O94091 (LIP1_CANAX) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Lipase 1
EC=3.1.1.3

Gene names

Name:

LIP1

Organism

Candida albicans (Yeast)

Taxonomic identifier

5476 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida

Protein attributes

Sequence length	468 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Hydrolyzes triglycerides.
Catalytic activity	Triacylglycerol + H2O = diacylglycerol + a carboxylate.
Subcellular location	Secreted Ref.1.
Sequence similarities	Belongs to the AB hydrolase superfamily. Lipase family.

Ontologies

Keywords
Biological process	Lipid degradation
Cellular component	Secreted
Domain	Signal
Molecular function	Hydrolase
PTM	Glycoprotein
Gene Ontology (GO)
Biological process	lipid catabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	triglyceride lipase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 16	16	Potential
	Chain	17 – 468	452	Lipase 1		PRO_0000017820
Sites
	Active site	196	1	Charge relay system By similarity
	Active site	344	1	Charge relay system By similarity
Amino acid modifications
	Glycosylation	79	1	N-linked (GlcNAc...) Potential
	Glycosylation	231	1	N-linked (GlcNAc...) Potential
	Glycosylation	319	1	N-linked (GlcNAc...) Potential
	Glycosylation	417	1	N-linked (GlcNAc...) Potential
	Glycosylation	422	1	N-linked (GlcNAc...) Potential
	Glycosylation	451	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	O94091 [UniParc]. Last modified November 21, 2003. Version 2. Checksum: 4FF3C05A948B14DA	FASTA	468	50,811
	10 20 30 40 50 60 MRGIAVFLAF ISLIFASPLT VKSPLVDDFY TAPDGYESAK LGEILKLRKT PSKLSSMFFE 70 80 90 100 110 120 IDIKNSWQLL VRSEDSFGNA TAIVTTVIEP YNADPSKVLS YQTFEDSANI ECSPSYGMQY 130 140 150 160 170 180 GAPWSTVATQ IDMALMVPML KQGYYVVSPD YEGPKSTFTV GRQSGKATLD SIRAILKSNK 190 200 210 220 230 240 FTGIKSDAKV AMWGYSGGSL ASGWAAALQP KYAPELKKNL IGAALGGFVT NITATAEATD 250 260 270 280 290 300 GTLFAGLVPN ALSGLANEYP EFKEILYQKV SKAATDNLRQ GTEHCIGGAI LYFAEDQYFT 310 320 330 340 350 360 GDDRAFPGGY GLLKEEVVNK TISENNLMQM DKDYLPDIPI FVYHGALDSI VPISNVHVTY 370 380 390 400 410 420 KNWCDWGINS FEFSEDLLNG HITETIVGAP AAITWLEARF DGEPVVKGCK KTSRITNFSY 430 440 450 460 PNISDSTSSI FEGILNSVTG SELGPGVTSD NITLDGLTGF LGNFIDLK

References

[1]	"Secreted lipases of Candida albicans: cloning, characterisation and expression analysis of a new gene family with at least ten members." Hube B., Stehr F., Bossenz M., Mazur A., Kretschmar M., Schaefer W. Arch. Microbiol. 174:362-374(2000) [PubMed: 11131027] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], SUBCELLULAR LOCATION. Strain: 1161.
[2]	"Cloning and characterization of a gene (LIP1) which encodes a lipase from the pathogenic yeast Candida albicans." Fu Y., Ibrahim A.S., Fonzi W., Zhou X., Ramos C.F., Ghannoum M.A. Microbiology 143:331-340(1997) [PubMed: 9043110] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 118-468. Strain: ATCC 36082.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF188894 Genomic DNA. Translation: AAF35171.1. U34807 Genomic DNA. Translation: AAC99990.1.
3D structure databases
ProteinModelPortal	O94091.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
OMA	SAMWELL.
Family and domain databases
InterPro	IPR005152. Lipase_secreted. [Graphical view]
Pfam	PF03583. LIP. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

LIP1_CANAX

Accession

Primary (citable) accession number: O94091
Secondary accession number(s): Q9P8W6

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	November 21, 2003
Last modified:	October 19, 2011
This is version 48 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program