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Protein

Exportin-T

Gene

los1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex. Involved in pre-tRNA splicing, probably by affecting the interaction of pre-tRNA with splicing endonuclease (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport, tRNA processing

Keywords - Ligandi

RNA-binding, tRNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Exportin-T
Alternative name(s):
Exportin(tRNA)
Karyopherin-beta
tRNA exportin
Gene namesi
Name:los1
ORF Names:SPBP8B7.09c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBP8B7.09c.
PomBaseiSPBP8B7.09c. los1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: GO_Central
  • cytosol Source: PomBase
  • nuclear envelope Source: PomBase
  • nuclear matrix Source: PomBase
  • nuclear pore Source: GO_Central
  • nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 978978Exportin-TPRO_0000343105Add
BLAST

Proteomic databases

MaxQBiO94258.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi277823. 26 interactions.
DIPiDIP-59297N.
MINTiMINT-4682634.

Structurei

Secondary structure

1
978
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi2 – 1413Combined sources
Helixi20 – 3516Combined sources
Beta strandi36 – 383Combined sources
Helixi39 – 468Combined sources
Turni50 – 523Combined sources
Helixi55 – 7117Combined sources
Turni74 – 763Combined sources
Helixi78 – 9417Combined sources
Helixi103 – 11917Combined sources
Turni120 – 1234Combined sources
Helixi127 – 13812Combined sources
Helixi141 – 15818Combined sources
Beta strandi161 – 1633Combined sources
Helixi167 – 18317Combined sources
Helixi185 – 20117Combined sources
Helixi205 – 21814Combined sources
Turni219 – 2213Combined sources
Helixi224 – 2285Combined sources
Helixi230 – 23910Combined sources
Helixi243 – 25816Combined sources
Helixi263 – 27917Combined sources
Helixi289 – 31022Combined sources
Helixi318 – 33013Combined sources
Helixi332 – 3398Combined sources
Helixi344 – 3485Combined sources
Helixi351 – 36414Combined sources
Turni365 – 3673Combined sources
Helixi372 – 38716Combined sources
Beta strandi393 – 3953Combined sources
Beta strandi401 – 4044Combined sources
Helixi406 – 42621Combined sources
Helixi428 – 44619Combined sources
Helixi451 – 46717Combined sources
Turni468 – 4714Combined sources
Helixi475 – 4773Combined sources
Beta strandi481 – 4833Combined sources
Helixi488 – 49811Combined sources
Turni501 – 5033Combined sources
Helixi507 – 51913Combined sources
Helixi521 – 5255Combined sources
Helixi528 – 5303Combined sources
Helixi531 – 5388Combined sources
Turni541 – 5455Combined sources
Turni549 – 5513Combined sources
Helixi552 – 56514Combined sources
Turni566 – 5694Combined sources
Beta strandi571 – 5733Combined sources
Helixi574 – 5807Combined sources
Helixi581 – 5855Combined sources
Helixi602 – 6076Combined sources
Turni608 – 6103Combined sources
Helixi611 – 62717Combined sources
Helixi632 – 65423Combined sources
Helixi663 – 67917Combined sources
Helixi691 – 70818Combined sources
Helixi713 – 72614Combined sources
Turni727 – 7304Combined sources
Helixi731 – 7344Combined sources
Turni735 – 7373Combined sources
Helixi738 – 74811Combined sources
Turni751 – 7533Combined sources
Helixi754 – 76714Combined sources
Turni768 – 7714Combined sources
Helixi773 – 79018Combined sources
Helixi800 – 82021Combined sources
Helixi825 – 8284Combined sources
Helixi830 – 8334Combined sources
Helixi836 – 84611Combined sources
Helixi854 – 86815Combined sources
Turni873 – 8753Combined sources
Helixi879 – 89214Combined sources
Helixi893 – 8953Combined sources
Helixi908 – 93427Combined sources
Turni935 – 9384Combined sources
Helixi946 – 9527Combined sources
Helixi971 – 9744Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3IBVX-ray3.10A/B1-978[»]
3ICQX-ray3.20T/U1-978[»]
ProteinModelPortaliO94258.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO94258.

Family & Domainsi

Sequence similaritiesi

Belongs to the exportin family.Curated

Phylogenomic databases

InParanoidiO94258.
KOiK14288.
OMAiMRYDETS.
OrthoDBiEOG7PZS5Q.
PhylomeDBiO94258.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
IPR013598. Exportin-1/Importin-b-like.
[Graphical view]
PfamiPF08389. Xpo1. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.

Sequencei

Sequence statusi: Complete.

O94258-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAQDVENAV EAALDPSVGP IIKQQATDFI GSLRSSSTGW KICHEIFSEK
60 70 80 90 100
TKYKPSTRLI CLQTLSEKVR EWNNESNLLE LQMIRDSVWS YIKELSFLDE
110 120 130 140 150
PAYISNAVQH LLTLLFLQLY PSNWNDFFAS LQGVIAASSQ SEFSNFYLKV
160 170 180 190 200
LLSIGDEIAD SLVLKTDVQI QKDNLVKDAI RANDMSDIVS FVYEMMLAYS
210 220 230 240 250
NAKNYGTVGL CLQVYAQWVS WININLIVNE PCMNLLYSFL QIEELRCAAC
260 270 280 290 300
ETMTEIVNKK MKPLEKLNLL NILNLNLFFS KSQEQSTDPN FDEHVAKLIN
310 320 330 340 350
AQGVELVAIK SDPSELSPEL KENCSFQLYN LFPYLIRYLS DDYDETSTAV
360 370 380 390 400
FPFLSDLLVS LRKESSSKEL SASLKEFLKS LLEAIIKKMK YDESQEWDDD
410 420 430 440 450
PDSEEEAEFQ EMRKKLKIFQ DTINSIDSSL FSSYMYSAIT SSLSTAATLS
460 470 480 490 500
PENSWQLIEF ALYETYIFGE GLRGPDAFFN EVDKSPTVLS QILALVTTSQ
510 520 530 540 550
VCRHPHPLVQ LLYMEILVRY ASFFDYESAA IPALIEYFVG PRGIHNTNER
560 570 580 590 600
VRPRAWYLFY RFVKSIKKQV VNYTESSLAM LGDLLNISVS PVTDMDAPVP
610 620 630 640 650
TLNSSIRNSD FNSQLYLFET VGVLISSGNL TPEEQALYCD SLINALIGKA
660 670 680 690 700
NAALSSDLSA LENIISVYCS LMAIGNFAKG FPARGSEEVA WLASFNKASD
710 720 730 740 750
EIFLILDRMG FNEDIRGAVR FTSGRIINVV GPDMLPKVPQ LISILLNSID
760 770 780 790 800
MNELVDVLSF ISQLIHIYKD NMMEITNRML PTLLMRIFSS LSAAPQGTDD
810 820 830 840 850
AVKQNDLRKS YISFILQLLN KGFGSILFTE ENQVYFDPLI NSILHFANLV
860 870 880 890 900
GEPATQKSSI ALVSKMVSLW GGKDGIAGFE NFTLSLTPLC FEMPVNPNFN
910 920 930 940 950
TRDGQSLVVL GELAGLQKII LEKLGDIYKS YLVTVYFPTV NFPDVMASEY
960 970
LQALSNLDSR SFKQFFQKFI QALKSGNV
Length:978
Mass (Da):110,114
Last modified:May 1, 1999 - v1
Checksum:i2875E1DBAE818829
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA21794.1.
PIRiT40803.
RefSeqiNP_596516.1. NM_001022437.2.

Genome annotation databases

EnsemblFungiiSPBP8B7.09c.1; SPBP8B7.09c.1:pep; SPBP8B7.09c.
GeneIDi2541311.
KEGGispo:SPBP8B7.09c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA21794.1.
PIRiT40803.
RefSeqiNP_596516.1. NM_001022437.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3IBVX-ray3.10A/B1-978[»]
3ICQX-ray3.20T/U1-978[»]
ProteinModelPortaliO94258.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi277823. 26 interactions.
DIPiDIP-59297N.
MINTiMINT-4682634.

Proteomic databases

MaxQBiO94258.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBP8B7.09c.1; SPBP8B7.09c.1:pep; SPBP8B7.09c.
GeneIDi2541311.
KEGGispo:SPBP8B7.09c.

Organism-specific databases

EuPathDBiFungiDB:SPBP8B7.09c.
PomBaseiSPBP8B7.09c. los1.

Phylogenomic databases

InParanoidiO94258.
KOiK14288.
OMAiMRYDETS.
OrthoDBiEOG7PZS5Q.
PhylomeDBiO94258.

Miscellaneous databases

EvolutionaryTraceiO94258.
PROiO94258.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
IPR013598. Exportin-1/Importin-b-like.
[Graphical view]
PfamiPF08389. Xpo1. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
    Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
    Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiXPOT_SCHPO
AccessioniPrimary (citable) accession number: O94258
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: May 1, 1999
Last modified: July 6, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.