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O94269

- UBP3_SCHPO

UniProt

O94269 - UBP3_SCHPO

Protein

Probable ubiquitin carboxyl-terminal hydrolase 3

Gene

ubp3

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei142 – 1421NucleophilePROSITE-ProRule annotation
    Active sitei453 – 4531Proton acceptorPROSITE-ProRule annotation

    GO - Molecular functioni

    1. protein binding Source: PomBase
    2. ubiquitin-specific protease activity Source: PomBase

    GO - Biological processi

    1. protein deubiquitination Source: PomBase
    2. regulation of ER to Golgi vesicle-mediated transport Source: PomBase
    3. ubiquitin-dependent protein catabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Keywords - Biological processi

    Ubl conjugation pathway

    Protein family/group databases

    MEROPSiC19.A57.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable ubiquitin carboxyl-terminal hydrolase 3 (EC:3.4.19.12)
    Alternative name(s):
    Deubiquitinating enzyme 3
    Ubiquitin thioesterase 3
    Ubiquitin-specific-processing protease 3
    Gene namesi
    Name:ubp3
    ORF Names:SPBP8B7.21
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome II

    Organism-specific databases

    PomBaseiSPBP8B7.21.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: PomBase
    2. cytosol Source: PomBase
    3. nucleus Source: PomBase

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 512512Probable ubiquitin carboxyl-terminal hydrolase 3PRO_0000080604Add
    BLAST

    Proteomic databases

    MaxQBiO94269.

    Interactioni

    Protein-protein interaction databases

    BioGridi277889. 117 interactions.
    MINTiMINT-4682738.
    STRINGi4896.SPBP8B7.21-1.

    Structurei

    3D structure databases

    ProteinModelPortaliO94269.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini133 – 511379USPAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase C19 family.Curated
    Contains 1 USP domain.Curated

    Phylogenomic databases

    eggNOGiCOG5533.
    KOiK11841.
    OMAiINTGNIC.
    OrthoDBiEOG7F2546.
    PhylomeDBiO94269.

    Family and domain databases

    InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    [Graphical view]
    PfamiPF00443. UCH. 1 hit.
    [Graphical view]
    PROSITEiPS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O94269-1 [UniParc]FASTAAdd to Basket

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    MRDLTSATDS ASLESDSSRN QFIINSLLPW YSCSEHEFPH RKARKRRSPK    50
    NLDWSVSVQM PLVTSKTKES EKSPKSWSAI AKKHVQGDSP VKKSHSVPVP 100
    SDRSEKKSFN SSLGELIETY SPSLDAPRPI QPRGFINTGN ICFMNSILQA 150
    LMYCVPFYNL LKQINRMVPY NFERTTPLIE SLTMLSRDFR EYSEKFDLQG 200
    DSILPEVVYS ATKGNPRFEM LQTGEQEDAE EFLNLFLDEL HEEFVRERRH 250
    YLLKNDERNP KSDIKISNGI KSGLDSFDDQ SSVEASGWTE VGKNKKPVIA 300
    RSATVERSPI SQIFGGQLRS TLRVPSARDS VLLEPFQPLQ LDIQAEDIHS 350
    VIDALEHMTA PEILPEWHSS KGNVTATKQM YIESLPPVLI LHLKRFFYEA 400
    SGGTQKNYKP IAYPARLSIP QNVFSPSVRG SIHPEYDLNA VVYHHGTSAS 450
    GGHYTVDVQQ LDKSGWFRID DTHIHRVPIH DVENSELSAD PSLSKLGHGD 500
    RVAYLLFYTR RS 512
    Length:512
    Mass (Da):58,081
    Last modified:May 1, 1999 - v1
    Checksum:i1F97DA2C7720695D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329671 Genomic DNA. Translation: CAA21806.1.
    PIRiT40815.
    RefSeqiNP_596528.1. NM_001022449.2.

    Genome annotation databases

    EnsemblFungiiSPBP8B7.21.1; SPBP8B7.21.1:pep; SPBP8B7.21.
    GeneIDi2541378.
    KEGGispo:SPBP8B7.21.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329671 Genomic DNA. Translation: CAA21806.1 .
    PIRi T40815.
    RefSeqi NP_596528.1. NM_001022449.2.

    3D structure databases

    ProteinModelPortali O94269.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 277889. 117 interactions.
    MINTi MINT-4682738.
    STRINGi 4896.SPBP8B7.21-1.

    Protein family/group databases

    MEROPSi C19.A57.

    Proteomic databases

    MaxQBi O94269.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPBP8B7.21.1 ; SPBP8B7.21.1:pep ; SPBP8B7.21 .
    GeneIDi 2541378.
    KEGGi spo:SPBP8B7.21.

    Organism-specific databases

    PomBasei SPBP8B7.21.

    Phylogenomic databases

    eggNOGi COG5533.
    KOi K11841.
    OMAi INTGNIC.
    OrthoDBi EOG7F2546.
    PhylomeDBi O94269.

    Miscellaneous databases

    NextBioi 20802487.

    Family and domain databases

    InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    [Graphical view ]
    Pfami PF00443. UCH. 1 hit.
    [Graphical view ]
    PROSITEi PS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.

    Entry informationi

    Entry nameiUBP3_SCHPO
    AccessioniPrimary (citable) accession number: O94269
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 2002
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 93 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3