Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

O94265 (THI21_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 1

EC=2.7.1.49
EC=2.7.4.7
Alternative name(s):
Hydroxymethylpyrimidine kinase 1
Short name=HMP kinase 1
Hydroxymethylpyrimidine phosphate kinase 1
Short name=HMP-P kinase 1
Short name=HMP-phosphate kinase 1
Short name=HMPP kinase 1
Gene names
ORF Names:SPBP8B7.17c
OrganismSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) [Reference proteome]
Taxonomic identifier284812 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces

Protein attributes

Sequence length506 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P By similarity.

Catalytic activity

ATP + 4-amino-5-hydroxymethyl-2-methylpyrimidine = ADP + 4-amino-5-phosphonooxymethyl-2-methylpyrimidine.

ATP + 4-amino-2-methyl-5-phosphomethylpyrimidine = ADP + 4-amino-2-methyl-5-diphosphomethylpyrimidine.

Pathway

Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-amino-2-methyl-5-diphosphomethylpyrimidine from 5-amino-1-(5-phospho-D-ribosyl)imidazole: step 2/3.

Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-amino-2-methyl-5-diphosphomethylpyrimidine from 5-amino-1-(5-phospho-D-ribosyl)imidazole: step 3/3.

Subcellular location

Cytoplasm. Nucleus Ref.2.

Sequence similarities

In the N-terminal section; belongs to the ThiD family.

In the C-terminal section; belongs to the thiaminase-2 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 506506Putative hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 1
PRO_0000315972

Sites

Binding site431Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
O94265 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: 139A034F41CF4482

FASTA50655,754
        10         20         30         40         50         60 
MISTCITVAG SDCSGGAGVQ ADLKVFTAHS VYGMSAVTAI TSQNTIGVNG VHLIPASYVE 

        70         80         90        100        110        120 
QQISACLLDV HCEVMKTGML FNQQILKVIV ESIDRFKIKK VVVDPLIATR KGALLVMPDY 

       130        140        150        160        170        180 
LELFVKELIP RAEVLIPNIA EALIILKHMT NEFVEIHHLE DVKAVGKKLI KAGCKNVVIR 

       190        200        210        220        230        240 
CDDIPFASDF FCSRETNMPP TWYLYVLCTS EGEVLLPQKW LASKTARGTS CALSSAVASN 

       250        260        270        280        290        300 
LAIGLDLVTA TQNAVSYTQR ALEMSFHLGR GANSLDYASA LTRLPYEKGE FINFVRYHPS 

       310        320        330        340        350        360 
ITPKWLSIVN HPFVEQLKAG TLSRLPFQKY LVLKYHMLIN NAQAAGMMAF SSSSISAIEH 

       370        380        390        400        410        420 
SAKIIQAIKE ENVTHLRICE QYGLSASQIT KSKPEIVKSH SLFIHDTAQQ DGLRGIQIAM 

       430        440        450        460        470        480 
LPFVFMIQEV VSQISASDGY PYVAWVEHCK DKSATSHIET LLESLETNSQ IISLSKVQHL 

       490        500 
LGILEKSLDF ERLVLDTSSS NESSVF 

« Hide

References

[1]"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. expand/collapse author list , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 972 / ATCC 24843.
[2]"ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CU329671 Genomic DNA. Translation: CAA21802.1.
PIRT40811.
RefSeqNP_596524.1. NM_001022445.2.

3D structure databases

ProteinModelPortalO94265.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid276740. 1 interaction.
MINTMINT-4682697.
STRING4896.SPBP8B7.17c-1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiSPBP8B7.17c.1; SPBP8B7.17c.1:pep; SPBP8B7.17c.
GeneID2540207.
KEGGspo:SPBP8B7.17c.

Organism-specific databases

PomBaseSPBP8B7.17c.

Phylogenomic databases

eggNOGCOG0351.
OMADCARNEL.
OrthoDBEOG75MW5D.

Enzyme and pathway databases

UniPathwayUPA00060; UER00137.
UPA00060; UER00138.

Family and domain databases

Gene3D1.20.910.10. 1 hit.
InterProIPR016084. Haem_Oase-like_multi-hlx.
IPR013749. HMP-P_kinase-1.
IPR004399. HMP-P_kinase-2.
IPR004305. Thiaminase-2/PQQC.
[Graphical view]
PfamPF08543. Phos_pyr_kin. 1 hit.
PF03070. TENA_THI-4. 1 hit.
[Graphical view]
SUPFAMSSF48613. SSF48613. 1 hit.
TIGRFAMsTIGR00097. HMP-P_kinase. 1 hit.
ProtoNetSearch...

Other

NextBio20801339.

Entry information

Entry nameTHI21_SCHPO
AccessionPrimary (citable) accession number: O94265
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 1, 1999
Last modified: February 19, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways