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O93939

- EXG1_HANAN

UniProt

O93939 - EXG1_HANAN

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Protein
Glucan 1,3-beta-glucosidase 1
Gene
EXG1
Organism
Hansenula anomala (Yeast) (Candida pelliculosa)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Beta-glucanases participate in the metabolism of beta-glucan, the main structural component of the cell wall. It could also function biosynthetically as a transglycosylase By similarity.

Catalytic activityi

Successive hydrolysis of beta-D-glucose units from the non-reducing ends of (1->3)-beta-D-glucans, releasing alpha-glucose.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei218 – 2181Proton donor By similarity
Active sitei341 – 3411Nucleophile By similarity

GO - Molecular functioni

  1. glucan exo-1,3-beta-glucosidase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Cell wall biogenesis/degradation

Protein family/group databases

CAZyiGH5. Glycoside Hydrolase Family 5.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucan 1,3-beta-glucosidase 1 (EC:3.2.1.58)
Alternative name(s):
Exo-1,3-beta-glucanase 1
Gene namesi
Name:EXG1
OrganismiHansenula anomala (Yeast) (Candida pelliculosa)
Taxonomic identifieri4927 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesPhaffomycetaceaeWickerhamomyces

Subcellular locationi

Secreted Reviewed prediction

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818 Reviewed prediction
Add
BLAST
Chaini19 – 498480Glucan 1,3-beta-glucosidase 1
PRO_0000007882Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi349 ↔ 394 By similarity

Keywords - PTMi

Disulfide bond, Zymogen

Structurei

3D structure databases

ProteinModelPortaliO93939.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
InterProiIPR001547. Glyco_hydro_5.
IPR018087. Glyco_hydro_5_CS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF00150. Cellulase. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.
PROSITEiPS00659. GLYCOSYL_HYDROL_F5. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O93939-1 [UniParc]FASTAAdd to Basket

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MLFNILILSA LSLQLCTCFH IKRNLNGSND VIWDYYDDSK KVQGVSLGGW    50
FVLEPYITPS LFEQFGEDEK KIPVDEYTFT EQLGKDEAQK QLDKHWATYF 100
TESDFKDIKD YGLNLVRIPI GYWAFYLLED DPYVQGQEPY LDKALEWAKQ 150
NDLKVWIDLH GVPGSQNGFD NSGKRGNVTW QDDEENIELS YKTLNYIFGK 200
YGGENLTDTV IGIEIVNEPF HSKLNETDML DFYYNSYYDF RIKHNSRNFF 250
LIQEAFEPIG FWNTHLNNDY TNVSKPFLND ELLEEGVPKN YFHDIVLDHH 300
HYEVFSVDQL DKSENARIQD IKNYGESVAK EQEYHPSLVG EWSGAITDCA 350
KWLNGVGTGA RYDGTFDESQ LVRTNAINGT AESQFKFKDK KRSCENVTFV 400
EDFSKQHKEN IRKFIEIQLL TYENSNSGWI FWNYKTENAI EWDFKKLVEH 450
KLFPHPFNEY KYFYENGTQI VESAASGNPQ NLLFITLSAL LVSLSTLL 498
Length:498
Mass (Da):58,063
Last modified:May 1, 1999 - v1
Checksum:i04B129CAD6ED6D31
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ002195 Genomic DNA. Translation: CAA05243.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ002195 Genomic DNA. Translation: CAA05243.1 .

3D structure databases

ProteinModelPortali O93939.
ModBasei Search...

Protein family/group databases

CAZyi GH5. Glycoside Hydrolase Family 5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.20.20.80. 1 hit.
InterProi IPR001547. Glyco_hydro_5.
IPR018087. Glyco_hydro_5_CS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
Pfami PF00150. Cellulase. 1 hit.
[Graphical view ]
SUPFAMi SSF51445. SSF51445. 1 hit.
PROSITEi PS00659. GLYCOSYL_HYDROL_F5. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Preliminary study of exo-beta-1,3-glucanase genes in relation to the protective activity of Pichia anomala (strain K) against Botrytis cinerea on postharvest apples."
    Grevesse C., Jijakli M.H., Duterme O., Colinet D., Lepoivre P.
    Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: K.

Entry informationi

Entry nameiEXG1_HANAN
AccessioniPrimary (citable) accession number: O93939
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: May 1, 1999
Last modified: October 16, 2013
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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