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Protein

D-arabinono-1,4-lactone oxidase

Gene

ALO1

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-arabinono-1,4-lactone + O2 = dehydro-D-arabinono-1,4-lactone + H2O2.

Cofactori

Pathwayi: D-erythroascorbate biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes dehydro-D-arabinono-1,4-lactone from D-arabinose.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. D-arabinono-1,4-lactone oxidase (ALO1)
This subpathway is part of the pathway D-erythroascorbate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes dehydro-D-arabinono-1,4-lactone from D-arabinose, the pathway D-erythroascorbate biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

  • cellular response to oxidative stress Source: CGD
  • cellular response to starvation Source: CGD
  • filamentous growth Source: CGD
  • filamentous growth of a population of unicellular organisms Source: CGD
  • filamentous growth of a population of unicellular organisms in response to starvation Source: CGD
  • pathogenesis Source: CGD
  • water-soluble vitamin metabolic process Source: CGD

Keywordsi

Molecular functionOxidoreductase
Biological processVirulence
LigandFAD, Flavoprotein

Enzyme and pathway databases

UniPathwayiUPA00771; UER00766.

Names & Taxonomyi

Protein namesi
Recommended name:
D-arabinono-1,4-lactone oxidase (EC:1.1.3.37)
Short name:
ALO
Alternative name(s):
L-galactono-gamma-lactone oxidase
Gene namesi
Name:ALO1
Synonyms:ALO
Ordered Locus Names:CAALFM_CR09790WA
ORF Names:CaO19.7551
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
Proteomesi
  • UP000000559 Componenti: Chromosome R

Organism-specific databases

CGDiCAL0000174500. ALO1.
EuPathDBiFungiDB:CR_09790W_A.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial membrane Source: UniProtKB-SubCell
  • mitochondrion Source: CGD
  • plasma membrane Source: CGD

Keywords - Cellular componenti

Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001281641 – 557D-arabinono-1,4-lactone oxidaseAdd BLAST557

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei62Pros-8alpha-FAD histidineBy similarity1

Proteomic databases

PRIDEiO93852.

Structurei

3D structure databases

ProteinModelPortaliO93852.
SMRiO93852.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 209FAD-binding PCMH-typePROSITE-ProRule annotationAdd BLAST185

Sequence similaritiesi

Phylogenomic databases

InParanoidiO93852.
KOiK00107.
OrthoDBiEOG092C14O7.

Family and domain databases

Gene3Di3.30.43.10. 1 hit.
3.30.465.10. 1 hit.
3.40.462.10. 1 hit.
InterProiView protein in InterPro
IPR007173. ALO.
IPR016169. CO_DH_flavot_FAD-bd_sub2.
IPR016166. FAD-bd_2.
IPR016167. FAD-bd_2_sub1.
IPR010031. FAD_lactone_oxidase.
IPR006094. Oxid_FAD_bind_N.
IPR006093. Oxy_OxRdtase_FAD_BS.
IPR030654. Sugar_lactone_oxidase.
IPR016170. V_Alc_oxidase/Cytok_DH_C_dom.
PANTHERiPTHR43762. PTHR43762. 1 hit.
PfamiView protein in Pfam
PF04030. ALO. 1 hit.
PF01565. FAD_binding_4. 1 hit.
PIRSFiPIRSF000136. LGO_GLO. 1 hit.
SUPFAMiSSF56176. SSF56176. 1 hit.
TIGRFAMsiTIGR01678. FAD_lactone_ox. 1 hit.
PROSITEiView protein in PROSITE
PS51387. FAD_PCMH. 1 hit.
PS00862. OX2_COVAL_FAD. 1 hit.

Sequencei

Sequence statusi: Complete.

O93852-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDIPESLKP FVTKKVIHST WAGTFLCKPQ AIFQPRNVEE IQELIKQARL
60 70 80 90 100
HGKTIMTVGS GHSPSDLTMT TEWLCNLDKF NHVLLEEPYY APKSPTDDTP
110 120 130 140 150
EIKFVDLTVE AGTRIFELNE YLKRNNLAIQ NLGSISDQSI AGLISTGTHG
160 170 180 190 200
STQYHGLVSQ QVVSVKFLNS AGELITCSSV DKPEYFRAIL LSLGKIGIIT
210 220 230 240 250
HVTLRTCPKY TIKSKQEIIN FETLLNNWDN LWLESEFIRI WWFPYTNKCV
260 270 280 290 300
LWRANKSTDP LSDPRPSWYG TKLGRFFYES LLWVSVHLFP RLTPFVEKFV
310 320 330 340 350
FGQQYGEVET LGKGDIAVQN SVEGLNMDCL FSQFVNEWSS PLNSGPEILT
360 370 380 390 400
ELKKIITDAS QTGDFFVHAP IEVRCSNVTY SDEPFTDDKN QKSLYPSQEW
410 420 430 440 450
LSNRSKTSAG PIPGNNLRPY LDNSPKLPYS KDGKITNDQL TLFINATMYR
460 470 480 490 500
PFGTNVETHK WFQLFEDVMS KAGGKPHWAK NFIGLTQDEK YDKQQDLKTQ
510 520 530 540 550
LEFGGKPFYT MLGFKPVMQD WFGKDLVAFN KVRKETDPDG VFLSGKVWAE

RNGILLD
Length:557
Mass (Da):63,447
Last modified:May 1, 1999 - v1
Checksum:i0348233954111D92
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF031228 Genomic DNA. Translation: AAC98913.1.
CP017630 Genomic DNA. Translation: AOW31636.1.
RefSeqiXP_719313.1. XM_714220.1.

Genome annotation databases

GeneIDi3638983.
KEGGical:CAALFM_CR09790WA.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF031228 Genomic DNA. Translation: AAC98913.1.
CP017630 Genomic DNA. Translation: AOW31636.1.
RefSeqiXP_719313.1. XM_714220.1.

3D structure databases

ProteinModelPortaliO93852.
SMRiO93852.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiO93852.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3638983.
KEGGical:CAALFM_CR09790WA.

Organism-specific databases

CGDiCAL0000174500. ALO1.
EuPathDBiFungiDB:CR_09790W_A.

Phylogenomic databases

InParanoidiO93852.
KOiK00107.
OrthoDBiEOG092C14O7.

Enzyme and pathway databases

UniPathwayiUPA00771; UER00766.

Family and domain databases

Gene3Di3.30.43.10. 1 hit.
3.30.465.10. 1 hit.
3.40.462.10. 1 hit.
InterProiView protein in InterPro
IPR007173. ALO.
IPR016169. CO_DH_flavot_FAD-bd_sub2.
IPR016166. FAD-bd_2.
IPR016167. FAD-bd_2_sub1.
IPR010031. FAD_lactone_oxidase.
IPR006094. Oxid_FAD_bind_N.
IPR006093. Oxy_OxRdtase_FAD_BS.
IPR030654. Sugar_lactone_oxidase.
IPR016170. V_Alc_oxidase/Cytok_DH_C_dom.
PANTHERiPTHR43762. PTHR43762. 1 hit.
PfamiView protein in Pfam
PF04030. ALO. 1 hit.
PF01565. FAD_binding_4. 1 hit.
PIRSFiPIRSF000136. LGO_GLO. 1 hit.
SUPFAMiSSF56176. SSF56176. 1 hit.
TIGRFAMsiTIGR01678. FAD_lactone_ox. 1 hit.
PROSITEiView protein in PROSITE
PS51387. FAD_PCMH. 1 hit.
PS00862. OX2_COVAL_FAD. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiALO_CANAL
AccessioniPrimary (citable) accession number: O93852
Secondary accession number(s): A0A1D8PU25, Q5ACU1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: May 1, 1999
Last modified: June 7, 2017
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.