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Protein

NADP-dependent mannitol dehydrogenase

Gene

mtdH

Organism
Agaricus bisporus (White button mushroom)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

D-mannitol + NADP+ = D-fructose + NADPH.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei149Substrate1
Active sitei169Proton acceptor1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi19 – 44NADP1 PublicationAdd BLAST26
Nucleotide bindingi150 – 174NADP1 PublicationAdd BLAST25

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NADP

Names & Taxonomyi

Protein namesi
Recommended name:
NADP-dependent mannitol dehydrogenase (EC:1.1.1.138)
Short name:
MtDH
Alternative name(s):
Mannitol 2-dehydrogenase [NADP(+)]
Gene namesi
Name:mtdH
OrganismiAgaricus bisporus (White button mushroom)
Taxonomic identifieri5341 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaAgaricomycetesAgaricomycetidaeAgaricalesAgaricaceaeAgaricus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000547262 – 262NADP-dependent mannitol dehydrogenaseAdd BLAST261

Interactioni

Subunit structurei

Homotetramer.1 Publication

Structurei

Secondary structure

1262
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi5 – 7Combined sources3
Beta strandi12 – 17Combined sources6
Turni18 – 20Combined sources3
Helixi22 – 33Combined sources12
Beta strandi36 – 44Combined sources9
Helixi48 – 59Combined sources12
Beta strandi63 – 67Combined sources5
Helixi73 – 86Combined sources14
Beta strandi89 – 95Combined sources7
Helixi105 – 107Combined sources3
Helixi110 – 120Combined sources11
Helixi122 – 138Combined sources17
Beta strandi142 – 147Combined sources6
Helixi150 – 152Combined sources3
Beta strandi157 – 159Combined sources3
Helixi167 – 187Combined sources21
Helixi188 – 190Combined sources3
Beta strandi192 – 199Combined sources8
Helixi205 – 209Combined sources5
Helixi212 – 220Combined sources9
Helixi230 – 233Combined sources4
Helixi234 – 241Combined sources8
Helixi243 – 245Combined sources3
Beta strandi252 – 255Combined sources4
Helixi259 – 261Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1H5QX-ray1.50A/B/C/D/E/F/G/H/I/J/K/L2-262[»]
ProteinModelPortaliO93868.
SMRiO93868.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO93868.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 2 hits.
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O93868-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPGFTISFV NKTIIVTGGN RGIGLAFTRA VAAAGANVAV IYRSAKDAVE
60 70 80 90 100
VTEKVGKEFG VKTKAYQCDV SNTDIVTKTI QQIDADLGAI SGLIANAGVS
110 120 130 140 150
VVKPATELTH EDFKFVYDVN VFGVFNTCRA VAKLWLQKQQ KGSIVVTSSM
160 170 180 190 200
SSQIINQSSL NGSLTQVFYN SSKAACSNLV KGLAAEWASA GIRVNALSPG
210 220 230 240 250
YVNTDQTAHM DKKIRDHQAS NIPLNRFAQP EEMTGQAILL LSDHATYMTG
260
GEYFIDGGQL IW
Length:262
Mass (Da):28,019
Last modified:January 23, 2007 - v3
Checksum:iD92DDC2720CE06EC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF053764 mRNA. Translation: AAC79985.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF053764 mRNA. Translation: AAC79985.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1H5QX-ray1.50A/B/C/D/E/F/G/H/I/J/K/L2-262[»]
ProteinModelPortaliO93868.
SMRiO93868.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiO93868.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 2 hits.
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMTDH_AGABI
AccessioniPrimary (citable) accession number: O93868
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 88 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.