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O94266

- THI22_SCHPO

UniProt

O94266 - THI22_SCHPO

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Protein

Putative hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 2

Gene

SPBP8B7.18c

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P.By similarity

Catalytic activityi

ATP + 4-amino-5-hydroxymethyl-2-methylpyrimidine = ADP + 4-amino-5-phosphonooxymethyl-2-methylpyrimidine.
ATP + 4-amino-2-methyl-5-phosphomethylpyrimidine = ADP + 4-amino-2-methyl-5-diphosphomethylpyrimidine.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei76 – 761SubstrateBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. hydroxymethylpyrimidine kinase activity Source: UniProtKB-EC
  3. phosphomethylpyrimidine kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. thiamine biosynthetic process Source: UniProtKB-KW
  2. thiamine diphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Thiamine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00060; UER00137.
UPA00060; UER00138.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 2 (EC:2.7.1.49, EC:2.7.4.7)
Alternative name(s):
Hydroxymethylpyrimidine kinase 2
Short name:
HMP kinase 2
Hydroxymethylpyrimidine phosphate kinase 2
Short name:
HMP-P kinase 2
Short name:
HMP-phosphate kinase 2
Short name:
HMPP kinase 2
Gene namesi
ORF Names:SPBP8B7.18c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome II

Organism-specific databases

PomBaseiSPBP8B7.18c.

Subcellular locationi

Cytoplasm 1 Publication

GO - Cellular componenti

  1. cytosol Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 551551Putative hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 2PRO_0000315973Add
BLAST

Proteomic databases

MaxQBiO94266.

Interactioni

Protein-protein interaction databases

BioGridi277884. 13 interactions.
MINTiMINT-4682707.
STRINGi4896.SPBP8B7.18c-1.

Structurei

3D structure databases

ProteinModelPortaliO94266.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

In the N-terminal section; belongs to the ThiD family.Curated
In the C-terminal section; belongs to the thiaminase-2 family.Curated

Phylogenomic databases

eggNOGiCOG0351.
HOGENOMiHOG000225275.
InParanoidiO94266.
KOiK00877.
OMAiGFWEMFP.
OrthoDBiEOG75MW5D.
PhylomeDBiO94266.

Family and domain databases

Gene3Di1.20.910.10. 1 hit.
3.40.1190.20. 1 hit.
InterProiIPR016084. Haem_Oase-like_multi-hlx.
IPR004399. HMP/HMP-P_kinase.
IPR013749. PM/HMP-P_kinase-1.
IPR029056. Ribokinase-like.
IPR004305. Thiaminase-2/PQQC.
[Graphical view]
PfamiPF08543. Phos_pyr_kin. 1 hit.
PF03070. TENA_THI-4. 1 hit.
[Graphical view]
SUPFAMiSSF48613. SSF48613. 1 hit.
SSF53613. SSF53613. 1 hit.
TIGRFAMsiTIGR00097. HMP-P_kinase. 1 hit.

Sequencei

Sequence statusi: Complete.

O94266-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPYNPLYESL SNQFDPSRIE TVLDPMGYTI KRRALPVSLT IAGSDCSGGA
60 70 80 90 100
GIQADLKTMT SLGVYGMSAI TCLVAENAGG VDSVEEMSPA FVESQIDCCI
110 120 130 140 150
RDIPCHVVKT GMLGSPEIVK AVARSAKKFN FSKLVVDPVM VATSGDSLVT
160 170 180 190 200
KDIVSVLNEE LLPLTYLVTP NIPEAIVLAK NQGLDISNIN SVSDMERCAA
210 220 230 240 250
VIHKLGPKHV LLKGGHMPVN NLGLKSSDDE DLRVVDILYD GNRFYHFSSS
260 270 280 290 300
YLKKGEVHGT GCTLSSAIAS FLAWEHSLTE AVQFGIDYVH GAITHSPPIN
310 320 330 340 350
NCSTNILNHM TRLRIVPFAP GHFIEYILSH PQVVPAWKEY INHKFTNMLA
360 370 380 390 400
KGTLPLPAFQ DYLKQDYLYL VNFARAYSLK GYKENTFPNI LEAAQSVIHV
410 420 430 440 450
IEEKELHVSM CSSYGVSLQD LKSCEESPAC TAYSRYILDT GAAQDVAALD
460 470 480 490 500
FVQAPCLIGY YVIAARLMKE PFRNPQGPYQ KWVDNYFCED YLSAVRRGCR
510 520 530 540 550
QIEEIVLKLS PERIQELIEI FIRATKFETL FWETPYYEYV TKQNLEDKEF

S
Length:551
Mass (Da):61,354
Last modified:May 1, 1999 - v1
Checksum:i8FA207F9F1472C00
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329671 Genomic DNA. Translation: CAA21803.1.
PIRiT40812.
RefSeqiNP_596525.1. NM_001022446.2.

Genome annotation databases

EnsemblFungiiSPBP8B7.18c.1; SPBP8B7.18c.1:pep; SPBP8B7.18c.
GeneIDi2541373.
KEGGispo:SPBP8B7.18c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329671 Genomic DNA. Translation: CAA21803.1 .
PIRi T40812.
RefSeqi NP_596525.1. NM_001022446.2.

3D structure databases

ProteinModelPortali O94266.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 277884. 13 interactions.
MINTi MINT-4682707.
STRINGi 4896.SPBP8B7.18c-1.

Proteomic databases

MaxQBi O94266.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPBP8B7.18c.1 ; SPBP8B7.18c.1:pep ; SPBP8B7.18c .
GeneIDi 2541373.
KEGGi spo:SPBP8B7.18c.

Organism-specific databases

PomBasei SPBP8B7.18c.

Phylogenomic databases

eggNOGi COG0351.
HOGENOMi HOG000225275.
InParanoidi O94266.
KOi K00877.
OMAi GFWEMFP.
OrthoDBi EOG75MW5D.
PhylomeDBi O94266.

Enzyme and pathway databases

UniPathwayi UPA00060 ; UER00137 .
UPA00060 ; UER00138 .

Miscellaneous databases

NextBioi 20802482.

Family and domain databases

Gene3Di 1.20.910.10. 1 hit.
3.40.1190.20. 1 hit.
InterProi IPR016084. Haem_Oase-like_multi-hlx.
IPR004399. HMP/HMP-P_kinase.
IPR013749. PM/HMP-P_kinase-1.
IPR029056. Ribokinase-like.
IPR004305. Thiaminase-2/PQQC.
[Graphical view ]
Pfami PF08543. Phos_pyr_kin. 1 hit.
PF03070. TENA_THI-4. 1 hit.
[Graphical view ]
SUPFAMi SSF48613. SSF48613. 1 hit.
SSF53613. SSF53613. 1 hit.
TIGRFAMsi TIGR00097. HMP-P_kinase. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
    Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
    Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiTHI22_SCHPO
AccessioniPrimary (citable) accession number: O94266
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 1, 1999
Last modified: October 29, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3