family and domain databases

Gene3Di 3.40.50.1000. 1 hit.
InterProi IPR023214. HAD-like_dom.
IPR010033. HAD_SF_ppase_IIIC.
IPR024734. MDP_1_eu.
IPR010036. MDP_1_eu_arc.
[Graphical view ]
PANTHERi PTHR17901. PTHR17901. 1 hit.
Pfami PF12689. Acid_PPase. 1 hit.
[Graphical view ]
SUPFAMi SSF56784. SSF56784. 1 hit.
TIGRFAMsi TIGR01681. HAD-SF-IIIC. 1 hit.
TIGR01685. MDP-1. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
    Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
    Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  3. "Augmented annotation of the Schizosaccharomyces pombe genome reveals additional genes required for growth and viability."
    Bitton D.A., Wood V., Scutt P.J., Grallert A., Yates T., Smith D.L., Hagan I.M., Miller C.J.
    Genetics 187:1207-1217(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVISION OF GENE MODEL, IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiMGDP1_SCHPO
AccessioniPrimary (citable) accession number: O94279
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 4, 2008
Last sequence update: February 22, 2012
Last modified: October 29, 2014
This is version 76 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3