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O94266

- THI22_SCHPO

UniProt

O94266 - THI22_SCHPO

Protein

Putative hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 2

Gene

SPBP8B7.18c

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 78 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P.By similarity

    Catalytic activityi

    ATP + 4-amino-5-hydroxymethyl-2-methylpyrimidine = ADP + 4-amino-5-phosphonooxymethyl-2-methylpyrimidine.
    ATP + 4-amino-2-methyl-5-phosphomethylpyrimidine = ADP + 4-amino-2-methyl-5-diphosphomethylpyrimidine.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei76 – 761SubstrateBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. hydroxymethylpyrimidine kinase activity Source: UniProtKB-EC
    3. phosphomethylpyrimidine kinase activity Source: UniProtKB-EC

    GO - Biological processi

    1. thiamine biosynthetic process Source: UniProtKB-KW
    2. thiamine diphosphate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Thiamine biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00060; UER00137.
    UPA00060; UER00138.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 2 (EC:2.7.1.49, EC:2.7.4.7)
    Alternative name(s):
    Hydroxymethylpyrimidine kinase 2
    Short name:
    HMP kinase 2
    Hydroxymethylpyrimidine phosphate kinase 2
    Short name:
    HMP-P kinase 2
    Short name:
    HMP-phosphate kinase 2
    Short name:
    HMPP kinase 2
    Gene namesi
    ORF Names:SPBP8B7.18c
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome II

    Organism-specific databases

    PomBaseiSPBP8B7.18c.

    Subcellular locationi

    Cytoplasm 1 Publication

    GO - Cellular componenti

    1. cytosol Source: PomBase

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 551551Putative hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 2PRO_0000315973Add
    BLAST

    Proteomic databases

    MaxQBiO94266.

    Interactioni

    Protein-protein interaction databases

    BioGridi277884. 13 interactions.
    MINTiMINT-4682707.
    STRINGi4896.SPBP8B7.18c-1.

    Structurei

    3D structure databases

    ProteinModelPortaliO94266.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    In the N-terminal section; belongs to the ThiD family.Curated
    In the C-terminal section; belongs to the thiaminase-2 family.Curated

    Phylogenomic databases

    eggNOGiCOG0351.
    HOGENOMiHOG000225275.
    KOiK00877.
    OMAiGFWEMFP.
    OrthoDBiEOG75MW5D.
    PhylomeDBiO94266.

    Family and domain databases

    Gene3Di1.20.910.10. 1 hit.
    3.40.1190.20. 1 hit.
    InterProiIPR016084. Haem_Oase-like_multi-hlx.
    IPR004399. HMP/HMP-P_kinase.
    IPR013749. PM/HMP-P_kinase-1.
    IPR029056. Ribokinase-like.
    IPR004305. Thiaminase-2/PQQC.
    [Graphical view]
    PfamiPF08543. Phos_pyr_kin. 1 hit.
    PF03070. TENA_THI-4. 1 hit.
    [Graphical view]
    SUPFAMiSSF48613. SSF48613. 1 hit.
    SSF53613. SSF53613. 1 hit.
    TIGRFAMsiTIGR00097. HMP-P_kinase. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    O94266-1 [UniParc]FASTAAdd to Basket

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    MPYNPLYESL SNQFDPSRIE TVLDPMGYTI KRRALPVSLT IAGSDCSGGA    50
    GIQADLKTMT SLGVYGMSAI TCLVAENAGG VDSVEEMSPA FVESQIDCCI 100
    RDIPCHVVKT GMLGSPEIVK AVARSAKKFN FSKLVVDPVM VATSGDSLVT 150
    KDIVSVLNEE LLPLTYLVTP NIPEAIVLAK NQGLDISNIN SVSDMERCAA 200
    VIHKLGPKHV LLKGGHMPVN NLGLKSSDDE DLRVVDILYD GNRFYHFSSS 250
    YLKKGEVHGT GCTLSSAIAS FLAWEHSLTE AVQFGIDYVH GAITHSPPIN 300
    NCSTNILNHM TRLRIVPFAP GHFIEYILSH PQVVPAWKEY INHKFTNMLA 350
    KGTLPLPAFQ DYLKQDYLYL VNFARAYSLK GYKENTFPNI LEAAQSVIHV 400
    IEEKELHVSM CSSYGVSLQD LKSCEESPAC TAYSRYILDT GAAQDVAALD 450
    FVQAPCLIGY YVIAARLMKE PFRNPQGPYQ KWVDNYFCED YLSAVRRGCR 500
    QIEEIVLKLS PERIQELIEI FIRATKFETL FWETPYYEYV TKQNLEDKEF 550
    S 551
    Length:551
    Mass (Da):61,354
    Last modified:May 1, 1999 - v1
    Checksum:i8FA207F9F1472C00
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329671 Genomic DNA. Translation: CAA21803.1.
    PIRiT40812.
    RefSeqiNP_596525.1. NM_001022446.2.

    Genome annotation databases

    EnsemblFungiiSPBP8B7.18c.1; SPBP8B7.18c.1:pep; SPBP8B7.18c.
    GeneIDi2541373.
    KEGGispo:SPBP8B7.18c.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329671 Genomic DNA. Translation: CAA21803.1 .
    PIRi T40812.
    RefSeqi NP_596525.1. NM_001022446.2.

    3D structure databases

    ProteinModelPortali O94266.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 277884. 13 interactions.
    MINTi MINT-4682707.
    STRINGi 4896.SPBP8B7.18c-1.

    Proteomic databases

    MaxQBi O94266.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPBP8B7.18c.1 ; SPBP8B7.18c.1:pep ; SPBP8B7.18c .
    GeneIDi 2541373.
    KEGGi spo:SPBP8B7.18c.

    Organism-specific databases

    PomBasei SPBP8B7.18c.

    Phylogenomic databases

    eggNOGi COG0351.
    HOGENOMi HOG000225275.
    KOi K00877.
    OMAi GFWEMFP.
    OrthoDBi EOG75MW5D.
    PhylomeDBi O94266.

    Enzyme and pathway databases

    UniPathwayi UPA00060 ; UER00137 .
    UPA00060 ; UER00138 .

    Miscellaneous databases

    NextBioi 20802482.

    Family and domain databases

    Gene3Di 1.20.910.10. 1 hit.
    3.40.1190.20. 1 hit.
    InterProi IPR016084. Haem_Oase-like_multi-hlx.
    IPR004399. HMP/HMP-P_kinase.
    IPR013749. PM/HMP-P_kinase-1.
    IPR029056. Ribokinase-like.
    IPR004305. Thiaminase-2/PQQC.
    [Graphical view ]
    Pfami PF08543. Phos_pyr_kin. 1 hit.
    PF03070. TENA_THI-4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48613. SSF48613. 1 hit.
    SSF53613. SSF53613. 1 hit.
    TIGRFAMsi TIGR00097. HMP-P_kinase. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.
    2. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
      Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
      Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiTHI22_SCHPO
    AccessioniPrimary (citable) accession number: O94266
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 78 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3