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O93852

- ALO_CANAL

UniProt

O93852 - ALO_CANAL

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Protein
D-arabinono-1,4-lactone oxidase
Gene
ALO1, ALO, CaO19.7551
Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 5 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

D-arabinono-1,4-lactone + O2 = dehydro-D-arabinono-1,4-lactone + H2O2.

Cofactori

FAD.

Pathwayi

GO - Molecular functioni

  1. D-arabinono-1,4-lactone oxidase activity Source: CGD
  2. UDP-N-acetylmuramate dehydrogenase activity Source: InterPro
  3. flavin adenine dinucleotide binding Source: InterPro

GO - Biological processi

  1. biosynthetic process Source: InterPro
  2. cellular response to oxidative stress Source: CGD
  3. cellular response to starvation Source: CGD
  4. filamentous growth Source: CGD
  5. filamentous growth of a population of unicellular organisms Source: CGD
  6. filamentous growth of a population of unicellular organisms in response to starvation Source: CGD
  7. pathogenesis Source: CGD
  8. water-soluble vitamin metabolic process Source: CGD
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Virulence

Keywords - Ligandi

FAD, Flavoprotein

Enzyme and pathway databases

UniPathwayiUPA00771; UER00766.

Names & Taxonomyi

Protein namesi
Recommended name:
D-arabinono-1,4-lactone oxidase (EC:1.1.3.37)
Short name:
ALO
Alternative name(s):
L-galactono-gamma-lactone oxidase
Gene namesi
Name:ALO1
Synonyms:ALO
ORF Names:CaO19.7551
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida
ProteomesiUP000000559: Unassembled WGS sequence

Organism-specific databases

CGDiCAL0000083. ALO1.

Subcellular locationi

Mitochondrion membrane By similarity
Note: Membrane-embedded By similarity.

GO - Cellular componenti

  1. mitochondrial membrane Source: UniProtKB-SubCell
  2. mitochondrion Source: CGD
  3. plasma membrane Source: CGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 557557D-arabinono-1,4-lactone oxidase
PRO_0000128164Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei62 – 621Pros-8alpha-FAD histidine By similarity

Interactioni

Protein-protein interaction databases

STRINGi5476.CAL0000083.

Structurei

3D structure databases

ProteinModelPortaliO93852.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 209185FAD-binding PCMH-type
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0277.
KOiK00107.
OrthoDBiEOG7JX3CZ.

Family and domain databases

Gene3Di3.30.43.10. 1 hit.
3.30.465.10. 1 hit.
InterProiIPR007173. ALO.
IPR016169. CO_DH_flavot_FAD-bd_sub2.
IPR016166. FAD-bd_2.
IPR016167. FAD-bd_2_sub1.
IPR010031. FAD_lactone_oxidase.
IPR023595. LGO_GLO.
IPR006094. Oxid_FAD_bind_N.
IPR006093. Oxy_OxRdtase_FAD_BS.
[Graphical view]
PfamiPF04030. ALO. 1 hit.
PF01565. FAD_binding_4. 1 hit.
[Graphical view]
PIRSFiPIRSF000136. LGO_GLO. 1 hit.
SUPFAMiSSF56176. SSF56176. 1 hit.
TIGRFAMsiTIGR01678. FAD_lactone_ox. 1 hit.
PROSITEiPS51387. FAD_PCMH. 1 hit.
PS00862. OX2_COVAL_FAD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O93852-1 [UniParc]FASTAAdd to Basket

« Hide

MTDIPESLKP FVTKKVIHST WAGTFLCKPQ AIFQPRNVEE IQELIKQARL    50
HGKTIMTVGS GHSPSDLTMT TEWLCNLDKF NHVLLEEPYY APKSPTDDTP 100
EIKFVDLTVE AGTRIFELNE YLKRNNLAIQ NLGSISDQSI AGLISTGTHG 150
STQYHGLVSQ QVVSVKFLNS AGELITCSSV DKPEYFRAIL LSLGKIGIIT 200
HVTLRTCPKY TIKSKQEIIN FETLLNNWDN LWLESEFIRI WWFPYTNKCV 250
LWRANKSTDP LSDPRPSWYG TKLGRFFYES LLWVSVHLFP RLTPFVEKFV 300
FGQQYGEVET LGKGDIAVQN SVEGLNMDCL FSQFVNEWSS PLNSGPEILT 350
ELKKIITDAS QTGDFFVHAP IEVRCSNVTY SDEPFTDDKN QKSLYPSQEW 400
LSNRSKTSAG PIPGNNLRPY LDNSPKLPYS KDGKITNDQL TLFINATMYR 450
PFGTNVETHK WFQLFEDVMS KAGGKPHWAK NFIGLTQDEK YDKQQDLKTQ 500
LEFGGKPFYT MLGFKPVMQD WFGKDLVAFN KVRKETDPDG VFLSGKVWAE 550
RNGILLD 557
Length:557
Mass (Da):63,447
Last modified:May 1, 1999 - v1
Checksum:i0348233954111D92
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF031228 Genomic DNA. Translation: AAC98913.1.
AACQ01000032 Genomic DNA. Translation: EAL00425.1.
RefSeqiXP_719313.1. XM_714220.1.

Genome annotation databases

GeneIDi3638983.
KEGGical:CaO19.7551.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF031228 Genomic DNA. Translation: AAC98913.1 .
AACQ01000032 Genomic DNA. Translation: EAL00425.1 .
RefSeqi XP_719313.1. XM_714220.1.

3D structure databases

ProteinModelPortali O93852.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5476.CAL0000083.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3638983.
KEGGi cal:CaO19.7551.

Organism-specific databases

CGDi CAL0000083. ALO1.

Phylogenomic databases

eggNOGi COG0277.
KOi K00107.
OrthoDBi EOG7JX3CZ.

Enzyme and pathway databases

UniPathwayi UPA00771 ; UER00766 .

Family and domain databases

Gene3Di 3.30.43.10. 1 hit.
3.30.465.10. 1 hit.
InterProi IPR007173. ALO.
IPR016169. CO_DH_flavot_FAD-bd_sub2.
IPR016166. FAD-bd_2.
IPR016167. FAD-bd_2_sub1.
IPR010031. FAD_lactone_oxidase.
IPR023595. LGO_GLO.
IPR006094. Oxid_FAD_bind_N.
IPR006093. Oxy_OxRdtase_FAD_BS.
[Graphical view ]
Pfami PF04030. ALO. 1 hit.
PF01565. FAD_binding_4. 1 hit.
[Graphical view ]
PIRSFi PIRSF000136. LGO_GLO. 1 hit.
SUPFAMi SSF56176. SSF56176. 1 hit.
TIGRFAMsi TIGR01678. FAD_lactone_ox. 1 hit.
PROSITEi PS51387. FAD_PCMH. 1 hit.
PS00862. OX2_COVAL_FAD. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Deficiency of D-erythroascorbic acid attenuates hyphal growth and virulence of Candida albicans."
    Huh W.-K., Kim S.-T., Kim H., Jeong G., Kang S.-O.
    Infect. Immun. 69:3939-3946(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 10231 / CBS 6431 / DSM 1386 / NBRC 1594.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.

Entry informationi

Entry nameiALO_CANAL
AccessioniPrimary (citable) accession number: O93852
Secondary accession number(s): Q5ACU1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: May 1, 1999
Last modified: April 16, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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