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O93869

- GYS_NEUCR

UniProt

O93869 - GYS_NEUCR

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Protein

Glycogen [starch] synthase

Gene

gsy-1

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan. Is believed to regulate the synthesis of glycogen.

Catalytic activityi

UDP-alpha-D-glucose + ((1->4)-alpha-D-glucosyl)(n) = UDP + ((1->4)-alpha-D-glucosyl)(n+1).

Enzyme regulationi

Allosteric activation by glucose-6-phosphate, and phosphorylation by a cAMP-dependent kinase.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei26 – 261UDP-glucoseBy similarity

GO - Molecular functioni

  1. glycogen (starch) synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. glycogen biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Glycogen biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00164.

Protein family/group databases

CAZyiGT3. Glycosyltransferase Family 3.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycogen [starch] synthase (EC:2.4.1.11)
Gene namesi
Name:gsy-1
ORF Names:7F4.080, NCU06687
OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Taxonomic identifieri367110 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
ProteomesiUP000001805: Chromosome 2, Linkage Group V

Subcellular locationi

GO - Cellular componenti

  1. mitochondrion Source: EnsemblFungi
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 706706Glycogen [starch] synthasePRO_0000194772Add
BLAST

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiO93869.

Interactioni

Protein-protein interaction databases

STRINGi5141.NCU06687.1.

Structurei

3D structure databases

ProteinModelPortaliO93869.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 3 family.Curated

Phylogenomic databases

eggNOGiCOG0438.
HOGENOMiHOG000160890.
InParanoidiO93869.
KOiK00693.
OMAiFAMKRHG.
OrthoDBiEOG7QK0MF.

Family and domain databases

InterProiIPR008631. Glycogen_synth.
[Graphical view]
PANTHERiPTHR10176. PTHR10176. 1 hit.
PfamiPF05693. Glycogen_syn. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O93869-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAHDNREPRE VKNHLLFEVA TEVAHRVGGI YSVLKSKAPV TTAEYGDRYT
60 70 80 90 100
LIGPLNHQSA AVEVEELEPS NPELKATIQA MRDRGIGILY GRWLIEGAPR
110 120 130 140 150
VLLFDTKTAY GYMNEWKTDL WNVASIPSPD NDEETNEAIV FGYLVAWFLG
160 170 180 190 200
EFVCHEKRKA VIAHFHEWLA GVALPLTKKR QIDVTTIFTT HATLLGRYLC
210 220 230 240 250
AGSVDFYNNL QWFDVDAEAG KRGIYHRYCI ERAAAHSCDV FTTVSHITAY
260 270 280 290 300
ESEHLLKRKP DGVLPNGLNV TKFSAMHEFQ NLHQQNKEKI HDFVRGHFYG
310 320 330 340 350
HYDFEPENTL YFFTAGRYEF RNKGVDMFIE SLARLNHRLK TAGSKTTVVA
360 370 380 390 400
FIIMPAQTTS LTVEALKGQA VIKSLRDTVD VIERGIGRRI FERSVKWHEG
410 420 430 440 450
DPLPEEKELI TSQDRVLLRR RLFAMKRHTL PPIVTHNMLN DHEDPILNQI
460 470 480 490 500
RRVQLFNHPS DRVKIVFHPE FLSSANPVLP LDYDDFVRGT HLGVFASYYE
510 520 530 540 550
PWGYTPAECT VMGVPSITTN LSGFGCYMEE LIENSSDYGI YIVDRRSKGV
560 570 580 590 600
DDSVNQLTQY MFEFTQKSRR QRINQRNRTE RLSDLLDWKR MGMEYVKARQ
610 620 630 640 650
LALRRAYPTS FNGEEEEDFI PGVEQKISRP FSVPGSPRDR TGMMTPGDFA
660 670 680 690 700
SLQESHEGLS TEDYVAWKLP EEEDPEEYPF PLTLKQRTGP GSPLDSIQGL

QLNGTR
Length:706
Mass (Da):80,907
Last modified:November 1, 1999 - v2
Checksum:iCDF0DB45549FF4BB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF056080 mRNA. Translation: AAC98780.2.
BX294020 Genomic DNA. Translation: CAD70912.1.
CM002240 Genomic DNA. Translation: ESA42591.1.
CM002240 Genomic DNA. Translation: ESA42592.1.
CM002240 Genomic DNA. Translation: ESA42593.1.
CM002240 Genomic DNA. Translation: ESA42594.1.
RefSeqiXP_961002.1. XM_955909.1.
UniGeneiNcr.31082.

Genome annotation databases

EnsemblFungiiEFNCRT00000006632; EFNCRP00000006623; EFNCRG00000006620.
GeneIDi3877149.
KEGGincr:NCU06687.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF056080 mRNA. Translation: AAC98780.2 .
BX294020 Genomic DNA. Translation: CAD70912.1 .
CM002240 Genomic DNA. Translation: ESA42591.1 .
CM002240 Genomic DNA. Translation: ESA42592.1 .
CM002240 Genomic DNA. Translation: ESA42593.1 .
CM002240 Genomic DNA. Translation: ESA42594.1 .
RefSeqi XP_961002.1. XM_955909.1.
UniGenei Ncr.31082.

3D structure databases

ProteinModelPortali O93869.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5141.NCU06687.1.

Protein family/group databases

CAZyi GT3. Glycosyltransferase Family 3.

Proteomic databases

PRIDEi O93869.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii EFNCRT00000006632 ; EFNCRP00000006623 ; EFNCRG00000006620 .
GeneIDi 3877149.
KEGGi ncr:NCU06687.

Phylogenomic databases

eggNOGi COG0438.
HOGENOMi HOG000160890.
InParanoidi O93869.
KOi K00693.
OMAi FAMKRHG.
OrthoDBi EOG7QK0MF.

Enzyme and pathway databases

UniPathwayi UPA00164 .

Family and domain databases

InterProi IPR008631. Glycogen_synth.
[Graphical view ]
PANTHERi PTHR10176. PTHR10176. 1 hit.
Pfami PF05693. Glycogen_syn. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. de Paula R., Terenzi H.F., Bertolini M.C.
    Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "What's in the genome of a filamentous fungus? Analysis of the Neurospora genome sequence."
    Mannhaupt G., Montrone C., Haase D., Mewes H.-W., Aign V., Hoheisel J.D., Fartmann B., Nyakatura G., Kempken F., Maier J., Schulte U.
    Nucleic Acids Res. 31:1944-1954(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.
  3. "The genome sequence of the filamentous fungus Neurospora crassa."
    Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D.
    , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.
    Nature 422:859-868(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.

Entry informationi

Entry nameiGYS_NEUCR
AccessioniPrimary (citable) accession number: O93869
Secondary accession number(s): Q7S7N0, V5IN77
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: November 1, 1999
Last modified: October 29, 2014
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Allosteric enzyme, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3