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O94198 (ACEA_ASHGO) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Isocitrate lyase

Short name=ICL
Short name=Isocitrase
Short name=Isocitratase
EC=4.1.3.1
Gene names
Name:ICL1
Ordered Locus Names:ADL066C
OrganismAshbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii) [Reference proteome]
Taxonomic identifier284811 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeEremothecium

Protein attributes

Sequence length560 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Isocitrate = succinate + glyoxylate.

Pathway

Carbohydrate metabolism; glyoxylate cycle; (S)-malate from isocitrate: step 1/2.

Subunit structure

Homotetramer By similarity.

Subcellular location

Peroxisome.

Sequence similarities

Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family.

Ontologies

Keywords
   Biological processGlyoxylate bypass
Tricarboxylic acid cycle
   Cellular componentPeroxisome
   Molecular functionLyase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processglyoxylate cycle

Inferred from electronic annotation. Source: UniProtKB-UniPathway

tricarboxylic acid cycle

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentperoxisome

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionisocitrate lyase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 560560Isocitrate lyase
PRO_0000068782

Regions

Motif558 – 5603Microbody targeting signal Potential

Sites

Active site2171 By similarity

Sequences

Sequence LengthMass (Da)Tools
O94198 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: 6E9FCA3A608438AD

FASTA56062,585
        10         20         30         40         50         60 
MSPSVRDARN DLASLQQQAA AEAEDIRRWW SQPRWAGTKR VYTAEDIVKR RGTFPVVEYP 

        70         80         90        100        110        120 
SSVMADKLVE TLARHSRNGT VSQTFGVLDP VQMTQMVKYL DTIYVSGWQC SATASTSNEP 

       130        140        150        160        170        180 
GPDLADYPMD TVPNKVEHLF MAQLFHDRKQ REARLSCTTQ RELDQLGPEI DYLRPIVADA 

       190        200        210        220        230        240 
DTGHGGLTAV FKLTKMFIER GAAGIHMEDQ SSSNKKCGHM AGRCVIPVQE HISRLVTVRM 

       250        260        270        280        290        300 
CADVMHSNLV LVARTDSEAA TLLSSNIDAR DHYYIVGASN PEVTVPLIEV LDAAQQAGAS 

       310        320        330        340        350        360 
GDRLAQLEED WCKKAKLRLF HEAFADQVNA SPSIKDKAGV IAKFNSQIGP QTGASIREMR 

       370        380        390        400        410        420 
KLGRELLGQD VYFDWDLPRA REGLYRYKGG TQCAIMRARA FAPYADLVWF ESNFPDFQQA 

       430        440        450        460        470        480 
KEFAQGVREK FPNKWMAYNL SPSFNWPKAM PPKEQENYIQ RLGEIGYVWQ FITLAGLHTN 

       490        500        510        520        530        540 
ALAIDNFSRE FSRFGMRAYA QGIQQREMDE GVDVLKHQKW AGAEYVDSIL KLAQGGVSST 

       550        560 
ASMGKGVTEE QFGSSNGAKL 

« Hide

References

« Hide 'large scale' references
[1]"Isocitrate lyase of Ashbya gossypii -- transcriptional regulation and peroxisomal localization."
Maeting I., Schmidt G., Sahm H., Revuelta J.L., Stierhof Y.D., Stahmann K.-P.
FEBS Lett. 444:15-21(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056.
[2]"The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces cerevisiae genome."
Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S., Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A., Gaffney T.D., Philippsen P.
Science 304:304-307(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056.
[3]"Genomes of Ashbya fungi isolated from insects reveal four mating-type loci, numerous translocations, lack of transposons, and distinct gene duplications."
Dietrich F.S., Voegeli S., Kuo S., Philippsen P.
G3 (Bethesda) 3:1225-1239(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ010727 Genomic DNA. Translation: CAB37065.1.
AE016817 Genomic DNA. Translation: AAS51854.1.
RefSeqNP_984030.1. NM_209383.1.

3D structure databases

ProteinModelPortalO94198.
SMRO94198. Positions 18-536.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING33169.AGOS_ADL066C.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiAAS51854; AAS51854; AGOS_ADL066C.
GeneID4620172.
KEGGago:AGOS_ADL066C.

Phylogenomic databases

eggNOGCOG2224.
HOGENOMHOG000238475.
KOK01637.
OMAGNQAIQQ.
OrthoDBEOG73Z331.

Enzyme and pathway databases

UniPathwayUPA00703; UER00719.

Family and domain databases

Gene3D3.20.20.60. 2 hits.
InterProIPR006254. Isocitrate_lyase.
IPR018523. Isocitrate_lyase_ph_CS.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PANTHERPTHR21631:SF3. PTHR21631:SF3. 1 hit.
PfamPF00463. ICL. 1 hit.
[Graphical view]
PIRSFPIRSF001362. Isocit_lyase. 1 hit.
SUPFAMSSF51621. SSF51621. 1 hit.
TIGRFAMsTIGR01346. isocit_lyase. 1 hit.
PROSITEPS00161. ISOCITRATE_LYASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameACEA_ASHGO
AccessionPrimary (citable) accession number: O94198
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: July 9, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways