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O94069

- HEM1_CANAL

UniProt

O94069 - HEM1_CANAL

Protein

5-aminolevulinate synthase, mitochondrial

Gene

HEM1

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2.

    Cofactori

    Pyridoxal phosphate.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei113 – 1131SubstrateBy similarity
    Binding sitei226 – 2261SubstrateBy similarity
    Binding sitei245 – 2451SubstrateBy similarity
    Binding sitei278 – 2781Pyridoxal phosphateBy similarity
    Binding sitei306 – 3061Pyridoxal phosphateBy similarity
    Binding sitei350 – 3501Pyridoxal phosphateBy similarity
    Active sitei353 – 3531By similarity
    Binding sitei382 – 3821Pyridoxal phosphateBy similarity
    Binding sitei383 – 3831Pyridoxal phosphateBy similarity
    Binding sitei468 – 4681SubstrateBy similarity

    GO - Molecular functioni

    1. 5-aminolevulinate synthase activity Source: CGD
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. cellular response to drug Source: CGD
    2. heme biosynthetic process Source: CGD
    3. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Keywords - Biological processi

    Heme biosynthesis

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    UniPathwayiUPA00251; UER00375.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    5-aminolevulinate synthase, mitochondrial (EC:2.3.1.37)
    Alternative name(s):
    5-aminolevulinic acid synthase
    Delta-ALA synthase
    Delta-aminolevulinate synthase
    Gene namesi
    Name:HEM1
    ORF Names:Ca49C4.15, CaO19.2601
    OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
    Taxonomic identifieri237561 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida
    ProteomesiUP000000559: Unassembled WGS sequence

    Organism-specific databases

    CGDiCAL0003351. HEM1.

    Subcellular locationi

    Mitochondrion matrix By similarity

    GO - Cellular componenti

    1. mitochondrial matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini? – 5645-aminolevulinate synthase, mitochondrialPRO_0000001237
    Transit peptidei1 – ?Mitochondrion

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei353 – 3531N6-(pyridoxal phosphate)lysineCurated

    Interactioni

    Protein-protein interaction databases

    STRINGi5476.CAL0003351.

    Structurei

    3D structure databases

    ProteinModelPortaliO94069.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0156.
    KOiK00643.
    OrthoDBiEOG7HHX1P.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    InterProiIPR010961. 4pyrrol_synth_NH2levulA_synth.
    IPR001917. Aminotrans_II_pyridoxalP_BS.
    IPR004839. Aminotransferase_I/II.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PfamiPF00155. Aminotran_1_2. 1 hit.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 1 hit.
    TIGRFAMsiTIGR01821. 5aminolev_synth. 1 hit.
    PROSITEiPS00599. AA_TRANSFER_CLASS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O94069-1 [UniParc]FASTAAdd to Basket

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    MESITKVSMS VCPFVRSTST QALRQLSQTS GALANQARQC PIAGNAIRAK    50
    EISIRSYSSA TKPVRATAAT PSTPEATFNV SSSFELGSKE TAFDYNGYLG 100
    NELEKKRSDK SYRYFNNINR LANEFPKAHR TQEEDKVTVW CSNDYLGMGK 150
    NENTLKEMKR VLDKYGSGAG GTRNIAGHNS HAIKLESELA ALHKHDAALV 200
    FSSCFVANDA VLSLLGQKIK DLVIFSDELN HASMIQGIRN SRARKHIFKH 250
    NNLADLESKL AQYPKSTPKL IAFESVYSMC GSIAPIEAIC DLAEKYGALT 300
    FLDEVHAVGM YGPHGAGVAE HLNFEAHLKS GIERPEITTV MSRVDMVTGT 350
    LGKAYGVVGG YITGKTNLID WFRSYAPGFI FTTSLPPAIM AGCSASIRYQ 400
    RATLKDRIAQ QKNTRLVKNN LNELGIPVIP NPSHIVPVLV GNAADAKRAS 450
    DLLLNKHDIY VQAINFPTVP IGEERLRITP TPGHGPELSK QLVEAVDSVF 500
    TELNLNRIND WKKLGGLVGV GVEGAAKVEH IWTEEQLALT DADLNPNVVN 550
    PAISPLDVSS GIST 564
    Length:564
    Mass (Da):61,395
    Last modified:May 1, 1999 - v1
    Checksum:iC984334068F40487
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL033503 Genomic DNA. Translation: CAA22025.1.
    AACQ01000044 Genomic DNA. Translation: EAK99337.1.
    PIRiT18251.
    RefSeqiXP_718266.1. XM_713173.1.

    Genome annotation databases

    GeneIDi3640149.
    KEGGical:CaO19.2601.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL033503 Genomic DNA. Translation: CAA22025.1 .
    AACQ01000044 Genomic DNA. Translation: EAK99337.1 .
    PIRi T18251.
    RefSeqi XP_718266.1. XM_713173.1.

    3D structure databases

    ProteinModelPortali O94069.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5476.CAL0003351.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 3640149.
    KEGGi cal:CaO19.2601.

    Organism-specific databases

    CGDi CAL0003351. HEM1.

    Phylogenomic databases

    eggNOGi COG0156.
    KOi K00643.
    OrthoDBi EOG7HHX1P.

    Enzyme and pathway databases

    UniPathwayi UPA00251 ; UER00375 .

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    InterProi IPR010961. 4pyrrol_synth_NH2levulA_synth.
    IPR001917. Aminotrans_II_pyridoxalP_BS.
    IPR004839. Aminotransferase_I/II.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    Pfami PF00155. Aminotran_1_2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 1 hit.
    TIGRFAMsi TIGR01821. 5aminolev_synth. 1 hit.
    PROSITEi PS00599. AA_TRANSFER_CLASS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Candida albicans strain 1161 genome pilot sequencing project."
      Murphy L., Harris D., Barrell B.G., Rajandream M.A.
      Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 1161.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SC5314 / ATCC MYA-2876.

    Entry informationi

    Entry nameiHEM1_CANAL
    AccessioniPrimary (citable) accession number: O94069
    Secondary accession number(s): Q5A965
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 97 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Candida albicans
      Candida albicans: entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3