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Protein

Probable E3 ubiquitin-protein ligase mug30

Gene

mug30

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable E3 ubiquitin-protein ligase. Has a role in meiosis.1 Publication

Catalytic activityi

S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N6-ubiquitinyl-[acceptor protein]-L-lysine.

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei775Glycyl thioester intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processMeiosis, Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiR-SPO-983168 Antigen processing: Ubiquitination & Proteasome degradation
UniPathwayiUPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
Probable E3 ubiquitin-protein ligase mug30 (EC:2.3.2.26)
Alternative name(s):
HECT-type E3 ubiquitin transferase mug30
Meiotically up-regulated gene 30 protein
Gene namesi
Name:mug30
ORF Names:SPBP8B7.27
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBP8B7.27
PomBaseiSPBP8B7.27 mug30

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003005021 – 807Probable E3 ubiquitin-protein ligase mug30Add BLAST807

Proteomic databases

PaxDbiO94275
PRIDEiO94275

Interactioni

Protein-protein interaction databases

BioGridi277890, 24 interactors
STRINGi4896.SPBP8B7.27.1

Structurei

3D structure databases

ProteinModelPortaliO94275
SMRiO94275
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini453 – 807HECTPROSITE-ProRule annotationAdd BLAST355

Phylogenomic databases

InParanoidiO94275
KOiK12232
OMAiQYGNDWH
OrthoDBiEOG092C12Z2
PhylomeDBiO94275

Family and domain databases

CDDicd00078 HECTc, 1 hit
InterProiView protein in InterPro
IPR000569 HECT_dom
IPR035983 Hect_E3_ubiquitin_ligase
IPR001607 Znf_UBP
PfamiView protein in Pfam
PF00632 HECT, 1 hit
SMARTiView protein in SMART
SM00119 HECTc, 1 hit
SM00290 ZnF_UBP, 1 hit
SUPFAMiSSF56204 SSF56204, 2 hits
PROSITEiView protein in PROSITE
PS50237 HECT, 1 hit

Sequencei

Sequence statusi: Complete.

O94275-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRPIEIANV SSGNRRTLPA LHGSSFSSRS ELDNNTNSKI SRRLRELVCQ
60 70 80 90 100
RMGENPLRLR QSFHETISND SYGNSEKLVI RPCICCNSVL RYPAQAMCFR
110 120 130 140 150
CSLCMTVNDV YFCLSGSQIK TKASTDGSQF ISVEHFVETI HQTRSALQLA
160 170 180 190 200
KQRTGNVQAI VAAGLPLREL ISLVFGSPPI LNKLFSVKNG CSIQSSGLNY
210 220 230 240 250
KLIYQLYHDI TNLDILITNE LLRAIESLLR RPMLYCHDPA DYQYLLILLE
260 270 280 290 300
NPLLNSKSKN IVNKSSSILK RILGVLSNLN EKTHHFFISC FKKQPYNNPK
310 320 330 340 350
FFRRKVDLIN KFIGQRLMET YSRNKRKHYY NNDWQIKSAA ITMALLYSAN
360 370 380 390 400
SQMRLIDRSS FYCIMADFIN LYHDFELWEQ KINCFCFCQY PFLLSMGAKI
410 420 430 440 450
SILQLDARRK MEIKAREAFF SSILSKMNVE PYLMIRVRRD RLLEDSLRQI
460 470 480 490 500
NDRNKDFRKA LKVEFLGEEG IDAGGLKREW LLLLTRKVFS PEFGLFVNCE
510 520 530 540 550
ESSNYLWFNY SHRSKEIDYY HMSGILMGIA IHNSINLDVQ MPRAFYKKLL
560 570 580 590 600
QLPLSFNDLD DFQPSLYRGL KELLLFEGDV KNTYGLNFTI NLKAVEGFRT
610 620 630 640 650
VELKEGGSEL SVDNENRKEY VLRYVDYLLN TTVKKQFSAF FDGFMKVCGG
660 670 680 690 700
NAISLFQDNE ISKLIRGSEE VIDWELLKNV CVYDFYDQNA ISNSISESEP
710 720 730 740 750
SMTASKYLCH SFVSKRKIIL WFWDLISHYS LKMQKLFLIF VTGSDRIPAT
760 770 780 790 800
GAHNFQLRIS VLGPDSDQLP ISHTCFNHLC IWEYSSREKL KKKLDTALLE

TNGFNIR
Length:807
Mass (Da):93,415
Last modified:May 1, 1999 - v1
Checksum:i7203EB2667E2D3AB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA Translation: CAA21812.1
PIRiT40821
RefSeqiNP_596534.1, NM_001022455.2

Genome annotation databases

EnsemblFungiiSPBP8B7.27.1; SPBP8B7.27.1:pep; SPBP8B7.27
GeneIDi2541379
KEGGispo:SPBP8B7.27

Entry informationi

Entry nameiMUG30_SCHPO
AccessioniPrimary (citable) accession number: O94275
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: May 1, 1999
Last modified: March 28, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health