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Protein

DNA polymerase alpha-associated DNA helicase A

Gene

hcs1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

DNA polymerase alpha-associated DNA helicase which may be involved in DNA replication.By similarity

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi232 – 239ATPBy similarity8

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Helicase, Hydrolase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymerase alpha-associated DNA helicase A (EC:3.6.4.12)
Gene namesi
Name:hcs1
ORF Names:SPCC737.07c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:SPCC737.07c.
PomBaseiSPCC737.07c.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: PomBase
  • DNA helicase A complex Source: PomBase
  • nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003538161 – 660DNA polymerase alpha-associated DNA helicase AAdd BLAST660

Proteomic databases

MaxQBiO94247.
PRIDEiO94247.

Interactioni

Subunit structurei

Associates with the hexameric DNA polymerase alpha.By similarity

Protein-protein interaction databases

BioGridi275977. 9 interactors.
MINTiMINT-4682562.

Structurei

3D structure databases

ProteinModelPortaliO94247.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DNA2/NAM7 helicase family.Curated

Phylogenomic databases

HOGENOMiHOG000185831.
InParanoidiO94247.
KOiK19783.
OMAiMYGPGIK.
OrthoDBiEOG092C0D29.
PhylomeDBiO94247.

Family and domain databases

Gene3Di3.40.50.300. 4 hits.
InterProiIPR003593. AAA+_ATPase.
IPR027417. P-loop_NTPase.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

O94247-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSSNEQICL DEDWIQKFGD REIEFVDEAQ KSEVDETEKS IKRFPLSVLQ
60 70 80 90 100
RKGLALINLR IGVVKTGFGG KTIIDFEKDP AFSNGEELPA NSFSPGDVVS
110 120 130 140 150
IRQDFQSSKK KRPNETDISV EGVVTRVHER HISVALKSEE DIPSSVTRLS
160 170 180 190 200
VVKLVNRVTY ERMRHTMLEF KRSIPEYRNS LFYTLIGRKK ADVSIDQKLI
210 220 230 240 250
GDIKYFNKEL NASQKKAVKF SIAVKELSLI HGPPGTGKTH TLVEIIQQLV
260 270 280 290 300
LRNKRILVCG ASNLAVDNIV DRLSSSGIPM VRLGHPARLL PSILDHSLDV
310 320 330 340 350
LSRTGDNGDV IRGISEDIDV CLSKITKTKN GRERREIYKN IRELRKDYRK
360 370 380 390 400
YEAKTVANIV SASKVVFCTL HGAGSRQLKG QRFDAVIIDE ASQALEPQCW
410 420 430 440 450
IPLLGMNKVI LAGDHMQLSP NVQSKRPYIS MFERLVKSQG DLVKCFLNIQ
460 470 480 490 500
YRMHELISKF PSDTFYDSKL VPAEEVKKRL LMDLENVEET ELTDSPIYFY
510 520 530 540 550
DTLGNYQEDD RSEDMQNFYQ DSKSNHWEAQ IVSYHISGLL EAGLEAKDIA
560 570 580 590 600
VVTPYNAQVA LIRQLLKEKG IEVEMGSVDK VQGREKEAII FSLVRSNDVR
610 620 630 640 650
EVGFLAEKRR LNVAITRPKR HLCVIGDSNT VKWASEFFHQ WVDFLEENAI
660
VMDIDATMFE
Length:660
Mass (Da):75,003
Last modified:May 1, 1999 - v1
Checksum:i676128986E5B61CC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA. Translation: CAA20863.1.
PIRiT41580.
RefSeqiNP_588369.1. NM_001023360.2.

Genome annotation databases

EnsemblFungiiSPCC737.07c.1; SPCC737.07c.1:pep; SPCC737.07c.
GeneIDi2539412.
KEGGispo:SPCC737.07c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA. Translation: CAA20863.1.
PIRiT41580.
RefSeqiNP_588369.1. NM_001023360.2.

3D structure databases

ProteinModelPortaliO94247.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi275977. 9 interactors.
MINTiMINT-4682562.

Proteomic databases

MaxQBiO94247.
PRIDEiO94247.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPCC737.07c.1; SPCC737.07c.1:pep; SPCC737.07c.
GeneIDi2539412.
KEGGispo:SPCC737.07c.

Organism-specific databases

EuPathDBiFungiDB:SPCC737.07c.
PomBaseiSPCC737.07c.

Phylogenomic databases

HOGENOMiHOG000185831.
InParanoidiO94247.
KOiK19783.
OMAiMYGPGIK.
OrthoDBiEOG092C0D29.
PhylomeDBiO94247.

Miscellaneous databases

PROiO94247.

Family and domain databases

Gene3Di3.40.50.300. 4 hits.
InterProiIPR003593. AAA+_ATPase.
IPR027417. P-loop_NTPase.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiHCS1_SCHPO
AccessioniPrimary (citable) accession number: O94247
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 4, 2008
Last sequence update: May 1, 1999
Last modified: November 30, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.