Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

O94127 (PYRF_CYBJA) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Orotidine 5'-phosphate decarboxylase

EC=4.1.1.23
Alternative name(s):
OMP decarboxylase
Short name=OMPDCase
Short name=OMPdecase
Uridine 5'-monophosphate synthase
Short name=UMP synthase
Gene names
Name:URA3
OrganismCyberlindnera jadinii (Torula yeast) (Pichia jadinii)
Taxonomic identifier4903 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesPhaffomycetaceaeCyberlindnera

Protein attributes

Sequence length266 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Orotidine 5'-phosphate = UMP + CO2.

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.

Sequence similarities

Belongs to the OMP decarboxylase family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 266266Orotidine 5'-phosphate decarboxylase
PRO_0000134673

Regions

Region59 – 613Substrate binding By similarity
Region91 – 10010Substrate binding By similarity

Sites

Active site931Proton donor By similarity
Binding site371Substrate By similarity
Binding site2171Substrate By similarity
Binding site2351Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
O94127 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: 4ED99416A0E80ADE

FASTA26629,301
        10         20         30         40         50         60 
MVTTLSYTER ASHPSPLAKR LFSLMESKKT NLCASVDVRT TEELLKLVDT LGPYICLLKT 

        70         80         90        100        110        120 
HIDIIDDFSM ESTVAPLLEL SKEHNFLIFE DRKFADIGNT VKAQYAGGAF KIAQWADITN 

       130        140        150        160        170        180 
AHGVTGRGIV KGLKEAAQET TDEPRGLLML AELSSKGSFA HGTYTEETVE IAKTDKDFCI 

       190        200        210        220        230        240 
GFIAQRDMGG REDGFDWIIM TPGVGLDDKG DSLGQQYRTV DEVVSGGCDI IIVGRGLFGK 

       250        260 
GRDPTVEGER YRKAGWDAYL KRYSAQ 

« Hide

References

[1]"Isolation and sequence analysis of the orotidine-5'-phosphate decarboxylase gene (URA3) of Candida utilis. Comparison with the OMP decarboxylase gene family."
Rodriguez L., Chavez F.P., Gonzalez M.E., Basabe L., Rivero T.
Yeast 14:1399-1406(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 9256 / CBS 841 / DSM 70167 / JCM 2311 / NBRC 0626 / NRRL Y-1084 / VKM Y-768.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Y12660 Genomic DNA. Translation: CAA73209.1.

3D structure databases

ProteinModelPortalO94127.
SMRO94127. Positions 6-266.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00070; UER00120.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
InterProIPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMSSF51366. SSF51366. 1 hit.
TIGRFAMsTIGR01740. pyrF. 1 hit.
PROSITEPS00156. OMPDECASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePYRF_CYBJA
AccessionPrimary (citable) accession number: O94127
Entry history
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: May 1, 1999
Last modified: June 11, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways