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O94127

- PYRF_CYBJA

UniProt

O94127 - PYRF_CYBJA

Protein

Orotidine 5'-phosphate decarboxylase

Gene

URA3

Organism
Cyberlindnera jadinii (Torula yeast) (Pichia jadinii)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Orotidine 5'-phosphate = UMP + CO2.PROSITE-ProRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei37 – 371SubstrateBy similarity
    Active sitei93 – 931Proton donorPROSITE-ProRule annotation
    Binding sitei217 – 2171SubstrateBy similarity
    Binding sitei235 – 2351SubstrateBy similarity

    GO - Molecular functioni

    1. orotidine-5'-phosphate decarboxylase activity Source: UniProtKB-EC

    GO - Biological processi

    1. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
    2. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Decarboxylase, Lyase

    Keywords - Biological processi

    Pyrimidine biosynthesis

    Enzyme and pathway databases

    UniPathwayiUPA00070; UER00120.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Orotidine 5'-phosphate decarboxylase (EC:4.1.1.23)
    Alternative name(s):
    OMP decarboxylase
    Short name:
    OMPDCase
    Short name:
    OMPdecase
    Uridine 5'-monophosphate synthase
    Short name:
    UMP synthase
    Gene namesi
    Name:URA3
    OrganismiCyberlindnera jadinii (Torula yeast) (Pichia jadinii)
    Taxonomic identifieri4903 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesPhaffomycetaceaeCyberlindnera

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 266266Orotidine 5'-phosphate decarboxylasePRO_0000134673Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliO94127.
    SMRiO94127. Positions 6-266.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni59 – 613Substrate bindingBy similarity
    Regioni91 – 10010Substrate bindingBy similarity

    Sequence similaritiesi

    Belongs to the OMP decarboxylase family.Curated

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    InterProiIPR013785. Aldolase_TIM.
    IPR014732. OMPdecase.
    IPR018089. OMPdecase_AS.
    IPR001754. OMPdeCOase_dom.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view]
    PfamiPF00215. OMPdecase. 1 hit.
    [Graphical view]
    SMARTiSM00934. OMPdecase. 1 hit.
    [Graphical view]
    SUPFAMiSSF51366. SSF51366. 1 hit.
    TIGRFAMsiTIGR01740. pyrF. 1 hit.
    PROSITEiPS00156. OMPDECASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O94127-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVTTLSYTER ASHPSPLAKR LFSLMESKKT NLCASVDVRT TEELLKLVDT    50
    LGPYICLLKT HIDIIDDFSM ESTVAPLLEL SKEHNFLIFE DRKFADIGNT 100
    VKAQYAGGAF KIAQWADITN AHGVTGRGIV KGLKEAAQET TDEPRGLLML 150
    AELSSKGSFA HGTYTEETVE IAKTDKDFCI GFIAQRDMGG REDGFDWIIM 200
    TPGVGLDDKG DSLGQQYRTV DEVVSGGCDI IIVGRGLFGK GRDPTVEGER 250
    YRKAGWDAYL KRYSAQ 266
    Length:266
    Mass (Da):29,301
    Last modified:May 1, 1999 - v1
    Checksum:i4ED99416A0E80ADE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y12660 Genomic DNA. Translation: CAA73209.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y12660 Genomic DNA. Translation: CAA73209.1 .

    3D structure databases

    ProteinModelPortali O94127.
    SMRi O94127. Positions 6-266.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    UniPathwayi UPA00070 ; UER00120 .

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    InterProi IPR013785. Aldolase_TIM.
    IPR014732. OMPdecase.
    IPR018089. OMPdecase_AS.
    IPR001754. OMPdeCOase_dom.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view ]
    Pfami PF00215. OMPdecase. 1 hit.
    [Graphical view ]
    SMARTi SM00934. OMPdecase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51366. SSF51366. 1 hit.
    TIGRFAMsi TIGR01740. pyrF. 1 hit.
    PROSITEi PS00156. OMPDECASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and sequence analysis of the orotidine-5'-phosphate decarboxylase gene (URA3) of Candida utilis. Comparison with the OMP decarboxylase gene family."
      Rodriguez L., Chavez F.P., Gonzalez M.E., Basabe L., Rivero T.
      Yeast 14:1399-1406(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 9256 / CBS 841 / DSM 70167 / JCM 2311 / NBRC 0626 / NRRL Y-1084 / VKM Y-768.

    Entry informationi

    Entry nameiPYRF_CYBJA
    AccessioniPrimary (citable) accession number: O94127
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 23, 2002
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3