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O94069

- HEM1_CANAL

UniProt

O94069 - HEM1_CANAL

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Protein
5-aminolevulinate synthase, mitochondrial
Gene
HEM1, Ca49C4.15, CaO19.2601
Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2.

Cofactori

Pyridoxal phosphate By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei113 – 1131Substrate By similarity
Binding sitei226 – 2261Substrate By similarity
Binding sitei245 – 2451Substrate By similarity
Binding sitei278 – 2781Pyridoxal phosphate By similarity
Binding sitei306 – 3061Pyridoxal phosphate By similarity
Binding sitei350 – 3501Pyridoxal phosphate By similarity
Active sitei353 – 3531 By similarity
Binding sitei382 – 3821Pyridoxal phosphate By similarity
Binding sitei383 – 3831Pyridoxal phosphate By similarity
Binding sitei468 – 4681Substrate By similarity

GO - Molecular functioni

  1. 5-aminolevulinate synthase activity Source: CGD
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. cellular response to drug Source: CGD
  2. heme biosynthetic process Source: CGD
  3. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Heme biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00251; UER00375.

Names & Taxonomyi

Protein namesi
Recommended name:
5-aminolevulinate synthase, mitochondrial (EC:2.3.1.37)
Alternative name(s):
5-aminolevulinic acid synthase
Delta-ALA synthase
Delta-aminolevulinate synthase
Gene namesi
Name:HEM1
ORF Names:Ca49C4.15, CaO19.2601
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida
ProteomesiUP000000559: Unassembled WGS sequence

Organism-specific databases

CGDiCAL0003351. HEM1.

Subcellular locationi

Mitochondrion matrix By similarity

GO - Cellular componenti

  1. mitochondrial matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 5645-aminolevulinate synthase, mitochondrialPRO_0000001237
Transit peptidei1 – ?Mitochondrion

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei353 – 3531N6-(pyridoxal phosphate)lysine Inferred

Interactioni

Protein-protein interaction databases

STRINGi5476.CAL0003351.

Structurei

3D structure databases

ProteinModelPortaliO94069.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0156.
KOiK00643.
OrthoDBiEOG7HHX1P.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR010961. 4pyrrol_synth_NH2levulA_synth.
IPR001917. Aminotrans_II_pyridoxalP_BS.
IPR004839. Aminotransferase_I/II.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01821. 5aminolev_synth. 1 hit.
PROSITEiPS00599. AA_TRANSFER_CLASS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O94069-1 [UniParc]FASTAAdd to Basket

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MESITKVSMS VCPFVRSTST QALRQLSQTS GALANQARQC PIAGNAIRAK    50
EISIRSYSSA TKPVRATAAT PSTPEATFNV SSSFELGSKE TAFDYNGYLG 100
NELEKKRSDK SYRYFNNINR LANEFPKAHR TQEEDKVTVW CSNDYLGMGK 150
NENTLKEMKR VLDKYGSGAG GTRNIAGHNS HAIKLESELA ALHKHDAALV 200
FSSCFVANDA VLSLLGQKIK DLVIFSDELN HASMIQGIRN SRARKHIFKH 250
NNLADLESKL AQYPKSTPKL IAFESVYSMC GSIAPIEAIC DLAEKYGALT 300
FLDEVHAVGM YGPHGAGVAE HLNFEAHLKS GIERPEITTV MSRVDMVTGT 350
LGKAYGVVGG YITGKTNLID WFRSYAPGFI FTTSLPPAIM AGCSASIRYQ 400
RATLKDRIAQ QKNTRLVKNN LNELGIPVIP NPSHIVPVLV GNAADAKRAS 450
DLLLNKHDIY VQAINFPTVP IGEERLRITP TPGHGPELSK QLVEAVDSVF 500
TELNLNRIND WKKLGGLVGV GVEGAAKVEH IWTEEQLALT DADLNPNVVN 550
PAISPLDVSS GIST 564
Length:564
Mass (Da):61,395
Last modified:May 1, 1999 - v1
Checksum:iC984334068F40487
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL033503 Genomic DNA. Translation: CAA22025.1.
AACQ01000044 Genomic DNA. Translation: EAK99337.1.
PIRiT18251.
RefSeqiXP_718266.1. XM_713173.1.

Genome annotation databases

GeneIDi3640149.
KEGGical:CaO19.2601.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL033503 Genomic DNA. Translation: CAA22025.1 .
AACQ01000044 Genomic DNA. Translation: EAK99337.1 .
PIRi T18251.
RefSeqi XP_718266.1. XM_713173.1.

3D structure databases

ProteinModelPortali O94069.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5476.CAL0003351.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3640149.
KEGGi cal:CaO19.2601.

Organism-specific databases

CGDi CAL0003351. HEM1.

Phylogenomic databases

eggNOGi COG0156.
KOi K00643.
OrthoDBi EOG7HHX1P.

Enzyme and pathway databases

UniPathwayi UPA00251 ; UER00375 .

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProi IPR010961. 4pyrrol_synth_NH2levulA_synth.
IPR001917. Aminotrans_II_pyridoxalP_BS.
IPR004839. Aminotransferase_I/II.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
Pfami PF00155. Aminotran_1_2. 1 hit.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 1 hit.
TIGRFAMsi TIGR01821. 5aminolev_synth. 1 hit.
PROSITEi PS00599. AA_TRANSFER_CLASS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Candida albicans strain 1161 genome pilot sequencing project."
    Murphy L., Harris D., Barrell B.G., Rajandream M.A.
    Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1161.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.

Entry informationi

Entry nameiHEM1_CANAL
AccessioniPrimary (citable) accession number: O94069
Secondary accession number(s): Q5A965
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 1999
Last modified: November 13, 2013
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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