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Protein

Allergen Alt a 2

Gene

ALTA2

Organism
Alternaria alternata (Alternaria rot fungus) (Torula alternata)
Status
Reviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Allergen Alt a 2
Alternative name(s):
Allergen: Alt a 2
Gene namesi
Name:ALTA2
OrganismiAlternaria alternata (Alternaria rot fungus) (Torula alternata)
Taxonomic identifieri5599 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaDothideomycetesPleosporomycetidaePleosporalesPleosporineaePleosporaceaeAlternariaAlternaria alternata group

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human. Binds to IgE.1 Publication

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei16. Alt a 2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 190190Allergen Alt a 2PRO_0000345087Add
BLAST

Sequencei

Sequence statusi: Complete.

O94095-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHSSNNFFKD NIFRSLSKED PDYSRNIEGQ VIRLHWDWAQ LLMLSAKRMK
60 70 80 90 100
VAFKLDIEKD QRVWDRCTAD DLKGRNGFKR CLQFTLYRPR DLLSLLNEAF
110 120 130 140 150
FSAFRENRET IINTDLEYAA KSISMARLED LWKEYQKIFP SIQVITSAFR
160 170 180 190
SIEPELTVYT CLKKIEASFE LIEENGDPKI TSEIQLLKAS
Length:190
Mass (Da):22,387
Last modified:May 1, 1999 - v1
Checksum:i4A2867362792C72A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U62442 mRNA. Translation: AAD00097.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U62442 mRNA. Translation: AAD00097.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

Allergomei16. Alt a 2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning of a major Alternaria alternata allergen, rAlt a 2."
    Bush R.K., Sanchez H., Geisler D.
    J. Allergy Clin. Immunol. 104:665-671(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], IGE-BINDING.
    Strain: ATCC 46582 / PD 1.
  2. "Diagnosis of Alternaria alternata sensitization with natural and recombinant Alt a 1 allergens."
    Asturias J.A., Ibarrola I., Ferrer A., Andreu C., Lopez-Pascual E., Quiralte J., Florido F., Martinez A.
    J. Allergy Clin. Immunol. 115:1210-1217(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: ALLERGEN.

Entry informationi

Entry nameiALTA2_ALTAL
AccessioniPrimary (citable) accession number: O94095
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: May 1, 1999
Last modified: October 1, 2014
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Caution

Was originally (PubMed:10482844) identified to be a major allergen, but a second study (PubMed:15940136) reported a very low prevalence.2 Publications

Documents

  1. Allergens
    Nomenclature of allergens and list of entries

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.