O94038 (ADH2_CANAL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Alcohol dehydrogenase 2
EC=1.1.1.1

Gene names

Name:	ADH2
ORF Names:	Ca41C10.04, CaO19.5113, CaO19.12579

Organism

Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)

Taxonomic identifier

237561 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida

Protein attributes

Sequence length	348 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Catalytic activity	An alcohol + NAD+ = an aldehyde or ketone + NADH.
Cofactor	Binds 2 zinc ions per subunit By similarity.
Subunit structure	Homotetramer By similarity.
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the zinc-containing alcohol dehydrogenase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Metal-binding NAD Zinc
Molecular function	Oxidoreductase
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell soluble fraction Inferred from direct assay. Source: CGD
Molecular function	alcohol dehydrogenase (NAD) activity Inferred from electronic annotation. Source: EC nucleotide binding Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 348	348	Alcohol dehydrogenase 2		PRO_0000160718
Regions
	Nucleotide binding	178 – 184	7	NAD By similarity
	Nucleotide binding	269 – 271	3	NAD By similarity
Sites
	Metal binding	44	1	Zinc 1; catalytic By similarity
	Metal binding	67	1	Zinc 1; catalytic By similarity
	Metal binding	98	1	Zinc 2 By similarity
	Metal binding	101	1	Zinc 2 By similarity
	Metal binding	104	1	Zinc 2 By similarity
	Metal binding	112	1	Zinc 2 By similarity
	Metal binding	154	1	Zinc 1; catalytic By similarity
	Binding site	202	1	NAD By similarity
	Binding site	207	1	NAD By similarity
	Binding site	341	1	NAD By similarity

Sequences

	Sequence		Length	Mass (Da)
	O94038 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: 3D6E67538522ADCF	FASTA	348	36,807
	10 20 30 40 50 60 MSVPTTQKAV IFETNGGKLE YKDIPVPKPK ANELLINVKY SGVCHTDLHA WKGDWPLATK 70 80 90 100 110 120 LPLVGGHEGA GVVVALGENV KGWKVGDYAG VKWLNGSCLN CEYCQSGAEP NCAEADLSGY 130 140 150 160 170 180 THDGSFQQYA TADAVQAARI PAGTDLANVA PILCAGVTVY KALKTAELEA GQWVAISGAA 190 200 210 220 230 240 GGLGSLAVQY AKAMGYRVLA IDGGEDKGEF VKSLGAETFI DFTKEKDVVE AVKKATNGGP 250 260 270 280 290 300 HGVINVSVSE RAIGQSTEYV RTLGKVVLVG LPAGAKISTP VFDAVIKTIQ IKGSYVGNRK 310 320 330 340 DTAEAVDFFT RGLIKCPIKI VGLSELPEVY KLMEEGKILG RYVLDNDK

References

[1]	"Candida albicans strain 1161 genome pilot sequencing project." Taylor K., Harris D., Barrell B.G., Rajandream M.A. Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 1161.
[2]	"The diploid genome sequence of Candida albicans." Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S. Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed: 15123810] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SC5314 / ATCC MYA-2876.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL033501 Genomic DNA. Translation: CAA21988.1. AACQ01000053 Genomic DNA. Translation: EAK98611.1. AACQ01000052 Genomic DNA. Translation: EAK98687.1.
PIR	T18230.
RefSeq	XP_717575.1. XM_712482.1. XP_717649.1. XM_712556.1.
3D structure databases
ProteinModelPortal	O94038.
SMR	O94038. Positions 2-348.
ModBase	Search...
Protein-protein interaction databases
STRING	O94038.
2D gel databases
COMPLUYEAST-2DPAGE	O94038.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3640751. 3640833.
KEGG	cal:CaO19.12579. cal:CaO19.5113.
Organism-specific databases
CGD	CAL0002509. ADH2.
Phylogenomic databases
OMA	KSNESNC.
PhylomeDB	O94038.
Family and domain databases
InterPro	IPR013149. ADH_C. IPR013154. ADH_GroES-like. IPR002085. ADH_SF_Zn-type. IPR002328. ADH_Zn_CS. IPR011032. GroES-like. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K13953.
PANTHER	PTHR11695. ADH_Sf_Zn. 1 hit.
Pfam	PF08240. ADH_N. 1 hit. PF00107. ADH_zinc_N. 1 hit. [Graphical view]
SUPFAM	SSF50129. GroES_like. 1 hit.
PROSITE	PS00059. ADH_ZINC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ADH2_CANAL

Accession

Primary (citable) accession number: O94038
Secondary accession number(s): Q5A749

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 26, 2001
Last sequence update:	May 1, 1999
Last modified:	January 25, 2012
This is version 72 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program