Reviewed, UniProtKB/Swiss-Prot O93919 (ADK_SCHCO)

Names and origin

Protein names

Recommended name:
    Adenosine kinase
    EC=2.7.1.20

Gene names

Name:

ADK

Organism

Schizophyllum commune (Bracket fungus)

Taxonomic identifier

5334 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Basidiomycota › Agaricomycotina › Homobasidiomycetes › Agaricomycetidae › Agaricales › Schizophyllaceae › Schizophyllum

Protein attributes

Sequence length	344 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	ATP + adenosine = ADP + AMP.
Cofactor	Magnesium By similarity.
Pathway	Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenosine 3',5'-bisphosphate: step 1/1.
Sequence similarities	Belongs to the carbohydrate kinase pfkB family.

Ontologies

Keywords
Biological process	Purine salvage
Ligand	ATP-binding Magnesium Nucleotide-binding
Molecular function	Kinase Transferase
Gene Ontology (GO)
Biological process	purine ribonucleoside salvage Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW adenosine kinase activity Inferred from electronic annotation. Source: EC magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 344	344	Adenosine kinase		PRO_0000080060
Sites
	Active site	298	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	O93919-1 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: 0870350A714E0264	FASTA	344	36,940
	10 20 30 40 50 60 MSSYKLFCMG NPLLDLQVRD GEKLLEKYGL KSNDAILAEE KHLLLYDEIV KEHEVTYVAG 70 80 90 100 110 120 GAAQNAARGA AYCLPPKSVV YTGCVGDDDL AEQLKAANKR EGLDEAYLVK KGEKTGACAV 130 140 150 160 170 180 IITGHDRSLV TTLRAAEKFE QSHLSSEAVA PLVDAVQFYY MEGYFVTHGL ASALELAGKS 190 200 210 220 230 240 AAKSKCFVLN FSAPFIPQFF MPAIQQLLPY VDIVIANESE AEAWASASGH PAPTDLAAVA 250 260 270 280 290 300 KSLAMQPKTN PARPRVVIFT HGAEETVVVN SAEPGRVRTF KVDKLAEGEI VDTNGAGDAF 310 320 330 340 AGGFLGALVA GRELDDSVEA GHKLAKISIQ QIGPQFKWPK VQIL

References

[1]	Hittinger C.T., Copeland T.K., Green A.E., Lilly W.W., Gathman A.C. Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: ATCC 44201 / CBS 340.81 / UVM 4-40 / 4-40.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF097765 mRNA. Translation: AAC69199.1.
3D structure databases
HSSP	HSSP built from PDB template 1BX4 based on UniProtKB P55263.
ModBase	Search...
Enzyme and pathway databases
BRENDA	2.7.1.20. 15239.
Family and domain databases
InterPro	IPR001805. Adenokinase. IPR011611. Carb/pur_kinase. IPR002173. Carboh/pur_kinase_PfkB_CS. [Graphical view]
PANTHER	PTHR10584:SF24. Adenokinase. 1 hit.
Pfam	PF00294. PfkB. 1 hit. [Graphical view]
PRINTS	PR00989. ADENOKINASE.
PROSITE	PS00583. PFKB_KINASES_1. False negative. PS00584. PFKB_KINASES_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ADK_SCHCO

Accession

Primary (citable) accession number: O93919

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 31, 2004
Last sequence update:	May 1, 1999
Last modified:	September 22, 2009
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)