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O94242 (SYDM_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Aspartate--tRNA ligase, mitochondrial
EC=6.1.1.12
Alternative name(s):
Aspartyl-tRNA synthetase
Short name=AspRS
Gene names
Name:msd1
ORF Names:SPCC736.06
OrganismSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifier284812 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces

Protein attributes

Sequence length611 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp).

Subcellular location

Mitochondrion Ref.2.

Sequence similarities

Belongs to the class-II aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentMitochondrion
   DomainTransit peptide
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processaspartyl-tRNA aminoacylation

Inferred from sequence or structural similarity. Source: GeneDB_Spombe

   Cellular componentmitochondrion

Inferred from direct assay. Source: GeneDB_Spombe

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

aspartate-tRNA ligase activity

Inferred from sequence or structural similarity. Source: GeneDB_Spombe

tRNA binding

Inferred by curator. Source: GeneDB_Spombe

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 3030Mitochondrion Probable
Chain31 – 611581Aspartate--tRNA ligase, mitochondrial
PRO_0000315952

Sequences

Sequence LengthMass (Da)Tools
O94242 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: A61059C7DB374E4C

FASTA61169,407
        10         20         30         40         50         60 
MVLSRLPACL LPLVGTKVSI QGWLVATSRQ VSKSISFHQL RDTHGTILQL LSTDKIILQQ 

        70         80         90        100        110        120 
KREPLVSSTD FSQQKSTSVM RTLSSIPPES VVQVTGKLQR RPEHDRRPGN EFELHVEDVK 

       130        140        150        160        170        180 
LLNVAKNLQL FPGDEKPGMR IQLANRHIQL RAPKYNSYLR QRSRLAYQVH SFFNDREFCE 

       190        200        210        220        230        240 
VETPLLFKST PEGAREFVVP SRLNPGKFYA LPQSPQQYKQ ILMASGIGNY YQIARCFRDE 

       250        260        270        280        290        300 
DLRFDRQPEF TQIDLEMSFV DKPHEIMEVV EDLLVRLVSF AKGITLAKPF QHITYQHAID 

       310        320        330        340        350        360 
KYGSDKPDIR FELPLKNITS LLPKQDPLIS TEILVYNDLS HSLSNAESRK LCEAVGENVV 

       370        380        390        400        410        420 
VTSIREHSQL QTWVKKLPQL RQLPIVAEEL NQKLQIGINS IVFMTNRPKY LVSGTTPLGK 

       430        440        450        460        470        480 
LRLLLHELLV KKKALPELDK DLLKFVWVVD FPLFSPTEEK NQSITSTHHP FTAPHWDDVH 

       490        500        510        520        530        540 
LLEKKPLSVR GLHYDIVVNG IELGGGSIRI HNPDIQRFVL KDVLKLPENR YATFEHLIRV 

       550        560        570        580        590        600 
LSSGCPPHGG IALGFDRLAA LLTNAPGIRE VIAFPKTSSG ADLLIGSPSA IPEEMLKDYN 

       610 
VAITRQTQNR N

« Hide

References

[1]"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. expand/collapse author list , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
Nature 415:871-880(2002) [PubMed: 11859360] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 972 / ATCC 24843.
[2]"ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
Nat. Biotechnol. 24:841-847(2006) [PubMed: 16823372] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CU329672 Genomic DNA. Translation: CAA19270.1.
PIRT41563.
RefSeqNP_587777.1. NM_001022770.1.

3D structure databases

HSSPHSSP built from PDB template 1BBW based on UniProtKB P0A8N3.
ProteinModelPortalO94242.
ModBaseSearch...

Protein-protein interaction databases

STRINGO94242.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiSPCC736.06.1; SPCC736.06.1:pep; SPCC736.06.
GeneID2538918.
GenomeReviewsGene locus msd1 in contig CU329672_GR.
KEGGspo:SPCC736.06.
NMPDRfig|4896.1.peg.115.

Organism-specific databases

GeneDB_SpombeSPCC736.06.

Phylogenomic databases

eggNOGfuNOG04336.
GeneTreeEFGT00050000003412.
HOGENOMHBG396032.
OMASFATGED.
OrthoDBEOG4J40R5.

Gene expression databases

ArrayExpressO94242.

Family and domain databases

InterProIPR004364. aa-tRNA-synt_II.
IPR018150. aa-tRNA-synt_II-like.
IPR006195. aa-tRNA-synth_II.
IPR004524. Asp-tRNA-synth_IIb_bac/mt.
IPR002312. Asp/Asn-tRNA-synth_IIb.
IPR004115. GAD_dom.
IPR012340. NA-bd_OB-fold.
IPR016027. NA-bd_OB-fold-like.
IPR004365. NA-bd_OB_tRNA-helicase.
[Graphical view]
Gene3DG3DSA:3.30.1360.30. GAD_dom. 1 hit.
G3DSA:2.40.50.140. OB_NA_bd_sub. 1 hit.
KOK01876.
PANTHERPTHR22594. aa-tRNA-synt_II. 1 hit.
PTHR22594:SF5. AspS_bac. 1 hit.
PfamPF00152. tRNA-synt_2. 1 hit.
PF01336. tRNA_anti. 1 hit.
[Graphical view]
PRINTSPR01042. TRNASYNTHASP.
SUPFAMSSF50249. Nucleic_acid_OB. 1 hit.
TIGRFAMsTIGR00459. AspS_bact. 1 hit.
PROSITEPS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYDM_SCHPO
AccessionPrimary (citable) accession number: O94242
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 1, 1999
Last modified: January 25, 2012
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents