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O94123

- PGK_AGABI

UniProt

O94123 - PGK_AGABI

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Protein

Phosphoglycerate kinase

Gene

pgkA

Organism
Agaricus bisporus (White button mushroom)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei39 – 391SubstrateBy similarity
Binding sitei122 – 1221SubstrateBy similarity
Binding sitei170 – 1701SubstrateBy similarity
Binding sitei219 – 2191ATPBy similarity
Binding sitei312 – 3121ATP; via carbonyl oxygenBy similarity
Binding sitei343 – 3431ATPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi372 – 3754ATPBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphoglycerate kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. glycolytic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00109; UER00185.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycerate kinase (EC:2.7.2.3)
Gene namesi
Name:pgkA
Synonyms:pgk
OrganismiAgaricus bisporus (White button mushroom)
Taxonomic identifieri5341 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaAgaricomycetesAgaricomycetidaeAgaricalesAgaricaceaeAgaricus

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 416416Phosphoglycerate kinasePRO_0000145873Add
BLAST

Proteomic databases

PRIDEiO94123.

Interactioni

Subunit structurei

Monomer.By similarity

Structurei

3D structure databases

ProteinModelPortaliO94123.
SMRiO94123. Positions 2-415.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni24 – 263Substrate bindingBy similarity
Regioni63 – 664Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the phosphoglycerate kinase family.Curated

Family and domain databases

Gene3Di3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPiMF_00145. Phosphoglyc_kinase.
InterProiIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERiPTHR11406. PTHR11406. 1 hit.
PfamiPF00162. PGK. 1 hit.
[Graphical view]
PIRSFiPIRSF000724. Pgk. 1 hit.
PRINTSiPR00477. PHGLYCKINASE.
SUPFAMiSSF53748. SSF53748. 1 hit.
PROSITEiPS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O94123 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSLSNKLSIT DLALTGKRVL IRVDFNSPIQ DGKITNPARI NAALPTIKYA
60 70 80 90 100
LDNGASKVIL MSHLGRPDGK AISKYSLKPV ASELEKLLKK PVFFLHDCVG
110 120 130 140 150
PDIEKAVLEA PEGAVVLLEN LRFHIEEEGS AKNEEGKKIK ADPSKVTQFR
160 170 180 190 200
EQLTRLGDVY VNDAFGTAHR AHSSMVGIKL PRRASGFLVK KELDYFAKAL
210 220 230 240 250
ENPERPFLAI LGGAKVSDKI QLIENMLDKV NCLVIGGGMA FTFKKTMQNV
260 270 280 290 300
AIGNSLFDKP GSEKVAGIVE KAKKNNVEIV FPVDYVVGDK FDANANHKIV
310 320 330 340 350
TDDEGVPDGW MGLDVGPKSN ELFREAVLKA KTILWNGPPG VFEFPAFAKG
360 370 380 390 400
SKVLLDATVE AVQKGATVIV GGGDTATVVA NHDAEEKLSH VSTGGGASLE
410
LLEGKTLPGV AELSNK
Length:416
Mass (Da):44,719
Last modified:May 1, 1999 - v1
Checksum:i655B4F35C2C622D4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X97580 Genomic DNA. Translation: CAA66195.1.
X91105 mRNA. Translation: CAA62559.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X97580 Genomic DNA. Translation: CAA66195.1 .
X91105 mRNA. Translation: CAA62559.1 .

3D structure databases

ProteinModelPortali O94123.
SMRi O94123. Positions 2-415.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi O94123.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00185 .

Family and domain databases

Gene3Di 3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPi MF_00145. Phosphoglyc_kinase.
InterProi IPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view ]
PANTHERi PTHR11406. PTHR11406. 1 hit.
Pfami PF00162. PGK. 1 hit.
[Graphical view ]
PIRSFi PIRSF000724. Pgk. 1 hit.
PRINTSi PR00477. PHGLYCKINASE.
SUPFAMi SSF53748. SSF53748. 1 hit.
PROSITEi PS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Sequence of the Agaricus bisporus pgkA gene."
    Schaap P.J., Mueller Y., van Griensven L.J.L.D., Visser J.
    Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Horst H39.
  2. "Biochemical and molecular aspects of growth on fruiting of the edible mushroom Agaricus bisporus."
    De Groot P.W.J., Visser J., van Griensven L.J.L.D., Schaap P.J.
    Mycol. Res. 102:1297-1308(1998)
    [AGRICOLA] [Europe PMC]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Horst U1.

Entry informationi

Entry nameiPGK_AGABI
AccessioniPrimary (citable) accession number: O94123
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: October 29, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3