Reviewed, UniProtKB/Swiss-Prot O94095 (ALTA2_ALTAL)

Names and origin

Protein names

Recommended name:
    Allergen Alt a 2
Alternative name(s):
    Allergen=Alt a 2

Gene names

Name:

ALTA2

Organism

Alternaria alternata (Alternaria rot fungus)

Taxonomic identifier

5599 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Dothideomycetes › Pleosporomycetidae › Pleosporales › Pleosporaceae › mitosporic Pleosporaceae › Alternaria › Alternaria alternata group

Protein attributes

Sequence length	190 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Allergenic properties	Causes an allergic reaction in human. Binds to IgE. Ref.2
Caution	Was originally (Ref.1) identified to be a major allergen, but a second study (Ref.2) reported a very low prevalence.

Ontologies

Keywords
Disease	Allergen
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 190	190	Allergen Alt a 2		PRO_0000345087

Sequences

	Sequence		Length	Mass (Da)
	O94095-1 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: 4A2867362792C72A	FASTA	190	22,387
	10 20 30 40 50 60 MHSSNNFFKD NIFRSLSKED PDYSRNIEGQ VIRLHWDWAQ LLMLSAKRMK VAFKLDIEKD 70 80 90 100 110 120 QRVWDRCTAD DLKGRNGFKR CLQFTLYRPR DLLSLLNEAF FSAFRENRET IINTDLEYAA 130 140 150 160 170 180 KSISMARLED LWKEYQKIFP SIQVITSAFR SIEPELTVYT CLKKIEASFE LIEENGDPKI 190 TSEIQLLKAS

References

[1]	"Molecular cloning of a major Alternaria alternata allergen, rAlt a 2." Bush R.K., Sanchez H., Geisler D. J. Allergy Clin. Immunol. 104:665-671(1999) [PubMed: 10482844] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], IGE-BINDING. Strain: ATCC 46582 / PD 1.
[2]	"Diagnosis of Alternaria alternata sensitization with natural and recombinant Alt a 1 allergens." Asturias J.A., Ibarrola I., Ferrer A., Andreu C., Lopez-Pascual E., Quiralte J., Florido F., Martinez A. J. Allergy Clin. Immunol. 115:1210-1217(2005) [PubMed: 15940136] [Abstract] Cited for: ALLERGENICITY.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U62442 mRNA. Translation: AAD00097.1.
3D structure databases
ModBase	Search...
Family and domain databases
ProtoNet	Search...

Entry information

Entry name

ALTA2_ALTAL

Accession

Primary (citable) accession number: O94095

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 22, 2008
Last sequence update:	May 1, 1999
Last modified:	July 22, 2008
This is version 18 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)