O94213 (TPS1_PICAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Alpha,alpha-trehalose-phosphate synthase [UDP-forming]
EC=2.4.1.15

Alternative name(s):
Trehalose-6-phosphate synthase
UDP-glucose-glucosephosphate glucosyltransferase

Gene names

Name:

TPS1

Organism

Pichia angusta (Yeast) (Hansenula polymorpha)

Taxonomic identifier

870730 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetales incertae sedis › Ogataea

Protein attributes

Sequence length	475 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	UDP-glucose + D-glucose 6-phosphate = UDP + alpha,alpha-trehalose 6-phosphate.
Sequence similarities	Belongs to the glycosyltransferase 20 family.

Ontologies

Keywords
Molecular function	Glycosyltransferase Transferase
Gene Ontology (GO)
Biological_process	trehalose biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular_function	alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 475	475	Alpha,alpha-trehalose-phosphate synthase [UDP-forming]		PRO_0000122499

Sequences

	Sequence		Length	Mass (Da)
	O94213 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: 14F1A07AE88E12AB	FASTA	475	54,407
	10 20 30 40 50 60 MVKGNVIVVS NRIPVTIKKT EDDENGKSRY DYTMSSGGLV TALQGLKNPF RWFGWPGMSV 70 80 90 100 110 120 DSEQGRQTVE RDLKEKFNCY PIWLSDEIAD LHYNGFSNSI LWPLFHYHPG EMNFDEIAWA 130 140 150 160 170 180 AYLEANKLFC QTILKEIKDG DVIWVHDYHL MLLPSLLRDQ LNSKGLPNVK IGFFLHTPFP 190 200 210 220 230 240 SSEIYRILPV RKEILEGVLS CDLIGFHTYD YVRHFLSSVE RILKLRTSPQ GVVYNDRQVT 250 260 270 280 290 300 VSAYPIGIDV DKFLNGLKTD EVKSRIKQLE TRFGKDCKLI IGVDRLDYIK GVPQKLHAFE 310 320 330 340 350 360 IFLERHPEWI GKVVLIQVAV PSRGDVEEYQ SLRAAVNELV GRINGRFGTV EFVPIHFLHK 370 380 390 400 410 420 SVNFQELISV YAASDVCVVS STRDGMNLVS YEYIACQQDR KGSLVLSEFA GAAQSLNGAL 430 440 450 460 470 VVNPWNTEEL SEAIYEGLIM SEEKRRGNFQ KMFKYIEKYT ASYWGENFVK ELTRV

References

[1]

"The thermophilic yeast hansenula polymorpha does not require trehalose synthesis for growth at high temperatures but does for normal acquisition of thermotolerance." Reinders A., Romano I., Wiemken A., De Virgilio C. J. Bacteriol. 181:4665-4668(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 34438 / CBS 4732 / DSM 70277 / JCM 3621 / NBRC 1476 / NRRL Y-5445.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ010725 Genomic DNA. Translation: CAB38058.1.
3D structure databases
ProteinModelPortal	O94213.
ModBase	Search...
Protein family/group databases
CAZy	GT20. Glycosyltransferase Family 20.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR001830. Glyco_trans_20. IPR012766. Trehalose_OtsA. [Graphical view]
Pfam	PF00982. Glyco_transf_20. 1 hit. [Graphical view]
TIGRFAMs	TIGR02400. trehalose_OtsA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

TPS1_PICAN

Accession

Primary (citable) accession number: O94213

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 6, 2002
Last sequence update:	May 1, 1999
Last modified:	April 3, 2013
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program