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Reviewed, UniProtKB/Swiss-Prot O94255 (CAN_SCHPO)

Last modified November 3, 2009. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Carbonic anhydrase
    EC=4.2.1.1
Alternative name(s):
    Carbonate dehydratase
Gene names
ORF Names: SPBP8B7.05c
OrganismSchizosaccharomyces pombe (Fission yeast) [Complete proteome]
Taxonomic identifier4896 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces

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Protein attributes

Sequence length244 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

Catalyzes the reversible hydration of CO2 to H2CO3. The main role may be to provide inorganic carbon for the bicarbonate-dependent carboxylation reactions catalyzed by pyruvate carboxylase, acetyl-CoA carboxylase and carbamoyl-phosphate synthetase By similarity.

Catalytic activity

H2CO3 = CO2 + H2O.

Cofactor

Binds 1 zinc ion per subunit By similarity.

Subcellular location

Cytoplasm By similarity. Nucleus.

Sequence similarities

Belongs to the beta-class carbonic anhydrase family.

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Ontologies

Keywords
   Cellular componentCytoplasm
Nucleus
   LigandMetal-binding
Zinc
   Molecular functionLyase
   PTMPhosphoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processcarbon utilization

Inferred from electronic annotation. Source: InterPro

cellular response to stress

Inferred from expression pattern. Source: GeneDB_SPombe

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

nucleus Ref.2

Inferred from direct assay. Source: GeneDB_SPombe

   Molecular functioncarbonate dehydratase activity

Inferred from electronic annotation. Source: EC

zinc ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 244244Carbonic anhydrase
PRO_0000311757

Sites

Metal binding791Zinc By similarity
Metal binding811Zinc By similarity
Metal binding1351Zinc By similarity
Metal binding1381Zinc By similarity

Amino acid modifications

Modified residue271Phosphoserine Ref.3

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Sequences

Sequence LengthMass (Da)Tools
O94255-1 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: A04CFD05C5146D35

FASTA24427,535
        10         20         30         40         50         60 
MPDRLKRRIE EIDHQDEIID REASTASPVS GAGKIDQNGE IKDLLERNLT WSQQTSRKYP 

        70         80         90        100        110        120 
SFFTATKDIQ TPQVLWIGCS DSRVPETTIL NLLPGEVFVH RNIANVVPRS DINALAVMEY 

       130        140        150        160        170        180 
SVTVLKVKHI IVCGHYGCGG VAAALGPNLN NLLDHWLRHI RDVIEDNREE LDAIEDPQLR 

       190        200        210        220        230        240 
RLKLAELNTR AQAISVTRVG FVREAMEKRG LQVHGWIYDL SNGQIKKLDI TDAIKKAKYG 


TYDS

« Hide

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References

[1]"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. expand/collapse author list , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
Nature 415:871-880(2002) [PubMed: 11859360] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 38366 / 972.
[2]"ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
Nat. Biotechnol. 24:841-847(2006) [PubMed: 16823372] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[3]"Phosphoproteome analysis of fission yeast."
Wilson-Grady J.T., Villen J., Gygi S.P.
J. Proteome Res. 7:1088-1097(2008) [PubMed: 18257517] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-27, MASS SPECTROMETRY.

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Cross-references

Sequence databases

CU329671 Genomic DNA. Translation: CAA21790.1.
PIRT40799.
RefSeqNP_596512.1.

3D structure databases

HSSPHSSP built from PDB template 1I6O based on UniProtKB P61517.
ModBaseSearch...

Protein-protein interaction databases

STRINGO94255.

Genome annotation databases

GeneID2541362.
KEGGspo:SPBP8B7.05c.
NMPDRfig|4896.1.peg.2378.

Organism-specific databases

GeneDB_SpombeSPBP8B7.05c.

Phylogenomic databases

OMAVQEAWAR.

Enzyme and pathway databases

BRENDA4.2.1.1. 653.

Gene expression databases

ArrayExpressO94255.

Family and domain databases

InterProIPR001765. Carbonic_anhydrase.
[Graphical view]
Gene3DG3DSA:3.40.1050.10. CO_anhd_prok_pln. 1 hit.
PANTHERPTHR11002. Carbonic_anhydrase. 1 hit.
PfamPF00484. Pro_CA. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameCAN_SCHPO
AccessionPrimary (citable) accession number: O94255
Entry history
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: May 1, 1999
Last modified: November 3, 2009
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectFPAP (Fungal Proteome Annotation Project)

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Relevant documents

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents