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Protein

Probable ubiquitin carboxyl-terminal hydrolase 3

Gene

ubp3

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei142NucleophilePROSITE-ProRule annotation1
Active sitei453Proton acceptorPROSITE-ProRule annotation1

GO - Molecular functioni

  • polysome binding Source: PomBase
  • thiol-dependent ubiquitin-specific protease activity Source: PomBase

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Thiol protease
Biological processUbl conjugation pathway

Enzyme and pathway databases

ReactomeiR-SPO-5656169 Termination of translesion DNA synthesis
R-SPO-5689880 Ub-specific processing proteases

Protein family/group databases

MEROPSiC19.A57

Names & Taxonomyi

Protein namesi
Recommended name:
Probable ubiquitin carboxyl-terminal hydrolase 3 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 3
Ubiquitin thioesterase 3
Ubiquitin-specific-processing protease 3
Gene namesi
Name:ubp3
ORF Names:SPBP8B7.21
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBP8B7.21
PomBaseiSPBP8B7.21 ubp3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000806041 – 512Probable ubiquitin carboxyl-terminal hydrolase 3Add BLAST512

Proteomic databases

MaxQBiO94269
PaxDbiO94269
PRIDEiO94269

PTM databases

iPTMnetiO94269

Interactioni

Protein-protein interaction databases

BioGridi277889, 115 interactors
STRINGi4896.SPBP8B7.21.1

Structurei

3D structure databases

ProteinModelPortaliO94269
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini133 – 511USPAdd BLAST379

Sequence similaritiesi

Belongs to the peptidase C19 family.Curated

Phylogenomic databases

InParanoidiO94269
KOiK11841
OMAiPAKNMEK
OrthoDBiEOG092C0VQG
PhylomeDBiO94269

Family and domain databases

InterProiView protein in InterPro
IPR001394 Peptidase_C19_UCH
IPR018200 USP_CS
IPR028889 USP_dom
PfamiView protein in Pfam
PF00443 UCH, 1 hit
PROSITEiView protein in PROSITE
PS00972 USP_1, 1 hit
PS00973 USP_2, 1 hit
PS50235 USP_3, 1 hit

Sequencei

Sequence statusi: Complete.

O94269-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRDLTSATDS ASLESDSSRN QFIINSLLPW YSCSEHEFPH RKARKRRSPK
60 70 80 90 100
NLDWSVSVQM PLVTSKTKES EKSPKSWSAI AKKHVQGDSP VKKSHSVPVP
110 120 130 140 150
SDRSEKKSFN SSLGELIETY SPSLDAPRPI QPRGFINTGN ICFMNSILQA
160 170 180 190 200
LMYCVPFYNL LKQINRMVPY NFERTTPLIE SLTMLSRDFR EYSEKFDLQG
210 220 230 240 250
DSILPEVVYS ATKGNPRFEM LQTGEQEDAE EFLNLFLDEL HEEFVRERRH
260 270 280 290 300
YLLKNDERNP KSDIKISNGI KSGLDSFDDQ SSVEASGWTE VGKNKKPVIA
310 320 330 340 350
RSATVERSPI SQIFGGQLRS TLRVPSARDS VLLEPFQPLQ LDIQAEDIHS
360 370 380 390 400
VIDALEHMTA PEILPEWHSS KGNVTATKQM YIESLPPVLI LHLKRFFYEA
410 420 430 440 450
SGGTQKNYKP IAYPARLSIP QNVFSPSVRG SIHPEYDLNA VVYHHGTSAS
460 470 480 490 500
GGHYTVDVQQ LDKSGWFRID DTHIHRVPIH DVENSELSAD PSLSKLGHGD
510
RVAYLLFYTR RS
Length:512
Mass (Da):58,081
Last modified:May 1, 1999 - v1
Checksum:i1F97DA2C7720695D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA Translation: CAA21806.1
PIRiT40815
RefSeqiNP_596528.1, NM_001022449.2

Genome annotation databases

EnsemblFungiiSPBP8B7.21.1; SPBP8B7.21.1:pep; SPBP8B7.21
GeneIDi2541378
KEGGispo:SPBP8B7.21

Similar proteinsi

Entry informationi

Entry nameiUBP3_SCHPO
AccessioniPrimary (citable) accession number: O94269
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: May 1, 1999
Last modified: March 28, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

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