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O93852

- ALO_CANAL

UniProt

O93852 - ALO_CANAL

Protein

D-arabinono-1,4-lactone oxidase

Gene

ALO1

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 5 out of 5- Protein inferred from homologyi
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    D-arabinono-1,4-lactone + O2 = dehydro-D-arabinono-1,4-lactone + H2O2.

    Cofactori

    FAD.

    Pathwayi

    GO - Molecular functioni

    1. D-arabinono-1,4-lactone oxidase activity Source: CGD
    2. flavin adenine dinucleotide binding Source: InterPro
    3. UDP-N-acetylmuramate dehydrogenase activity Source: InterPro

    GO - Biological processi

    1. biosynthetic process Source: InterPro
    2. cellular response to oxidative stress Source: CGD
    3. cellular response to starvation Source: CGD
    4. filamentous growth Source: CGD
    5. filamentous growth of a population of unicellular organisms Source: CGD
    6. filamentous growth of a population of unicellular organisms in response to starvation Source: CGD
    7. pathogenesis Source: CGD
    8. water-soluble vitamin metabolic process Source: CGD

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Virulence

    Keywords - Ligandi

    FAD, Flavoprotein

    Enzyme and pathway databases

    UniPathwayiUPA00771; UER00766.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    D-arabinono-1,4-lactone oxidase (EC:1.1.3.37)
    Short name:
    ALO
    Alternative name(s):
    L-galactono-gamma-lactone oxidase
    Gene namesi
    Name:ALO1
    Synonyms:ALO
    ORF Names:CaO19.7551
    OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
    Taxonomic identifieri237561 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida
    ProteomesiUP000000559: Unassembled WGS sequence

    Organism-specific databases

    CGDiCAL0000083. ALO1.

    Subcellular locationi

    Mitochondrion membrane By similarity
    Note: Membrane-embedded.By similarity

    GO - Cellular componenti

    1. mitochondrial membrane Source: UniProtKB-SubCell
    2. mitochondrion Source: CGD
    3. plasma membrane Source: CGD

    Keywords - Cellular componenti

    Membrane, Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 557557D-arabinono-1,4-lactone oxidasePRO_0000128164Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei62 – 621Pros-8alpha-FAD histidineBy similarity

    Interactioni

    Protein-protein interaction databases

    STRINGi5476.CAL0000083.

    Structurei

    3D structure databases

    ProteinModelPortaliO93852.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini25 – 209185FAD-binding PCMH-typePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 FAD-binding PCMH-type domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0277.
    KOiK00107.
    OrthoDBiEOG7JX3CZ.

    Family and domain databases

    Gene3Di3.30.43.10. 1 hit.
    3.30.465.10. 1 hit.
    InterProiIPR007173. ALO.
    IPR016169. CO_DH_flavot_FAD-bd_sub2.
    IPR016166. FAD-bd_2.
    IPR016167. FAD-bd_2_sub1.
    IPR010031. FAD_lactone_oxidase.
    IPR023595. LGO_GLO.
    IPR006094. Oxid_FAD_bind_N.
    IPR006093. Oxy_OxRdtase_FAD_BS.
    [Graphical view]
    PfamiPF04030. ALO. 1 hit.
    PF01565. FAD_binding_4. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000136. LGO_GLO. 1 hit.
    SUPFAMiSSF56176. SSF56176. 1 hit.
    TIGRFAMsiTIGR01678. FAD_lactone_ox. 1 hit.
    PROSITEiPS51387. FAD_PCMH. 1 hit.
    PS00862. OX2_COVAL_FAD. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O93852-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTDIPESLKP FVTKKVIHST WAGTFLCKPQ AIFQPRNVEE IQELIKQARL    50
    HGKTIMTVGS GHSPSDLTMT TEWLCNLDKF NHVLLEEPYY APKSPTDDTP 100
    EIKFVDLTVE AGTRIFELNE YLKRNNLAIQ NLGSISDQSI AGLISTGTHG 150
    STQYHGLVSQ QVVSVKFLNS AGELITCSSV DKPEYFRAIL LSLGKIGIIT 200
    HVTLRTCPKY TIKSKQEIIN FETLLNNWDN LWLESEFIRI WWFPYTNKCV 250
    LWRANKSTDP LSDPRPSWYG TKLGRFFYES LLWVSVHLFP RLTPFVEKFV 300
    FGQQYGEVET LGKGDIAVQN SVEGLNMDCL FSQFVNEWSS PLNSGPEILT 350
    ELKKIITDAS QTGDFFVHAP IEVRCSNVTY SDEPFTDDKN QKSLYPSQEW 400
    LSNRSKTSAG PIPGNNLRPY LDNSPKLPYS KDGKITNDQL TLFINATMYR 450
    PFGTNVETHK WFQLFEDVMS KAGGKPHWAK NFIGLTQDEK YDKQQDLKTQ 500
    LEFGGKPFYT MLGFKPVMQD WFGKDLVAFN KVRKETDPDG VFLSGKVWAE 550
    RNGILLD 557
    Length:557
    Mass (Da):63,447
    Last modified:May 1, 1999 - v1
    Checksum:i0348233954111D92
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF031228 Genomic DNA. Translation: AAC98913.1.
    AACQ01000032 Genomic DNA. Translation: EAL00425.1.
    RefSeqiXP_719313.1. XM_714220.1.

    Genome annotation databases

    GeneIDi3638983.
    KEGGical:CaO19.7551.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF031228 Genomic DNA. Translation: AAC98913.1 .
    AACQ01000032 Genomic DNA. Translation: EAL00425.1 .
    RefSeqi XP_719313.1. XM_714220.1.

    3D structure databases

    ProteinModelPortali O93852.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5476.CAL0000083.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 3638983.
    KEGGi cal:CaO19.7551.

    Organism-specific databases

    CGDi CAL0000083. ALO1.

    Phylogenomic databases

    eggNOGi COG0277.
    KOi K00107.
    OrthoDBi EOG7JX3CZ.

    Enzyme and pathway databases

    UniPathwayi UPA00771 ; UER00766 .

    Family and domain databases

    Gene3Di 3.30.43.10. 1 hit.
    3.30.465.10. 1 hit.
    InterProi IPR007173. ALO.
    IPR016169. CO_DH_flavot_FAD-bd_sub2.
    IPR016166. FAD-bd_2.
    IPR016167. FAD-bd_2_sub1.
    IPR010031. FAD_lactone_oxidase.
    IPR023595. LGO_GLO.
    IPR006094. Oxid_FAD_bind_N.
    IPR006093. Oxy_OxRdtase_FAD_BS.
    [Graphical view ]
    Pfami PF04030. ALO. 1 hit.
    PF01565. FAD_binding_4. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000136. LGO_GLO. 1 hit.
    SUPFAMi SSF56176. SSF56176. 1 hit.
    TIGRFAMsi TIGR01678. FAD_lactone_ox. 1 hit.
    PROSITEi PS51387. FAD_PCMH. 1 hit.
    PS00862. OX2_COVAL_FAD. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Deficiency of D-erythroascorbic acid attenuates hyphal growth and virulence of Candida albicans."
      Huh W.-K., Kim S.-T., Kim H., Jeong G., Kang S.-O.
      Infect. Immun. 69:3939-3946(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 10231 / CBS 6431 / DSM 1386 / NBRC 1594.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SC5314 / ATCC MYA-2876.

    Entry informationi

    Entry nameiALO_CANAL
    AccessioniPrimary (citable) accession number: O93852
    Secondary accession number(s): Q5ACU1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 14, 2001
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 91 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Candida albicans
      Candida albicans: entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3