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O93869

- GYS_NEUCR

UniProt

O93869 - GYS_NEUCR

Protein

Glycogen [starch] synthase

Gene

gsy-1

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 2 (01 Nov 1999)
      Previous versions | rss
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    Functioni

    Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan. Is believed to regulate the synthesis of glycogen.

    Catalytic activityi

    UDP-alpha-D-glucose + ((1->4)-alpha-D-glucosyl)(n) = UDP + ((1->4)-alpha-D-glucosyl)(n+1).

    Enzyme regulationi

    Allosteric activation by glucose-6-phosphate, and phosphorylation by a cAMP-dependent kinase.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei26 – 261UDP-glucoseBy similarity

    GO - Molecular functioni

    1. glycogen (starch) synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. glycogen biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Glycogen biosynthesis

    Enzyme and pathway databases

    UniPathwayiUPA00164.

    Protein family/group databases

    CAZyiGT3. Glycosyltransferase Family 3.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycogen [starch] synthase (EC:2.4.1.11)
    Gene namesi
    Name:gsy-1
    ORF Names:7F4.080, NCU06687
    OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
    Taxonomic identifieri367110 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
    ProteomesiUP000001805: Chromosome 2, Linkage Group V

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrion Source: EnsemblFungi

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 706706Glycogen [starch] synthasePRO_0000194772Add
    BLAST

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiO93869.

    Interactioni

    Protein-protein interaction databases

    STRINGi5141.NCU06687.1.

    Structurei

    3D structure databases

    ProteinModelPortaliO93869.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyltransferase 3 family.Curated

    Phylogenomic databases

    eggNOGiCOG0438.
    HOGENOMiHOG000160890.
    KOiK00693.
    OMAiFAMKRHG.
    OrthoDBiEOG7QK0MF.

    Family and domain databases

    InterProiIPR008631. Glycogen_synth.
    [Graphical view]
    PANTHERiPTHR10176. PTHR10176. 1 hit.
    PfamiPF05693. Glycogen_syn. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O93869-1 [UniParc]FASTAAdd to Basket

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    MAHDNREPRE VKNHLLFEVA TEVAHRVGGI YSVLKSKAPV TTAEYGDRYT    50
    LIGPLNHQSA AVEVEELEPS NPELKATIQA MRDRGIGILY GRWLIEGAPR 100
    VLLFDTKTAY GYMNEWKTDL WNVASIPSPD NDEETNEAIV FGYLVAWFLG 150
    EFVCHEKRKA VIAHFHEWLA GVALPLTKKR QIDVTTIFTT HATLLGRYLC 200
    AGSVDFYNNL QWFDVDAEAG KRGIYHRYCI ERAAAHSCDV FTTVSHITAY 250
    ESEHLLKRKP DGVLPNGLNV TKFSAMHEFQ NLHQQNKEKI HDFVRGHFYG 300
    HYDFEPENTL YFFTAGRYEF RNKGVDMFIE SLARLNHRLK TAGSKTTVVA 350
    FIIMPAQTTS LTVEALKGQA VIKSLRDTVD VIERGIGRRI FERSVKWHEG 400
    DPLPEEKELI TSQDRVLLRR RLFAMKRHTL PPIVTHNMLN DHEDPILNQI 450
    RRVQLFNHPS DRVKIVFHPE FLSSANPVLP LDYDDFVRGT HLGVFASYYE 500
    PWGYTPAECT VMGVPSITTN LSGFGCYMEE LIENSSDYGI YIVDRRSKGV 550
    DDSVNQLTQY MFEFTQKSRR QRINQRNRTE RLSDLLDWKR MGMEYVKARQ 600
    LALRRAYPTS FNGEEEEDFI PGVEQKISRP FSVPGSPRDR TGMMTPGDFA 650
    SLQESHEGLS TEDYVAWKLP EEEDPEEYPF PLTLKQRTGP GSPLDSIQGL 700
    QLNGTR 706
    Length:706
    Mass (Da):80,907
    Last modified:November 1, 1999 - v2
    Checksum:iCDF0DB45549FF4BB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF056080 mRNA. Translation: AAC98780.2.
    BX294020 Genomic DNA. Translation: CAD70912.1.
    CM002240 Genomic DNA. Translation: ESA42591.1.
    CM002240 Genomic DNA. Translation: ESA42592.1.
    CM002240 Genomic DNA. Translation: ESA42593.1.
    CM002240 Genomic DNA. Translation: ESA42594.1.
    RefSeqiXP_961002.1. XM_955909.1.
    UniGeneiNcr.31082.

    Genome annotation databases

    EnsemblFungiiEFNCRT00000006632; EFNCRP00000006623; EFNCRG00000006620.
    GeneIDi3877149.
    KEGGincr:NCU06687.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF056080 mRNA. Translation: AAC98780.2 .
    BX294020 Genomic DNA. Translation: CAD70912.1 .
    CM002240 Genomic DNA. Translation: ESA42591.1 .
    CM002240 Genomic DNA. Translation: ESA42592.1 .
    CM002240 Genomic DNA. Translation: ESA42593.1 .
    CM002240 Genomic DNA. Translation: ESA42594.1 .
    RefSeqi XP_961002.1. XM_955909.1.
    UniGenei Ncr.31082.

    3D structure databases

    ProteinModelPortali O93869.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5141.NCU06687.1.

    Protein family/group databases

    CAZyi GT3. Glycosyltransferase Family 3.

    Proteomic databases

    PRIDEi O93869.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii EFNCRT00000006632 ; EFNCRP00000006623 ; EFNCRG00000006620 .
    GeneIDi 3877149.
    KEGGi ncr:NCU06687.

    Phylogenomic databases

    eggNOGi COG0438.
    HOGENOMi HOG000160890.
    KOi K00693.
    OMAi FAMKRHG.
    OrthoDBi EOG7QK0MF.

    Enzyme and pathway databases

    UniPathwayi UPA00164 .

    Family and domain databases

    InterProi IPR008631. Glycogen_synth.
    [Graphical view ]
    PANTHERi PTHR10176. PTHR10176. 1 hit.
    Pfami PF05693. Glycogen_syn. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. de Paula R., Terenzi H.F., Bertolini M.C.
      Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
    2. "What's in the genome of a filamentous fungus? Analysis of the Neurospora genome sequence."
      Mannhaupt G., Montrone C., Haase D., Mewes H.-W., Aign V., Hoheisel J.D., Fartmann B., Nyakatura G., Kempken F., Maier J., Schulte U.
      Nucleic Acids Res. 31:1944-1954(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.
    3. "The genome sequence of the filamentous fungus Neurospora crassa."
      Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D.
      , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.
      Nature 422:859-868(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.

    Entry informationi

    Entry nameiGYS_NEUCR
    AccessioniPrimary (citable) accession number: O93869
    Secondary accession number(s): Q7S7N0, V5IN77
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 11, 2001
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 98 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Allosteric enzyme, Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3