Reviewed,
UniProtKB/Swiss-Prot O94069 (HEM1_CANAL)
Last modified
June 16, 2009.
Version 62.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: 5-aminolevulinate synthase, mitochondrial EC=2.3.1.37 Alternative name(s): 5-aminolevulinic acid synthase Delta-aminolevulinate synthase Delta-ALA synthetase | ||||
| Gene names |
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| Organism | Candida albicans (Yeast) | ||||
| Taxonomic identifier | 5476 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida |
Protein attributes
| Sequence length | 564 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Catalytic activity | Succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2. |
| Cofactor | Pyridoxal phosphate By similarity. |
| Pathway | Porphyrin metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from glycine: step 1/1. |
| Subcellular location | Mitochondrion matrix By similarity. |
| Sequence similarities | Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Heme biosynthesis |
| Cellular component | Mitochondrion |
| Domain | Transit peptide |
| Ligand | Pyridoxal phosphate |
| Molecular function | Acyltransferase Transferase |
| Gene Ontology (GO) | |
| Biological process | heme biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | mitochondrial matrix Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | 5-aminolevulinate synthase activity Inferred from electronic annotation. Source: EC pyridoxal phosphate bindingInferred from electronic annotation. Source: InterPro transferase activity, transferring nitrogenous groupsInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Transit peptide | 1 – ? | Mitochondrion | |||||||
| Chain | ? – 564 | 5-aminolevulinate synthase, mitochondrial | PRO_0000001237 | ||||||
Amino acid modifications | |||||||||
| Modified residue | 353 | 1 | N6-(pyridoxal phosphate)lysine Probable | ||||||
Sequences
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References
| [1] | "Candida albicans strain 1161 genome pilot sequencing project." Murphy L., Harris D., Barrell B.G., Rajandream M.A. Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 1161. |
| [2] | "The diploid genome sequence of Candida albicans." Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S. Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed: 15123810] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SC5314. |
Cross-references
Sequence databases | |
|---|---|
| AL033503 Genomic DNA. Translation: CAA22025.1. AACQ01000044 Genomic DNA. Translation: EAK99337.1. | |
| PIR | T18251. |
| RefSeq | XP_718266.1. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1FC4 based on UniProtKB P07912. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 3640149. |
Organism-specific databases | |
| CGD | CAL0003351. HEM1. |
Enzyme and pathway databases | |
| BRENDA | 2.3.1.37. 1124. |
Family and domain databases | |
| InterPro | IPR010961. 4pyrrol_synth_NH2levulA_synth. IPR004839. Aminotrans_I/II. IPR001917. Aminotrans_II_pyridoxalP_BS. IPR015421. PyrdxlP-dep_Trfase_major_sub1. [Graphical view] |
| Gene3D | G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit. |
| Pfam | PF00155. Aminotran_1_2. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR01821. 5aminolev_synth. 1 hit. |
| PROSITE | PS00599. AA_TRANSFER_CLASS_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | HEM1_CANAL | ||||||||
| Accession | Primary (citable) accession number: O94069 Secondary accession number(s): Q5A965 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | FPAP (Fungal Proteome Annotation Project) | ||||||||
Relevant documents
| Candida albicans Candida albicans: entries and gene names |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


