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O94123 (PGK_AGABI) Reviewed, UniProtKB/Swiss-Prot

Last modified March 6, 2013. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phosphoglycerate kinase
EC=2.7.2.3
Gene names
Name:pgkA
Synonyms:pgk
OrganismAgaricus bisporus (White button mushroom)
Taxonomic identifier5341 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Basidiomycota › Agaricomycotina › Agaricomycetes › Agaricomycetidae › Agaricales › Agaricaceae › Agaricus

Protein attributes

Sequence length416 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.

Pathway

Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5.

Subunit structure

Monomer By similarity.

Subcellular location

Cytoplasm.

Sequence similarities

Belongs to the phosphoglycerate kinase family.

Ontologies

Keywords
   Biological processGlycolysis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
Gene Ontology (GO)
   Biological_processglycolysis

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

phosphoglycerate kinase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 416416Phosphoglycerate kinase
PRO_0000145873

Regions

Nucleotide binding372 – 3754ATP By similarity
Region24 – 263Substrate binding By similarity
Region63 – 664Substrate binding By similarity

Sites

Binding site391Substrate By similarity
Binding site1221Substrate By similarity
Binding site1701Substrate By similarity
Binding site2191ATP By similarity
Binding site3121ATP; via carbonyl oxygen By similarity
Binding site3431ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
O94123 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: 655B4F35C2C622D4

FASTA41644,719
        10         20         30         40         50         60 
MSLSNKLSIT DLALTGKRVL IRVDFNSPIQ DGKITNPARI NAALPTIKYA LDNGASKVIL 

        70         80         90        100        110        120 
MSHLGRPDGK AISKYSLKPV ASELEKLLKK PVFFLHDCVG PDIEKAVLEA PEGAVVLLEN 

       130        140        150        160        170        180 
LRFHIEEEGS AKNEEGKKIK ADPSKVTQFR EQLTRLGDVY VNDAFGTAHR AHSSMVGIKL 

       190        200        210        220        230        240 
PRRASGFLVK KELDYFAKAL ENPERPFLAI LGGAKVSDKI QLIENMLDKV NCLVIGGGMA 

       250        260        270        280        290        300 
FTFKKTMQNV AIGNSLFDKP GSEKVAGIVE KAKKNNVEIV FPVDYVVGDK FDANANHKIV 

       310        320        330        340        350        360 
TDDEGVPDGW MGLDVGPKSN ELFREAVLKA KTILWNGPPG VFEFPAFAKG SKVLLDATVE 

       370        380        390        400        410 
AVQKGATVIV GGGDTATVVA NHDAEEKLSH VSTGGGASLE LLEGKTLPGV AELSNK

« Hide

References

[1]"Sequence of the Agaricus bisporus pgkA gene."
Schaap P.J., Mueller Y., van Griensven L.J.L.D., Visser J.
Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: Horst H39.
[2]"Biochemical and molecular aspects of growth on fruiting of the edible mushroom Agaricus bisporus."
De Groot P.W.J., Visser J., van Griensven L.J.L.D., Schaap P.J.
Mycol. Res. 102:1297-1308(1998) [AGRICOLA] [Europe PMC]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Horst U1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		X97580 Genomic DNA. Translation: CAA66195.1.
X91105 mRNA. Translation: CAA62559.1.

3D structure databases

ProteinModelPortalO94123.
SMRO94123. Positions 2-415.
ModBaseSearch...

Proteomic databases

PRIDEO94123.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00109; UER00185.

Family and domain databases

Gene3D3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
InterProIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERPTHR11406. PTHR11406. 1 hit.
PfamPF00162. PGK. 1 hit.
[Graphical view]
PIRSFPIRSF000724. Pgk. 1 hit.
PRINTSPR00477. PHGLYCKINASE.
SUPFAMSSF53748. PGK. 1 hit.
PROSITEPS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePGK_AGABI
AccessionPrimary (citable) accession number: O94123
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: March 6, 2013
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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