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Protein

Probable E3 ubiquitin-protein ligase mug30

Gene

mug30

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Probable E3 ubiquitin-protein ligase. Has a role in meiosis.1 Publication

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei775 – 7751Glycyl thioester intermediatePROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Meiosis, Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiR-SPO-983168. Antigen processing: Ubiquitination & Proteasome degradation.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable E3 ubiquitin-protein ligase mug30 (EC:6.3.2.-)
Alternative name(s):
Meiotically up-regulated gene 30 protein
Gene namesi
Name:mug30
ORF Names:SPBP8B7.27
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBP8B7.27.
PomBaseiSPBP8B7.27. mug30.

Subcellular locationi

GO - Cellular componenti

  • cell division site Source: PomBase
  • cell tip Source: PomBase
  • cytoplasm Source: GO_Central
  • mitotic spindle pole body Source: PomBase
  • nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 807807Probable E3 ubiquitin-protein ligase mug30PRO_0000300502Add
BLAST

Proteomic databases

PRIDEiO94275.

Interactioni

Protein-protein interaction databases

BioGridi277890. 24 interactions.
MINTiMINT-4682792.

Structurei

3D structure databases

ProteinModelPortaliO94275.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini453 – 807355HECTPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain.PROSITE-ProRule annotation

Phylogenomic databases

InParanoidiO94275.
KOiK12232.
OMAiTHYEGFG.
OrthoDBiEOG092C12Z2.
PhylomeDBiO94275.

Family and domain databases

InterProiIPR000569. HECT_dom.
IPR001607. Znf_UBP.
[Graphical view]
PfamiPF00632. HECT. 1 hit.
[Graphical view]
SMARTiSM00119. HECTc. 1 hit.
SM00290. ZnF_UBP. 1 hit.
[Graphical view]
SUPFAMiSSF56204. SSF56204. 2 hits.
PROSITEiPS50237. HECT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O94275-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRPIEIANV SSGNRRTLPA LHGSSFSSRS ELDNNTNSKI SRRLRELVCQ
60 70 80 90 100
RMGENPLRLR QSFHETISND SYGNSEKLVI RPCICCNSVL RYPAQAMCFR
110 120 130 140 150
CSLCMTVNDV YFCLSGSQIK TKASTDGSQF ISVEHFVETI HQTRSALQLA
160 170 180 190 200
KQRTGNVQAI VAAGLPLREL ISLVFGSPPI LNKLFSVKNG CSIQSSGLNY
210 220 230 240 250
KLIYQLYHDI TNLDILITNE LLRAIESLLR RPMLYCHDPA DYQYLLILLE
260 270 280 290 300
NPLLNSKSKN IVNKSSSILK RILGVLSNLN EKTHHFFISC FKKQPYNNPK
310 320 330 340 350
FFRRKVDLIN KFIGQRLMET YSRNKRKHYY NNDWQIKSAA ITMALLYSAN
360 370 380 390 400
SQMRLIDRSS FYCIMADFIN LYHDFELWEQ KINCFCFCQY PFLLSMGAKI
410 420 430 440 450
SILQLDARRK MEIKAREAFF SSILSKMNVE PYLMIRVRRD RLLEDSLRQI
460 470 480 490 500
NDRNKDFRKA LKVEFLGEEG IDAGGLKREW LLLLTRKVFS PEFGLFVNCE
510 520 530 540 550
ESSNYLWFNY SHRSKEIDYY HMSGILMGIA IHNSINLDVQ MPRAFYKKLL
560 570 580 590 600
QLPLSFNDLD DFQPSLYRGL KELLLFEGDV KNTYGLNFTI NLKAVEGFRT
610 620 630 640 650
VELKEGGSEL SVDNENRKEY VLRYVDYLLN TTVKKQFSAF FDGFMKVCGG
660 670 680 690 700
NAISLFQDNE ISKLIRGSEE VIDWELLKNV CVYDFYDQNA ISNSISESEP
710 720 730 740 750
SMTASKYLCH SFVSKRKIIL WFWDLISHYS LKMQKLFLIF VTGSDRIPAT
760 770 780 790 800
GAHNFQLRIS VLGPDSDQLP ISHTCFNHLC IWEYSSREKL KKKLDTALLE

TNGFNIR
Length:807
Mass (Da):93,415
Last modified:May 1, 1999 - v1
Checksum:i7203EB2667E2D3AB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA21812.1.
PIRiT40821.
RefSeqiNP_596534.1. NM_001022455.2.

Genome annotation databases

EnsemblFungiiSPBP8B7.27.1; SPBP8B7.27.1:pep; SPBP8B7.27.
GeneIDi2541379.
KEGGispo:SPBP8B7.27.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA21812.1.
PIRiT40821.
RefSeqiNP_596534.1. NM_001022455.2.

3D structure databases

ProteinModelPortaliO94275.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi277890. 24 interactions.
MINTiMINT-4682792.

Proteomic databases

PRIDEiO94275.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBP8B7.27.1; SPBP8B7.27.1:pep; SPBP8B7.27.
GeneIDi2541379.
KEGGispo:SPBP8B7.27.

Organism-specific databases

EuPathDBiFungiDB:SPBP8B7.27.
PomBaseiSPBP8B7.27. mug30.

Phylogenomic databases

InParanoidiO94275.
KOiK12232.
OMAiTHYEGFG.
OrthoDBiEOG092C12Z2.
PhylomeDBiO94275.

Enzyme and pathway databases

UniPathwayiUPA00143.
ReactomeiR-SPO-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Miscellaneous databases

PROiO94275.

Family and domain databases

InterProiIPR000569. HECT_dom.
IPR001607. Znf_UBP.
[Graphical view]
PfamiPF00632. HECT. 1 hit.
[Graphical view]
SMARTiSM00119. HECTc. 1 hit.
SM00290. ZnF_UBP. 1 hit.
[Graphical view]
SUPFAMiSSF56204. SSF56204. 2 hits.
PROSITEiPS50237. HECT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMUG30_SCHPO
AccessioniPrimary (citable) accession number: O94275
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: May 1, 1999
Last modified: September 7, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.