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O94279

- MGDP1_SCHPO

UniProt

O94279 - MGDP1_SCHPO

Protein

Putative magnesium-dependent phosphatase P8B7.31

Gene

SPBP8B7.31

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 2 (22 Feb 2012)
      Previous versions | rss
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    Functioni

    Magnesium-dependent phosphatase which may act as a tyrosine phosphatase.By similarity

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei14 – 141NucleophileBy similarity
    Metal bindingi14 – 141MagnesiumBy similarity
    Binding sitei15 – 151Phosphate; via amide nitrogenBy similarity
    Active sitei16 – 161Proton donorBy similarity
    Metal bindingi16 – 161MagnesiumBy similarity
    Binding sitei16 – 161Phosphate; via amide nitrogenBy similarity
    Binding sitei23 – 231SubstrateBy similarity
    Binding sitei74 – 741PhosphateBy similarity
    Binding sitei75 – 751PhosphateBy similarity
    Binding sitei75 – 751SubstrateBy similarity
    Binding sitei114 – 1141PhosphateBy similarity
    Metal bindingi137 – 1371MagnesiumBy similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. protein tyrosine phosphatase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Ligandi

    Magnesium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative magnesium-dependent phosphatase P8B7.31 (EC:3.1.3.48)
    Gene namesi
    ORF Names:SPBP8B7.31
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome II

    Organism-specific databases

    PomBaseiSPBP8B7.31.

    Subcellular locationi

    Cytoplasm 1 Publication. Nucleus 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: PomBase
    2. cytosol Source: PomBase
    3. nucleus Source: PomBase

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 172172Putative magnesium-dependent phosphatase P8B7.31PRO_0000352835Add
    BLAST

    Proteomic databases

    MaxQBiO94279.

    Interactioni

    Protein-protein interaction databases

    BioGridi277886. 12 interactions.
    MINTiMINT-4682827.
    STRINGi4896.SPBP8B7.31-1.

    Structurei

    3D structure databases

    ProteinModelPortaliO94279.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the HAD-like hydrolase superfamily.Curated

    Phylogenomic databases

    eggNOGiNOG279690.
    HOGENOMiHOG000216653.
    KOiK17619.
    OrthoDBiEOG718KQX.

    Family and domain databases

    Gene3Di3.40.50.1000. 1 hit.
    InterProiIPR023214. HAD-like_dom.
    IPR010033. HAD_SF_ppase_IIIC.
    IPR024734. MDP_1_eu.
    IPR010036. MDP_1_eu_arc.
    [Graphical view]
    PANTHERiPTHR17901. PTHR17901. 1 hit.
    PfamiPF12689. Acid_PPase. 1 hit.
    [Graphical view]
    SUPFAMiSSF56784. SSF56784. 1 hit.
    TIGRFAMsiTIGR01681. HAD-SF-IIIC. 1 hit.
    TIGR01685. MDP-1. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    O94279-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVKNIEFPKC VVFDLDYTLW PLWIDTHVTA PFKPSKNDPG VLIDKYGTEI    50
    CFYSDITGIL QELRNQKVTL CVASRTCAPK YAKQALNLMK VPIDGSLKPA 100
    IEFFTYVKAW PGSKMDHFKE IHNESGIDYR EMVFFDDESR NREVERLGVT 150
    FLEKIKKNSL NILSFLKNHM HG 172
    Length:172
    Mass (Da):19,909
    Last modified:February 22, 2012 - v2
    Checksum:i2FFB1F981F7F5EBF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329671 Genomic DNA. Translation: CAA21816.2.
    PIRiT40825.
    RefSeqiNP_596538.2. NM_001022459.2.

    Genome annotation databases

    EnsemblFungiiSPBP8B7.31.1; SPBP8B7.31.1:pep; SPBP8B7.31.
    GeneIDi2541375.
    KEGGispo:SPBP8B7.31.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329671 Genomic DNA. Translation: CAA21816.2 .
    PIRi T40825.
    RefSeqi NP_596538.2. NM_001022459.2.

    3D structure databases

    ProteinModelPortali O94279.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 277886. 12 interactions.
    MINTi MINT-4682827.
    STRINGi 4896.SPBP8B7.31-1.

    Proteomic databases

    MaxQBi O94279.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPBP8B7.31.1 ; SPBP8B7.31.1:pep ; SPBP8B7.31 .
    GeneIDi 2541375.
    KEGGi spo:SPBP8B7.31.

    Organism-specific databases

    PomBasei SPBP8B7.31.

    Phylogenomic databases

    eggNOGi NOG279690.
    HOGENOMi HOG000216653.
    KOi K17619.
    OrthoDBi EOG718KQX.

    Miscellaneous databases

    NextBioi 20802484.

    Family and domain databases

    Gene3Di 3.40.50.1000. 1 hit.
    InterProi IPR023214. HAD-like_dom.
    IPR010033. HAD_SF_ppase_IIIC.
    IPR024734. MDP_1_eu.
    IPR010036. MDP_1_eu_arc.
    [Graphical view ]
    PANTHERi PTHR17901. PTHR17901. 1 hit.
    Pfami PF12689. Acid_PPase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56784. SSF56784. 1 hit.
    TIGRFAMsi TIGR01681. HAD-SF-IIIC. 1 hit.
    TIGR01685. MDP-1. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.
    2. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
      Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
      Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    3. "Augmented annotation of the Schizosaccharomyces pombe genome reveals additional genes required for growth and viability."
      Bitton D.A., Wood V., Scutt P.J., Grallert A., Yates T., Smith D.L., Hagan I.M., Miller C.J.
      Genetics 187:1207-1217(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVISION OF GENE MODEL, IDENTIFICATION BY MASS SPECTROMETRY.

    Entry informationi

    Entry nameiMGDP1_SCHPO
    AccessioniPrimary (citable) accession number: O94279
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 4, 2008
    Last sequence update: February 22, 2012
    Last modified: October 1, 2014
    This is version 75 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3