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O94265

- THI21_SCHPO

UniProt

O94265 - THI21_SCHPO

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Protein

Putative hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 1

Gene

SPBP8B7.17c

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P.By similarity

Catalytic activityi

ATP + 4-amino-5-hydroxymethyl-2-methylpyrimidine = ADP + 4-amino-5-phosphonooxymethyl-2-methylpyrimidine.
ATP + 4-amino-2-methyl-5-phosphomethylpyrimidine = ADP + 4-amino-2-methyl-5-diphosphomethylpyrimidine.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei43 – 431SubstrateBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. hydroxymethylpyrimidine kinase activity Source: UniProtKB-EC
  3. phosphomethylpyrimidine kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. thiamine biosynthetic process Source: UniProtKB-KW
  2. thiamine diphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Thiamine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00060; UER00137.
UPA00060; UER00138.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 1 (EC:2.7.1.49, EC:2.7.4.7)
Alternative name(s):
Hydroxymethylpyrimidine kinase 1
Short name:
HMP kinase 1
Hydroxymethylpyrimidine phosphate kinase 1
Short name:
HMP-P kinase 1
Short name:
HMP-phosphate kinase 1
Short name:
HMPP kinase 1
Gene namesi
ORF Names:SPBP8B7.17c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome II

Organism-specific databases

PomBaseiSPBP8B7.17c.

Subcellular locationi

Cytoplasm 1 Publication. Nucleus 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: PomBase
  2. cytosol Source: PomBase
  3. nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 506506Putative hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 1PRO_0000315972Add
BLAST

Proteomic databases

MaxQBiO94265.

Interactioni

Protein-protein interaction databases

BioGridi276740. 1 interaction.
MINTiMINT-4682697.
STRINGi4896.SPBP8B7.17c-1.

Structurei

3D structure databases

ProteinModelPortaliO94265.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

In the N-terminal section; belongs to the ThiD family.Curated
In the C-terminal section; belongs to the thiaminase-2 family.Curated

Phylogenomic databases

eggNOGiCOG0351.
InParanoidiO94265.
OMAiDCARNEL.
OrthoDBiEOG75MW5D.
PhylomeDBiO94265.

Family and domain databases

Gene3Di1.20.910.10. 1 hit.
3.40.1190.20. 1 hit.
InterProiIPR016084. Haem_Oase-like_multi-hlx.
IPR004399. HMP/HMP-P_kinase.
IPR013749. PM/HMP-P_kinase-1.
IPR029056. Ribokinase-like.
IPR004305. Thiaminase-2/PQQC.
[Graphical view]
PfamiPF08543. Phos_pyr_kin. 1 hit.
PF03070. TENA_THI-4. 1 hit.
[Graphical view]
SUPFAMiSSF48613. SSF48613. 1 hit.
SSF53613. SSF53613. 1 hit.
TIGRFAMsiTIGR00097. HMP-P_kinase. 1 hit.

Sequencei

Sequence statusi: Complete.

O94265-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MISTCITVAG SDCSGGAGVQ ADLKVFTAHS VYGMSAVTAI TSQNTIGVNG
60 70 80 90 100
VHLIPASYVE QQISACLLDV HCEVMKTGML FNQQILKVIV ESIDRFKIKK
110 120 130 140 150
VVVDPLIATR KGALLVMPDY LELFVKELIP RAEVLIPNIA EALIILKHMT
160 170 180 190 200
NEFVEIHHLE DVKAVGKKLI KAGCKNVVIR CDDIPFASDF FCSRETNMPP
210 220 230 240 250
TWYLYVLCTS EGEVLLPQKW LASKTARGTS CALSSAVASN LAIGLDLVTA
260 270 280 290 300
TQNAVSYTQR ALEMSFHLGR GANSLDYASA LTRLPYEKGE FINFVRYHPS
310 320 330 340 350
ITPKWLSIVN HPFVEQLKAG TLSRLPFQKY LVLKYHMLIN NAQAAGMMAF
360 370 380 390 400
SSSSISAIEH SAKIIQAIKE ENVTHLRICE QYGLSASQIT KSKPEIVKSH
410 420 430 440 450
SLFIHDTAQQ DGLRGIQIAM LPFVFMIQEV VSQISASDGY PYVAWVEHCK
460 470 480 490 500
DKSATSHIET LLESLETNSQ IISLSKVQHL LGILEKSLDF ERLVLDTSSS

NESSVF
Length:506
Mass (Da):55,754
Last modified:May 1, 1999 - v1
Checksum:i139A034F41CF4482
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329671 Genomic DNA. Translation: CAA21802.1.
PIRiT40811.
RefSeqiNP_596524.1. NM_001022445.2.

Genome annotation databases

EnsemblFungiiSPBP8B7.17c.1; SPBP8B7.17c.1:pep; SPBP8B7.17c.
GeneIDi2540207.
KEGGispo:SPBP8B7.17c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329671 Genomic DNA. Translation: CAA21802.1 .
PIRi T40811.
RefSeqi NP_596524.1. NM_001022445.2.

3D structure databases

ProteinModelPortali O94265.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 276740. 1 interaction.
MINTi MINT-4682697.
STRINGi 4896.SPBP8B7.17c-1.

Proteomic databases

MaxQBi O94265.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPBP8B7.17c.1 ; SPBP8B7.17c.1:pep ; SPBP8B7.17c .
GeneIDi 2540207.
KEGGi spo:SPBP8B7.17c.

Organism-specific databases

PomBasei SPBP8B7.17c.

Phylogenomic databases

eggNOGi COG0351.
InParanoidi O94265.
OMAi DCARNEL.
OrthoDBi EOG75MW5D.
PhylomeDBi O94265.

Enzyme and pathway databases

UniPathwayi UPA00060 ; UER00137 .
UPA00060 ; UER00138 .

Miscellaneous databases

NextBioi 20801339.

Family and domain databases

Gene3Di 1.20.910.10. 1 hit.
3.40.1190.20. 1 hit.
InterProi IPR016084. Haem_Oase-like_multi-hlx.
IPR004399. HMP/HMP-P_kinase.
IPR013749. PM/HMP-P_kinase-1.
IPR029056. Ribokinase-like.
IPR004305. Thiaminase-2/PQQC.
[Graphical view ]
Pfami PF08543. Phos_pyr_kin. 1 hit.
PF03070. TENA_THI-4. 1 hit.
[Graphical view ]
SUPFAMi SSF48613. SSF48613. 1 hit.
SSF53613. SSF53613. 1 hit.
TIGRFAMsi TIGR00097. HMP-P_kinase. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
    Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
    Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiTHI21_SCHPO
AccessioniPrimary (citable) accession number: O94265
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 1, 1999
Last modified: October 29, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3