Reviewed, UniProtKB/Swiss-Prot O94083 (IF5A_CANAL)

Names and origin

Protein names

Recommended name:
    Eukaryotic translation initiation factor 5A
      Short name=eIF-5A
Alternative name(s):
    eIF-4D

Gene names

Name:	ANB1
Synonyms:	TIF51
ORF Names:	CaO19.3426, CaO19.10930

Organism

Candida albicans (Yeast)

Taxonomic identifier

5476 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida

Protein attributes

Sequence length	157 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. Functions as a regulator of apoptosis By similarity.
Subcellular location	Cytoplasm By similarity.
Post-translational modification	eIF-5A seems to be the only eukaryotic protein to have an hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group (from spermidine).
Sequence similarities	Belongs to the eIF-5A family.
Sequence caution	The sequence EAK97682.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence EAK97745.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Cytoplasm
Ligand	RNA-binding
Molecular function	Elongation factor
PTM	Hypusine
Gene Ontology (GO)
Biological process	peptidyl-lysine modification to hypusine Inferred from electronic annotation. Source: InterPro positive regulation of translational elongation Inferred from electronic annotation. Source: InterPro positive regulation of translational termination Inferred from electronic annotation. Source: InterPro translation Inferred from electronic annotation. Source: UniProtKB-KW translational frameshifting Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	RNA binding Inferred from electronic annotation. Source: UniProtKB-KW ribosome binding Inferred from electronic annotation. Source: InterPro translation elongation factor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 157	157	Eukaryotic translation initiation factor 5A		PRO_0000142483
Amino acid modifications
	Modified residue	50	1	Hypusine By similarity

Sequences

	Sequence		Length	Mass (Da)
	O94083-1 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: 6092FF794155D11A	FASTA	157	16,995
	10 20 30 40 50 60 MAEEDTFETA DAGAALTFPM QCSALRKNGH VVIKNRPCKI VDMSTSKTGK HGHAKVHLVA 70 80 90 100 110 120 IDIFTGKKLE DLSPSTHNME VPNVSRQEFQ LLDIDDGYLS LMTADGDTKD DVKVPEGELG 130 140 150 DKLQSEFDEG KDLIVTIISA MGEEAAISYK EAPKGSA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Organization of the Candida albicans TIF51 gene encoding the translation initiation factor eIF-5A." Pereira S.A., Ganguly S., Livi G.P. Submitted (MAR-1994) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 11651 / B792 / 171D.
[2]	"The diploid genome sequence of Candida albicans." Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S. Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed: 15123810] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SC5314.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U07366 Genomic DNA. Translation: AAD10697.1. AACQ01000065 Genomic DNA. Translation: EAK97682.1. Sequence problems. AACQ01000064 Genomic DNA. Translation: EAK97745.1. Sequence problems.
RefSeq	XP_716674.1. XP_716733.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3641648. 3641709.
KEGG	cal:CaO19.10930. cal:CaO19.3426.
Organism-specific databases
CGD	CAL0066785. ANB1.
Family and domain databases
InterPro	IPR012340. NA-bd_OB-fold. IPR016027. NA-bd_OB-fold-like. IPR019769. Trans_elong_IF5A_hypusine_site. IPR001884. Transl_elong_IF5A. IPR020189. Transl_elong_IF5A_C. IPR014722. Transl_SH3-like_sub. IPR008991. Translation_prot_SH3-like. [Graphical view]
Gene3D	G3DSA:2.40.50.140. OB_NA_bd_sub. 1 hit. G3DSA:2.30.30.30. Ribosomal_L2. 1 hit.
PANTHER	PTHR11673. EIF5A_hypusine. 1 hit.
Pfam	PF01287. eIF-5a. 1 hit. [Graphical view]
PIRSF	PIRSF003025. eIF5A. 1 hit.
TIGRFAMs	TIGR00037. eIF_5A. 1 hit.
PROSITE	PS00302. IF5A_HYPUSINE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

IF5A_CANAL

Accession

Primary (citable) accession number: O94083
Secondary accession number(s): Q5A4L5

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	May 1, 1999
Last modified:	November 24, 2009
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)