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Protein

Alcohol dehydrogenase 2

Gene

ADH2

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

An alcohol + NAD+ = an aldehyde or ketone + NADH.

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi44Zinc 1; catalyticBy similarity1
Metal bindingi67Zinc 1; catalyticBy similarity1
Metal bindingi98Zinc 2By similarity1
Metal bindingi101Zinc 2By similarity1
Metal bindingi104Zinc 2By similarity1
Metal bindingi112Zinc 2By similarity1
Metal bindingi154Zinc 1; catalyticBy similarity1
Binding sitei202NADBy similarity1
Binding sitei207NADBy similarity1
Binding sitei341NADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi178 – 184NADBy similarity7
Nucleotide bindingi269 – 271NADBy similarity3

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, NAD, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase 2 (EC:1.1.1.1)
Gene namesi
Name:ADH2
Ordered Locus Names:CAALFM_C108330CA
ORF Names:Ca41C10.04, CaO19.12579, CaO19.5113
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
Proteomesi
  • UP000000559 Componenti: Chromosome 1

Organism-specific databases

CGDiCAL0000200753. ADH2.

Subcellular locationi

GO - Cellular componenti

  • biofilm matrix Source: CGD
  • cytoplasm Source: UniProtKB-SubCell

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001607181 – 348Alcohol dehydrogenase 2Add BLAST348

Proteomic databases

PRIDEiO94038.

2D gel databases

COMPLUYEAST-2DPAGEiO94038.

Interactioni

Subunit structurei

Homotetramer.By similarity

Structurei

3D structure databases

ProteinModelPortaliO94038.
SMRiO94038.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

InParanoidiO94038.
KOiK13953.
OrthoDBiEOG092C2Q8E.

Family and domain databases

InterProiView protein in InterPro
IPR013149. ADH_C.
IPR013154. ADH_N.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
IPR020843. PKS_ER.
PfamiView protein in Pfam
PF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
SMARTiView protein in SMART
SM00829. PKS_ER. 1 hit.
SUPFAMiSSF50129. SSF50129. 1 hit.
SSF51735. SSF51735. 1 hit.
PROSITEiView protein in PROSITE
PS00059. ADH_ZINC. 1 hit.

Sequencei

Sequence statusi: Complete.

O94038-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVPTTQKAV IFETNGGKLE YKDIPVPKPK ANELLINVKY SGVCHTDLHA
60 70 80 90 100
WKGDWPLATK LPLVGGHEGA GVVVALGENV KGWKVGDYAG VKWLNGSCLN
110 120 130 140 150
CEYCQSGAEP NCAEADLSGY THDGSFQQYA TADAVQAARI PAGTDLANVA
160 170 180 190 200
PILCAGVTVY KALKTAELEA GQWVAISGAA GGLGSLAVQY AKAMGYRVLA
210 220 230 240 250
IDGGEDKGEF VKSLGAETFI DFTKEKDVVE AVKKATNGGP HGVINVSVSE
260 270 280 290 300
RAIGQSTEYV RTLGKVVLVG LPAGAKISTP VFDAVIKTIQ IKGSYVGNRK
310 320 330 340
DTAEAVDFFT RGLIKCPIKI VGLSELPEVY KLMEEGKILG RYVLDNDK
Length:348
Mass (Da):36,807
Last modified:May 1, 1999 - v1
Checksum:i3D6E67538522ADCF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL033501 Genomic DNA. Translation: CAA21988.1.
CP017623 Genomic DNA. Translation: AOW26471.1.
PIRiT18230.
RefSeqiXP_717649.1. XM_712556.2.

Genome annotation databases

GeneIDi3640751.
KEGGical:CAALFM_C108330CA.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiADH2_CANAL
AccessioniPrimary (citable) accession number: O94038
Secondary accession number(s): A0A1D8PED4, Q5A749
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: May 1, 1999
Last modified: June 7, 2017
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families