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O93934 (DHE4_BOTFU) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NADP-specific glutamate dehydrogenase

Short name=NADP-GDH
EC=1.4.1.4
Alternative name(s):
NADP-dependent glutamate dehydrogenase
Gene names
Name:gdhA
OrganismBotryotinia fuckeliana (Noble rot fungus) (Botrytis cinerea)
Taxonomic identifier40559 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaLeotiomycetesHelotialesSclerotiniaceaeBotrytis

Protein attributes

Sequence length450 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

L-glutamate + H2O + NADP+ = 2-oxoglutarate + NH3 + NADPH.

Subunit structure

Homohexamer By similarity.

Sequence similarities

Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

Ontologies

Keywords
   LigandNADP
   Molecular functionOxidoreductase
Gene Ontology (GO)
   Biological_processcellular amino acid metabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functionglutamate dehydrogenase (NADP+) activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 450450NADP-specific glutamate dehydrogenase
PRO_0000182784

Sites

Active site1141 By similarity

Sequences

Sequence LengthMass (Da)Tools
O93934 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: 6EDAFAB75B03C93A

FASTA45049,044
        10         20         30         40         50         60 
MSNLPSEPEF EQAYNELAST LENSTLFEKN PEYRTALKVV SIPERVIQFR VVWEDDKNQV 

        70         80         90        100        110        120 
QVNRGYRVQF NSALGPYKGG LRFHPTVNLS VLKFLGFEQI FKNALTGLNI GGGKGGADFD 

       130        140        150        160        170        180 
PKGKSDNEIR RFCVSFMREL SKHIGADTDV PAGDINVGGR EIGFLFGAYK AIQNKWEGVL 

       190        200        210        220        230        240 
TGKGGSWGGS LIRPEATGYG LVYYVAHMIQ YAGQGSFQGK RVAISGSGNV AQYAALKCIE 

       250        260        270        280        290        300 
LGATVVSLSD SQGSLIAEGD AYFTPEDVGK IAELKLKRQS LTAFEHGGKY KYIEGSRPWT 

       310        320        330        340        350        360 
HVKVDVALPC ATQNEVSKEE AESLVASGAR YIAEGSNMGC TQEAIDVFEA ERKEKKDKAI 

       370        380        390        400        410        420 
WYAPGKAANA GGVAVSGLEM AQNSARISWT QEEVDEKLKD IMKNAFETGL ETPKKYVEAK 

       430        440        450 
DGEYPSLVAG SNIAGFVKVA SAMHNHGDWW 

« Hide

References

[1]"Cloning and regulation of the gdhA gene from Botrytis cinerea."
Santos M.
Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 2850.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF109684 Genomic DNA. Translation: AAC95390.1.

3D structure databases

ProteinModelPortalO93934.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEO93934.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.40.50.720. 1 hit.
InterProIPR006095. Glu/Leu/Phe/Val_DH.
IPR006096. Glu/Leu/Phe/Val_DH_C.
IPR006097. Glu/Leu/Phe/Val_DH_dimer_dom.
IPR014362. Glu_DH.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamPF00208. ELFV_dehydrog. 1 hit.
PF02812. ELFV_dehydrog_N. 1 hit.
[Graphical view]
PIRSFPIRSF000185. Glu_DH. 1 hit.
PRINTSPR00082. GLFDHDRGNASE.
SMARTSM00839. ELFV_dehydrog. 1 hit.
[Graphical view]
PROSITEPS00074. GLFV_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDHE4_BOTFU
AccessionPrimary (citable) accession number: O93934
Entry history
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: May 1, 1999
Last modified: July 9, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families