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Protein

Probable ubiquitin carboxyl-terminal hydrolase 3

Gene

ubp3

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei142NucleophilePROSITE-ProRule annotation1
Active sitei453Proton acceptorPROSITE-ProRule annotation1

GO - Molecular functioni

  • thiol-dependent ubiquitin-specific protease activity Source: PomBase

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiR-SPO-5656169. Termination of translesion DNA synthesis.
R-SPO-5689880. Ub-specific processing proteases.

Protein family/group databases

MEROPSiC19.A57.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable ubiquitin carboxyl-terminal hydrolase 3 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 3
Ubiquitin thioesterase 3
Ubiquitin-specific-processing protease 3
Gene namesi
Name:ubp3
ORF Names:SPBP8B7.21
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBP8B7.21.
PomBaseiSPBP8B7.21. ubp3.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: PomBase
  • cytosol Source: PomBase
  • nucleus Source: PomBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000806041 – 512Probable ubiquitin carboxyl-terminal hydrolase 3Add BLAST512

Proteomic databases

MaxQBiO94269.
PRIDEiO94269.

Interactioni

Protein-protein interaction databases

BioGridi277889. 116 interactors.
MINTiMINT-4682738.

Structurei

3D structure databases

ProteinModelPortaliO94269.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini133 – 511USPAdd BLAST379

Sequence similaritiesi

Belongs to the peptidase C19 family.Curated
Contains 1 USP domain.Curated

Phylogenomic databases

InParanoidiO94269.
KOiK11841.
OMAiFQPLQLD.
OrthoDBiEOG092C0VQG.
PhylomeDBiO94269.

Family and domain databases

InterProiIPR001394. Peptidase_C19_UCH.
IPR018200. USP_CS.
IPR028889. USP_dom.
[Graphical view]
PfamiPF00443. UCH. 1 hit.
[Graphical view]
PROSITEiPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O94269-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRDLTSATDS ASLESDSSRN QFIINSLLPW YSCSEHEFPH RKARKRRSPK
60 70 80 90 100
NLDWSVSVQM PLVTSKTKES EKSPKSWSAI AKKHVQGDSP VKKSHSVPVP
110 120 130 140 150
SDRSEKKSFN SSLGELIETY SPSLDAPRPI QPRGFINTGN ICFMNSILQA
160 170 180 190 200
LMYCVPFYNL LKQINRMVPY NFERTTPLIE SLTMLSRDFR EYSEKFDLQG
210 220 230 240 250
DSILPEVVYS ATKGNPRFEM LQTGEQEDAE EFLNLFLDEL HEEFVRERRH
260 270 280 290 300
YLLKNDERNP KSDIKISNGI KSGLDSFDDQ SSVEASGWTE VGKNKKPVIA
310 320 330 340 350
RSATVERSPI SQIFGGQLRS TLRVPSARDS VLLEPFQPLQ LDIQAEDIHS
360 370 380 390 400
VIDALEHMTA PEILPEWHSS KGNVTATKQM YIESLPPVLI LHLKRFFYEA
410 420 430 440 450
SGGTQKNYKP IAYPARLSIP QNVFSPSVRG SIHPEYDLNA VVYHHGTSAS
460 470 480 490 500
GGHYTVDVQQ LDKSGWFRID DTHIHRVPIH DVENSELSAD PSLSKLGHGD
510
RVAYLLFYTR RS
Length:512
Mass (Da):58,081
Last modified:May 1, 1999 - v1
Checksum:i1F97DA2C7720695D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA21806.1.
PIRiT40815.
RefSeqiNP_596528.1. NM_001022449.2.

Genome annotation databases

EnsemblFungiiSPBP8B7.21.1; SPBP8B7.21.1:pep; SPBP8B7.21.
GeneIDi2541378.
KEGGispo:SPBP8B7.21.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA21806.1.
PIRiT40815.
RefSeqiNP_596528.1. NM_001022449.2.

3D structure databases

ProteinModelPortaliO94269.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi277889. 116 interactors.
MINTiMINT-4682738.

Protein family/group databases

MEROPSiC19.A57.

Proteomic databases

MaxQBiO94269.
PRIDEiO94269.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBP8B7.21.1; SPBP8B7.21.1:pep; SPBP8B7.21.
GeneIDi2541378.
KEGGispo:SPBP8B7.21.

Organism-specific databases

EuPathDBiFungiDB:SPBP8B7.21.
PomBaseiSPBP8B7.21. ubp3.

Phylogenomic databases

InParanoidiO94269.
KOiK11841.
OMAiFQPLQLD.
OrthoDBiEOG092C0VQG.
PhylomeDBiO94269.

Enzyme and pathway databases

ReactomeiR-SPO-5656169. Termination of translesion DNA synthesis.
R-SPO-5689880. Ub-specific processing proteases.

Miscellaneous databases

PROiO94269.

Family and domain databases

InterProiIPR001394. Peptidase_C19_UCH.
IPR018200. USP_CS.
IPR028889. USP_dom.
[Graphical view]
PfamiPF00443. UCH. 1 hit.
[Graphical view]
PROSITEiPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiUBP3_SCHPO
AccessioniPrimary (citable) accession number: O94269
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: May 1, 1999
Last modified: November 30, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.