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O93869 (GYS_NEUCR) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 97. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glycogen [starch] synthase

EC=2.4.1.11
Gene names
Name:gsy-1
ORF Names:7F4.080, NCU06687
OrganismNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) [Reference proteome]
Taxonomic identifier367110 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora

Protein attributes

Sequence length706 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan. Is believed to regulate the synthesis of glycogen.

Catalytic activity

UDP-glucose ((1->4)-alpha-D-glucosyl)(n) = UDP + ((1->4)-alpha-D-glucosyl)(n+1).

Enzyme regulation

Allosteric activation by glucose-6-phosphate, and phosphorylation by a cAMP-dependent kinase By similarity.

Pathway

Glycan biosynthesis; glycogen biosynthesis.

Sequence similarities

Belongs to the glycosyltransferase 3 family.

Ontologies

Keywords
   Biological processGlycogen biosynthesis
   Molecular functionGlycosyltransferase
Transferase
   PTMPhosphoprotein
   Technical termAllosteric enzyme
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processglycogen biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentmitochondrion

Inferred from electronic annotation. Source: EnsemblFungi

   Molecular_functionglycogen (starch) synthase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 706706Glycogen [starch] synthase
PRO_0000194772

Sites

Binding site261UDP-glucose By similarity

Sequences

Sequence LengthMass (Da)Tools
O93869 [UniParc].

Last modified November 1, 1999. Version 2.
Checksum: CDF0DB45549FF4BB

FASTA70680,907
        10         20         30         40         50         60 
MAHDNREPRE VKNHLLFEVA TEVAHRVGGI YSVLKSKAPV TTAEYGDRYT LIGPLNHQSA 

        70         80         90        100        110        120 
AVEVEELEPS NPELKATIQA MRDRGIGILY GRWLIEGAPR VLLFDTKTAY GYMNEWKTDL 

       130        140        150        160        170        180 
WNVASIPSPD NDEETNEAIV FGYLVAWFLG EFVCHEKRKA VIAHFHEWLA GVALPLTKKR 

       190        200        210        220        230        240 
QIDVTTIFTT HATLLGRYLC AGSVDFYNNL QWFDVDAEAG KRGIYHRYCI ERAAAHSCDV 

       250        260        270        280        290        300 
FTTVSHITAY ESEHLLKRKP DGVLPNGLNV TKFSAMHEFQ NLHQQNKEKI HDFVRGHFYG 

       310        320        330        340        350        360 
HYDFEPENTL YFFTAGRYEF RNKGVDMFIE SLARLNHRLK TAGSKTTVVA FIIMPAQTTS 

       370        380        390        400        410        420 
LTVEALKGQA VIKSLRDTVD VIERGIGRRI FERSVKWHEG DPLPEEKELI TSQDRVLLRR 

       430        440        450        460        470        480 
RLFAMKRHTL PPIVTHNMLN DHEDPILNQI RRVQLFNHPS DRVKIVFHPE FLSSANPVLP 

       490        500        510        520        530        540 
LDYDDFVRGT HLGVFASYYE PWGYTPAECT VMGVPSITTN LSGFGCYMEE LIENSSDYGI 

       550        560        570        580        590        600 
YIVDRRSKGV DDSVNQLTQY MFEFTQKSRR QRINQRNRTE RLSDLLDWKR MGMEYVKARQ 

       610        620        630        640        650        660 
LALRRAYPTS FNGEEEEDFI PGVEQKISRP FSVPGSPRDR TGMMTPGDFA SLQESHEGLS 

       670        680        690        700 
TEDYVAWKLP EEEDPEEYPF PLTLKQRTGP GSPLDSIQGL QLNGTR 

« Hide

References

« Hide 'large scale' references
[1]de Paula R., Terenzi H.F., Bertolini M.C.
Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
[2]"What's in the genome of a filamentous fungus? Analysis of the Neurospora genome sequence."
Mannhaupt G., Montrone C., Haase D., Mewes H.-W., Aign V., Hoheisel J.D., Fartmann B., Nyakatura G., Kempken F., Maier J., Schulte U.
Nucleic Acids Res. 31:1944-1954(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.
[3]"The genome sequence of the filamentous fungus Neurospora crassa."
Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D. expand/collapse author list , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.
Nature 422:859-868(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF056080 mRNA. Translation: AAC98780.2.
BX294020 Genomic DNA. Translation: CAD70912.1.
CM002240 Genomic DNA. Translation: ESA42591.1.
CM002240 Genomic DNA. Translation: ESA42592.1.
CM002240 Genomic DNA. Translation: ESA42593.1.
CM002240 Genomic DNA. Translation: ESA42594.1.
RefSeqXP_961002.1. XM_955909.1.
UniGeneNcr.31082.

3D structure databases

ProteinModelPortalO93869.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5141.NCU06687.1.

Protein family/group databases

CAZyGT3. Glycosyltransferase Family 3.

Proteomic databases

PRIDEO93869.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiEFNCRT00000006632; EFNCRP00000006623; EFNCRG00000006620.
GeneID3877149.
KEGGncr:NCU06687.

Phylogenomic databases

eggNOGCOG0438.
HOGENOMHOG000160890.
KOK00693.
OMAFAMKRHG.
OrthoDBEOG7QK0MF.

Enzyme and pathway databases

UniPathwayUPA00164.

Family and domain databases

InterProIPR008631. Glycogen_synth.
[Graphical view]
PANTHERPTHR10176. PTHR10176. 1 hit.
PfamPF05693. Glycogen_syn. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGYS_NEUCR
AccessionPrimary (citable) accession number: O93869
Secondary accession number(s): Q7S7N0, V5IN77
Entry history
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: November 1, 1999
Last modified: April 16, 2014
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways