O94083 (IF5A_CANAL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Eukaryotic translation initiation factor 5A
Short name=eIF-5A

Alternative name(s):
eIF-4D

Gene names

Name:	ANB1
Synonyms:	TIF51
ORF Names:	CaO19.10930, CaO19.3426

Organism

Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [Reference proteome]

Taxonomic identifier

237561 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida › Candida albicans

Protein attributes

Sequence length	157 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. Functions as a regulator of apoptosis By similarity.
Subcellular location	Cytoplasm By similarity.
Post-translational modification	eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group (from spermidine).
Sequence similarities	Belongs to the eIF-5A family.
Sequence caution	The sequence EAK97682.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence EAK97745.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Cytoplasm
Ligand	RNA-binding
Molecular function	Elongation factor
PTM	Hypusine
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	peptidyl-lysine modification to hypusine Inferred from electronic annotation. Source: InterPro positive regulation of translational elongation Inferred from electronic annotation. Source: InterPro positive regulation of translational termination Inferred from electronic annotation. Source: InterPro translational frameshifting Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ribosome binding Inferred from electronic annotation. Source: InterPro translation elongation factor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 157	157	Eukaryotic translation initiation factor 5A		PRO_0000142483
Amino acid modifications
	Modified residue	50	1	Hypusine By similarity

Sequences

	Sequence		Length	Mass (Da)
	O94083 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: 6092FF794155D11A	FASTA	157	16,995
	10 20 30 40 50 60 MAEEDTFETA DAGAALTFPM QCSALRKNGH VVIKNRPCKI VDMSTSKTGK HGHAKVHLVA 70 80 90 100 110 120 IDIFTGKKLE DLSPSTHNME VPNVSRQEFQ LLDIDDGYLS LMTADGDTKD DVKVPEGELG 130 140 150 DKLQSEFDEG KDLIVTIISA MGEEAAISYK EAPKGSA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Organization of the Candida albicans TIF51 gene encoding the translation initiation factor eIF-5A." Pereira S.A., Ganguly S., Livi G.P. Submitted (MAR-1994) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 11651 / B792 / 171D.
[2]	"The diploid genome sequence of Candida albicans." Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S. Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SC5314 / ATCC MYA-2876.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U07366 Genomic DNA. Translation: AAD10697.1. AACQ01000065 Genomic DNA. Translation: EAK97682.1. Sequence problems. AACQ01000064 Genomic DNA. Translation: EAK97745.1. Sequence problems.
RefSeq	XP_716674.1. XM_711581.1. XP_716733.1. XM_711640.1.
3D structure databases
ProteinModelPortal	O94083.
SMR	O94083. Positions 17-150.
ModBase	Search...
Protein-protein interaction databases
STRING	5476.CAL0004932.
Proteomic databases
PRIDE	O94083.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3641648. 3641709.
KEGG	cal:CaO19.10930. cal:CaO19.3426.
Organism-specific databases
CGD	CAL0066785. ANB1.
Phylogenomic databases
eggNOG	COG0231.
KO	K03263.
Family and domain databases
Gene3D	2.30.30.30. 1 hit. 2.40.50.140. 1 hit.
InterPro	IPR005824. KOW. IPR012340. NA-bd_OB-fold. IPR014722. Rib_L2_dom2. IPR019769. Trans_elong_IF5A_hypusine_site. IPR001884. Transl_elong_IF5A. IPR020189. Transl_elong_IF5A_C. IPR008991. Translation_prot_SH3-like. [Graphical view]
PANTHER	PTHR11673. PTHR11673. 1 hit.
Pfam	PF01287. eIF-5a. 1 hit. PF00467. KOW. 1 hit. [Graphical view]
PIRSF	PIRSF003025. eIF5A. 1 hit.
SUPFAM	SSF50249. Nucleic_acid_OB. 1 hit. SSF50104. Transl_SH3_like. 1 hit.
TIGRFAMs	TIGR00037. eIF_5A. 1 hit.
PROSITE	PS00302. IF5A_HYPUSINE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

IF5A_CANAL

Accession

Primary (citable) accession number: O94083
Secondary accession number(s): Q5A4L5

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	May 1, 1999
Last modified:	April 3, 2013
This is version 72 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program