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Reviewed, UniProtKB/Swiss-Prot O94038 (ADH2_CANAL)

Last modified June 16, 2009. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Alcohol dehydrogenase 2
    EC=1.1.1.1
Gene names
Name: ADH2
ORF Names: Ca41C10.04, CaO19.5113, CaO19.12579
OrganismCandida albicans (Yeast)
Taxonomic identifier5476 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida

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Protein attributes

Sequence length348 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

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General annotation (Comments)

Catalytic activity

An alcohol + NAD+ = an aldehyde or ketone + NADH.

Cofactor

Binds 2 zinc ions per subunit By similarity.

Subunit structure

Homotetramer By similarity.

Subcellular location

Cytoplasm Probable.

Sequence similarities

Belongs to the zinc-containing alcohol dehydrogenase family.

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Ontologies

Keywords
   Cellular componentCytoplasm
   LigandMetal-binding
NAD
Zinc
   Molecular functionOxidoreductase
Gene Ontology (GO)
   Biological processoxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionalcohol dehydrogenase activity

Inferred from electronic annotation. Source: EC

zinc ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 348348Alcohol dehydrogenase 2
PRO_0000160718

Regions

Nucleotide binding178 – 1847NAD By similarity
Nucleotide binding269 – 2713NAD By similarity

Sites

Metal binding441Zinc 1; catalytic By similarity
Metal binding671Zinc 1; catalytic By similarity
Metal binding981Zinc 2 By similarity
Metal binding1011Zinc 2 By similarity
Metal binding1041Zinc 2 By similarity
Metal binding1121Zinc 2 By similarity
Metal binding1541Zinc 1; catalytic By similarity
Binding site2021NAD By similarity
Binding site2071NAD By similarity
Binding site3411NAD By similarity

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Sequences

Sequence LengthMass (Da)Tools
O94038-1 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: 3D6E67538522ADCF

FASTA34836,807
        10         20         30         40         50         60 
MSVPTTQKAV IFETNGGKLE YKDIPVPKPK ANELLINVKY SGVCHTDLHA WKGDWPLATK 

        70         80         90        100        110        120 
LPLVGGHEGA GVVVALGENV KGWKVGDYAG VKWLNGSCLN CEYCQSGAEP NCAEADLSGY 

       130        140        150        160        170        180 
THDGSFQQYA TADAVQAARI PAGTDLANVA PILCAGVTVY KALKTAELEA GQWVAISGAA 

       190        200        210        220        230        240 
GGLGSLAVQY AKAMGYRVLA IDGGEDKGEF VKSLGAETFI DFTKEKDVVE AVKKATNGGP 

       250        260        270        280        290        300 
HGVINVSVSE RAIGQSTEYV RTLGKVVLVG LPAGAKISTP VFDAVIKTIQ IKGSYVGNRK 

       310        320        330        340 
DTAEAVDFFT RGLIKCPIKI VGLSELPEVY KLMEEGKILG RYVLDNDK

« Hide

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References

[1]"Candida albicans strain 1161 genome pilot sequencing project."
Taylor K., Harris D., Barrell B.G., Rajandream M.A.
Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 1161.
[2]"The diploid genome sequence of Candida albicans."
Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S.
Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed: 15123810] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SC5314.

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Cross-references

Sequence databases

AL033501 Genomic DNA. Translation: CAA21988.1.
AACQ01000053 Genomic DNA. Translation: EAK98611.1.
AACQ01000052 Genomic DNA. Translation: EAK98687.1.
PIRT18230.
RefSeqXP_717575.1.
XP_717649.1.

3D structure databases

HSSPHSSP built from PDB template 1JVB based on UniProtKB P39462.
SMRO94038. Positions 2-348.
ModBaseSearch...

Genome annotation databases

GeneID3640751.
3640833.

Organism-specific databases

CGDCAL0002509. ADH2.

Phylogenomic databases

OMAO94038. TEGGPHG.

Enzyme and pathway databases

BRENDA1.1.1.1. 1124.

Family and domain databases

InterProIPR013154. ADH_GroES-like.
IPR002085. ADH_SF_Zn.
IPR013149. ADH_Zn-bd.
IPR002328. ADH_Zn_CS.
[Graphical view]
PANTHERPTHR11695. ADH_Sf_Zn. 1 hit.
PfamPF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view]
PROSITEPS00059. ADH_ZINC. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameADH2_CANAL
AccessionPrimary (citable) accession number: O94038
Secondary accession number(s): Q5A749
Entry history
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: May 1, 1999
Last modified: June 16, 2009
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectFPAP (Fungal Proteome Annotation Project)

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Relevant documents

Candida albicans

Candida albicans: entries and gene names

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents