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O94198

- ACEA_ASHGO

UniProt

O94198 - ACEA_ASHGO

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Protein

Isocitrate lyase

Gene

ICL1

Organism
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate = succinate + glyoxylate.PROSITE-ProRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei217 – 2171PROSITE-ProRule annotation

GO - Molecular functioni

  1. isocitrate lyase activity Source: UniProtKB-EC

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-UniPathway
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Glyoxylate bypass, Tricarboxylic acid cycle

Enzyme and pathway databases

UniPathwayiUPA00703; UER00719.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate lyase (EC:4.1.3.1)
Short name:
ICL
Short name:
Isocitrase
Short name:
Isocitratase
Gene namesi
Name:ICL1
Ordered Locus Names:ADL066C
OrganismiAshbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
Taxonomic identifieri284811 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeEremothecium
ProteomesiUP000000591: Chromosome IV

Subcellular locationi

GO - Cellular componenti

  1. peroxisome Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 560560Isocitrate lyasePRO_0000068782Add
BLAST

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

STRINGi33169.AGOS_ADL066C.

Structurei

3D structure databases

ProteinModelPortaliO94198.
SMRiO94198. Positions 18-536.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi558 – 5603Microbody targeting signalSequence Analysis

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2224.
HOGENOMiHOG000238475.
InParanoidiO94198.
KOiK01637.
OMAiGNQAIQQ.
OrthoDBiEOG73Z331.

Family and domain databases

Gene3Di3.20.20.60. 2 hits.
InterProiIPR006254. Isocitrate_lyase.
IPR018523. Isocitrate_lyase_ph_CS.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PANTHERiPTHR21631:SF3. PTHR21631:SF3. 1 hit.
PfamiPF00463. ICL. 1 hit.
[Graphical view]
PIRSFiPIRSF001362. Isocit_lyase. 1 hit.
SUPFAMiSSF51621. SSF51621. 1 hit.
TIGRFAMsiTIGR01346. isocit_lyase. 1 hit.
PROSITEiPS00161. ISOCITRATE_LYASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O94198-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSPSVRDARN DLASLQQQAA AEAEDIRRWW SQPRWAGTKR VYTAEDIVKR
60 70 80 90 100
RGTFPVVEYP SSVMADKLVE TLARHSRNGT VSQTFGVLDP VQMTQMVKYL
110 120 130 140 150
DTIYVSGWQC SATASTSNEP GPDLADYPMD TVPNKVEHLF MAQLFHDRKQ
160 170 180 190 200
REARLSCTTQ RELDQLGPEI DYLRPIVADA DTGHGGLTAV FKLTKMFIER
210 220 230 240 250
GAAGIHMEDQ SSSNKKCGHM AGRCVIPVQE HISRLVTVRM CADVMHSNLV
260 270 280 290 300
LVARTDSEAA TLLSSNIDAR DHYYIVGASN PEVTVPLIEV LDAAQQAGAS
310 320 330 340 350
GDRLAQLEED WCKKAKLRLF HEAFADQVNA SPSIKDKAGV IAKFNSQIGP
360 370 380 390 400
QTGASIREMR KLGRELLGQD VYFDWDLPRA REGLYRYKGG TQCAIMRARA
410 420 430 440 450
FAPYADLVWF ESNFPDFQQA KEFAQGVREK FPNKWMAYNL SPSFNWPKAM
460 470 480 490 500
PPKEQENYIQ RLGEIGYVWQ FITLAGLHTN ALAIDNFSRE FSRFGMRAYA
510 520 530 540 550
QGIQQREMDE GVDVLKHQKW AGAEYVDSIL KLAQGGVSST ASMGKGVTEE
560
QFGSSNGAKL
Length:560
Mass (Da):62,585
Last modified:May 1, 1999 - v1
Checksum:i6E9FCA3A608438AD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ010727 Genomic DNA. Translation: CAB37065.1.
AE016817 Genomic DNA. Translation: AAS51854.1.
RefSeqiNP_984030.1. NM_209383.1.

Genome annotation databases

EnsemblFungiiAAS51854; AAS51854; AGOS_ADL066C.
GeneIDi4620172.
KEGGiago:AGOS_ADL066C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ010727 Genomic DNA. Translation: CAB37065.1 .
AE016817 Genomic DNA. Translation: AAS51854.1 .
RefSeqi NP_984030.1. NM_209383.1.

3D structure databases

ProteinModelPortali O94198.
SMRi O94198. Positions 18-536.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 33169.AGOS_ADL066C.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii AAS51854 ; AAS51854 ; AGOS_ADL066C .
GeneIDi 4620172.
KEGGi ago:AGOS_ADL066C.

Phylogenomic databases

eggNOGi COG2224.
HOGENOMi HOG000238475.
InParanoidi O94198.
KOi K01637.
OMAi GNQAIQQ.
OrthoDBi EOG73Z331.

Enzyme and pathway databases

UniPathwayi UPA00703 ; UER00719 .

Family and domain databases

Gene3Di 3.20.20.60. 2 hits.
InterProi IPR006254. Isocitrate_lyase.
IPR018523. Isocitrate_lyase_ph_CS.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view ]
PANTHERi PTHR21631:SF3. PTHR21631:SF3. 1 hit.
Pfami PF00463. ICL. 1 hit.
[Graphical view ]
PIRSFi PIRSF001362. Isocit_lyase. 1 hit.
SUPFAMi SSF51621. SSF51621. 1 hit.
TIGRFAMsi TIGR01346. isocit_lyase. 1 hit.
PROSITEi PS00161. ISOCITRATE_LYASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isocitrate lyase of Ashbya gossypii -- transcriptional regulation and peroxisomal localization."
    Maeting I., Schmidt G., Sahm H., Revuelta J.L., Stierhof Y.D., Stahmann K.-P.
    FEBS Lett. 444:15-21(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056.
  2. "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces cerevisiae genome."
    Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S., Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A., Gaffney T.D., Philippsen P.
    Science 304:304-307(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056.
  3. "Genomes of Ashbya fungi isolated from insects reveal four mating-type loci, numerous translocations, lack of transposons, and distinct gene duplications."
    Dietrich F.S., Voegeli S., Kuo S., Philippsen P.
    G3 (Bethesda) 3:1225-1239(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056.

Entry informationi

Entry nameiACEA_ASHGO
AccessioniPrimary (citable) accession number: O94198
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: October 29, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3