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Protein

Exportin-T

Gene

los1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex. Involved in pre-tRNA splicing, probably by affecting the interaction of pre-tRNA with splicing endonuclease (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport, tRNA processing

Keywords - Ligandi

RNA-binding, tRNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Exportin-T
Alternative name(s):
Exportin(tRNA)
Karyopherin-beta
tRNA exportin
Gene namesi
Name:los1
ORF Names:SPBP8B7.09c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBP8B7.09c.
PomBaseiSPBP8B7.09c. los1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: GO_Central
  • cytosol Source: PomBase
  • nuclear envelope Source: PomBase
  • nuclear matrix Source: PomBase
  • nuclear pore Source: GO_Central
  • nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003431051 – 978Exportin-TAdd BLAST978

Proteomic databases

MaxQBiO94258.
PRIDEiO94258.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi277823. 26 interactors.
DIPiDIP-59297N.
MINTiMINT-4682634.

Structurei

Secondary structure

1978
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi2 – 14Combined sources13
Helixi20 – 35Combined sources16
Beta strandi36 – 38Combined sources3
Helixi39 – 46Combined sources8
Turni50 – 52Combined sources3
Helixi55 – 71Combined sources17
Turni74 – 76Combined sources3
Helixi78 – 94Combined sources17
Helixi103 – 119Combined sources17
Turni120 – 123Combined sources4
Helixi127 – 138Combined sources12
Helixi141 – 158Combined sources18
Beta strandi161 – 163Combined sources3
Helixi167 – 183Combined sources17
Helixi185 – 201Combined sources17
Helixi205 – 218Combined sources14
Turni219 – 221Combined sources3
Helixi224 – 228Combined sources5
Helixi230 – 239Combined sources10
Helixi243 – 258Combined sources16
Helixi263 – 279Combined sources17
Helixi289 – 310Combined sources22
Helixi318 – 330Combined sources13
Helixi332 – 339Combined sources8
Helixi344 – 348Combined sources5
Helixi351 – 364Combined sources14
Turni365 – 367Combined sources3
Helixi372 – 387Combined sources16
Beta strandi393 – 395Combined sources3
Beta strandi401 – 404Combined sources4
Helixi406 – 426Combined sources21
Helixi428 – 446Combined sources19
Helixi451 – 467Combined sources17
Turni468 – 471Combined sources4
Helixi475 – 477Combined sources3
Beta strandi481 – 483Combined sources3
Helixi488 – 498Combined sources11
Turni501 – 503Combined sources3
Helixi507 – 519Combined sources13
Helixi521 – 525Combined sources5
Helixi528 – 530Combined sources3
Helixi531 – 538Combined sources8
Turni541 – 545Combined sources5
Turni549 – 551Combined sources3
Helixi552 – 565Combined sources14
Turni566 – 569Combined sources4
Beta strandi571 – 573Combined sources3
Helixi574 – 580Combined sources7
Helixi581 – 585Combined sources5
Helixi602 – 607Combined sources6
Turni608 – 610Combined sources3
Helixi611 – 627Combined sources17
Helixi632 – 654Combined sources23
Helixi663 – 679Combined sources17
Helixi691 – 708Combined sources18
Helixi713 – 726Combined sources14
Turni727 – 730Combined sources4
Helixi731 – 734Combined sources4
Turni735 – 737Combined sources3
Helixi738 – 748Combined sources11
Turni751 – 753Combined sources3
Helixi754 – 767Combined sources14
Turni768 – 771Combined sources4
Helixi773 – 790Combined sources18
Helixi800 – 820Combined sources21
Helixi825 – 828Combined sources4
Helixi830 – 833Combined sources4
Helixi836 – 846Combined sources11
Helixi854 – 868Combined sources15
Turni873 – 875Combined sources3
Helixi879 – 892Combined sources14
Helixi893 – 895Combined sources3
Helixi908 – 934Combined sources27
Turni935 – 938Combined sources4
Helixi946 – 952Combined sources7
Helixi971 – 974Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3IBVX-ray3.10A/B1-978[»]
3ICQX-ray3.20T/U1-978[»]
ProteinModelPortaliO94258.
SMRiO94258.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO94258.

Family & Domainsi

Sequence similaritiesi

Belongs to the exportin family.Curated

Phylogenomic databases

InParanoidiO94258.
KOiK14288.
OMAiMRYDETS.
OrthoDBiEOG092C0BAM.
PhylomeDBiO94258.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
IPR013598. Exportin-1/Importin-b-like.
[Graphical view]
PfamiPF08389. Xpo1. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.

Sequencei

Sequence statusi: Complete.

O94258-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAQDVENAV EAALDPSVGP IIKQQATDFI GSLRSSSTGW KICHEIFSEK
60 70 80 90 100
TKYKPSTRLI CLQTLSEKVR EWNNESNLLE LQMIRDSVWS YIKELSFLDE
110 120 130 140 150
PAYISNAVQH LLTLLFLQLY PSNWNDFFAS LQGVIAASSQ SEFSNFYLKV
160 170 180 190 200
LLSIGDEIAD SLVLKTDVQI QKDNLVKDAI RANDMSDIVS FVYEMMLAYS
210 220 230 240 250
NAKNYGTVGL CLQVYAQWVS WININLIVNE PCMNLLYSFL QIEELRCAAC
260 270 280 290 300
ETMTEIVNKK MKPLEKLNLL NILNLNLFFS KSQEQSTDPN FDEHVAKLIN
310 320 330 340 350
AQGVELVAIK SDPSELSPEL KENCSFQLYN LFPYLIRYLS DDYDETSTAV
360 370 380 390 400
FPFLSDLLVS LRKESSSKEL SASLKEFLKS LLEAIIKKMK YDESQEWDDD
410 420 430 440 450
PDSEEEAEFQ EMRKKLKIFQ DTINSIDSSL FSSYMYSAIT SSLSTAATLS
460 470 480 490 500
PENSWQLIEF ALYETYIFGE GLRGPDAFFN EVDKSPTVLS QILALVTTSQ
510 520 530 540 550
VCRHPHPLVQ LLYMEILVRY ASFFDYESAA IPALIEYFVG PRGIHNTNER
560 570 580 590 600
VRPRAWYLFY RFVKSIKKQV VNYTESSLAM LGDLLNISVS PVTDMDAPVP
610 620 630 640 650
TLNSSIRNSD FNSQLYLFET VGVLISSGNL TPEEQALYCD SLINALIGKA
660 670 680 690 700
NAALSSDLSA LENIISVYCS LMAIGNFAKG FPARGSEEVA WLASFNKASD
710 720 730 740 750
EIFLILDRMG FNEDIRGAVR FTSGRIINVV GPDMLPKVPQ LISILLNSID
760 770 780 790 800
MNELVDVLSF ISQLIHIYKD NMMEITNRML PTLLMRIFSS LSAAPQGTDD
810 820 830 840 850
AVKQNDLRKS YISFILQLLN KGFGSILFTE ENQVYFDPLI NSILHFANLV
860 870 880 890 900
GEPATQKSSI ALVSKMVSLW GGKDGIAGFE NFTLSLTPLC FEMPVNPNFN
910 920 930 940 950
TRDGQSLVVL GELAGLQKII LEKLGDIYKS YLVTVYFPTV NFPDVMASEY
960 970
LQALSNLDSR SFKQFFQKFI QALKSGNV
Length:978
Mass (Da):110,114
Last modified:May 1, 1999 - v1
Checksum:i2875E1DBAE818829
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA21794.1.
PIRiT40803.
RefSeqiNP_596516.1. NM_001022437.2.

Genome annotation databases

EnsemblFungiiSPBP8B7.09c.1; SPBP8B7.09c.1:pep; SPBP8B7.09c.
GeneIDi2541311.
KEGGispo:SPBP8B7.09c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA21794.1.
PIRiT40803.
RefSeqiNP_596516.1. NM_001022437.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3IBVX-ray3.10A/B1-978[»]
3ICQX-ray3.20T/U1-978[»]
ProteinModelPortaliO94258.
SMRiO94258.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi277823. 26 interactors.
DIPiDIP-59297N.
MINTiMINT-4682634.

Proteomic databases

MaxQBiO94258.
PRIDEiO94258.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBP8B7.09c.1; SPBP8B7.09c.1:pep; SPBP8B7.09c.
GeneIDi2541311.
KEGGispo:SPBP8B7.09c.

Organism-specific databases

EuPathDBiFungiDB:SPBP8B7.09c.
PomBaseiSPBP8B7.09c. los1.

Phylogenomic databases

InParanoidiO94258.
KOiK14288.
OMAiMRYDETS.
OrthoDBiEOG092C0BAM.
PhylomeDBiO94258.

Miscellaneous databases

EvolutionaryTraceiO94258.
PROiO94258.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
IPR013598. Exportin-1/Importin-b-like.
[Graphical view]
PfamiPF08389. Xpo1. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiXPOT_SCHPO
AccessioniPrimary (citable) accession number: O94258
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: May 1, 1999
Last modified: November 30, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.