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O94269 (UBP3_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable ubiquitin carboxyl-terminal hydrolase 3

EC=3.4.19.12
Alternative name(s):
Deubiquitinating enzyme 3
Ubiquitin thioesterase 3
Ubiquitin-specific-processing protease 3
Gene names
Name:ubp3
ORF Names:SPBP8B7.21
OrganismSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) [Reference proteome]
Taxonomic identifier284812 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces

Protein attributes

Sequence length512 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sequence similarities

Belongs to the peptidase C19 family.

Contains 1 USP domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 512512Probable ubiquitin carboxyl-terminal hydrolase 3
PRO_0000080604

Regions

Domain133 – 511379USP

Sites

Active site1421Nucleophile By similarity
Active site4531Proton acceptor By similarity

Sequences

Sequence LengthMass (Da)Tools
O94269 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: 1F97DA2C7720695D

FASTA51258,081
        10         20         30         40         50         60 
MRDLTSATDS ASLESDSSRN QFIINSLLPW YSCSEHEFPH RKARKRRSPK NLDWSVSVQM 

        70         80         90        100        110        120 
PLVTSKTKES EKSPKSWSAI AKKHVQGDSP VKKSHSVPVP SDRSEKKSFN SSLGELIETY 

       130        140        150        160        170        180 
SPSLDAPRPI QPRGFINTGN ICFMNSILQA LMYCVPFYNL LKQINRMVPY NFERTTPLIE 

       190        200        210        220        230        240 
SLTMLSRDFR EYSEKFDLQG DSILPEVVYS ATKGNPRFEM LQTGEQEDAE EFLNLFLDEL 

       250        260        270        280        290        300 
HEEFVRERRH YLLKNDERNP KSDIKISNGI KSGLDSFDDQ SSVEASGWTE VGKNKKPVIA 

       310        320        330        340        350        360 
RSATVERSPI SQIFGGQLRS TLRVPSARDS VLLEPFQPLQ LDIQAEDIHS VIDALEHMTA 

       370        380        390        400        410        420 
PEILPEWHSS KGNVTATKQM YIESLPPVLI LHLKRFFYEA SGGTQKNYKP IAYPARLSIP 

       430        440        450        460        470        480 
QNVFSPSVRG SIHPEYDLNA VVYHHGTSAS GGHYTVDVQQ LDKSGWFRID DTHIHRVPIH 

       490        500        510 
DVENSELSAD PSLSKLGHGD RVAYLLFYTR RS 

« Hide

References

[1]"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. expand/collapse author list , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 972 / ATCC 24843.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CU329671 Genomic DNA. Translation: CAA21806.1.
PIRT40815.
RefSeqNP_596528.1. NM_001022449.2.

3D structure databases

ProteinModelPortalO94269.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid277889. 117 interactions.
MINTMINT-4682738.
STRING4896.SPBP8B7.21-1.

Protein family/group databases

MEROPSC19.A57.

Proteomic databases

MaxQBO94269.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiSPBP8B7.21.1; SPBP8B7.21.1:pep; SPBP8B7.21.
GeneID2541378.
KEGGspo:SPBP8B7.21.

Organism-specific databases

PomBaseSPBP8B7.21.

Phylogenomic databases

eggNOGCOG5533.
KOK11841.
OMAINTGNIC.
OrthoDBEOG7F2546.
PhylomeDBO94269.

Family and domain databases

InterProIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view]
PfamPF00443. UCH. 1 hit.
[Graphical view]
PROSITEPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20802487.

Entry information

Entry nameUBP3_SCHPO
AccessionPrimary (citable) accession number: O94269
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: May 1, 1999
Last modified: June 11, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names

Peptidase families

Classification of peptidase families and list of entries